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Breast neoplasm

MedGen UID:
264172
•Concept ID:
C1458155
•
Neoplastic Process
Synonyms: Breast Neoplasms; Breast tumor; Neoplasm of breast; Neoplasm of the breast
SNOMED CT: Neoplasm of breast (126926005); Breast tumor (126926005); Tumor of breast (126926005)
 
Related genes: BRIP1, PALB2, CHEK2, RB1CC1, PPM1D, RAD54L, XRCC3, TP53, STK11, RAD51D, RAD51C, RAD51, PTEN, PIK3CA, PHB1, SLC22A18, NQO2, KRAS, HMMR, ESR1, CDH1, CASP8, BRCA2, BRCA1, BARD1, ATM, AKT1
 
HPO: HP:0100013
Monarch Initiative: MONDO:0021100

Definition

A tumor (abnormal growth of tissue) of the breast. [from HPO]

Term Hierarchy

Professional guidelines

PubMed

Clinical Practices and Institutional Protocols on Prophylaxis, Monitoring, and Management of Selected Adverse Events Associated with Trastuzumab Deruxtecan.
Bardia A, Harnden K, Mauro L, Pennisi A, Armitage M, Soliman H
Oncologist 2022 Aug 5;27(8):637-645. doi: 10.1093/oncolo/oyac107. PMID: 35642907Free PMC Article
Body composition and breast cancer risk and treatment: mechanisms and impact.
Iwase T, Wang X, Shrimanker TV, Kolonin MG, Ueno NT
Breast Cancer Res Treat 2021 Apr;186(2):273-283. Epub 2021 Jan 21 doi: 10.1007/s10549-020-06092-5. PMID: 33475878
A comprehensive approach to rehabilitation interventions following breast cancer treatment - a systematic review of systematic reviews.
Olsson Möller U, Beck I, Rydén L, Malmström M
BMC Cancer 2019 May 20;19(1):472. doi: 10.1186/s12885-019-5648-7. PMID: 31109309Free PMC Article

Curated

NCCN Task Force report: Evaluating the clinical utility of tumor markers in oncology.
Febbo PG, Ladanyi M, Aldape KD, De Marzo AM, Hammond ME, Hayes DF, Iafrate AJ, Kelley RK, Marcucci G, Ogino S, Pao W, Sgroi DC, Birkeland ML
J Natl Compr Canc Netw 2011 Nov;9 Suppl 5:S1-32; quiz S33. doi: 10.6004/jnccn.2011.0137. PMID: 22138009

Breast Cancer, NCCN Guidelines Version 4.2022

Breast Cancer Screening and Diagnosis, NCCN, Version 1.2022

Tumour profiling tests to guide adjuvant chemotherapy decisions in early breast cancer (DG34)

Tumour profiling tests to guide adjuvant chemotherapy decisions in early breast cancer, NICE, 2018

National Comprehensive Cancer Network Clinical Practice Guidelines in Oncology. Breast Cancer (See 2022 Update)

DG10 Gene expression profiling and expanded immunohistochemistry tests for guiding adjuvant chemotherapy decisions in early breast cancer management: MammaPrint, Oncotype DX, IHC4 and Mammostrat: information for the public

Technology Assessment on Genetic Testing or Molecular Pathology Testing of Cancers with Unknown Primary Site to Determine Origin (ARCHIVED)

Suggested Reading

PubMed

70-Gene Signature as an Aid to Treatment Decisions in Early-Stage Breast Cancer.
Cardoso F, van't Veer LJ, Bogaerts J, Slaets L, Viale G, Delaloge S, Pierga JY, Brain E, Causeret S, DeLorenzi M, Glas AM, Golfinopoulos V, Goulioti T, Knox S, Matos E, Meulemans B, Neijenhuis PA, Nitz U, Passalacqua R, Ravdin P, Rubio IT, Saghatchian M, Smilde TJ, Sotiriou C, Stork L, Straehle C, Thomas G, Thompson AM, van der Hoeven JM, Vuylsteke P, Bernards R, Tryfonidis K, Rutgers E, Piccart M; MINDACT Investigators
N Engl J Med 2016 Aug 25;375(8):717-29. doi: 10.1056/NEJMoa1602253. PMID: 27557300
Gene expression profiling and expanded immunohistochemistry tests to guide the use of adjuvant chemotherapy in breast cancer management: a systematic review and cost-effectiveness analysis.
Ward S, Scope A, Rafia R, Pandor A, Harnan S, Evans P, Wyld L
Health Technol Assess 2013 Oct;17(44):1-302. doi: 10.3310/hta17440. PMID: 24088296Free PMC Article

