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Laryngopharyngeal reflux

MedGen UID:: 257909
•Concept ID:: C1168250
•: Disease or Syndrome

Synonyms:	Laryngopharyngeal Reflux; Reflux, Laryngopharyngeal
SNOMED CT:	Laryngopharyngeal reflux (414581006)

Definition

Back flow of gastric contents to the LARYNGOPHARYNX where it comes in contact with tissues of the upper aerodigestive tract. Laryngopharyngeal reflux is an extraesophageal manifestation of GASTROESOPHAGEAL REFLUX. [from MeSH]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVLaryngopharyngeal reflux

Abnormality of digestive system physiology
- Functional abnormality of the gastrointestinal tract
  - Abnormal esophagus physiology
    - Dysphagia
      - Dyskinesia of esophagus
        Gastroesophageal reflux disease
        Laryngopharyngeal reflux

Professional guidelines

PubMed

An update on current treatment strategies for laryngopharyngeal reflux symptoms.

Krause AJ, Walsh EH, Weissbrod PA, Taft TH, Yadlapati R
Ann N Y Acad Sci 2022 Apr;1510(1):5-17. Epub 2021 Dec 17 doi: 10.1111/nyas.14728. PMID: 34921412 Free PMC Article

Advances in the diagnosis and management of gastroesophageal reflux disease.

Katzka DA, Kahrilas PJ
BMJ 2020 Nov 23;371:m3786. doi: 10.1136/bmj.m3786. PMID: 33229333

Asthma in adults: Principles of treatment.

Kwah JH, Peters AT
Allergy Asthma Proc 2019 Nov 1;40(6):396-402. doi: 10.2500/aap.2019.40.4256. PMID: 31690379

See all (118)

Recent clinical studies

Etiology

How to Understand and Treat Laryngopharyngeal Reflux.

Snow G, Dhar SI, Akst LM
Gastroenterol Clin North Am 2021 Dec;50(4):871-884. Epub 2021 Oct 6 doi: 10.1016/j.gtc.2021.08.002. PMID: 34717876

Dysphagia and Swallowing Disorders.

McCarty EB, Chao TN
Med Clin North Am 2021 Sep;105(5):939-954. doi: 10.1016/j.mcna.2021.05.013. PMID: 34391544

Reinke's Edema.

Tavaluc R, Tan-Geller M
Otolaryngol Clin North Am 2019 Aug;52(4):627-635. Epub 2019 May 14 doi: 10.1016/j.otc.2019.03.006. PMID: 31101355

Laryngopharyngeal Reflux and Voice Disorders: A Multifactorial Model of Etiology and Pathophysiology.

Lechien JR, Saussez S, Harmegnies B, Finck C, Burns JA
J Voice 2017 Nov;31(6):733-752. Epub 2017 Apr 21 doi: 10.1016/j.jvoice.2017.03.015. PMID: 28438489

Nasolaryngoscopy.

Moser SE
Prim Care 2014 Mar;41(1):109-13. doi: 10.1016/j.pop.2013.10.009. PMID: 24439885

See all (884)

Diagnosis

An update on current treatment strategies for laryngopharyngeal reflux symptoms.

Krause AJ, Walsh EH, Weissbrod PA, Taft TH, Yadlapati R
Ann N Y Acad Sci 2022 Apr;1510(1):5-17. Epub 2021 Dec 17 doi: 10.1111/nyas.14728. PMID: 34921412 Free PMC Article

Dysphagia and Swallowing Disorders.

McCarty EB, Chao TN
Med Clin North Am 2021 Sep;105(5):939-954. doi: 10.1016/j.mcna.2021.05.013. PMID: 34391544

Review of management of laryngopharyngeal reflux disease.

Lechien JR, Mouawad F, Bobin F, Bartaire E, Crevier-Buchman L, Saussez S
Eur Ann Otorhinolaryngol Head Neck Dis 2021 Sep;138(4):257-267. Epub 2020 Nov 27 doi: 10.1016/j.anorl.2020.11.002. PMID: 33257265

Reinke's Edema.

Tavaluc R, Tan-Geller M
Otolaryngol Clin North Am 2019 Aug;52(4):627-635. Epub 2019 May 14 doi: 10.1016/j.otc.2019.03.006. PMID: 31101355

Airway reflux.

Johnston N, Ondrey F, Rosen R, Hurley BP, Gould J, Allen J, DelGaudio J, Altman KW
Ann N Y Acad Sci 2016 Oct;1381(1):5-13. Epub 2016 Jun 16 doi: 10.1111/nyas.13080. PMID: 27310222

See all (949)

Therapy

AGA Clinical Practice Update on the Diagnosis and Management of Extraesophageal Gastroesophageal Reflux Disease: Expert Review.

Chen JW, Vela MF, Peterson KA, Carlson DA
Clin Gastroenterol Hepatol 2023 Jun;21(6):1414-1421.e3. Epub 2023 Apr 14 doi: 10.1016/j.cgh.2023.01.040. PMID: 37061897

An update on current treatment strategies for laryngopharyngeal reflux symptoms.

Krause AJ, Walsh EH, Weissbrod PA, Taft TH, Yadlapati R
Ann N Y Acad Sci 2022 Apr;1510(1):5-17. Epub 2021 Dec 17 doi: 10.1111/nyas.14728. PMID: 34921412 Free PMC Article

Advances in the diagnosis and management of gastroesophageal reflux disease.

Katzka DA, Kahrilas PJ
BMJ 2020 Nov 23;371:m3786. doi: 10.1136/bmj.m3786. PMID: 33229333

Reinke's Edema.

