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Basaloid squamous cell carcinoma

MedGen UID:
266085
•Concept ID:
C1266005
•
Neoplastic Process
Synonyms: Basaloid Squamous Cell Carcinoma; basaloid squamous cell carcinoma; basaloid squamous cell carcinoma (morphologic abnormality)
SNOMED CT: Basaloid squamous cell carcinoma (128634009)
 
Monarch Initiative: MONDO:0003486

Definition

A squamous cell carcinoma characterized by the presence of cells with hyperchromatic nuclei, scant amount of cytoplasm, and peripheral nuclear palisading. [from NCI]

Professional guidelines

PubMed

How phenotype guides management of non-conventional squamous cell carcinomas of the larynx?
López F, Williams MD, Cardesa A, Hunt JL, Strojan P, Rinaldo A, Nixon IJ, Rodrigo JP, Saba NF, Mendenhall WM, Quer M, Suárez C, Ferlito A
Eur Arch Otorhinolaryngol 2017 Jul;274(7):2709-2726. Epub 2017 Mar 31 doi: 10.1007/s00405-017-4533-8. PMID: 28364287
Basaloid squamous cell carcinoma of the head and neck: role of HPV and implication in treatment and prognosis.
Thariat J, Badoual C, Faure C, Butori C, Marcy PY, Righini CA
J Clin Pathol 2010 Oct;63(10):857-66. doi: 10.1136/jcp.2010.078154. PMID: 20876315
A reappraisal of "basaloid carcinoma" of the cervix, and the differential diagnosis of basaloid cervical neoplasms.
Grayson W, Cooper K
Adv Anat Pathol 2002 Sep;9(5):290-300. doi: 10.1097/00125480-200209000-00003. PMID: 12195218

Recent clinical studies

Etiology

Clinical predictors of special type of esophageal cancer.
Suzuki Y, Ohkura Y, Koseki M, Nomura K, Matsui A, Ueno M, Kikuchi D, Ohashi K, Hoteya S
Esophagus 2023 Jul;20(3):484-491. Epub 2023 Apr 10 doi: 10.1007/s10388-023-01003-1. PMID: 37036546
Basaloid squamous cell carcinoma of the hypopharynx: an analysis of 213 cases.
Xie C, Liao J, Huang C, Wei F, Liu T, Wen W, Sun W
Eur Arch Otorhinolaryngol 2022 Apr;279(4):2099-2107. Epub 2021 Jul 28 doi: 10.1007/s00405-021-07007-w. PMID: 34319483
Basaloid squamous cell carcinoma: a 31-year retrospective study and analysis of 214 cases reported in the literature.
Schuch LF, Nóbrega KHS, Gomes APN, Vasconcelos ACU
Oral Maxillofac Surg 2020 Mar;24(1):103-108. Epub 2020 Jan 8 doi: 10.1007/s10006-020-00828-9. PMID: 31912260
Human Papillomavirus-Independent Squamous Lesions of the Vulva.
Watkins JC
Surg Pathol Clin 2019 Jun;12(2):249-261. Epub 2019 Apr 5 doi: 10.1016/j.path.2019.01.001. PMID: 31097103
Basaloid Squamous Cell Carcinoma of the Larynx: A National Cancer Database Analysis.
Jumaily M, Faraji F, Zhang D, Walker RJ, Ward GM
Otolaryngol Head Neck Surg 2019 May;160(5):847-854. Epub 2019 Feb 5 doi: 10.1177/0194599818816299. PMID: 30717636

Diagnosis

Clinical predictors of special type of esophageal cancer.
Suzuki Y, Ohkura Y, Koseki M, Nomura K, Matsui A, Ueno M, Kikuchi D, Ohashi K, Hoteya S
Esophagus 2023 Jul;20(3):484-491. Epub 2023 Apr 10 doi: 10.1007/s10388-023-01003-1. PMID: 37036546
POU2F3 in SCLC: Clinicopathologic and Genomic Analysis With a Focus on Its Diagnostic Utility in Neuroendocrine-Low SCLC.
Baine MK, Febres-Aldana CA, Chang JC, Jungbluth AA, Sethi S, Antonescu CR, Travis WD, Hsieh MS, Roh MS, Homer RJ, Ladanyi M, Egger JV, Lai WV, Rudin CM, Rekhtman N
J Thorac Oncol 2022 Sep;17(9):1109-1121. Epub 2022 Jun 24 doi: 10.1016/j.jtho.2022.06.004. PMID: 35760287Free PMC Article
Basaloid squamous cell carcinoma of the hypopharynx: an analysis of 213 cases.
Xie C, Liao J, Huang C, Wei F, Liu T, Wen W, Sun W
Eur Arch Otorhinolaryngol 2022 Apr;279(4):2099-2107. Epub 2021 Jul 28 doi: 10.1007/s00405-021-07007-w. PMID: 34319483
Esophageal basaloid squamous cell carcinoma presenting as a subepithelial lesion.
Shiratori Y, Kanomata N, Takagi K, Fukuda K
Clin J Gastroenterol 2021 Oct;14(5):1324-1328. Epub 2021 Jul 5 doi: 10.1007/s12328-021-01449-9. PMID: 34224084
Squamous cell carcinoma of the upper aerodigestive tract: dysplasia and select variants.
Wenig BM
Mod Pathol 2017 Jan;30(s1):S112-S118. doi: 10.1038/modpathol.2016.207. PMID: 28060368

