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Bone Neoplasm

MedGen UID:: 2701
•Concept ID:: C0005967
•: Neoplastic Process

Synonyms:	Bone Neoplasms; Neoplasm, Bone; Neoplasms, Bone
SNOMED CT:	Bone tumor (115239009); Neoplasm of bone (126537000)

Definition

A benign, intermediate, or malignant neoplasm involving the bone or articular cartilage. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVBone Neoplasm

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Disorder by Site
      - Connective and Soft Tissue Disorder
        Connective tissue disorder
        Bone Neoplasm
        Adamantinoma
        Tibial adamantinoma
        Bone benign neoplasm
        Aneurysmal bone cyst
        Benign neoplasm of lower jaw bone
        Benign Notochordal Cell Tumor
        Benign Osteoclastic Giant Cell-Rich Tumor of Bone
        Giant Cell Lesion of Small Bones
        Bone Hemangioma
        Bone epithelioid hemangioma
        Bone Lipoma
        Bone Hibernoma
        Bone Schwannoma
        Chondroblastoma
        Maxillofacial Chondroblastoma
        Chondromyxoid fibroma
        Maxillofacial Chondromyxoid Fibroma
        Sternal Chondromyxoid Fibroma
        Enchondroma
        Enchondromatosis
        Fibrous dysplasia
        Craniofacial Fibrous Dysplasia
        Fibrous dysplasia of jaw
        Monostotic fibrous dysplasia
        Polyostotic fibrous dysplasia of bone
        Fibrous Histiocytoma of Bone
        Non-Ossifying Fibroma
        Osteoblastoma
        Cementoma
        Maxillofacial Osteoblastoma
        Osteochondroma
        Multiple Osteochondromas
        Solitary Osteochondroma
        Osteochondromyxoma
        Osteoid osteoma
        Maxillofacial Osteoid Osteoma
        Osteoma
        Enostosis
        Ivory Exostosis
        Skull Osteoma
        Periosteal chondroma
        Periosteal Fibroma
        Bone cancer
        Bone Cancer by AJCC v7 Stage
        Bone Sarcoma by AJCC v7 Stage
        Stage I Bone Cancer AJCC v7
        Stage II Bone Cancer AJCC v7
        Stage III Bone Cancer AJCC v7
        Stage IV Bone Cancer AJCC v7
        Bone Cancer by AJCC v8 Stage
        Stage I Bone Cancer AJCC v8
        Stage II Bone Cancer AJCC v8
        Stage III Bone Cancer AJCC v8
        Stage IV Bone Cancer AJCC v8
        Bone Epithelioid Hemangioendothelioma
        Bone sarcoma
        Bone angiosarcoma
        Bone fibrosarcoma
        Bone leiomyosarcoma
        Bone osteosarcoma
        Chondrosarcoma
        Clear cell chondrosarcoma
        Dedifferentiated chondrosarcoma
        Ewing sarcoma
        Ewing sarcoma of bone
        Fibrosarcoma
        Giant cell tumor of bone
        Liposarcoma of bone
        Malignancy in giant cell tumor of bone
        Malignant fibrous histiocytoma
        Maxillofacial Sarcoma
        Mesenchymal Chondrosarcoma of Bone
        Metastatic Bone Sarcoma
        Periosteal chondrosarcoma
        Peripheral primitive neuroectodermal tumor
        Primary Central Chondrosarcoma
        Secondary Chondrosarcoma
        Undifferentiated high grade pleomorphic sarcoma of bone
        Unresectable Bone Sarcoma
        Chest wall bone cancer
        Chordoma
        Conventional Chordoma
        Dedifferentiated Chordoma
        Metastatic Chordoma
        Poorly differentiated chordoma
        Recurrent Chordoma
        Refractory Chordoma
        Skull base chordoma
        Spinal chordoma
        Unresectable Chordoma
        Ewing sarcoma/peripheral primitive neuroectodermal tumor of bone
        Peripheral primitive neuroectodermal tumor of bone
        Malignant Osteoclastic Giant Cell-Rich Tumor of Bone
        Mandibular cancer
        Metastatic malignant neoplasm to bone
        Metastatic carcinoma in the bone
        Metastatic malignant neoplasm to vertebral column
        Primary bone lymphoma
        Primary Bone Hodgkin Lymphoma
        Primary Bone Non-Hodgkin Lymphoma
        Recurrent Primary Bone Lymphoma
        Refractory Primary Bone Lymphoma
        Recurrent Malignant Bone Neoplasm
        Recurrent Bone Ewing Sarcoma
        Recurrent Peripheral Primitive Neuroectodermal Tumor of Bone
        Refractory Malignant Bone Neoplasm
        Solitary osseous plasmacytoma
        Bone Erdheim-Chester Disease
        Bone Glomus Tumor
        Bone Langerhans Cell Histiocytosis
        Intermediate Bone Neoplasm
        Aggressive Osteoblastoma
        Fibrocartilaginous Mesenchymoma
        Intermediate Osteoclastic Giant Cell-Rich Tumor of Bone
        Metastasizing Chondroblastoma
        Maxillofacial Neoplasm
        Benign Maxillofacial Neoplasm
        Maxillofacial Chondroma
        Maxillofacial Desmoplastic Fibroma
        Maxillofacial Osteoma
        Neoplasm of femur
        Notochordal tumor
        Osteoclastic Giant Cell-Rich Tumor of Bone
        Skull neoplasm
        Benign Skull Neoplasm
        Benign Skull Base Neoplasm
        Ossifying Fibroma
        Jaw neoplasm
        Maxillary neoplasm
        Neoplasm of mandible
        Palate neoplasm
        Neoplasm of the nose
        Paranasal sinus neoplasm
        Orbit neoplasm
        Benign Orbit Neoplasm
        Intraorbital meningioma
        Orbit Paraganglioma
        Orbital cancer
        Skull base neoplasm
        Malignant Skull Base Neoplasm
        Sella turcica neoplasm
        Skull base meningioma
        Spindle cell oncocytoma
        Skull cancer
        Spinal Neoplasm
        Cervical Spine Neoplasm
        Cervical spinal canal and spinal cord meningioma
        Intraspinal Neoplasm
        Cauda equina neoplasm
        Epidural spinal canal neoplasm
        Intradural extramedullary spinal canal neoplasm
        Intraspinal meningioma
        Spinal cord tumor
        Lumbar Spine Neoplasm
        Lumbar spinal canal and spinal cord meningioma
        Lumbosacral Spine Neoplasm
        Lumbosacral lipoma
        Lumbosacral Spinal Cord Ependymal Tumor
        Sacral Spine Neoplasm
        Sacral Chordoma
        Sacral spinal canal and spinal cord meningioma
        Sacrococcygeal teratoma
        Thoracic Spine Neoplasm
        Thoracic Chordoma
        Thoracic spinal canal and spinal cord meningioma
        Thoracic Spinal Cord Ependymal Tumor
        Vascular bone neoplasm

