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Grade 1 Rectal Adenocarcinoma

MedGen UID:
272683
Concept ID:
C1333870
Neoplastic Process
Synonyms: Grade I Rectal Adenocarcinoma; Well Differentiated Rectal Adenocarcinoma

Definition

A rectal adenocarcinoma characterized by the presence of a malignant cellular infiltrate with more than 95% glandular formation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrade 1 Rectal Adenocarcinoma

Professional guidelines

PubMed

Attard G, Murphy L, Clarke NW, Cross W, Jones RJ, Parker CC, Gillessen S, Cook A, Brawley C, Amos CL, Atako N, Pugh C, Buckner M, Chowdhury S, Malik Z, Russell JM, Gilson C, Rush H, Bowen J, Lydon A, Pedley I, O'Sullivan JM, Birtle A, Gale J, Srihari N, Thomas C, Tanguay J, Wagstaff J, Das P, Gray E, Alzoueb M, Parikh O, Robinson A, Syndikus I, Wylie J, Zarkar A, Thalmann G, de Bono JS, Dearnaley DP, Mason MD, Gilbert D, Langley RE, Millman R, Matheson D, Sydes MR, Brown LC, Parmar MKB, James ND; Systemic Therapy in Advancing or Metastatic Prostate cancer: Evaluation of Drug Efficacy (STAMPEDE) investigators
Lancet 2022 Jan 29;399(10323):447-460. Epub 2021 Dec 23 doi: 10.1016/S0140-6736(21)02437-5. PMID: 34953525Free PMC Article
Chin RI, Roy A, Pedersen KS, Huang Y, Hunt SR, Glasgow SC, Tan BR, Wise PE, Silviera ML, Smith RK, Suresh R, Badiyan SN, Shetty AS, Henke LE, Mutch MG, Kim H
Int J Radiat Oncol Biol Phys 2022 Mar 1;112(3):715-725. Epub 2021 Oct 12 doi: 10.1016/j.ijrobp.2021.10.004. PMID: 34653579
Smith J, Reidy-Lagunes D
Semin Oncol 2013 Feb;40(1):100-8. doi: 10.1053/j.seminoncol.2012.11.011. PMID: 23391117

Recent clinical studies

Etiology

Antunez AG, Kanters AE, Regenbogen SE
Dis Colon Rectum 2023 Jan 1;66(1):59-66. Epub 2022 Oct 27 doi: 10.1097/DCR.0000000000002485. PMID: 35905174
Li J, Gao X, Dominik Nickel M, Cheng J, Zhu J
Cancer Imaging 2022 Jun 17;22(1):30. doi: 10.1186/s40644-022-00461-7. PMID: 35715848Free PMC Article
Silva-Velazco J, Stocchi L, Valente MA, Church JM, Liska D, Gorgun E, Kalady MF, Kessler H, Steele SR, Delaney CP
Colorectal Dis 2019 Mar;21(3):315-325. Epub 2019 Jan 17 doi: 10.1111/codi.14535. PMID: 30565830
Kanso F, Lefevre JH, Svrcek M, Chafai N, Parc Y, Tiret E
Clin Colorectal Cancer 2016 Mar;15(1):82-90.e1. Epub 2015 Aug 1 doi: 10.1016/j.clcc.2015.07.008. PMID: 26372333
Garcia-Aguilar J, Chow OS, Smith DD, Marcet JE, Cataldo PA, Varma MG, Kumar AS, Oommen S, Coutsoftides T, Hunt SR, Stamos MJ, Ternent CA, Herzig DO, Fichera A, Polite BN, Dietz DW, Patil S, Avila K; Timing of Rectal Cancer Response to Chemoradiation Consortium
Lancet Oncol 2015 Aug;16(8):957-66. Epub 2015 Jul 14 doi: 10.1016/S1470-2045(15)00004-2. PMID: 26187751Free PMC Article