Therapy

Basaloid Squamous Cell Carcinoma of the Uterine Cervix: Report of a Case With Molecular Analysis.
Munkhdelger J, Shimooka T, Koyama Y, Ikeda S, Mikami Y, Fukuoka J, Hori T, Bychkov A
Int J Surg Pathol 2021 Oct;29(7):770-774. Epub 2021 Apr 1 doi: 10.1177/1066896921997132. PMID: 33792431
Cetuximab and paclitaxel combination therapy for recurrent basaloid squamous cell carcinoma in the ethmoid sinus.
Koyama S, Fujiwara K, Morisaki T, Fujii T, Nakamura Y, Fukuhara T, Takeuchi H
Auris Nasus Larynx 2021 Dec;48(6):1189-1192. Epub 2020 Jul 16 doi: 10.1016/j.anl.2020.07.002. PMID: 32684403
Molecular pathology and potential therapeutic targets in esophageal basaloid squamous cell carcinoma.
Saito T, Mitomi H, Yao T
Int J Clin Exp Pathol 2015;8(3):2267-73. Epub 2015 Mar 1 PMID: 26045734Free PMC Article
Basaloid squamous cell carcinoma of the oral cavity: an analysis of 92 cases.
Fritsch VA, Gerry DR, Lentsch EJ
Laryngoscope 2014 Jul;124(7):1573-8. Epub 2014 Apr 29 doi: 10.1002/lary.24384. PMID: 23946211
Basaloid squamous cell carcinoma of the larynx--A systematic review.
Thankappan K
Auris Nasus Larynx 2012 Aug;39(4):397-401. Epub 2011 Aug 24 doi: 10.1016/j.anl.2011.07.018. PMID: 21868181

Prognosis

Clinical predictors of special type of esophageal cancer.
Suzuki Y, Ohkura Y, Koseki M, Nomura K, Matsui A, Ueno M, Kikuchi D, Ohashi K, Hoteya S
Esophagus 2023 Jul;20(3):484-491. Epub 2023 Apr 10 doi: 10.1007/s10388-023-01003-1. PMID: 37036546
Basaloid squamous cell carcinoma of the hypopharynx: an analysis of 213 cases.
Xie C, Liao J, Huang C, Wei F, Liu T, Wen W, Sun W
Eur Arch Otorhinolaryngol 2022 Apr;279(4):2099-2107. Epub 2021 Jul 28 doi: 10.1007/s00405-021-07007-w. PMID: 34319483
Esophageal basaloid squamous cell carcinoma presenting as a subepithelial lesion.
Shiratori Y, Kanomata N, Takagi K, Fukuda K
Clin J Gastroenterol 2021 Oct;14(5):1324-1328. Epub 2021 Jul 5 doi: 10.1007/s12328-021-01449-9. PMID: 34224084
Squamous cell carcinoma of the upper aerodigestive tract: dysplasia and select variants.
Wenig BM
Mod Pathol 2017 Jan;30(s1):S112-S118. doi: 10.1038/modpathol.2016.207. PMID: 28060368
HPV-related squamous cell carcinoma variants in the head and neck.
El-Mofty SK
Head Neck Pathol 2012 Jul;6 Suppl 1(Suppl 1):S55-62. Epub 2012 Jul 3 doi: 10.1007/s12105-012-0363-6. PMID: 22782224Free PMC Article

Clinical prediction guides

Clinical predictors of special type of esophageal cancer.
Suzuki Y, Ohkura Y, Koseki M, Nomura K, Matsui A, Ueno M, Kikuchi D, Ohashi K, Hoteya S
Esophagus 2023 Jul;20(3):484-491. Epub 2023 Apr 10 doi: 10.1007/s10388-023-01003-1. PMID: 37036546
Difference in characteristics and outcomes of basaloid squamous cell carcinoma and squamous cell carcinoma, usual type in cervix: A population-based study from SEER 18 database.
Li L, Du Q, Zhang X, An J, Song Y
Asia Pac J Clin Oncol 2020 Oct;16(5):e236-e241. Epub 2020 Jun 23 doi: 10.1111/ajco.13383. PMID: 32573088
PD-L1 expression in basaloid squamous cell lung carcinoma: Relationship to PD-1(+) and CD8(+) tumor-infiltrating T cells and outcome.
Ilie M, Falk AT, Butori C, Chamorey E, Bonnetaud C, Long E, Lassalle S, Zahaf K, Vénissac N, Mouroux J, Cohen C, Brambilla E, Marquette CH, Hofman V, Hofman P
Mod Pathol 2016 Dec;29(12):1552-1564. Epub 2016 Aug 26 doi: 10.1038/modpathol.2016.149. PMID: 27562497
Sinonasal small round blue cell tumors: An approach to diagnosis.
Simons SA, Bridge JA, Leon ME
Semin Diagn Pathol 2016 Mar;33(2):91-103. Epub 2015 Sep 10 doi: 10.1053/j.semdp.2015.09.010. PMID: 26585346
Molecular pathology and potential therapeutic targets in esophageal basaloid squamous cell carcinoma.
Saito T, Mitomi H, Yao T
Int J Clin Exp Pathol 2015;8(3):2267-73. Epub 2015 Mar 1 PMID: 26045734Free PMC Article

Recent systematic reviews

Human Papillomavirus-Related Multiphenotypic Sinonasal Carcinoma-An Even Broader Tumor Entity?
Zupancic M, Näsman A
Viruses 2021 Sep 17;13(9) doi: 10.3390/v13091861. PMID: 34578442Free PMC Article
Basaloid squamous cell carcinoma of the larynx--A systematic review.
Thankappan K
Auris Nasus Larynx 2012 Aug;39(4):397-401. Epub 2011 Aug 24 doi: 10.1016/j.anl.2011.07.018. PMID: 21868181

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