Recent clinical studies

Etiology

Impact of exercise interventions on physical fitness in breast cancer patients and survivors: a systematic review.
Ficarra S, Thomas E, Bianco A, Gentile A, Thaller P, Grassadonio F, Papakonstantinou S, Schulz T, Olson N, Martin A, Wagner C, Nordström A, Hofmann H
Breast Cancer 2022 May;29(3):402-418. Epub 2022 Mar 12 doi: 10.1007/s12282-022-01347-z. PMID: 35278203Free PMC Article
Menopausal hormone therapy and breast cancer risk.
Rozenberg S, Di Pietrantonio V, Vandromme J, Gilles C
Best Pract Res Clin Endocrinol Metab 2021 Dec;35(6):101577. Epub 2021 Sep 10 doi: 10.1016/j.beem.2021.101577. PMID: 34535397
Body composition and breast cancer risk and treatment: mechanisms and impact.
Iwase T, Wang X, Shrimanker TV, Kolonin MG, Ueno NT
Breast Cancer Res Treat 2021 Apr;186(2):273-283. Epub 2021 Jan 21 doi: 10.1007/s10549-020-06092-5. PMID: 33475878
Resistance exercise and breast cancer-related lymphedema-a systematic review update and meta-analysis.
Hasenoehrl T, Palma S, Ramazanova D, Kölbl H, Dorner TE, Keilani M, Crevenna R
Support Care Cancer 2020 Aug;28(8):3593-3603. Epub 2020 May 15 doi: 10.1007/s00520-020-05521-x. PMID: 32415386Free PMC Article
A Review of the Epidemiology of Breast Cancer in Asia: Focus on Risk Factors.
Youn HJ, Han W
Asian Pac J Cancer Prev 2020 Apr 1;21(4):867-880. doi: 10.31557/APJCP.2020.21.4.867. PMID: 32334446Free PMC Article

Diagnosis

Surgical Management of Breast Amyloidosis.
Bacos JT, Doren E, D'Souza A, Jorns J, Kong A
Clin Breast Cancer 2023 Aug;23(6):e359-e367. Epub 2023 Jun 16 doi: 10.1016/j.clbc.2023.06.001. PMID: 37357131
Divorce after breast cancer diagnosis and its impact on quality of life.
Kang D, Kim N, Han G, Kim S, Kim H, Lim J, Kim H, Shim S, Lee M, Lee JE, Nam SJ, Kim SW, Yu J, Lee SK, Cho J
Palliat Support Care 2022 Dec;20(6):807-812. doi: 10.1017/S1478951521001711. PMID: 36942579
Overview in Breast Cancer Screening in Lebanon.
Sbaity E, Bejjany R, Kreidieh M, Temraz S, Shamseddine A
Cancer Control 2021 Jan-Dec;28:10732748211039443. doi: 10.1177/10732748211039443. PMID: 34538124Free PMC Article
Breast fibroadenomas: a review in the light of current literature.
Salati SA
Pol Przegl Chir 2020 Dec 7;93(1):40-48. doi: 10.5604/01.3001.0014.5676. PMID: 33729177
A Review of the Epidemiology of Breast Cancer in Asia: Focus on Risk Factors.
Youn HJ, Han W
Asian Pac J Cancer Prev 2020 Apr 1;21(4):867-880. doi: 10.31557/APJCP.2020.21.4.867. PMID: 32334446Free PMC Article

