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Breast columnar cell mucinous carcinoma

MedGen UID:
307307
•Concept ID:
C1511305
•
Neoplastic Process
Synonyms: Breast Columnar Cell Mucinous Adenocarcinoma; Breast Columnar Cell Mucinous Carcinoma; breast columnar cell mucinous carcinoma
 
Monarch Initiative: MONDO:0004472

Definition

An invasive breast adenocarcinoma characterized by the presence of tall columnar neoplastic cells that contain intracytoplasmic mucin. Grossly, cystic changes are not identified. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBreast columnar cell mucinous carcinoma

Recent clinical studies

Etiology

Mucinous breast carcinomas lack PIK3CA and AKT1 mutations.
Kehr EL, Jorns JM, Ang D, Warrick A, Neff T, Degnin M, Lewis R, Beadling C, Corless CL, Troxell ML
Hum Pathol 2012 Dec;43(12):2207-12. Epub 2012 Jun 15 doi: 10.1016/j.humpath.2012.03.012. PMID: 22705004
The mucinous variant of columnar cell lesions.
Verschuur-Maes AH, Van Diest PJ
Histopathology 2011 May;58(6):847-53. doi: 10.1111/j.1365-2559.2011.03837.x. PMID: 21585423
Mucin extravasation in breast core biopsies--clinical significance and outcome correlation.
Begum SM, Jara-Lazaro AR, Thike AA, Tse GM, Wong JS, Ho JT, Tan PH
Histopathology 2009 Nov;55(5):609-17. doi: 10.1111/j.1365-2559.2009.03422.x. PMID: 19912367
Mucinous (so-called colloid) carcinomas of lung.
Moran CA, Hochholzer L, Fishback N, Travis WD, Koss MN
Mod Pathol 1992 Nov;5(6):634-8. PMID: 1369799

Diagnosis

Mucinous breast carcinoma with tall columnar cells.
Tsoukalas N, Kiakou M, Tolia M, Kostakis ID, Galanopoulos M, Nakos G, Tryfonopoulos D, Kyrgias G, Koumakis G
Ann R Coll Surg Engl 2018 May;100(5):e132-e135. Epub 2018 Apr 16 doi: 10.1308/rcsann.2018.0060. PMID: 29658333Free PMC Article
The mucinous variant of columnar cell lesions.
Verschuur-Maes AH, Van Diest PJ
Histopathology 2011 May;58(6):847-53. doi: 10.1111/j.1365-2559.2011.03837.x. PMID: 21585423
Mucin extravasation in breast core biopsies--clinical significance and outcome correlation.
Begum SM, Jara-Lazaro AR, Thike AA, Tse GM, Wong JS, Ho JT, Tan PH
Histopathology 2009 Nov;55(5):609-17. doi: 10.1111/j.1365-2559.2009.03422.x. PMID: 19912367
Mucinous cystadenocarcinoma of the breast.
Koenig C, Tavassoli FA
Am J Surg Pathol 1998 Jun;22(6):698-703. doi: 10.1097/00000478-199806000-00006. PMID: 9630176
Cytologic diagnosis of papillary carcinoma of the breast in needle aspirates.
Naran S, Simpson J, Gupta RK
Diagn Cytopathol 1988 Mar;4(1):33-7. doi: 10.1002/dc.2840040109. PMID: 2837372

Prognosis

Mucinous breast carcinoma with tall columnar cells.
Tsoukalas N, Kiakou M, Tolia M, Kostakis ID, Galanopoulos M, Nakos G, Tryfonopoulos D, Kyrgias G, Koumakis G
Ann R Coll Surg Engl 2018 May;100(5):e132-e135. Epub 2018 Apr 16 doi: 10.1308/rcsann.2018.0060. PMID: 29658333Free PMC Article
Primary mammary mucinous cystadenocarcinoma: cytological and histological findings.
Sentani K, Tashiro T, Uraoka N, Aosaki Y, Yano S, Takaeko F, Yasui W
Diagn Cytopathol 2012 Jul;40(7):624-8. Epub 2011 Apr 6 doi: 10.1002/dc.21638. PMID: 21472867
Mucin extravasation in breast core biopsies--clinical significance and outcome correlation.
Begum SM, Jara-Lazaro AR, Thike AA, Tse GM, Wong JS, Ho JT, Tan PH
Histopathology 2009 Nov;55(5):609-17. doi: 10.1111/j.1365-2559.2009.03422.x. PMID: 19912367
Mucinous (so-called colloid) carcinomas of lung.
Moran CA, Hochholzer L, Fishback N, Travis WD, Koss MN
Mod Pathol 1992 Nov;5(6):634-8. PMID: 1369799

Clinical prediction guides

Mucin extravasation in breast core biopsies--clinical significance and outcome correlation.
Begum SM, Jara-Lazaro AR, Thike AA, Tse GM, Wong JS, Ho JT, Tan PH
Histopathology 2009 Nov;55(5):609-17. doi: 10.1111/j.1365-2559.2009.03422.x. PMID: 19912367
Can true papillary neoplasms of breast and their mimickers be accurately classified by cytology?
Michael CW, Buschmann B
Cancer 2002 Apr 25;96(2):92-100. doi: 10.1002/cncr.10481. PMID: 11954026
Heterogeneity of mucin gene expression in normal and neoplastic tissues.
Ho SB, Niehans GA, Lyftogt C, Yan PS, Cherwitz DL, Gum ET, Dahiya R, Kim YS
Cancer Res 1993 Feb 1;53(3):641-51. PMID: 7678777
Mucinous (so-called colloid) carcinomas of lung.
Moran CA, Hochholzer L, Fishback N, Travis WD, Koss MN
Mod Pathol 1992 Nov;5(6):634-8. PMID: 1369799

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