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Endocrine Syndrome

MedGen UID:: 272569
•Concept ID:: C1333387
•: Disease or Syndrome

Definition

A group of signs, symptoms, and clinicopathological characteristics that result from the pathologic function of one or more endocrine organs. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVEndocrine Syndrome

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Disorder by Site
      - Disorder of endocrine system
        Endocrine Syndrome
        46,XY Disorder of Androgen Action
        Abnormal development of female secondary sexual characteristics
        Acquired Feminization
        Androgen resistance syndrome
        Androgen insensitivity syndrome, mild
        Complete androgen insensitivity syndrome
        Partial androgen insensitivity syndrome
        Autoimmune polyendocrinopathy
        Autoimmune polyendocrinopathy type 3
        Autoimmune polyendocrinopathy type 4
        Polyglandular autoimmune syndrome, type 1
        Polyglandular autoimmune syndrome, type 2
        Contrasexual Sexual Development
        Iatrogenic Contrasexual Pubertal Development
        Cushing syndrome
        ACTH-dependent Cushing syndrome
        Ectopic Cushing syndrome
        Pituitary dependent hypercortisolism
        ACTH-independent Cushing syndrome
        ACTH-independent Cushing syndrome due to rare cortisol-producing adrenal tumor
        Cushing syndrome due to macronodular adrenal hyperplasia
        Primary pigmented nodular adrenocortical disease
        Endogenous Cushing syndrome
        Recurrent Endogenous Cushing Syndrome
        Iatrogenic Cushing disease
        Ectopic hormone secretion syndrome associated with neoplasia
        Carcinoid syndrome
        Carcinoid heart disease
        Ectopic ACTH secretion syndrome
        Ectopic aldosterone secretion
        Ectopic calcitonin production
        Ectopic Chorionic Gonadotropin Secretion Syndrome
        Ectopic growth hormone secretion
        Ectopic Parathormone Secretion Syndrome
        Ectopic prolactin secretion
        Ectopic renin secretion
        Inappropriate antidiuretic hormone secretion
        Hereditary pheochromocytoma-paraganglioma
        Paragangliomas 1
        Paragangliomas with sensorineural hearing loss
        Paragangliomas 2
        Paragangliomas 3
        Paragangliomas 4
        Paragangliomas 5
        Hypogonadism with anosmia
        Hypogonadotropic hypogonadism 1 with or without anosmia
        Hypogonadotropic hypogonadism 2 with or without anosmia
        Hypogonadotropic hypogonadism 3 with or without anosmia
        Hypogonadotropic hypogonadism 4 with or without anosmia
        Hypogonadotropic hypogonadism 5 with or without anosmia
        Hypogonadotropic hypogonadism 6 with or without anosmia
        Klinefelter syndrome
        McCune-Albright syndrome
        Pancreatic cholera
        Primary aldosteronism
        Dexamethasone-suppressible primary hyperaldosteronism
        Glucocortocoid-insensitive primary hyperaldosteronism
        Rare insulin-resistance syndrome
        Acanthosis nigricans-insulin resistance-muscle cramps-acral enlargement syndrome
        Acquired generalized lipodystrophy
        Autosomal semi-dominant severe lipodystrophic laminopathy
        Berardinelli-Seip congenital lipodystrophy
        Congenital generalized lipodystrophy
        Partial lipodystrophy, congenital cataracts, and neurodegeneration syndrome
        Insulin-resistance syndrome type B
        Insulin-resistant diabetes mellitus AND acanthosis nigricans
        Intrauterine growth restriction-short stature-early adult-onset diabetes syndrome
        Leprechaunism syndrome
        Microcephalic primordial dwarfism-insulin resistance syndrome
        PLIN1-related familial partial lipodystrophy
        Rabson-Mendenhall syndrome
        Short fifth metacarpals-insulin resistance syndrome
        SHORT syndrome
        SERKAL syndrome
        Turner syndrome
        Monosomy X
        Mosaic Turner syndrome
        Turner syndrome due to structural X chromosome anomalies
        Zollinger-Ellison syndrome

Professional guidelines

PubMed

ASO Practice Guidelines Series: Surgical Management of Gastrointestinal (Midgut) Neuroendocrine Neoplasms.