Therapy

Impact of exercise interventions on physical fitness in breast cancer patients and survivors: a systematic review.
Ficarra S, Thomas E, Bianco A, Gentile A, Thaller P, Grassadonio F, Papakonstantinou S, Schulz T, Olson N, Martin A, Wagner C, Nordström A, Hofmann H
Breast Cancer 2022 May;29(3):402-418. Epub 2022 Mar 12 doi: 10.1007/s12282-022-01347-z. PMID: 35278203Free PMC Article
Menopausal hormone therapy and breast cancer risk.
Rozenberg S, Di Pietrantonio V, Vandromme J, Gilles C
Best Pract Res Clin Endocrinol Metab 2021 Dec;35(6):101577. Epub 2021 Sep 10 doi: 10.1016/j.beem.2021.101577. PMID: 34535397
Body composition and breast cancer risk and treatment: mechanisms and impact.
Iwase T, Wang X, Shrimanker TV, Kolonin MG, Ueno NT
Breast Cancer Res Treat 2021 Apr;186(2):273-283. Epub 2021 Jan 21 doi: 10.1007/s10549-020-06092-5. PMID: 33475878
Resistance exercise and breast cancer-related lymphedema-a systematic review update and meta-analysis.
Hasenoehrl T, Palma S, Ramazanova D, Kölbl H, Dorner TE, Keilani M, Crevenna R
Support Care Cancer 2020 Aug;28(8):3593-3603. Epub 2020 May 15 doi: 10.1007/s00520-020-05521-x. PMID: 32415386Free PMC Article
A comprehensive approach to rehabilitation interventions following breast cancer treatment - a systematic review of systematic reviews.
Olsson Möller U, Beck I, Rydén L, Malmström M
BMC Cancer 2019 May 20;19(1):472. doi: 10.1186/s12885-019-5648-7. PMID: 31109309Free PMC Article

Prognosis

Overview in Breast Cancer Screening in Lebanon.
Sbaity E, Bejjany R, Kreidieh M, Temraz S, Shamseddine A
Cancer Control 2021 Jan-Dec;28:10732748211039443. doi: 10.1177/10732748211039443. PMID: 34538124Free PMC Article
Hormone Resistance.
Yu J
Adv Exp Med Biol 2021;1187:391-401. doi: 10.1007/978-981-32-9620-6_20. PMID: 33983590
Perspectives on the Systemic Staging in Newly Diagnosed Breast Cancer.
Reinert T, de Souza ABA, Rosa ML, Bedin SR, Barrios CH
Clin Breast Cancer 2021 Aug;21(4):309-316. Epub 2021 Mar 27 doi: 10.1016/j.clbc.2021.03.010. PMID: 33962905
A Review of the Epidemiology of Breast Cancer in Asia: Focus on Risk Factors.
Youn HJ, Han W
Asian Pac J Cancer Prev 2020 Apr 1;21(4):867-880. doi: 10.31557/APJCP.2020.21.4.867. PMID: 32334446Free PMC Article
Luminal A Breast Cancer and Molecular Assays: A Review.
Gao JJ, Swain SM
Oncologist 2018 May;23(5):556-565. Epub 2018 Feb 22 doi: 10.1634/theoncologist.2017-0535. PMID: 29472313Free PMC Article

