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Low Grade Breast Mucoepidermoid Carcinoma

MedGen UID:
272798
•Concept ID:
C1334417
•
Neoplastic Process
Synonyms: Low Grade Mucoepidermoid Breast Carcinoma; Low-Grade Mucoepidermoid Carcinoma of Breast; Low-Grade Mucoepidermoid Carcinoma of the Breast

Definition

A slow growing mucoepidermoid carcinoma characterized by the presence of keratinization in the neoplastic squamous cells and lumina formation by glandular neoplastic cells. Complete excision may be curative. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLow Grade Breast Mucoepidermoid Carcinoma

Professional guidelines

PubMed

The Role of Molecular Testing in the Differential Diagnosis of Salivary Gland Carcinomas.
Skálová A, Stenman G, Simpson RHW, Hellquist H, Slouka D, Svoboda T, Bishop JA, Hunt JL, Nibu KI, Rinaldo A, Vander Poorten V, Devaney KO, Steiner P, Ferlito A
Am J Surg Pathol 2018 Feb;42(2):e11-e27. doi: 10.1097/PAS.0000000000000980. PMID: 29076877

Recent clinical studies

Etiology

Genomics and tumor microenvironment of breast mucoepidermoid carcinoma based on whole-exome and RNA sequencing.
Ge Y, Lin X, He J, Chen W, Lin D, Zheng Y, Yang L, Xu F, Li Z
Diagn Pathol 2024 Jan 19;19(1):15. doi: 10.1186/s13000-024-01439-8. PMID: 38243319Free PMC Article
The molecular landscape of breast mucoepidermoid carcinoma.
Venetis K, Sajjadi E, Ivanova M, Andaloro S, Pessina S, Zanetti C, Ranghiero A, Citelli G, Rossi C, Lucioni M, Malapelle U, Pagni F, Barberis M, Guerini-Rocco E, Viale G, Fusco N
Cancer Med 2023 May;12(9):10725-10737. Epub 2023 Mar 14 doi: 10.1002/cam4.5754. PMID: 36916425Free PMC Article
The Role of Molecular Testing in the Differential Diagnosis of Salivary Gland Carcinomas.
Skálová A, Stenman G, Simpson RHW, Hellquist H, Slouka D, Svoboda T, Bishop JA, Hunt JL, Nibu KI, Rinaldo A, Vander Poorten V, Devaney KO, Steiner P, Ferlito A
Am J Surg Pathol 2018 Feb;42(2):e11-e27. doi: 10.1097/PAS.0000000000000980. PMID: 29076877
Salivary gland-like tumours of the breast: surgical and molecular pathology.
Pia-Foschini M, Reis-Filho JS, Eusebi V, Lakhani SR
J Clin Pathol 2003 Jul;56(7):497-506. doi: 10.1136/jcp.56.7.497. PMID: 12835294Free PMC Article
Histopathology of malignant salivary gland tumours.
Seifert G
Eur J Cancer B Oral Oncol 1992 Jul;28B(1):49-56. doi: 10.1016/0964-1955(92)90013-q. PMID: 1330147

Diagnosis

Mucoepidermoid carcinoma of the breast, 3 cases report and literature review.
He X, You J, Chen Y, Tang H, Ran J, Guo D
Medicine (Baltimore) 2023 May 5;102(18):e33707. doi: 10.1097/MD.0000000000033707. PMID: 37144989Free PMC Article
The molecular landscape of breast mucoepidermoid carcinoma.
Venetis K, Sajjadi E, Ivanova M, Andaloro S, Pessina S, Zanetti C, Ranghiero A, Citelli G, Rossi C, Lucioni M, Malapelle U, Pagni F, Barberis M, Guerini-Rocco E, Viale G, Fusco N
Cancer Med 2023 May;12(9):10725-10737. Epub 2023 Mar 14 doi: 10.1002/cam4.5754. PMID: 36916425Free PMC Article
Mucoepidermoid carcinoma of the breast: A case report and literature review focused on radiological findings.
Bak S, Choi HY, Lee JH, Na JB, Choi DS, Cho JM, Choi HC, Park MJ, Kim JE, Shin HS, Won JH, Kim JY, Kim JM
Medicine (Baltimore) 2022 Jul 1;101(26):e29745. doi: 10.1097/MD.0000000000029745. PMID: 35777033Free PMC Article
The Role of Molecular Testing in the Differential Diagnosis of Salivary Gland Carcinomas.
Skálová A, Stenman G, Simpson RHW, Hellquist H, Slouka D, Svoboda T, Bishop JA, Hunt JL, Nibu KI, Rinaldo A, Vander Poorten V, Devaney KO, Steiner P, Ferlito A
Am J Surg Pathol 2018 Feb;42(2):e11-e27. doi: 10.1097/PAS.0000000000000980. PMID: 29076877
Mucoepidermoid carcinoma of the breast: Four case reports and review of the literature.
Cheng M, Geng C, Tang T, Song Z
Medicine (Baltimore) 2017 Dec;96(51):e9385. doi: 10.1097/MD.0000000000009385. PMID: 29390541Free PMC Article

