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Endometrioid adenocarcinoma

MedGen UID:
293976
•Concept ID:
C1569637
•
Neoplastic Process
Synonyms: Adenocarcinoma, Endometrioid; Adenocarcinomas, Endometrioid; Endometrioid Adenocarcinoma; Endometrioid Adenocarcinomas
SNOMED CT: Endometrioid adenocarcinoma (30289006); Endometrioid cystadenocarcinoma (30289006)
 
Monarch Initiative: MONDO:0005026

Definition

An adenocarcinoma characterized by the presence of malignant glandular epithelial cells resembling endometrial cells. It can arise from the uterine body, ovary, fallopian tube, cervix, vagina, and uterine ligament. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Endometrioid adenocarcinoma

Professional guidelines

PubMed

Evolving treatment paradigms in metastatic or recurrent low-grade endometrial cancer: When is hormonal-based therapy the preferred option?
Mahdi H, Ray-Coquard I, Lorusso D, Mirza MR, Monk BJ, Slomovitz B
Int J Gynecol Cancer 2023 Nov 6;33(11):1675-1681. doi: 10.1136/ijgc-2023-004454. PMID: 37640446Free PMC Article
Challenges and controversies in the conservative management of uterine and ovarian cancer.
Janda M, McGrath S, Obermair A
Best Pract Res Clin Obstet Gynaecol 2019 Feb;55:93-108. Epub 2018 Aug 31 doi: 10.1016/j.bpobgyn.2018.08.004. PMID: 30243603
Therapeutic options for management of endometrial hyperplasia.
Chandra V, Kim JJ, Benbrook DM, Dwivedi A, Rai R
J Gynecol Oncol 2016 Jan;27(1):e8. Epub 2015 Dec 1 doi: 10.3802/jgo.2016.27.e8. PMID: 26463434Free PMC Article

Recent clinical studies

Etiology

Endometrial hyperplasia as a risk factor of endometrial cancer.
Nees LK, Heublein S, Steinmacher S, Juhasz-Böss I, Brucker S, Tempfer CB, Wallwiener M
Arch Gynecol Obstet 2022 Aug;306(2):407-421. Epub 2022 Jan 10 doi: 10.1007/s00404-021-06380-5. PMID: 35001185Free PMC Article
Endometrium and steroids, a pathologic overview.
Plaza-Parrochia F, Romero C, Valladares L, Vega M
Steroids 2017 Oct;126:85-91. Epub 2017 Aug 18 doi: 10.1016/j.steroids.2017.08.007. PMID: 28827068
Endometrial cancer.
Morice P, Leary A, Creutzberg C, Abu-Rustum N, Darai E
Lancet 2016 Mar 12;387(10023):1094-1108. Epub 2015 Sep 6 doi: 10.1016/S0140-6736(15)00130-0. PMID: 26354523
Papillary proliferation of the endometrium: a clinicopathologic study of 59 cases of simple and complex papillae without cytologic atypia.
Ip PP, Irving JA, McCluggage WG, Clement PB, Young RH
Am J Surg Pathol 2013 Feb;37(2):167-77. doi: 10.1097/PAS.0b013e318272d428. PMID: 23211295
Endometrial hyperplasia.
Mills AM, Longacre TA
Semin Diagn Pathol 2010 Nov;27(4):199-214. doi: 10.1053/j.semdp.2010.09.002. PMID: 21309256

Diagnosis

Primary endometrial gastric (gastro-intestinal)-type carcinoma: A practical approach.
Dridi M, Peoc'h M, Karpathiou G
Pathol Res Pract 2023 Jan;241:154271. Epub 2022 Dec 6 doi: 10.1016/j.prp.2022.154271. PMID: 36502736
Endometriosis-associated ovarian neoplasia.
Matias-Guiu X, Stewart CJR
Pathology 2018 Feb;50(2):190-204. Epub 2017 Dec 11 doi: 10.1016/j.pathol.2017.10.006. PMID: 29241974
Cervical Adenocarcinoma: Diagnosis of Human Papillomavirus-Positive and Human Papillomavirus-Negative Tumors.
Pirog EC
Arch Pathol Lab Med 2017 Dec;141(12):1653-1667. Epub 2017 Jun 23 doi: 10.5858/arpa.2016-0356-RA. PMID: 28644686
Endometrial cancer.
Morice P, Leary A, Creutzberg C, Abu-Rustum N, Darai E
Lancet 2016 Mar 12;387(10023):1094-1108. Epub 2015 Sep 6 doi: 10.1016/S0140-6736(15)00130-0. PMID: 26354523
Endometrial hyperplasia.
Mills AM, Longacre TA
Semin Diagn Pathol 2010 Nov;27(4):199-214. doi: 10.1053/j.semdp.2010.09.002. PMID: 21309256