Hallet J, Clarke CN
Ann Surg Oncol 2024 Mar;31(3):1704-1713. Epub 2024 Jan 2 doi: 10.1245/s10434-023-14802-8. PMID: 38167813

Polycystic ovary syndrome. Long term sequelae and management.

Legro RS
Minerva Ginecol 2002 Apr;54(2):97-114. PMID: 12032449

Metformin therapy in the management of polycystic ovary syndrome: endocrine, metabolic and reproductive effects.

Nardo LG, Rai R
Gynecol Endocrinol 2001 Oct;15(5):373-80. doi: 10.1080/gye.15.5.373.380. PMID: 11727360

See all (9)

Recent clinical studies

Etiology

Clinical Factors Predicting Multiple Endocrine Neoplasia Type 1 and Type 4 in Patients with Neuroendocrine Tumors.

Faggiano A, Fazzalari B, Mikovic N, Russo F, Zamponi V, Mazzilli R, Guarnieri V, Piane M, Visco V, Petrucci S
Genes (Basel) 2023 Sep 10;14(9) doi: 10.3390/genes14091782. PMID: 37761922 Free PMC Article

Metabolic and Endocrine Challenges.

Martucci G, Bonicolini E, Parekh D, Thein OS, Scherkl M, Amrein K
Semin Respir Crit Care Med 2021 Feb;42(1):78-97. Epub 2020 Sep 3 doi: 10.1055/s-0040-1713084. PMID: 32882734

Pediatric adrenocortical tumours.

Pinto EM, Zambetti GP, Rodriguez-Galindo C
Best Pract Res Clin Endocrinol Metab 2020 May;34(3):101448. Epub 2020 Jul 3 doi: 10.1016/j.beem.2020.101448. PMID: 32636100

Primary Aldosteronism: Novel Insights.

Stavropoulos K, Imprialos K, Papademetriou V, Faselis C, Tsioufis K, Dimitriadis K, Doumas M
Curr Hypertens Rev 2020;16(1):19-23. doi: 10.2174/1573402115666190415155512. PMID: 30987572

Syndromic infertility.

Guerri G, Maniscalchi T, Barati S, Dhuli K, Busetto GM, Del Giudice F, De Berardinis E, De Antoni L, Miertus J, Bertelli M
Acta Biomed 2019 Sep 30;90(10-S):75-82. doi: 10.23750/abm.v90i10-S.8764. PMID: 31577259 Free PMC Article

See all (33)

Diagnosis

Metabolic and Endocrine Challenges.

Martucci G, Bonicolini E, Parekh D, Thein OS, Scherkl M, Amrein K
Semin Respir Crit Care Med 2021 Feb;42(1):78-97. Epub 2020 Sep 3 doi: 10.1055/s-0040-1713084. PMID: 32882734

Pediatric adrenocortical tumours.

Pinto EM, Zambetti GP, Rodriguez-Galindo C
Best Pract Res Clin Endocrinol Metab 2020 May;34(3):101448. Epub 2020 Jul 3 doi: 10.1016/j.beem.2020.101448. PMID: 32636100

Primary Aldosteronism: Novel Insights.

Stavropoulos K, Imprialos K, Papademetriou V, Faselis C, Tsioufis K, Dimitriadis K, Doumas M
Curr Hypertens Rev 2020;16(1):19-23. doi: 10.2174/1573402115666190415155512. PMID: 30987572

Syndromic infertility.

Adrenal imaging.

Korobkin M, Francis IR
Semin Ultrasound CT MR 1995 Aug;16(4):317-30. doi: 10.1016/0887-2171(95)90036-5. PMID: 7576778

See all (53)

Therapy

Serum metabolomics probes the molecular mechanism of action of acupuncture on metabolic pathways related to glucose metabolism in patients with polycystic ovary syndrome-related obesity.

Yang N, Ma K, Liu W, Zhang N, Shi Z, Ren J, Xu W, Li Y, Su R, Liang Y, Wang S, Li X
Biomed Chromatogr 2023 Oct;37(10):e5710. Epub 2023 Aug 18 doi: 10.1002/bmc.5710. PMID: 37593801

A PCOS Paradox: Does Inositol Therapy Find a Rationale in All the Different Phenotypes?

