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Large cell keratinizing variant squamous cell breast carcinoma

MedGen UID:
274269
•Concept ID:
C1519486
•
Neoplastic Process
Synonyms: Breast Squamous Cell Carcinoma, Large Cell Keratinizing Variant; large cell keratinizing variant squamous cell breast carcinoma; Squamous Cell Breast Carcinoma, Large Cell Keratinizing Variant; squamous cell breast carcinoma, large cell keratinizing variant
 
Monarch Initiative: MONDO:0004232

Definition

A squamous cell carcinoma that arises from the breast parenchyma and is characterized by the presence of large malignant cells that exhibit keratinization. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLarge cell keratinizing variant squamous cell breast carcinoma

Recent clinical studies

Etiology

Pleomorphic carcinoma of the breast with expression of macrophage markers: report of two cases.
Córdoba A, Del Rosario Mercado M, Vicente F, Ederra M, Torrea N, Guerrero-Setas D
Pathol Int 2012 Jul;62(7):491-5. Epub 2012 May 7 doi: 10.1111/j.1440-1827.2012.02817.x. PMID: 22726069

Diagnosis

Metaplastic breast carcinoma with chondroid differentiation: a rare variant of infiltrative carcinoma in a 38-year-old woman.
Taghipour Zahir S, Javannejad M
BMJ Case Rep 2017 Jun 15;2017 doi: 10.1136/bcr-2016-217687. PMID: 28623243Free PMC Article
Acantholytic variant of squamous cell carcinoma of the breast: a case report.
Parramore B, Hanly M, Yeh KA, McNeely T
Am Surg 1999 May;65(5):467-9. PMID: 10231220
Epidermotropically metastatic breast carcinomas. Rare histopathologic variants mimicking melanoma and Paget's disease.
Requena L, Sánchez Yus E, Núñez C, White CR Jr, Sangueza OP
Am J Dermatopathol 1996 Aug;18(4):385-95. doi: 10.1097/00000372-199608000-00010. PMID: 8879303

Therapy

Coexistence of primary squamous cell carcinoma of thyroid with classic papillary thyroid carcinoma.
Eom TI, Koo BY, Kim BS, Kang KH, Jung SK, Jun SY, Bae HS, Kim LS
Pathol Int 2008 Dec;58(12):797-800. doi: 10.1111/j.1440-1827.2008.02314.x. PMID: 19067856

Prognosis

Acantholytic variant of squamous cell carcinoma of the breast: a case report.
Parramore B, Hanly M, Yeh KA, McNeely T
Am Surg 1999 May;65(5):467-9. PMID: 10231220

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