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Skin Fibrous Histiocytoma, Fibroblastic Variant

MedGen UID:
310645
•Concept ID:
C1707545
•
Neoplastic Process
Synonym: Cutaneous Fibrous Histiocytoma, Fibroblastic Variant

Definition

A morphologic variant of fibrous histiocytoma of the skin. It is characterized by the presence of spindle-shaped fibrohistiocytic cells and associated acanthosis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSkin Fibrous Histiocytoma, Fibroblastic Variant

Professional guidelines

PubMed

High proliferative activity excludes dermatofibroma: report of the utility of MIB-1 in the differential diagnosis of selected fibrohistiocytic tumors.
Hanly AJ, Jordà M, Elgart GW, Badiavas E, Nassiri M, Nadji M
Arch Pathol Lab Med 2006 Jun;130(6):831-4. doi: 10.5858/2006-130-831-HPAEDR. PMID: 16740036

Recent clinical studies

Etiology

Cutaneous soft tissue tumors: how do we make sense of fibrous and "fibrohistiocytic" tumors with confusing names and similar appearances?
Hornick JL
Mod Pathol 2020 Jan;33(Suppl 1):56-65. Epub 2019 Oct 25 doi: 10.1038/s41379-019-0388-4. PMID: 31653978
Cutaneous fibrohistiocytic tumours - an update.
Luzar B, Calonje E
Histopathology 2010 Jan;56(1):148-65. doi: 10.1111/j.1365-2559.2009.03447.x. PMID: 20055912
Dermal and subcutaneous variants of plexiform fibrohistiocytic tumor.
Zelger B, Weinlich G, Steiner H, Zelger BG, Egarter-Vigl E
Am J Surg Pathol 1997 Feb;21(2):235-41. doi: 10.1097/00000478-199702000-00015. PMID: 9042292
Malignant fibrous histiocytoma: morphologic pattern or pathologic entity?
Hollowood K, Fletcher CD
Semin Diagn Pathol 1995 Aug;12(3):210-20. PMID: 8545588
Solitary fibrous tumor: histological and immunohistochemical spectrum of benign and malignant variants presenting at different sites.
Hanau CA, Miettinen M
Hum Pathol 1995 Apr;26(4):440-9. doi: 10.1016/0046-8177(95)90147-7. PMID: 7705824

Diagnosis

Cutaneous soft tissue tumors: how do we make sense of fibrous and "fibrohistiocytic" tumors with confusing names and similar appearances?
Hornick JL
Mod Pathol 2020 Jan;33(Suppl 1):56-65. Epub 2019 Oct 25 doi: 10.1038/s41379-019-0388-4. PMID: 31653978
Epithelioid Fibrous Histiocytoma: A Concise Review.
Felty CC, Linos K
Am J Dermatopathol 2019 Dec;41(12):879-883. doi: 10.1097/DAD.0000000000001272. PMID: 30289773
Fibrous and fibrohistiocytic neoplasms: an update.
Clarke LE
Dermatol Clin 2012 Oct;30(4):643-56, vi. Epub 2012 Aug 11 doi: 10.1016/j.det.2012.06.005. PMID: 23021051
Myofibroblastic malignancies.
Fisher C
Adv Anat Pathol 2004 Jul;11(4):190-201. doi: 10.1097/01.pap.0000131773.16130.aa. PMID: 15220822
Myofibrosarcoma.
Fisher C
Virchows Arch 2004 Sep;445(3):215-23. Epub 2004 Jun 2 doi: 10.1007/s00428-004-1038-9. PMID: 15173943

Therapy

Fibrous and fibrohistiocytic neoplasms: an update.
Clarke LE
Dermatol Clin 2012 Oct;30(4):643-56, vi. Epub 2012 Aug 11 doi: 10.1016/j.det.2012.06.005. PMID: 23021051
The pathology of malignant fibrous histiocytoma of bone. A study of 130 patients.
Huvos AG, Heilweil M, Bretsky SS
Am J Surg Pathol 1985 Dec;9(12):853-71. doi: 10.1097/00000478-198512000-00002. PMID: 3000204

Prognosis

Cutaneous soft tissue tumors: how do we make sense of fibrous and "fibrohistiocytic" tumors with confusing names and similar appearances?
Hornick JL
Mod Pathol 2020 Jan;33(Suppl 1):56-65. Epub 2019 Oct 25 doi: 10.1038/s41379-019-0388-4. PMID: 31653978
Coagulation Factor XIII-A Subunit Missense Mutation in the Pathobiology of Autosomal Dominant Multiple Dermatofibromas.
Supsrisunjai C, Hsu CK, Michael M, Duval C, Lee JYW, Yang HS, Huang HY, Chaikul T, Onoufriadis A, Steiner RA, Ariëns RAS, Sarig O, Sprecher E, Eskin-Schwartz M, Samlaska C, Simpson MA, Calonje E, Parsons M, McGrath JA
J Invest Dermatol 2020 Mar;140(3):624-635.e7. Epub 2019 Sep 4 doi: 10.1016/j.jid.2019.08.441. PMID: 31493396
Epithelioid Fibrous Histiocytoma: A Concise Review.
Felty CC, Linos K
Am J Dermatopathol 2019 Dec;41(12):879-883. doi: 10.1097/DAD.0000000000001272. PMID: 30289773
Fibrous and fibrohistiocytic neoplasms: an update.
Clarke LE
Dermatol Clin 2012 Oct;30(4):643-56, vi. Epub 2012 Aug 11 doi: 10.1016/j.det.2012.06.005. PMID: 23021051
Solitary fibrous tumor: histological and immunohistochemical spectrum of benign and malignant variants presenting at different sites.
Hanau CA, Miettinen M
Hum Pathol 1995 Apr;26(4):440-9. doi: 10.1016/0046-8177(95)90147-7. PMID: 7705824

Clinical prediction guides

Cutaneous soft tissue tumors: how do we make sense of fibrous and "fibrohistiocytic" tumors with confusing names and similar appearances?
Hornick JL
Mod Pathol 2020 Jan;33(Suppl 1):56-65. Epub 2019 Oct 25 doi: 10.1038/s41379-019-0388-4. PMID: 31653978
Epithelioid Fibrous Histiocytoma: A Concise Review.
Felty CC, Linos K
Am J Dermatopathol 2019 Dec;41(12):879-883. doi: 10.1097/DAD.0000000000001272. PMID: 30289773
Orbital solitary fibrous tumor: encompassing terminology for hemangiopericytoma, giant cell angiofibroma, and fibrous histiocytoma of the orbit: reappraisal of 41 cases.
Furusato E, Valenzuela IA, Fanburg-Smith JC, Auerbach A, Furusato B, