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Ovarian stromal hyperthecosis

MedGen UID:
309519
•Concept ID:
C1518743
•
Disease or Syndrome
Synonyms: Ovarian Stromal Hyperthecosis; ovarian stromal hyperthecosis
 
Monarch Initiative: MONDO:0004194

Definition

A non-neoplastic disorder that usually affects postmenopausal women. It is characterized by the leuteinization of ovarian stromal cells. The ovaries are bilaterally involved and enlarged. When it affects women in reproductive age, it causes virilization, high blood pressure, and increased insulin levels. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOvarian stromal hyperthecosis

Professional guidelines

PubMed

Ovarian pathology in risk-reducing salpingo-oophorectomies from women with BRCA mutations, emphasizing the differential diagnosis of occult primary and metastatic carcinoma.
Rabban JT, Barnes M, Chen LM, Powell CB, Crawford B, Zaloudek CJ
Am J Surg Pathol 2009 Aug;33(8):1125-36. doi: 10.1097/PAS.0b013e31819e986a. PMID: 19440148
Ovarian spindle cell lesions: a review with emphasis on recent developments and differential diagnosis.
Irving JA, McCluggage WG
Adv Anat Pathol 2007 Sep;14(5):305-19. doi: 10.1097/PAP.0b013e3180ca8a5b. PMID: 17717430

Recent clinical studies

Etiology

Discriminating between virilizing ovary tumors and ovary hyperthecosis in postmenopausal women: clinical data, hormonal profiles and image studies.
Yance VRV, Marcondes JAM, Rocha MP, Barcellos CRG, Dantas WS, Avila AFA, Baroni RH, Carvalho FM, Hayashida SAY, Mendonca BB, Domenice S
Eur J Endocrinol 2017 Jul;177(1):93-102. Epub 2017 Apr 21 doi: 10.1530/EJE-17-0111. PMID: 28432270
Cell adhesion and apoptosis in ovarian stromal hyperplasia and hyperthecosis.
Sharabidze N, Burkadze G, Sabakhtarashvili M
Georgian Med News 2006 Feb;(131):33-7. PMID: 16575127
Proliferation and apoptosis in ovarian stromal hyperplasia and hyperthecosis.
Sharabidze N, Sabakhtarashvili M, Burkadze G
Georgian Med News 2005 Dec;(129):26-9. PMID: 16444023
Effects of sex steroids on women's health: implications for practitioners.
Derman RJ
Am J Med 1995 Jan 16;98(1A):137S-143S. doi: 10.1016/s0002-9343(99)80072-2. PMID: 7825634

Diagnosis

Discriminating between virilizing ovary tumors and ovary hyperthecosis in postmenopausal women: clinical data, hormonal profiles and image studies.
Yance VRV, Marcondes JAM, Rocha MP, Barcellos CRG, Dantas WS, Avila AFA, Baroni RH, Carvalho FM, Hayashida SAY, Mendonca BB, Domenice S
Eur J Endocrinol 2017 Jul;177(1):93-102. Epub 2017 Apr 21 doi: 10.1530/EJE-17-0111. PMID: 28432270
Magnetic resonance imaging findings of ovarian stromal hyperthecosis.
Fujii S, Kiyokawa T, Tsukihara S, Senda T, Tahara T, Kaminou T, Ogawa T
Acta Radiol 2009 Oct;50(8):954-7. doi: 10.1080/02841850903207188. PMID: 19863423
Cell adhesion and apoptosis in ovarian stromal hyperplasia and hyperthecosis.
Sharabidze N, Burkadze G, Sabakhtarashvili M
Georgian Med News 2006 Feb;(131):33-7. PMID: 16575127
Proliferation and apoptosis in ovarian stromal hyperplasia and hyperthecosis.
Sharabidze N, Sabakhtarashvili M, Burkadze G
Georgian Med News 2005 Dec;(129):26-9. PMID: 16444023
Effects of sex steroids on women's health: implications for practitioners.
Derman RJ
Am J Med 1995 Jan 16;98(1A):137S-143S. doi: 10.1016/s0002-9343(99)80072-2. PMID: 7825634

Therapy

Effects of sex steroids on women's health: implications for practitioners.
Derman RJ
Am J Med 1995 Jan 16;98(1A):137S-143S. doi: 10.1016/s0002-9343(99)80072-2. PMID: 7825634

Prognosis

Value of selective venous catheterization in the diagnosis of hyperandrogenism.
Hickman LC, Goodman L, Falcone T
Fertil Steril 2017 Dec;108(6):1085. Epub 2017 Oct 31 doi: 10.1016/j.fertnstert.2017.08.037. PMID: 29100622
Discriminating between virilizing ovary tumors and ovary hyperthecosis in postmenopausal women: clinical data, hormonal profiles and image studies.
Yance VRV, Marcondes JAM, Rocha MP, Barcellos CRG, Dantas WS, Avila AFA, Baroni RH, Carvalho FM, Hayashida SAY, Mendonca BB, Domenice S
Eur J Endocrinol 2017 Jul;177(1):93-102. Epub 2017 Apr 21 doi: 10.1530/EJE-17-0111. PMID: 28432270

Clinical prediction guides

Value of selective venous catheterization in the diagnosis of hyperandrogenism.
Hickman LC, Goodman L, Falcone T
Fertil Steril 2017 Dec;108(6):1085. Epub 2017 Oct 31 doi: 10.1016/j.fertnstert.2017.08.037. PMID: 29100622
Magnetic resonance imaging findings of ovarian stromal hyperthecosis.
Fujii S, Kiyokawa T, Tsukihara S, Senda T, Tahara T, Kaminou T, Ogawa T
Acta Radiol 2009 Oct;50(8):954-7. doi: 10.1080/02841850903207188. PMID: 19863423

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