Professional guidelines

PubMed

Current approaches in tissue engineering-based nanotherapeutics for osteosarcoma treatment.

Shanmugavadivu A, Lekhavadhani S, Miranda PJ, Selvamurugan N
Biomed Mater 2024 Feb 26;19(2) doi: 10.1088/1748-605X/ad270b. PMID: 38324905

Metastatic giant cell tumour of bone: a narrative review of management options and approaches.

Xu R, Choong PFM
ANZ J Surg 2022 Apr;92(4):691-696. Epub 2022 Feb 10 doi: 10.1111/ans.17520. PMID: 35143093 Free PMC Article

Atraumatic vertebral compression fractures: differential diagnosis between benign osteoporotic and malignant fractures by MRI.

Cicala D, Briganti F, Casale L, Rossi C, Cagini L, Cesarano E, Brunese L, Giganti M
Musculoskelet Surg 2013 Aug;97 Suppl 2:S169-79. Epub 2013 Aug 15 doi: 10.1007/s12306-013-0277-9. PMID: 23949939

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Recent clinical studies

Etiology

Towards the Search for Potential Biomarkers in Osteosarcoma: State-of-the-Art and Translational Expectations.

Pekarek L, De la Torre-Escuredo B, Fraile-Martinez O, García-Montero C, Saez MA, Cobo-Prieto D, Guijarro LG, Saz JV, De Castro-Martinez P, Torres-Carranza D, Pekarek T, Carrera AC, Alvarez-Mon M, Ortega MA
Int J Mol Sci 2022 Nov 29;23(23) doi: 10.3390/ijms232314939. PMID: 36499267 Free PMC Article

Metastatic giant cell tumour of bone: a narrative review of management options and approaches.

