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Peripheral nerve schwannoma

MedGen UID:
274155
•Concept ID:
C1519001
•
Neoplastic Process
Synonyms: Peripheral Nerve Schwannoma; peripheral nerve schwannoma
 
Monarch Initiative: MONDO:0004820

Definition

A benign, usually encapsulated slow growing tumor of the peripheral nervous system composed of Schwann cells. It recurs infrequently and only rare cases associated with malignant transformation have been reported. [from NCI]

Professional guidelines

PubMed

Management of Central and Peripheral Nervous System Tumors in Patients with Neurofibromatosis.
Brown R
Curr Oncol Rep 2023 Dec;25(12):1409-1417. Epub 2023 Oct 31 doi: 10.1007/s11912-023-01451-z. PMID: 37906356
ERN GENTURIS clinical practice guidelines for the diagnosis, treatment, management and surveillance of people with schwannomatosis.
Evans DG, Mostaccioli S, Pang D, Fadzil O Connor M, Pittara M, Champollion N, Wolkenstein P, Thomas N, Ferner RE, Kalamarides M, Peyre M, Papi L, Legius E, Becerra JL, King A, Duff C, Stivaros S, Blanco I
Eur J Hum Genet 2022 Jul;30(7):812-817. Epub 2022 Apr 1 doi: 10.1038/s41431-022-01086-x. PMID: 35361920Free PMC Article
The many faces of solitary fibrous tumor; diversity of histological features, differential diagnosis and role of molecular studies and surrogate markers in avoiding misdiagnosis and predicting the behavior.
Tariq MU, Din NU, Abdul-Ghafar J, Park YK
Diagn Pathol 2021 Apr 20;16(1):32. doi: 10.1186/s13000-021-01095-2. PMID: 33879215Free PMC Article

Recent clinical studies

Etiology

Surgical Management of Peripheral Nerve Pathology in Patients With Neurofibromatosis Type 2.
Peyre M, Tran S, Parfait B, Bernat I, Bielle F, Kalamarides M
Neurosurgery 2023 Feb 1;92(2):317-328. Epub 2022 Nov 10 doi: 10.1227/neu.0000000000002202. PMID: 36637268
Diagnostic accuracy of multiparametric ultrasound for peripheral nerve schwannoma.
Yuan Y, Gao J, Xiong G, Guo L
Acta Radiol 2023 Apr;64(4):1608-1614. Epub 2022 Sep 7 doi: 10.1177/02841851221125109. PMID: 36071627
Clinical results after surgical resection of benign solitary schwannomas: A review of 150 cases.
El Sayed L, H Masmejean E, Lavollé A, Biau D, Peyre M
Orthop Traumatol Surg Res 2022 Jun;108(4):103281. Epub 2022 Apr 25 doi: 10.1016/j.otsr.2022.103281. PMID: 35477039
Analysis of Peripheral Nerve Schwannoma Pseudocapsule.
Stone JJ, Boland JM, Spinner RJ
World Neurosurg 2018 Nov;119:e986-e990. Epub 2018 Aug 13 doi: 10.1016/j.wneu.2018.08.022. PMID: 30114537
Comparison of outcomes of peripheral nerve schwannoma excision in neurofibromatosis type 2 patients and non-neurofibromatosis type 2 patients: A case control study.
Bendon CL, Furniss D, Giele HP
J Plast Reconstr Aesthet Surg 2015 Sep;68(9):1199-203. Epub 2015 May 29 doi: 10.1016/j.bjps.2015.05.026. PMID: 26139580

