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Vulvar nodular hidradenoma

MedGen UID:
276994
•Concept ID:
C1520091
•
Neoplastic Process
Synonyms: mammalian vulva nodular hidradenoma; nodular hidradenoma of mammalian vulva; Vulvar Nodular Hidradenoma; vulvar nodular hidradenoma
 
Monarch Initiative: MONDO:0002188

Definition

A benign neoplasm that arises from sweat glands in the vulva. It is characterized by the presence of lobules composed of epithelial cells with clear cytoplasm. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVulvar nodular hidradenoma

Professional guidelines

PubMed

Management of Bartholin's duct cyst and gland abscess.
Omole F, Simmons BJ, Hacker Y
Am Fam Physician 2003 Jul 1;68(1):135-40. PMID: 12887119

Recent clinical studies

Etiology

Vulvar hidradenoma papilliferum (HP) is located on the sites of mammary-like anogenital glands (MLAGs): Analysis of the photographs of 52 tumors.
El-Khoury J, Renald MH, Plantier F, Avril MF, Moyal-Barracco M
J Am Acad Dermatol 2016 Aug;75(2):380-4. Epub 2016 Mar 2 doi: 10.1016/j.jaad.2016.01.034. PMID: 26944596
Diagnosis of hidradenoma papilliferum of the vulva on cytologic smears: a case report.
Uke MS, Kulkarni MB, Ajit D, Gujral S
Acta Cytol 2010 Sep-Oct;54(5 Suppl):907-10. PMID: 21053567
A large porocarcinoma of perineal region: MR findings and review of the literature.
Iannicelli E, Galluzzo A, Salvi PF, Ziparo V, David V
Abdom Imaging 2008 Nov-Dec;33(6):744-7. doi: 10.1007/s00261-007-9356-4. PMID: 18196314

Diagnosis

PIK3CA and AKT1 mutations in hidradenoma papilliferum.
Goto K, Maeda D, Kudo-Asabe Y, Hibiya T, Hayashi A, Fukayama M, Ohashi K, Goto A
J Clin Pathol 2017 May;70(5):424-427. Epub 2016 Oct 14 doi: 10.1136/jclinpath-2016-204003. PMID: 27742746
Benign Tumors and Tumor-like Lesions of the Vulva.
Heller DS
Clin Obstet Gynecol 2015 Sep;58(3):526-35. doi: 10.1097/GRF.0000000000000133. PMID: 26125957
Lesions of anogenital mammary-like glands: an update.
Kazakov DV, Spagnolo DV, Kacerovska D, Michal M
Adv Anat Pathol 2011 Jan;18(1):1-28. doi: 10.1097/PAP.0b013e318202eba5. PMID: 21169735
Management of Bartholin's duct cyst and gland abscess.
Omole F, Simmons BJ, Hacker Y
Am Fam Physician 2003 Jul 1;68(1):135-40. PMID: 12887119
Vulvar eccrine porocarcinoma.
Katsanis WA, Doering DL, Bosscher JR, O'Connor DM
Gynecol Oncol 1996 Sep;62(3):396-9. doi: 10.1006/gyno.1996.0255. PMID: 8812539

Prognosis

Hidradenoma Papilliferum: A Clinicopathologic Study of 264 Tumors From 261 Patients, With Emphasis on Mammary-Type Alterations.
Konstantinova AM, Michal M, Kacerovska D, Spagnolo DV, Stewart CJ, Kutzner H, Zelger B, Plaza JA, Denisjuk N, Hejda V, Shelekhova K, Bisceglia M, Danis D, Zamecnik M, Kerl K, Guenova E, Kazakov DV
Am J Dermatopathol 2016 Aug;38(8):598-607. doi: 10.1097/DAD.0000000000000495. PMID: 26863059
Mutations in genes encoding PI3K-AKT and MAPK signaling define anogenital papillary hidradenoma.
Pfarr N, Sinn HP, Klauschen F, Flechtenmacher C, Bockmayr M, Ridinger K, von Winterfeld M, Warth A, Lorenz K, Budczies J, Penzel R, Lennerz JK, Endris V, Weichert W, Stenzinger A
Genes Chromosomes Cancer 2016 Feb;55(2):113-9. Epub 2015 Oct 23 doi: 10.1002/gcc.22315. PMID: 26493284
A large porocarcinoma of perineal region: MR findings and review of the literature.
Iannicelli E, Galluzzo A, Salvi PF, Ziparo V, David V
Abdom Imaging 2008 Nov-Dec;33(6):744-7. doi: 10.1007/s00261-007-9356-4. PMID: 18196314

Clinical prediction guides

Hidradenoma Papilliferum: A Clinicopathologic Study of 264 Tumors From 261 Patients, With Emphasis on Mammary-Type Alterations.
Konstantinova AM, Michal M, Kacerovska D, Spagnolo DV, Stewart CJ, Kutzner H, Zelger B, Plaza JA, Denisjuk N, Hejda V, Shelekhova K, Bisceglia M, Danis D, Zamecnik M, Kerl K, Guenova E, Kazakov DV
Am J Dermatopathol 2016 Aug;38(8):598-607. doi: 10.1097/DAD.0000000000000495. PMID: 26863059

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