Xu R, Choong PFM
ANZ J Surg 2022 Apr;92(4):691-696. Epub 2022 Feb 10 doi: 10.1111/ans.17520. PMID: 35143093 Free PMC Article

Quantitative bone SPECT/CT applications for primary bone neoplasms.

Kitajima K, Futani H, Komoto H, Tsuchitani T, Takahashi Y, Tachibana T, Yamakado K
Hell J Nucl Med 2021 Jan-Apr;24(1):36-44. Epub 2021 Apr 20 doi: 10.1967/s002449912304. PMID: 33866337

Whole-body MRI of bone marrow: A review.

Hynes JP, Hughes N, Cunningham P, Kavanagh EC, Eustace SJ
J Magn Reson Imaging 2019 Dec;50(6):1687-1701. Epub 2019 Apr 23 doi: 10.1002/jmri.26759. PMID: 31016800

Dedifferentiated Chondrosarcoma Demonstrating Osteosarcomatous Differentiation.

Dhinsa BS, DeLisa M, Pollock R, Flanagan AM, Whelan J, Gregory J
Oncol Res Treat 2018;41(7-8):456-460. Epub 2018 Jun 15 doi: 10.1159/000487803. PMID: 29902785

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Diagnosis

Recent Advances in Nanotechnology-Based Diagnosis and Treatments of Human Osteosarcoma.

Barani M, Mukhtar M, Rahdar A, Sargazi S, Pandey S, Kang M
Biosensors (Basel) 2021 Feb 20;11(2) doi: 10.3390/bios11020055. PMID: 33672770 Free PMC Article

Skeletal Survey in Multiple Myeloma: Role of Imaging.

Spinnato P, Filonzi G, Conficoni A, Facchini G, Ponti F, Sambri A, De Paolis M, Cavo M, Salizzoni E, Nanni C
Curr Med Imaging 2021;17(8):956-965. doi: 10.2174/1573405617666210126155129. PMID: 33573573

MR Imaging of Osteoid Osteoma: Pearls and Pitfalls.

French J, Epelman M, Johnson CM, Stinson Z, Meyers AB
Semin Ultrasound CT MR 2020 Oct;41(5):488-497. Epub 2020 May 28 doi: 10.1053/j.sult.2020.05.013. PMID: 32980095

Multiparametric MR Imaging of Benign and Malignant Bone Lesions.

Tang H, Ahlawat S, Fayad LM
Magn Reson Imaging Clin N Am 2018 Nov;26(4):559-569. doi: 10.1016/j.mric.2018.06.010. PMID: 30316467

Primary Tumors of the Foot and Ankle.

Kennedy JG, Ross KA, Smyth NA, Hogan MV, Murawski CD
Foot Ankle Spec 2016 Feb;9(1):58-68. Epub 2015 Dec 7 doi: 10.1177/1938640015620634. PMID: 26644034

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Therapy

Metastatic giant cell tumour of bone: a narrative review of management options and approaches.

Xu R, Choong PFM
ANZ J Surg 2022 Apr;92(4):691-696. Epub 2022 Feb 10 doi: 10.1111/ans.17520. PMID: 35143093 Free PMC Article

Clinicopathologic and molecular features of denosumab-treated giant cell tumour of bone (GCTB): Analysis of 21 cases.

Yang L, Zhang H, Zhang X, Tang Y, Wu Z, Wang Y, Huang H, Fu X, Liu J, Hogendoorn PCW, Cheng H
Ann Diagn Pathol 2022 Apr;57:151882. Epub 2021 Dec 23 doi: 10.1016/j.anndiagpath.2021.151882. PMID: 34995868

Recent Advances in Nanotechnology-Based Diagnosis and Treatments of Human Osteosarcoma.

Barani M, Mukhtar M, Rahdar A, Sargazi S, Pandey S, Kang M
Biosensors (Basel) 2021 Feb 20;11(2) doi: 10.3390/bios11020055. PMID: 33672770 Free PMC Article

Concomitant radiotherapy and transarterial chemoembolization reduce skeletal-related events related to bone metastases from renal cell carcinoma.