Clinical prediction guides

Impact of exercise interventions on physical fitness in breast cancer patients and survivors: a systematic review.
Ficarra S, Thomas E, Bianco A, Gentile A, Thaller P, Grassadonio F, Papakonstantinou S, Schulz T, Olson N, Martin A, Wagner C, Nordström A, Hofmann H
Breast Cancer 2022 May;29(3):402-418. Epub 2022 Mar 12 doi: 10.1007/s12282-022-01347-z. PMID: 35278203Free PMC Article
Body composition and breast cancer risk and treatment: mechanisms and impact.
Iwase T, Wang X, Shrimanker TV, Kolonin MG, Ueno NT
Breast Cancer Res Treat 2021 Apr;186(2):273-283. Epub 2021 Jan 21 doi: 10.1007/s10549-020-06092-5. PMID: 33475878
Breast fibroadenomas: a review in the light of current literature.
Salati SA
Pol Przegl Chir 2020 Dec 7;93(1):40-48. doi: 10.5604/01.3001.0014.5676. PMID: 33729177
Resistance exercise and breast cancer-related lymphedema-a systematic review update and meta-analysis.
Hasenoehrl T, Palma S, Ramazanova D, Kölbl H, Dorner TE, Keilani M, Crevenna R
Support Care Cancer 2020 Aug;28(8):3593-3603. Epub 2020 May 15 doi: 10.1007/s00520-020-05521-x. PMID: 32415386Free PMC Article
Luminal A Breast Cancer and Molecular Assays: A Review.
Gao JJ, Swain SM
Oncologist 2018 May;23(5):556-565. Epub 2018 Feb 22 doi: 10.1634/theoncologist.2017-0535. PMID: 29472313Free PMC Article

Recent systematic reviews

Impact of exercise interventions on physical fitness in breast cancer patients and survivors: a systematic review.
Ficarra S, Thomas E, Bianco A, Gentile A, Thaller P, Grassadonio F, Papakonstantinou S, Schulz T, Olson N, Martin A, Wagner C, Nordström A, Hofmann H
Breast Cancer 2022 May;29(3):402-418. Epub 2022 Mar 12 doi: 10.1007/s12282-022-01347-z. PMID: 35278203Free PMC Article
Resistance exercise and breast cancer-related lymphedema-a systematic review update and meta-analysis.
Hasenoehrl T, Palma S, Ramazanova D, Kölbl H, Dorner TE, Keilani M, Crevenna R
Support Care Cancer 2020 Aug;28(8):3593-3603. Epub 2020 May 15 doi: 10.1007/s00520-020-05521-x. PMID: 32415386Free PMC Article
Effect of complementary and alternative medicine interventions on cancer related pain among breast cancer patients: A systematic review.
Behzadmehr R, Dastyar N, Moghadam MP, Abavisani M, Moradi M
Complement Ther Med 2020 Mar;49:102318. Epub 2020 Jan 17 doi: 10.1016/j.ctim.2020.102318. PMID: 32147038
Systematic review of shift work and nurses' health.
Rosa D, Terzoni S, Dellafiore F, Destrebecq A
Occup Med (Lond) 2019 Jun 24;69(4):237-243. doi: 10.1093/occmed/kqz063. PMID: 31132107
A comprehensive approach to rehabilitation interventions following breast cancer treatment - a systematic review of systematic reviews.
Olsson Möller U, Beck I, Rydén L, Malmström M
BMC Cancer 2019 May 20;19(1):472. doi: 10.1186/s12885-019-5648-7. PMID: 31109309Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2023
      Breast Cancer, NCCN Guidelines Version 4.2022
    • NCCN, 2022
      Breast Cancer Screening and Diagnosis, NCCN, Version 1.2022
    • NICE, 2018
      Tumour profiling tests to guide adjuvant chemotherapy decisions in early breast cancer (DG34)
    • NICE, 2018
      Tumour profiling tests to guide adjuvant chemotherapy decisions in early breast cancer, NICE, 2018
    • NCCN, 2014
      National Comprehensive Cancer Network Clinical Practice Guidelines in Oncology. Breast Cancer (See 2022 Update)
    • NICE, 2013
      DG10 Gene expression profiling and expanded immunohistochemistry tests for guiding adjuvant chemotherapy decisions in early breast cancer management: MammaPrint, Oncotype DX, IHC4 and Mammostrat: information for the public
    • AHRQ, 2013
      Technology Assessment on Genetic Testing or Molecular Pathology Testing of Cancers with Unknown Primary Site to Determine Origin (ARCHIVED)
    • NCCN, 2011
      NCCN Task Force report: Evaluating the clinical utility of tumor markers in oncology.

    Consumer resources

    Reviews

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