Diagnosis

Diagnostic accuracy of multiparametric ultrasound for peripheral nerve schwannoma.
Yuan Y, Gao J, Xiong G, Guo L
Acta Radiol 2023 Apr;64(4):1608-1614. Epub 2022 Sep 7 doi: 10.1177/02841851221125109. PMID: 36071627
Epineural glomus tumor of the posterior interosseous nerve: Case report.
Drabent P, Bielle F, Bernat I, Peyre M
J Clin Neurosci 2020 Apr;74:232-234. Epub 2020 Jan 6 doi: 10.1016/j.jocn.2019.12.062. PMID: 31917057
Erdheim-Chester disease mimicking lumbar nerve schwannoma: case report and literature review.
Huang Z, Li S, Hong J, Peng Y, Liang A, Huang D, Ye W
Spinal Cord Ser Cases 2019;5:90. Epub 2019 Oct 31 doi: 10.1038/s41394-019-0234-4. PMID: 31700688Free PMC Article
Peripheral Nerve Schwannoma: A Review of Varying Clinical Presentations and Imaging Findings.
Albert P, Patel J, Badawy K, Weissinger W, Brenner M, Bourhill I, Parnell J
J Foot Ankle Surg 2017 May-Jun;56(3):632-637. Epub 2017 Feb 22 doi: 10.1053/j.jfas.2016.12.003. PMID: 28237565
Comparison of outcomes of peripheral nerve schwannoma excision in neurofibromatosis type 2 patients and non-neurofibromatosis type 2 patients: A case control study.
Bendon CL, Furniss D, Giele HP
J Plast Reconstr Aesthet Surg 2015 Sep;68(9):1199-203. Epub 2015 May 29 doi: 10.1016/j.bjps.2015.05.026. PMID: 26139580

Therapy

Extracapsular dissection in peripheral nerve schwannoma surgery using bright light and fluorescein sodium visualization: case series.
Kalamarides M, Bernat I, Peyre M
Acta Neurochir (Wien) 2019 Dec;161(12):2447-2452. Epub 2019 Nov 2 doi: 10.1007/s00701-019-04071-4. PMID: 31679103

Prognosis

Epineural glomus tumor of the posterior interosseous nerve: Case report.
Drabent P, Bielle F, Bernat I, Peyre M
J Clin Neurosci 2020 Apr;74:232-234. Epub 2020 Jan 6 doi: 10.1016/j.jocn.2019.12.062. PMID: 31917057
Comparison of outcomes of peripheral nerve schwannoma excision in neurofibromatosis type 2 patients and non-neurofibromatosis type 2 patients: A case control study.
Bendon CL, Furniss D, Giele HP
J Plast Reconstr Aesthet Surg 2015 Sep;68(9):1199-203. Epub 2015 May 29 doi: 10.1016/j.bjps.2015.05.026. PMID: 26139580
Peripheral nerve schwannoma: two cases exhibiting increased FDG uptake in early and delayed PET imaging.
Hamada K, Ueda T, Higuchi I, Inoue A, Tamai N, Myoi A, Tomita Y, Aozasa K, Yoshikawa H, Hatazawa J
Skeletal Radiol 2005 Jan;34(1):52-7. Epub 2004 Oct 9 doi: 10.1007/s00256-004-0845-z. PMID: 15480645

Clinical prediction guides

Diagnostic accuracy of multiparametric ultrasound for peripheral nerve schwannoma.
Yuan Y, Gao J, Xiong G, Guo L
Acta Radiol 2023 Apr;64(4):1608-1614. Epub 2022 Sep 7 doi: 10.1177/02841851221125109. PMID: 36071627
Clinical results after surgical resection of benign solitary schwannomas: A review of 150 cases.
El Sayed L, H Masmejean E, Lavollé A, Biau D, Peyre M
Orthop Traumatol Surg Res 2022 Jun;108(4):103281. Epub 2022 Apr 25 doi: 10.1016/j.otsr.2022.103281. PMID: 35477039
Comparison of outcomes of peripheral nerve schwannoma excision in neurofibromatosis type 2 patients and non-neurofibromatosis type 2 patients: A case control study.
Bendon CL, Furniss D, Giele HP
J Plast Reconstr Aesthet Surg 2015 Sep;68(9):1199-203. Epub 2015 May 29 doi: 10.1016/j.bjps.2015.05.026. PMID: 26139580
Preoperative localization of spinal and peripheral pathologies for surgery by computed tomography-guided placement of a specialized needle system.
Slotty P Jr, Kröpil P, Klingenhöfer M, Steiger HJ, Hänggi D, Stummer W
Neurosurgery 2010 Apr;66(4):784-7. doi: 10.1227/01.NEU.0000367450.79418.5B. PMID: 20190662
Fluid-fluid level in peripheral nerve schwannoma: report of a case with histological correlation.
Chang WC, Huang GS, Lee HS, Lee CH, Hsu YC
Clin Imaging 2009 May-Jun;33(3):248-51. doi: 10.1016/j.clinimag.2008.11.001. PMID: 19411036

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