Heianna J, Makino W, Ariga T, Ishikawa K, Kusada T, Maemoto H, Toguchi M, Ito J, Goya M, Miyazato M, Iraha Y, Murayama S
Eur Radiol 2020 Mar;30(3):1525-1533. Epub 2019 Nov 14 doi: 10.1007/s00330-019-06454-8. PMID: 31728686

Dedifferentiated Chondrosarcoma Demonstrating Osteosarcomatous Differentiation.

Dhinsa BS, DeLisa M, Pollock R, Flanagan AM, Whelan J, Gregory J
Oncol Res Treat 2018;41(7-8):456-460. Epub 2018 Jun 15 doi: 10.1159/000487803. PMID: 29902785

See all (29)

Prognosis

Towards the Search for Potential Biomarkers in Osteosarcoma: State-of-the-Art and Translational Expectations.

Clinical differences between central and peripheral chondrosarcomas.

Laitinen MK, Evans S, Stevenson J, Sumathi V, Kask G, Jeys LM, Parry MC
Bone Joint J 2021 May;103-B(5):984-990. doi: 10.1302/0301-620X.103B5.BJJ-2020-1082.R2. PMID: 33934657

Skeletal Survey in Multiple Myeloma: Role of Imaging.

CDKL3 promotes osteosarcoma progression by activating Akt/PKB.

He A, Ma L, Huang Y, Zhang H, Duan W, Li Z, Fei T, Yuan J, Wu H, Liu L, Bai Y, Dai W, Wang Y, Li H, Sun Y, Wang Y, Wang C, Yuan T, Yang Q, Tian S, Dong M, Sheng R, Xiang D
Life Sci Alliance 2020 May;3(5) Epub 2020 Mar 31 doi: 10.26508/lsa.202000648. PMID: 32234750 Free PMC Article

Dedifferentiated Chondrosarcoma Demonstrating Osteosarcomatous Differentiation.

Dhinsa BS, DeLisa M, Pollock R, Flanagan AM, Whelan J, Gregory J
Oncol Res Treat 2018;41(7-8):456-460. Epub 2018 Jun 15 doi: 10.1159/000487803. PMID: 29902785

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Clinical prediction guides

3D-printed hemipelvic prosthesis combined with a dual mobility bearing in patients with primary malignant neoplasm involving the acetabulum: clinical outcomes and finite element analysis.

Wang M, Liu T, Xu C, Liu C, Li B, Lian Q, Chen T, Qiao S, Wang Z
BMC Surg 2022 Oct 6;22(1):357. doi: 10.1186/s12893-022-01804-8. PMID: 36203147 Free PMC Article

Sclerosing epithelioid fibrosarcoma of bone: morphological, immunophenotypical, and molecular findings of 9 cases.

Kosemehmetoglu K, Ardic F, Kilpatrick SE, Aydingoz U, Sumathi VP, Michal M
Virchows Arch 2021 Apr;478(4):767-777. Epub 2020 Oct 21 doi: 10.1007/s00428-020-02953-y. PMID: 33084978

Pathologic Fractures in Benign Neoplasms of the Fingers.

Oflazoglu K, Lans J, Castelein RM, Lozano Calderón SA, Chen NC
Hand (N Y) 2021 May;16(3):326-331. Epub 2019 Jun 17 doi: 10.1177/1558944719855443. PMID: 31203664 Free PMC Article

Mutation-driven epigenetic alterations as a defining hallmark of central cartilaginous tumours, giant cell tumour of bone and chondroblastoma.

Venneker S, Szuhai K, Hogendoorn PCW, Bovée JVMG
Virchows Arch 2020 Jan;476(1):135-146. Epub 2019 Nov 14 doi: 10.1007/s00428-019-02699-2. PMID: 31728625 Free PMC Article

Osteosarcoma of the jaw bones.

Chindia ML
Oral Oncol 2001 Oct;37(7):545-7. doi: 10.1016/s1368-8375(00)00129-9. PMID: 11564573

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Recent systematic reviews

Facial Schwannoma Management Outcomes: A Systematic Review of the Literature.

Bartindale M, Heiferman J, Joyce C, Anderson D, Leonetti J
Otolaryngol Head Neck Surg 2020 Aug;163(2):293-301. Epub 2020 Mar 31 doi: 10.1177/0194599820913639. PMID: 32228141

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MedGen

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Send to:

Bone Neoplasm

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Practice guidelines

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