Therapy

Mucoepidermoid carcinoma of the breast.
Hornychová H, Ryska A, Betlach J, Bohác R, Cízek T, Tomsová M, Obermannová R
Neoplasma 2007;54(2):168-72. PMID: 17319792

Prognosis

Mucoepidermoid carcinoma of the breast, 3 cases report and literature review.
He X, You J, Chen Y, Tang H, Ran J, Guo D
Medicine (Baltimore) 2023 May 5;102(18):e33707. doi: 10.1097/MD.0000000000033707. PMID: 37144989Free PMC Article
Mucoepidermoid carcinoma of the breast: A case report and literature review focused on radiological findings.
Bak S, Choi HY, Lee JH, Na JB, Choi DS, Cho JM, Choi HC, Park MJ, Kim JE, Shin HS, Won JH, Kim JY, Kim JM
Medicine (Baltimore) 2022 Jul 1;101(26):e29745. doi: 10.1097/MD.0000000000029745. PMID: 35777033Free PMC Article
Mucoepidermoid Carcinoma of the Breast With MAML2 Rearrangement: A Case Report and Literature Review.
Yan M, Gilmore H, Harbhajanka A
Int J Surg Pathol 2020 Oct;28(7):787-792. Epub 2020 May 4 doi: 10.1177/1066896920916779. PMID: 32362174
The Role of Molecular Testing in the Differential Diagnosis of Salivary Gland Carcinomas.
Skálová A, Stenman G, Simpson RHW, Hellquist H, Slouka D, Svoboda T, Bishop JA, Hunt JL, Nibu KI, Rinaldo A, Vander Poorten V, Devaney KO, Steiner P, Ferlito A
Am J Surg Pathol 2018 Feb;42(2):e11-e27. doi: 10.1097/PAS.0000000000000980. PMID: 29076877
Histopathology of malignant salivary gland tumours.
Seifert G
Eur J Cancer B Oral Oncol 1992 Jul;28B(1):49-56. doi: 10.1016/0964-1955(92)90013-q. PMID: 1330147

Clinical prediction guides

Mucoepidermoid carcinoma of the breast, 3 cases report and literature review.
He X, You J, Chen Y, Tang H, Ran J, Guo D
Medicine (Baltimore) 2023 May 5;102(18):e33707. doi: 10.1097/MD.0000000000033707. PMID: 37144989Free PMC Article
The molecular landscape of breast mucoepidermoid carcinoma.
Venetis K, Sajjadi E, Ivanova M, Andaloro S, Pessina S, Zanetti C, Ranghiero A, Citelli G, Rossi C, Lucioni M, Malapelle U, Pagni F, Barberis M, Guerini-Rocco E, Viale G, Fusco N
Cancer Med 2023 May;12(9):10725-10737. Epub 2023 Mar 14 doi: 10.1002/cam4.5754. PMID: 36916425Free PMC Article
The Role of Molecular Testing in the Differential Diagnosis of Salivary Gland Carcinomas.
Skálová A, Stenman G, Simpson RHW, Hellquist H, Slouka D, Svoboda T, Bishop JA, Hunt JL, Nibu KI, Rinaldo A, Vander Poorten V, Devaney KO, Steiner P, Ferlito A
Am J Surg Pathol 2018 Feb;42(2):e11-e27. doi: 10.1097/PAS.0000000000000980. PMID: 29076877
GATA3 immunohistochemical expression in salivary gland neoplasms.
Schwartz LE, Begum S, Westra WH, Bishop JA
Head Neck Pathol 2013 Dec;7(4):311-5. Epub 2013 Apr 20 doi: 10.1007/s12105-013-0442-3. PMID: 23604756Free PMC Article
Human epidermal growth factor receptor 2 (HER2) in salivary gland carcinomas.
Clauditz TS, Reiff M, Gravert L, Gnoss A, Tsourlakis MC, Münscher A, Sauter G, Bokemeyer C, Knecht R, Wilczak W
Pathology 2011 Aug;43(5):459-64. doi: 10.1097/PAT.0b013e3283484a60. PMID: 21670724

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