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Intraneural perineurioma

MedGen UID:
237162
Concept ID:
C1370658
Neoplastic Process
Synonyms: Intraneural Perineurioma; intraneural perineurioma; Intraneural Perineurioma (WHO Grade I); intraneural perineurioma (WHO grade I)
SNOMED CT: Intraneural perineurioma (768934004)
 
Monarch Initiative: MONDO:0015032
Orphanet: ORPHA100003

Definition

A rare tumor of cranial and spinal nerves arising from peripheral nerve sheath and composed exclusively or predominantly of cells showing perineurial differentiation. It presents as a localized, tubular or fusiform enlargement of a nerve or nerve segment, usually in the extremities or the trunk, associated with a motor-predominant mononeuropathy including slow, painless, gradual loss of motor function in the involved nerve trunk with muscle weakness and atrophy and, rarely, sensory dysfunction. Cranial nerve involvement is rare. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIntraneural perineurioma
Follow this link to review classifications for Intraneural perineurioma in Orphanet.

Professional guidelines

PubMed

Espinoza DP, Kalbermatten DF, Egloff DV, Raffoul W
Scand J Plast Reconstr Surg Hand Surg 2010 Feb;44(1):12-6. doi: 10.3109/02844310903351335. PMID: 20136464

Recent clinical studies

Etiology

Brand C, Pedro MT, Pala A, Heinen C, Scheuerle A, Braun M, Antoniadis G
J Neurol Surg A Cent Eur Neurosurg 2022 Jan;83(1):1-5. Epub 2021 May 24 doi: 10.1055/s-0041-1726110. PMID: 34030186
Wilson TJ, Amrami KK, Howe BM, Spinner RJ
Neurosurgery 2019 Dec 1;85(6):786-792. doi: 10.1093/neuros/nyy476. PMID: 30481319
Alkhaili J, Cambon-Binder A, Belkheyar Z
Pan Afr Med J 2018;30:275. Epub 2018 Aug 14 doi: 10.11604/pamj.2018.30.275.16072. PMID: 30637060Free PMC Article
Wilson TJ, Howe BM, Stewart SA, Spinner RJ, Amrami KK
J Neurosurg 2018 Oct;129(4):1034-1040. Epub 2017 Dec 1 doi: 10.3171/2017.5.JNS17905. PMID: 29192862
Restrepo CE, Amrami KK, Howe BM, Dyck PJ, Mauermann ML, Spinner RJ
Neurosurg Focus 2015 Sep;39(3):E13. doi: 10.3171/2015.6.FOCUS15225. PMID: 26323815

Diagnosis

Lenartowicz KA, Smith BW, Jack MM, Wilson TJ, Klein CJ, Amrami KK, Spinner RJ
Acta Neurochir (Wien) 2023 Nov;165(11):3539-3547. Epub 2023 Sep 9 doi: 10.1007/s00701-023-05765-6. PMID: 37684428
Prasad NK, Tubbs RS, Amrami KK, Dyck PJB, Mauermann ML, Giannini C, de Divitiis O, Spinner RJ
Neurosurgery 2017 Feb 1;80(2):226-234. doi: 10.1093/neuros/nyw028. PMID: 28173435
Restrepo CE, Amrami KK, Howe BM, Dyck PJ, Mauermann ML, Spinner RJ
Neurosurg Focus 2015 Sep;39(3):E13. doi: 10.3171/2015.6.FOCUS15225. PMID: 26323815
Woertler K
Semin Musculoskelet Radiol 2010 Nov;14(5):547-58. Epub 2010 Nov 11 doi: 10.1055/s-0030-1268073. PMID: 21072731
Lee HY, Manasseh RG, Edis RH, Page R, Keith-Rokosh J, Walsh P, Song S, Laycock A, Griffiths L, Fabian VA
J Clin Neurosci 2009 Dec;16(12):1633-6. Epub 2009 Sep 17 doi: 10.1016/j.jocn.2009.02.013. PMID: 19766004

Prognosis

Wilson TJ, Amrami KK, Howe BM, Spinner RJ
Neurosurgery 2019 Dec 1;85(6):786-792. doi: 10.1093/neuros/nyy476. PMID: 30481319
Kurihara J, Yokoo S, Ichikawa M, Shimizu T, Ogawa M, Seki M
World J Surg Oncol 2018 Sep 13;16(1):189. doi: 10.1186/s12957-018-1481-8. PMID: 30213264Free PMC Article
Wilson TJ, Howe BM, Stewart SA, Spinner RJ, Amrami KK
J Neurosurg 2018 Oct;129(4):1034-1040. Epub 2017 Dec 1 doi: 10.3171/2017.5.JNS17905. PMID: 29192862
Restrepo CE, Amrami KK, Howe BM, Dyck PJ, Mauermann ML, Spinner RJ
Neurosurg Focus 2015 Sep;39(3):E13. doi: 10.3171/2015.6.FOCUS15225. PMID: 26323815
De Smet K, De Maeseneer M, Talebian Yazdi A, Stadnik T, De Mey J
Clin Radiol 2013 Mar;68(3):317-22. Epub 2012 Sep 7 doi: 10.1016/j.crad.2012.07.014. PMID: 22959851

Clinical prediction guides

Pendleton C, Spinner RJ, Dyck PJB, Mauermann ML, Ladak A, Restrepo CE, Baheti S, Klein CJ
Acta Neurochir (Wien) 2020 Aug;162(8):1891-1897. Epub 2020 Jun 11 doi: 10.1007/s00701-020-04439-x. PMID: 32529330
Kurihara J, Yokoo S, Ichikawa M, Shimizu T, Ogawa M, Seki M
World J Surg Oncol 2018 Sep 13;16(1):189. doi: 10.1186/s12957-018-1481-8. PMID: 30213264Free PMC Article
Wilson TJ, Howe BM, Stewart SA, Spinner RJ, Amrami KK
J Neurosurg 2018 Oct;129(4):1034-1040. Epub 2017 Dec 1 doi: 10.3171/2017.5.JNS17905. PMID: 29192862
Agaimy A
Ann Diagn Pathol 2014 Apr;18(2):95-8. Epub 2013 Dec 24 doi: 10.1016/j.anndiagpath.2013.12.005. PMID: 24461704
Lee HY, Manasseh RG, Edis RH, Page R, Keith-Rokosh J, Walsh P, Song S, Laycock A, Griffiths L, Fabian VA
J Clin Neurosci 2009 Dec;16(12):1633-6. Epub 2009 Sep 17 doi: 10.1016/j.jocn.2009.02.013. PMID: 19766004

Recent systematic reviews

Lenartowicz KA, Goyal A, Mauermann ML, Wilson TJ, Spinner RJ
World Neurosurg 2021 Oct;154:120-131.e8. Epub 2021 Jul 17 doi: 10.1016/j.wneu.2021.07.042. PMID: 34284162
Uerschels AK, Krogias C, Junker A, Sure U, Wrede KH, Gembruch O
BMC Neurol 2020 Feb 13;20(1):55. doi: 10.1186/s12883-020-01637-z. PMID: 32054523Free PMC Article
Boyanton BL Jr, Jones JK, Shenaq SM, Hicks MJ, Bhattacharjee MB
Arch Pathol Lab Med 2007 Sep;131(9):1382-92. doi: 10.5858/2007-131-1382-IPASRW. PMID: 17824794

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