Therapy

Evolving treatment paradigms in metastatic or recurrent low-grade endometrial cancer: When is hormonal-based therapy the preferred option?
Mahdi H, Ray-Coquard I, Lorusso D, Mirza MR, Monk BJ, Slomovitz B
Int J Gynecol Cancer 2023 Nov 6;33(11):1675-1681. doi: 10.1136/ijgc-2023-004454. PMID: 37640446Free PMC Article
Endometrial hyperplasia as a risk factor of endometrial cancer.
Nees LK, Heublein S, Steinmacher S, Juhasz-Böss I, Brucker S, Tempfer CB, Wallwiener M
Arch Gynecol Obstet 2022 Aug;306(2):407-421. Epub 2022 Jan 10 doi: 10.1007/s00404-021-06380-5. PMID: 35001185Free PMC Article
SOX17, β-catenin and CyclinD1 expression in the endometrioid adenocarcinoma and influence of 5-AZA on expression.
Liao YM, Song Y, Li YK, Du JH, Zhou Y
Cancer Gene Ther 2020 Apr;27(3-4):256-263. Epub 2019 Sep 23 doi: 10.1038/s41417-019-0135-5. PMID: 31543512
ARID1A gene mutation in ovarian and endometrial cancers (Review).
Takeda T, Banno K, Okawa R, Yanokura M, Iijima M, Irie-Kunitomi H, Nakamura K, Iida M, Adachi M, Umene K, Nogami Y, Masuda K, Kobayashi Y, Tominaga E, Aoki D
Oncol Rep 2016 Feb;35(2):607-13. Epub 2015 Nov 16 doi: 10.3892/or.2015.4421. PMID: 26572704Free PMC Article
Endometrial cancer.
Morice P, Leary A, Creutzberg C, Abu-Rustum N, Darai E
Lancet 2016 Mar 12;387(10023):1094-1108. Epub 2015 Sep 6 doi: 10.1016/S0140-6736(15)00130-0. PMID: 26354523

Prognosis

It is not the time to abandon intraoperative frozen section in endometrioid adenocarcinoma: A large-scale, multi-center, and retrospective study.
Yang X, Yin J, Fu Y, Shen Y, Zhang C, Yao S, Xu C, Xia M, Lou G, Liu J, Lin B, Wang J, Zhao W, Zhang J, Cheng W, Guo H, Guo R, Xue F, Wang X, Han L, Li X, Zhang P, Zhao J, Li W, Dou Y, Wang Z, Liu J, Li K, Chen G, Sun C, Wang B, Yang X
Cancer Med 2023 Apr;12(7):8897-8910. Epub 2023 Jan 31 doi: 10.1002/cam4.5643. PMID: 36718983Free PMC Article
Challenges and controversies in the conservative management of uterine and ovarian cancer.
Janda M, McGrath S, Obermair A
Best Pract Res Clin Obstet Gynaecol 2019 Feb;55:93-108. Epub 2018 Aug 31 doi: 10.1016/j.bpobgyn.2018.08.004. PMID: 30243603
Endometriosis-associated ovarian neoplasia.
Matias-Guiu X, Stewart CJR
Pathology 2018 Feb;50(2):190-204. Epub 2017 Dec 11 doi: 10.1016/j.pathol.2017.10.006. PMID: 29241974
Endometrial cancer.
Morice P, Leary A, Creutzberg C, Abu-Rustum N, Darai E
Lancet 2016 Mar 12;387(10023):1094-1108. Epub 2015 Sep 6 doi: 10.1016/S0140-6736(15)00130-0. PMID: 26354523
Management and prognosis of endometrioid borderline tumors of the ovary.
Uzan C, Berretta R, Rolla M, Gouy S, Fauvet R, Darai E, Duvillard P, Morice P
Surg Oncol 2012 Sep;21(3):178-84. Epub 2012 Mar 13 doi: 10.1016/j.suronc.2012.02.002. PMID: 22418038

