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Drop Metastasis in the Spinal Cord

MedGen UID:
272548
•Concept ID:
C1333313
•
Neoplastic Process
Synonyms: Drop Metastasis to the Spinal Cord; Drop Metastatic Neoplasm to the Spinal Cord; Drop Metastatic Tumor to the Spinal Cord; Drop Secondary Malignant Neoplasm to the Spinal Cord; Drop Secondary Malignant Tumor to the Spinal Cord

Definition

An intradural extramedullary spinal metastasis from an intracranial tumor through the cerebrospinal fluid. [from NCI]

Professional guidelines

PubMed

Clinical management and prognosis of spinal myxopapillary ependymoma: a single-institution cohort of 72 patients.
Zhang YW, Wang B, An SY, Liu WH, Wang C, Yan H, Xu YL, Wang YZ, Jia WQ
Eur Spine J 2023 Jul;32(7):2459-2467. Epub 2023 Apr 7 doi: 10.1007/s00586-023-07690-9. PMID: 37027035
The clinical experience of medulloblastoma treatment and the significance of time sequence for development of leptomeningeal metastasis.
Hsieh PC, Wu CT, Lin KL, Jaing TH, Tseng CK, Lui TN, Jung SM
Childs Nerv Syst 2008 Dec;24(12):1463-7. Epub 2008 Sep 19 doi: 10.1007/s00381-008-0697-2. PMID: 18802711

Recent clinical studies

Etiology

Clinical management and prognosis of spinal myxopapillary ependymoma: a single-institution cohort of 72 patients.
Zhang YW, Wang B, An SY, Liu WH, Wang C, Yan H, Xu YL, Wang YZ, Jia WQ
Eur Spine J 2023 Jul;32(7):2459-2467. Epub 2023 Apr 7 doi: 10.1007/s00586-023-07690-9. PMID: 37027035
Spinal Seeding Metastasis of Myxopapillary Ependymoma: Report of Three Pediatric Patients and a Brief Literature Review.
Abdallah A
Pediatr Neurosurg 2020;55(3):127-140. Epub 2020 Aug 10 doi: 10.1159/000509061. PMID: 32777780
Long-Term Surgical Resection Outcomes of Pediatric Myxopapillary Ependymoma: Experience of Two Centers and Brief Literature Review.
Abdallah A, Emel E, Gündüz HB, Sofuoğlu ÖE, Asiltürk M, Abdallah BG
World Neurosurg 2020 Apr;136:e245-e261. Epub 2019 Dec 30 doi: 10.1016/j.wneu.2019.12.128. PMID: 31899399
Pediatric Spinal Ependymomas.
Sofuoğlu ÖE, Abdallah A
Med Sci Monit 2018 Oct 5;24:7072-7089. doi: 10.12659/MSM.910447. PMID: 30287802Free PMC Article
Cranial Pilocytic Astrocytoma With Spinal Drop Metastasis in an Adult: Case Report and Literature Review.
Munshey A, Moore J, Maclean C, Longano A, Goldschlager T
World Neurosurg 2017 Feb;98:883.e7-883.e12. Epub 2016 Aug 12 doi: 10.1016/j.wneu.2016.08.013. PMID: 27535634

Diagnosis

Clinical management and prognosis of spinal myxopapillary ependymoma: a single-institution cohort of 72 patients.
Zhang YW, Wang B, An SY, Liu WH, Wang C, Yan H, Xu YL, Wang YZ, Jia WQ
Eur Spine J 2023 Jul;32(7):2459-2467. Epub 2023 Apr 7 doi: 10.1007/s00586-023-07690-9. PMID: 37027035
Diffuse spinal cord metastasis after resection of SMARCB1 sinonasal carcinoma manifesting with a right foot drop-a case report.
da Silva MA, Bentes RGL, Teixeira HS, Carvalho BM, Queiroz ALG, Schmid MF, Lima KDF, Ferreira WSM, Campos CMS, Neto MR, Baeta AM
Spinal Cord Ser Cases 2022 Jul 1;8(1):64. doi: 10.1038/s41394-022-00532-8. PMID: 35778377Free PMC Article
Multifocal lumbar myxopapillary ependymoma presenting with drop metastasis: a case report and review of the literature.
Tabor JK, Ryu B, Schneider D, Sciubba DM, Narayana A, Zlochower A, Amico RS
Spinal Cord Ser Cases 2022 Apr 22;8(1):43. doi: 10.1038/s41394-022-00513-x. PMID: 35459220Free PMC Article
Spinal Seeding Metastasis of Myxopapillary Ependymoma: Report of Three Pediatric Patients and a Brief Literature Review.
Abdallah A
Pediatr Neurosurg 2020;55(3):127-140. Epub 2020 Aug 10 doi: 10.1159/000509061. PMID: 32777780
Spinal Metastasis of Cerebral Glioblastoma with Genetic Profile: Case Report and Review of Literature.
Shaaban A, Babu R A, Elbadry RG, Haddad R, Al-Bozom I, Ayyad A, Belkhair S
World Neurosurg 2020 Nov;143:480-489. Epub 2020 Jul 31 doi: 10.1016/j.wneu.2020.07.163. PMID: 32745649

