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Cerebellar Glioneuronal and Neuronal Tumors

MedGen UID:
272448
•Concept ID:
C1332901
•
Neoplastic Process
Synonyms: Cerebellar Neuronal and Mixed Neuronal-Glial Tumor; Neuronal and Mixed Neuronal-Glial Tumor of Cerebellum

Definition

Glioneuronal and neuronal tumors occurring in the cerebellum. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCerebellar Glioneuronal and Neuronal Tumors

Professional guidelines

PubMed

Treatment of Pediatric Low-Grade Gliomas.
Sait SF, Giantini-Larsen AM, Tringale KR, Souweidane MM, Karajannis MA
Curr Neurol Neurosci Rep 2023 Apr;23(4):185-199. Epub 2023 Mar 7 doi: 10.1007/s11910-023-01257-3. PMID: 36881254Free PMC Article
The Children's Cancer and Leukaemia Group guidelines for the diagnosis and management of dysembryoplastic neuroepithelial tumours.
O'Brien DF, Farrell M, Delanty N, Traunecker H, Perrin R, Smyth MD, Park TS; Children's Cancer and Leukaemia Group
Br J Neurosurg 2007 Dec;21(6):539-49. doi: 10.1080/02688690701594817. PMID: 18071981

Recent clinical studies

Etiology

Treatment of Pediatric Low-Grade Gliomas.
Sait SF, Giantini-Larsen AM, Tringale KR, Souweidane MM, Karajannis MA
Curr Neurol Neurosci Rep 2023 Apr;23(4):185-199. Epub 2023 Mar 7 doi: 10.1007/s11910-023-01257-3. PMID: 36881254Free PMC Article
Immune Microenvironment and Lineage Tracing Help to Decipher Rosette-Forming Glioneuronal Tumors: A Multi-Omics Analysis.
Lerond J, Morisse MC, Letourneur Q, Gimonnet C, Navarro S, Gaspar C, Idbaih A, Bielle F
J Neuropathol Exp Neurol 2022 Oct 18;81(11):873-884. doi: 10.1093/jnen/nlac074. PMID: 35984315
Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma.
Schindler G, Capper D, Meyer J, Janzarik W, Omran H, Herold-Mende C, Schmieder K, Wesseling P, Mawrin C, Hasselblatt M, Louis DN, Korshunov A, Pfister S, Hartmann C, Paulus W, Reifenberger G, von Deimling A
Acta Neuropathol 2011 Mar;121(3):397-405. Epub 2011 Jan 29 doi: 10.1007/s00401-011-0802-6. PMID: 21274720
Atypical cell clusters expressing both neuronal and oligodendrocytic markers: novel histological pattern of glioneuronal tumors?
Phi JH, Park SH, Chung CK, Wang KC, Cho BK, Kim SK
Pathol Int 2009 Oct;59(10):735-43. doi: 10.1111/j.1440-1827.2009.02436.x. PMID: 19788619
Glioneuronal migration and development disorders: histological and immunohistochemical study with a comment on evolution.
Pal L, Shankar SK, Santosh V, Yasha TC
Neurol India 2002 Dec;50(4):444-51. PMID: 12577093

Diagnosis

Treatment of Pediatric Low-Grade Gliomas.
Sait SF, Giantini-Larsen AM, Tringale KR, Souweidane MM, Karajannis MA
Curr Neurol Neurosci Rep 2023 Apr;23(4):185-199. Epub 2023 Mar 7 doi: 10.1007/s11910-023-01257-3. PMID: 36881254Free PMC Article
Immunotherapy for Pediatric Brain and Spine Tumors: Current State and Future Directions.
Estevez-Ordonez D, Gary SE, Atchley TJ, Maleknia PD, George JA, Laskay NMB, Gross EG, Devulapalli RK, Johnston JM
Pediatr Neurosurg 2023;58(5):313-336. Epub 2022 Dec 22 doi: 10.1159/000528792. PMID: 36549282Free PMC Article
Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma.
Schindler G, Capper D, Meyer J, Janzarik W, Omran H, Herold-Mende C, Schmieder K, Wesseling P, Mawrin C, Hasselblatt M, Louis DN, Korshunov A, Pfister S, Hartmann C, Paulus W, Reifenberger G, von Deimling A
Acta Neuropathol 2011 Mar;121(3):397-405. Epub 2011 Jan 29 doi: 10.1007/s00401-011-0802-6. PMID: 21274720
Atypical cell clusters expressing both neuronal and oligodendrocytic markers: novel histological pattern of glioneuronal tumors?
Phi JH, Park SH, Chung CK, Wang KC, Cho BK, Kim SK
Pathol Int 2009 Oct;59(10):735-43. doi: 10.1111/j.1440-1827.2009.02436.x. PMID: 19788619
The Children's Cancer and Leukaemia Group guidelines for the diagnosis and management of dysembryoplastic neuroepithelial tumours.
O'Brien DF, Farrell M, Delanty N, Traunecker H, Perrin R, Smyth MD, Park TS; Children's Cancer and Leukaemia Group
Br J Neurosurg 2007 Dec;21(6):539-49. doi: 10.1080/02688690701594817. PMID: 18071981