Tavaluc R, Tan-Geller M
Otolaryngol Clin North Am 2019 Aug;52(4):627-635. Epub 2019 May 14 doi: 10.1016/j.otc.2019.03.006. PMID: 31101355

Pathophysiology and treatment of muscle tension dysphonia: a review of the current knowledge.

Van Houtte E, Van Lierde K, Claeys S
J Voice 2011 Mar;25(2):202-7. Epub 2010 Apr 18 doi: 10.1016/j.jvoice.2009.10.009. PMID: 20400263

See all (485)

Prognosis

AGA Clinical Practice Update on the Diagnosis and Management of Extraesophageal Gastroesophageal Reflux Disease: Expert Review.

Chen JW, Vela MF, Peterson KA, Carlson DA
Clin Gastroenterol Hepatol 2023 Jun;21(6):1414-1421.e3. Epub 2023 Apr 14 doi: 10.1016/j.cgh.2023.01.040. PMID: 37061897

Laryngopharyngeal Reflux and Voice Disorders: A Multifactorial Model of Etiology and Pathophysiology.

Lechien JR, Saussez S, Harmegnies B, Finck C, Burns JA
J Voice 2017 Nov;31(6):733-752. Epub 2017 Apr 21 doi: 10.1016/j.jvoice.2017.03.015. PMID: 28438489

Laryngopharyngeal reflux and Helicobacter pylori.

Yılmaz T, Bajin MD, Günaydın RÖ, Ozer S, Sözen T
World J Gastroenterol 2014 Jul 21;20(27):8964-70. doi: 10.3748/wjg.v20.i27.8964. PMID: 25083069 Free PMC Article

Pathophysiology and treatment of muscle tension dysphonia: a review of the current knowledge.

Van Houtte E, Van Lierde K, Claeys S
J Voice 2011 Mar;25(2):202-7. Epub 2010 Apr 18 doi: 10.1016/j.jvoice.2009.10.009. PMID: 20400263

Esophagopharyngeal reflux.

Belafsky PC, Rees CJ, Rodriguez K, Pryor JS, Katz PO
Otolaryngol Head Neck Surg 2008 Jan;138(1):57-61. doi: 10.1016/j.otohns.2007.09.006. PMID: 18164994

See all (329)

Clinical prediction guides

Diet and Health in Otolaryngology.

Juszczak HM, Rosenfeld RM
Otolaryngol Clin North Am 2022 Oct;55(5):909-927. Epub 2022 Sep 7 doi: 10.1016/j.otc.2022.06.001. PMID: 36088162

Review of management of laryngopharyngeal reflux disease.

Food Sensitivity and Laryngopharyngeal Reflux: Preliminary Observations.

Vora A, Vance D, Alnouri G, Sataloff RT
J Voice 2021 May;35(3):497.e5-497.e7. Epub 2019 Nov 1 doi: 10.1016/j.jvoice.2019.09.005. PMID: 31685326

The role of pepsin in the laryngopharyngeal reflux.

Kowalik K, Krzeski A
Otolaryngol Pol 2017 Dec 30;71(6):7-13. doi: 10.5604/01.3001.0010.7194. PMID: 29327685

Pathophysiology and treatment of muscle tension dysphonia: a review of the current knowledge.

Van Houtte E, Van Lierde K, Claeys S
J Voice 2011 Mar;25(2):202-7. Epub 2010 Apr 18 doi: 10.1016/j.jvoice.2009.10.009. PMID: 20400263

See all (670)

Recent systematic reviews

Association between laryngopharyngeal reflux, gastroesophageal reflux and recalcitrant chronic rhinosinusitis: A systematic review.

Lechien JR, Saussez S, Hopkins C
Clin Otolaryngol 2023 Jul;48(4):501-514. Epub 2023 Mar 9 doi: 10.1111/coa.14047. PMID: 36895147

Association Between Laryngopharyngeal Reflux and Media Otitis: A Systematic Review.

Lechien JR, Hans S, Simon F, Horoi M, Calvo-Henriquez C, Chiesa-Estomba CM, Mayo-Yáñez M, Bartel R, Piersiala K, Nguyen Y, Saussez S
Otol Neurotol 2021 Aug 1;42(7):e801-e814. doi: 10.1097/MAO.0000000000003123. PMID: 33710157

Dysphonia and reflux in children: A systematic review.

Saniasiaya J, Kulasegarah J
Int J Pediatr Otorhinolaryngol 2020 Dec;139:110473. Epub 2020 Oct 28 doi: 10.1016/j.ijporl.2020.110473. PMID: 33137676

Laryngopharyngeal reflux, gastroesophageal reflux and dental disorders: A systematic review.

Lechien JR, Chiesa-Estomba CM, Calvo Henriquez C, Mouawad F, Ristagno C, Barillari MR, Schindler A, Nacci A, Bouland C, Laino L, Saussez S
PLoS One 2020;15(8):e0237581. Epub 2020 Aug 14 doi: 10.1371/journal.pone.0237581. PMID: 32797062 Free PMC Article

Laryngopharyngeal reflux in obstructive sleep apnoea patients: Literature review and meta-analysis.

Magliulo G, Iannella G, Polimeni A, De Vincentiis M, Meccariello G, Gulotta G, Pasquariello B, Montevecchi F, De Vito A, D'Agostino G, Gobbi R, Cammaroto G, Vicini C
Am J Otolaryngol 2018 Nov-Dec;39(6):776-780. Epub 2018 Sep 12 doi: 10.1016/j.amjoto.2018.09.006. PMID: 30224217

See all (49)

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Laryngopharyngeal reflux

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Practice guidelines

Related information

Recent activity