Diagnosis

Cercek A, Lumish M, Sinopoli J, Weiss J, Shia J, Lamendola-Essel M, El Dika IH, Segal N, Shcherba M, Sugarman R, Stadler Z, Yaeger R, Smith JJ, Rousseau B, Argiles G, Patel M, Desai A, Saltz LB, Widmar M, Iyer K, Zhang J, Gianino N, Crane C, Romesser PB, Pappou EP, Paty P, Garcia-Aguilar J, Gonen M, Gollub M, Weiser MR, Schalper KA, Diaz LA Jr
N Engl J Med 2022 Jun 23;386(25):2363-2376. Epub 2022 Jun 5 doi: 10.1056/NEJMoa2201445. PMID: 35660797Free PMC Article
Attard G, Murphy L, Clarke NW, Cross W, Jones RJ, Parker CC, Gillessen S, Cook A, Brawley C, Amos CL, Atako N, Pugh C, Buckner M, Chowdhury S, Malik Z, Russell JM, Gilson C, Rush H, Bowen J, Lydon A, Pedley I, O'Sullivan JM, Birtle A, Gale J, Srihari N, Thomas C, Tanguay J, Wagstaff J, Das P, Gray E, Alzoueb M, Parikh O, Robinson A, Syndikus I, Wylie J, Zarkar A, Thalmann G, de Bono JS, Dearnaley DP, Mason MD, Gilbert D, Langley RE, Millman R, Matheson D, Sydes MR, Brown LC, Parmar MKB, James ND; Systemic Therapy in Advancing or Metastatic Prostate cancer: Evaluation of Drug Efficacy (STAMPEDE) investigators
Lancet 2022 Jan 29;399(10323):447-460. Epub 2021 Dec 23 doi: 10.1016/S0140-6736(21)02437-5. PMID: 34953525Free PMC Article
Conroy T, Bosset JF, Etienne PL, Rio E, François É, Mesgouez-Nebout N, Vendrely V, Artignan X, Bouché O, Gargot D, Boige V, Bonichon-Lamichhane N, Louvet C, Morand C, de la Fouchardière C, Lamfichekh N, Juzyna B, Jouffroy-Zeller C, Rullier E, Marchal F, Gourgou S, Castan F, Borg C; Unicancer Gastrointestinal Group and Partenariat de Recherche en Oncologie Digestive (PRODIGE) Group
Lancet Oncol 2021 May;22(5):702-715. Epub 2021 Apr 13 doi: 10.1016/S1470-2045(21)00079-6. PMID: 33862000
Bahadoer RR, Dijkstra EA, van Etten B, Marijnen CAM, Putter H, Kranenbarg EM, Roodvoets AGH, Nagtegaal ID, Beets-Tan RGH, Blomqvist LK, Fokstuen T, Ten Tije AJ, Capdevila J, Hendriks MP, Edhemovic I, Cervantes A, Nilsson PJ, Glimelius B, van de Velde CJH, Hospers GAP; RAPIDO collaborative investigators
Lancet Oncol 2021 Jan;22(1):29-42. Epub 2020 Dec 7 doi: 10.1016/S1470-2045(20)30555-6. PMID: 33301740
Kyrgiou M, Kalliala I, Markozannes G, Gunter MJ, Paraskevaidis E, Gabra H, Martin-Hirsch P, Tsilidis KK
BMJ 2017 Feb 28;356:j477. doi: 10.1136/bmj.j477. PMID: 28246088Free PMC Article