Therapy

Treatment of Pediatric Low-Grade Gliomas.
Sait SF, Giantini-Larsen AM, Tringale KR, Souweidane MM, Karajannis MA
Curr Neurol Neurosci Rep 2023 Apr;23(4):185-199. Epub 2023 Mar 7 doi: 10.1007/s11910-023-01257-3. PMID: 36881254Free PMC Article
Mixed neuronal-glial tumor of the fourth ventricle and successful treatment of postoperative mutism with bromocriptine: case report.
Adachi J, Nishikawa R, Hirose T, Matsutani M
Surg Neurol 2005 Apr;63(4):375-9. doi: 10.1016/j.surneu.2004.05.039. PMID: 15808729

Prognosis

Treatment of Pediatric Low-Grade Gliomas.
Sait SF, Giantini-Larsen AM, Tringale KR, Souweidane MM, Karajannis MA
Curr Neurol Neurosci Rep 2023 Apr;23(4):185-199. Epub 2023 Mar 7 doi: 10.1007/s11910-023-01257-3. PMID: 36881254Free PMC Article
Immunotherapy for Pediatric Brain and Spine Tumors: Current State and Future Directions.
Estevez-Ordonez D, Gary SE, Atchley TJ, Maleknia PD, George JA, Laskay NMB, Gross EG, Devulapalli RK, Johnston JM
Pediatr Neurosurg 2023;58(5):313-336. Epub 2022 Dec 22 doi: 10.1159/000528792. PMID: 36549282Free PMC Article
Cryptic developmental events determine medulloblastoma radiosensitivity and cellular heterogeneity without altering transcriptomic profile.
Malawsky DS, Weir SJ, Ocasio JK, Babcock B, Dismuke T, Cleveland AH, Donson AM, Vibhakar R, Wilhelmsen K, Gershon TR
Commun Biol 2021 May 21;4(1):616. doi: 10.1038/s42003-021-02099-w. PMID: 34021242Free PMC Article
Disseminated glioneuronal tumor with neuropil-like islands of the spinal cord: a distinctive entity.
Serra SM, Dabdoub CB, da Cunha AH, Salazar B, Lima TP, Azevedo-Filho HC
World Neurosurg 2013 Nov;80(5):655.e1-5. Epub 2013 Feb 9 doi: 10.1016/j.wneu.2013.02.029. PMID: 23403348
Central liponeurocytoma.
George DH, Scheithauer BW
Am J Surg Pathol 2001 Dec;25(12):1551-5. doi: 10.1097/00000478-200112000-00013. PMID: 11717547

Clinical prediction guides

Cerebellar liponeurocytoma with atypical histological features - a rare example of a glioneuronal tumor.
Hermann B, Woznica M, Kloc W, Borkowski P, Libionka W, Izycka-Swieszewska E
Folia Neuropathol 2017;55(3):227-234. doi: 10.5114/fn.2017.70488. PMID: 28984116
Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma.
Schindler G, Capper D, Meyer J, Janzarik W, Omran H, Herold-Mende C, Schmieder K, Wesseling P, Mawrin C, Hasselblatt M, Louis DN, Korshunov A, Pfister S, Hartmann C, Paulus W, Reifenberger G, von Deimling A
Acta Neuropathol 2011 Mar;121(3):397-405. Epub 2011 Jan 29 doi: 10.1007/s00401-011-0802-6. PMID: 21274720
Infratentorial dysembryoplastic neuroepithelial tumor (DNT) associated with Arnold-Chiari malformation.
Yasha TC, Mohanty A, Radhesh S, Santosh V, Das S, Shankar SK
Clin Neuropathol 1998 Nov-Dec;17(6):305-10. PMID: 9832257
Synaptophysin: a reliable marker for medulloblastomas.
Schwechheimer K, Wiedenmann B, Franke WW
Virchows Arch A Pathol Anat Histopathol 1987;411(1):53-9. doi: 10.1007/BF00734514. PMID: 3107209

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