Clinical prediction guides

Clinical and multiparametric MRI features for differentiating uterine carcinosarcoma from endometrioid adenocarcinoma.
Chen X, Guo Q, Chen X, Zheng W, Kang Y, Cao D
BMC Med Imaging 2024 Feb 19;24(1):48. doi: 10.1186/s12880-024-01225-4. PMID: 38373912Free PMC Article
It is not the time to abandon intraoperative frozen section in endometrioid adenocarcinoma: A large-scale, multi-center, and retrospective study.
Yang X, Yin J, Fu Y, Shen Y, Zhang C, Yao S, Xu C, Xia M, Lou G, Liu J, Lin B, Wang J, Zhao W, Zhang J, Cheng W, Guo H, Guo R, Xue F, Wang X, Han L, Li X, Zhang P, Zhao J, Li W, Dou Y, Wang Z, Liu J, Li K, Chen G, Sun C, Wang B, Yang X
Cancer Med 2023 Apr;12(7):8897-8910. Epub 2023 Jan 31 doi: 10.1002/cam4.5643. PMID: 36718983Free PMC Article
The Prediction of Recurrence in Low-Risk Endometrial Cancer: Is It Time for a Paradigm Shift in Adjuvant Therapy?
Laban M, El-Swaify ST, Ali SH, Refaat MA, Sabbour M, Farrag N, Hassanin AS
Reprod Sci 2022 Apr;29(4):1068-1085. Epub 2021 Apr 15 doi: 10.1007/s43032-021-00565-8. PMID: 33856667
Mixed Endometrioid Adenocarcinoma and Müllerian Adenosarcoma of the Uterus and Ovary: Clinicopathologic Characterization With Emphasis on its Distinction From Carcinosarcoma.
El Hallani S, Arora R, Lin DI, Måsbäc A, Mateoiu C, McCluggage WG, Nucci MR, Otis CN, Parkash V, Parra-Herran C, Longacre TA
Am J Surg Pathol 2021 Mar 1;45(3):374-383. doi: 10.1097/PAS.0000000000001643. PMID: 33565764
Endometriosis-associated ovarian neoplasia.
Matias-Guiu X, Stewart CJR
Pathology 2018 Feb;50(2):190-204. Epub 2017 Dec 11 doi: 10.1016/j.pathol.2017.10.006. PMID: 29241974

Recent systematic reviews

Endometrial cancer after endometrial ablation: a systematic review.
Oderkerk TJ, van de Kar MRD, Cornel KMC, Bongers MY, Geomini PMAJ
Int J Gynecol Cancer 2022 Dec 5;32(12):1555-1560. doi: 10.1136/ijgc-2022-003866. PMID: 36375895
Endometrial hyperplasia as a risk factor of endometrial cancer.
Nees LK, Heublein S, Steinmacher S, Juhasz-Böss I, Brucker S, Tempfer CB, Wallwiener M
Arch Gynecol Obstet 2022 Aug;306(2):407-421. Epub 2022 Jan 10 doi: 10.1007/s00404-021-06380-5. PMID: 35001185Free PMC Article
Malignant transformation of abdominal wall endometriosis: A systematic review of the epidemiology, diagnosis, treatment, and outcomes.
Liu G, Wang Y, Chen Y, Ren F
Eur J Obstet Gynecol Reprod Biol 2021 Sep;264:363-367. Epub 2021 Aug 8 doi: 10.1016/j.ejogrb.2021.08.006. PMID: 34391052
Endometriosis-associated malignant transformation in abdominal surgical scar: A PRISMA-compliant systematic review.
Mihailovici A, Rottenstreich M, Kovel S, Wassermann I, Smorgick N, Vaknin Z
Medicine (Baltimore) 2017 Dec;96(49):e9136. doi: 10.1097/MD.0000000000009136. PMID: 29245355Free PMC Article
A case of ovarian adenosquamous carcinoma arising from endometrioid adenocarcinoma: a case report and systematic review.
Shoji T, Takatori E, Murakami K, Kaido Y, Takeuchi S, Kikuchi A, Sugiyama T
J Ovarian Res 2016 Aug 11;9(1):48. doi: 10.1186/s13048-016-0255-6. PMID: 27514842Free PMC Article

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