Therapy

Cercek A, Lumish M, Sinopoli J, Weiss J, Shia J, Lamendola-Essel M, El Dika IH, Segal N, Shcherba M, Sugarman R, Stadler Z, Yaeger R, Smith JJ, Rousseau B, Argiles G, Patel M, Desai A, Saltz LB, Widmar M, Iyer K, Zhang J, Gianino N, Crane C, Romesser PB, Pappou EP, Paty P, Garcia-Aguilar J, Gonen M, Gollub M, Weiser MR, Schalper KA, Diaz LA Jr
N Engl J Med 2022 Jun 23;386(25):2363-2376. Epub 2022 Jun 5 doi: 10.1056/NEJMoa2201445. PMID: 35660797Free PMC Article
Attard G, Murphy L, Clarke NW, Cross W, Jones RJ, Parker CC, Gillessen S, Cook A, Brawley C, Amos CL, Atako N, Pugh C, Buckner M, Chowdhury S, Malik Z, Russell JM, Gilson C, Rush H, Bowen J, Lydon A, Pedley I, O'Sullivan JM, Birtle A, Gale J, Srihari N, Thomas C, Tanguay J, Wagstaff J, Das P, Gray E, Alzoueb M, Parikh O, Robinson A, Syndikus I, Wylie J, Zarkar A, Thalmann G, de Bono JS, Dearnaley DP, Mason MD, Gilbert D, Langley RE, Millman R, Matheson D, Sydes MR, Brown LC, Parmar MKB, James ND; Systemic Therapy in Advancing or Metastatic Prostate cancer: Evaluation of Drug Efficacy (STAMPEDE) investigators
Lancet 2022 Jan 29;399(10323):447-460. Epub 2021 Dec 23 doi: 10.1016/S0140-6736(21)02437-5. PMID: 34953525Free PMC Article
Fokas E, Schlenska-Lange A, Polat B, Klautke G, Grabenbauer GG, Fietkau R, Kuhnt T, Staib L, Brunner T, Grosu AL, Kirste S, Jacobasch L, Allgäuer M, Flentje M, Germer CT, Grützmann R, Hildebrandt G, Schwarzbach M, Bechstein WO, Sülberg H, Friede T, Gaedcke J, Ghadimi M, Hofheinz RD, Rödel C; German Rectal Cancer Study Group
JAMA Oncol 2022 Jan 1;8(1):e215445. Epub 2022 Jan 20 doi: 10.1001/jamaoncol.2021.5445. PMID: 34792531Free PMC Article
Conroy T, Bosset JF, Etienne PL, Rio E, François É, Mesgouez-Nebout N, Vendrely V, Artignan X, Bouché O, Gargot D, Boige V, Bonichon-Lamichhane N, Louvet C, Morand C, de la Fouchardière C, Lamfichekh N, Juzyna B, Jouffroy-Zeller C, Rullier E, Marchal F, Gourgou S, Castan F, Borg C; Unicancer Gastrointestinal Group and Partenariat de Recherche en Oncologie Digestive (PRODIGE) Group
Lancet Oncol 2021 May;22(5):702-715. Epub 2021 Apr 13 doi: 10.1016/S1470-2045(21)00079-6. PMID: 33862000
Bahadoer RR, Dijkstra EA, van Etten B, Marijnen CAM, Putter H, Kranenbarg EM, Roodvoets AGH, Nagtegaal ID, Beets-Tan RGH, Blomqvist LK, Fokstuen T, Ten Tije AJ, Capdevila J, Hendriks MP, Edhemovic I, Cervantes A, Nilsson PJ, Glimelius B, van de Velde CJH, Hospers GAP; RAPIDO collaborative investigators
Lancet Oncol 2021 Jan;22(1):29-42. Epub 2020 Dec 7 doi: 10.1016/S1470-2045(20)30555-6. PMID: 33301740

Prognosis

Antunez AG, Kanters AE, Regenbogen SE
Dis Colon Rectum 2023 Jan 1;66(1):59-66. Epub 2022 Oct 27 doi: 10.1097/DCR.0000000000002485. PMID: 35905174
Silva-Velazco J, Stocchi L, Valente MA, Church JM, Liska D, Gorgun E, Kalady MF, Kessler H, Steele SR, Delaney CP
Colorectal Dis 2019 Mar;21(3):315-325. Epub 2019 Jan 17 doi: 10.1111/codi.14535. PMID: 30565830
Kanso F, Lefevre JH, Svrcek M, Chafai N, Parc Y, Tiret E
Clin Colorectal Cancer 2016 Mar;15(1):82-90.e1. Epub 2015 Aug 1 doi: 10.1016/j.clcc.2015.07.008. PMID: 26372333
Garcia-Aguilar J, Chow OS, Smith DD, Marcet JE, Cataldo PA, Varma MG, Kumar AS, Oommen S, Coutsoftides T, Hunt SR, Stamos MJ, Ternent CA, Herzig DO, Fichera A, Polite BN, Dietz DW, Patil S, Avila K; Timing of Rectal Cancer Response to Chemoradiation Consortium
Lancet Oncol 2015 Aug;16(8):957-66. Epub 2015 Jul 14 doi: 10.1016/S1470-2045(15)00004-2. PMID: 26187751Free PMC Article
Pierredon-Foulongne MA, Nougaret S, Bibeau F, Rouanet P, Delhom E, Lonjon J, Ragu N, Colleau J, Schembri V, Guiu B, Gallix B
Diagn Interv Imaging 2014 May;95(5):495-503. Epub 2014 Apr 22 doi: 10.1016/j.diii.2014.03.010. PMID: 24767672