Therapy

Scurvy presenting as lower limb ecchymoses in the setting of metastatic colorectal cancer.
Inglis JM, Tan J
BMJ Case Rep 2020 Dec 18;13(12) doi: 10.1136/bcr-2020-237507. PMID: 33370932Free PMC Article
Von Hippel-Lindau with early onset of hemangioblastoma and multiple drop-metastases like spinal lesions: A case report.
Nguyen TH, Pham T, Strickland T, Brewer D, Belirgen M, Al-Rahawan MM
Medicine (Baltimore) 2018 Sep;97(39):e12477. doi: 10.1097/MD.0000000000012477. PMID: 30278534Free PMC Article
Intracranial glioblastoma with drop metastases to the spine after stereotactic biopsy.
Albert G, Wassef S, Dahdaleh NS, Lindley T, Bruch L, Hitchon P
J Neurol Surg A Cent Eur Neurosurg 2013 Dec;74 Suppl 1:e221-4. Epub 2013 Jun 26 doi: 10.1055/s-0033-1345685. PMID: 23804229
The impact of fluorescence guidance on spinal intradural tumour surgery.
Eicker SO, Floeth FW, Kamp M, Steiger HJ, Hänggi D
Eur Spine J 2013 Jun;22(6):1394-401. Epub 2013 Jan 10 doi: 10.1007/s00586-013-2657-0. PMID: 23307195Free PMC Article
Central neurocytoma responsive to topotecan, ifosfamide, carboplatin.
Amini E, Roffidal T, Lee A, Fuller GN, Mahajan A, Ketonen L, Kobrinsky N, Cairo MS, Wells RJ, Wolff JE
Pediatr Blood Cancer 2008 Jul;51(1):137-40. doi: 10.1002/pbc.21551. PMID: 18338396

Prognosis

Clinical management and prognosis of spinal myxopapillary ependymoma: a single-institution cohort of 72 patients.
Zhang YW, Wang B, An SY, Liu WH, Wang C, Yan H, Xu YL, Wang YZ, Jia WQ
Eur Spine J 2023 Jul;32(7):2459-2467. Epub 2023 Apr 7 doi: 10.1007/s00586-023-07690-9. PMID: 37027035
Diffuse spinal cord metastasis after resection of SMARCB1 sinonasal carcinoma manifesting with a right foot drop-a case report.
da Silva MA, Bentes RGL, Teixeira HS, Carvalho BM, Queiroz ALG, Schmid MF, Lima KDF, Ferreira WSM, Campos CMS, Neto MR, Baeta AM
Spinal Cord Ser Cases 2022 Jul 1;8(1):64. doi: 10.1038/s41394-022-00532-8. PMID: 35778377Free PMC Article
Spinal Metastasis of Cerebral Glioblastoma with Genetic Profile: Case Report and Review of Literature.
Shaaban A, Babu R A, Elbadry RG, Haddad R, Al-Bozom I, Ayyad A, Belkhair S
World Neurosurg 2020 Nov;143:480-489. Epub 2020 Jul 31 doi: 10.1016/j.wneu.2020.07.163. PMID: 32745649
Pediatric Spinal Ependymomas.
Sofuoğlu ÖE, Abdallah A
Med Sci Monit 2018 Oct 5;24:7072-7089. doi: 10.12659/MSM.910447. PMID: 30287802Free PMC Article
Cranial Pilocytic Astrocytoma With Spinal Drop Metastasis in an Adult: Case Report and Literature Review.
Munshey A, Moore J, Maclean C, Longano A, Goldschlager T
World Neurosurg 2017 Feb;98:883.e7-883.e12. Epub 2016 Aug 12 doi: 10.1016/j.wneu.2016.08.013. PMID: 27535634

Clinical prediction guides

Clinical management and prognosis of spinal myxopapillary ependymoma: a single-institution cohort of 72 patients.
Zhang YW, Wang B, An SY, Liu WH, Wang C, Yan H, Xu YL, Wang YZ, Jia WQ
Eur Spine J 2023 Jul;32(7):2459-2467. Epub 2023 Apr 7 doi: 10.1007/s00586-023-07690-9. PMID: 37027035
Von Hippel-Lindau with early onset of hemangioblastoma and multiple drop-metastases like spinal lesions: A case report.
Nguyen TH, Pham T, Strickland T, Brewer D, Belirgen M, Al-Rahawan MM
Medicine (Baltimore) 2018 Sep;97(39):e12477. doi: 10.1097/MD.0000000000012477. PMID: 30278534Free PMC Article
Malignant spinal cord compression in cerebral glioblastoma multiforme: a multicenter case series and review of the literature.
Tinchon A, Oberndorfer S, Marosi C, Rudà R, Sax C, Calabek B, Grisold W
J Neurooncol 2012 Nov;110(2):221-6. Epub 2012 Aug 14 doi: 10.1007/s11060-012-0955-8. PMID: 22886532
Utility of administrative claims data for the study of brain metastases: a validation study.
Eichler AF, Lamont EB
J Neurooncol 2009 Dec;95(3):427-431. Epub 2009 Jun 27 doi: 10.1007/s11060-009-9943-z. PMID: 19562256

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