Unfer V, Dinicola S, Russo M
Int J Mol Sci 2023 Mar 25;24(7) doi: 10.3390/ijms24076213. PMID: 37047186 Free PMC Article

Pediatric adrenocortical tumours.

Pinto EM, Zambetti GP, Rodriguez-Galindo C
Best Pract Res Clin Endocrinol Metab 2020 May;34(3):101448. Epub 2020 Jul 3 doi: 10.1016/j.beem.2020.101448. PMID: 32636100

Primary Aldosteronism: Novel Insights.

Stavropoulos K, Imprialos K, Papademetriou V, Faselis C, Tsioufis K, Dimitriadis K, Doumas M
Curr Hypertens Rev 2020;16(1):19-23. doi: 10.2174/1573402115666190415155512. PMID: 30987572

Childhood adrenocortical tumours.

Ribeiro RC, Figueiredo B
Eur J Cancer 2004 May;40(8):1117-26. doi: 10.1016/j.ejca.2004.01.031. PMID: 15110875

See all (17)

Prognosis

Clinical Factors Predicting Multiple Endocrine Neoplasia Type 1 and Type 4 in Patients with Neuroendocrine Tumors.

Pediatric adrenocortical tumours.

Pinto EM, Zambetti GP, Rodriguez-Galindo C
Best Pract Res Clin Endocrinol Metab 2020 May;34(3):101448. Epub 2020 Jul 3 doi: 10.1016/j.beem.2020.101448. PMID: 32636100

Polycystic Ovary Syndrome: Special Diagnostic and Therapeutic Considerations for Children.

Kamangar F, Okhovat JP, Schmidt T, Beshay A, Pasch L, Cedars MI, Huddleston H, Shinkai K
Pediatr Dermatol 2015 Sep-Oct;32(5):571-8. Epub 2015 Mar 19 doi: 10.1111/pde.12566. PMID: 25787290

Childhood adrenocortical tumours.

Ribeiro RC, Figueiredo B
Eur J Cancer 2004 May;40(8):1117-26. doi: 10.1016/j.ejca.2004.01.031. PMID: 15110875

Historical background and natural history of carcinoids.

Creutzfeldt W
Digestion 1994;55 Suppl 3:3-10. doi: 10.1159/000201195. PMID: 7698535

See all (24)

Clinical prediction guides

Clinical Factors Predicting Multiple Endocrine Neoplasia Type 1 and Type 4 in Patients with Neuroendocrine Tumors.

Diseases caused by mutations in the Na(+)/K(+) pump α1 gene ATP1A1.

Biondo ED, Spontarelli K, Ababioh G, Méndez L, Artigas P
Am J Physiol Cell Physiol 2021 Aug 1;321(2):C394-C408. Epub 2021 Jul 7 doi: 10.1152/ajpcell.00059.2021. PMID: 34232746 Free PMC Article

The silent variants of pituitary tumors: demographic, radiological and molecular characteristics.

Torregrosa-Quesada ME, García-Martínez A, Sánchez-Barbie A, Silva-Ortega S, Cámara R, Fajardo C, Lamas C, Aranda I, Pico A
J Endocrinol Invest 2021 Aug;44(8):1637-1648. Epub 2021 Jan 21 doi: 10.1007/s40618-020-01468-2. PMID: 33476035

Yttrium-labelled peptides for therapy of NET.

Bodei L, Cremonesi M, Grana CM, Chinol M, Baio SM, Severi S, Paganelli G
Eur J Nucl Med Mol Imaging 2012 Feb;39 Suppl 1:S93-102. doi: 10.1007/s00259-011-2002-y. PMID: 22388625

Historical background and natural history of carcinoids.

Creutzfeldt W
Digestion 1994;55 Suppl 3:3-10. doi: 10.1159/000201195. PMID: 7698535

See all (15)

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Endocrine Syndrome

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Supplemental Content

Table of contents

Practice guidelines

Related information

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