Clinical prediction guides

Antunez AG, Kanters AE, Regenbogen SE
Dis Colon Rectum 2023 Jan 1;66(1):59-66. Epub 2022 Oct 27 doi: 10.1097/DCR.0000000000002485. PMID: 35905174
Attard G, Murphy L, Clarke NW, Cross W, Jones RJ, Parker CC, Gillessen S, Cook A, Brawley C, Amos CL, Atako N, Pugh C, Buckner M, Chowdhury S, Malik Z, Russell JM, Gilson C, Rush H, Bowen J, Lydon A, Pedley I, O'Sullivan JM, Birtle A, Gale J, Srihari N, Thomas C, Tanguay J, Wagstaff J, Das P, Gray E, Alzoueb M, Parikh O, Robinson A, Syndikus I, Wylie J, Zarkar A, Thalmann G, de Bono JS, Dearnaley DP, Mason MD, Gilbert D, Langley RE, Millman R, Matheson D, Sydes MR, Brown LC, Parmar MKB, James ND; Systemic Therapy in Advancing or Metastatic Prostate cancer: Evaluation of Drug Efficacy (STAMPEDE) investigators
Lancet 2022 Jan 29;399(10323):447-460. Epub 2021 Dec 23 doi: 10.1016/S0140-6736(21)02437-5. PMID: 34953525Free PMC Article
Fokas E, Schlenska-Lange A, Polat B, Klautke G, Grabenbauer GG, Fietkau R, Kuhnt T, Staib L, Brunner T, Grosu AL, Kirste S, Jacobasch L, Allgäuer M, Flentje M, Germer CT, Grützmann R, Hildebrandt G, Schwarzbach M, Bechstein WO, Sülberg H, Friede T, Gaedcke J, Ghadimi M, Hofheinz RD, Rödel C; German Rectal Cancer Study Group
JAMA Oncol 2022 Jan 1;8(1):e215445. Epub 2022 Jan 20 doi: 10.1001/jamaoncol.2021.5445. PMID: 34792531Free PMC Article
Bahadoer RR, Dijkstra EA, van Etten B, Marijnen CAM, Putter H, Kranenbarg EM, Roodvoets AGH, Nagtegaal ID, Beets-Tan RGH, Blomqvist LK, Fokstuen T, Ten Tije AJ, Capdevila J, Hendriks MP, Edhemovic I, Cervantes A, Nilsson PJ, Glimelius B, van de Velde CJH, Hospers GAP; RAPIDO collaborative investigators
Lancet Oncol 2021 Jan;22(1):29-42. Epub 2020 Dec 7 doi: 10.1016/S1470-2045(20)30555-6. PMID: 33301740
Kyrgiou M, Kalliala I, Markozannes G, Gunter MJ, Paraskevaidis E, Gabra H, Martin-Hirsch P, Tsilidis KK
BMJ 2017 Feb 28;356:j477. doi: 10.1136/bmj.j477. PMID: 28246088Free PMC Article

Recent systematic reviews

Lauricella S, Fabris S, Sylla P
Surg Endosc 2023 Jan;37(1):48-61. Epub 2022 Aug 3 doi: 10.1007/s00464-022-09462-w. PMID: 35920906
Piozzi GN, Rusli SM, Baek SJ, Kwak JM, Kim J, Kim SH
Eur J Surg Oncol 2022 Apr;48(4):718-726. Epub 2021 Dec 4 doi: 10.1016/j.ejso.2021.12.005. PMID: 34893366
Peng J, Lv J, Peng J
Int J Colorectal Dis 2021 Aug;36(8):1781-1790. Epub 2021 Mar 24 doi: 10.1007/s00384-021-03911-z. PMID: 33760952
Sajid MS, Farag S, Leung P, Sains P, Miles WF, Baig MK
Colorectal Dis 2014 Jan;16(1):2-14. doi: 10.1111/codi.12474. PMID: 24330432
Breukink S, Pierie J, Wiggers T
Cochrane Database Syst Rev 2006 Oct 18;(4):CD005200. doi: 10.1002/14651858.CD005200.pub2. PMID: 17054246

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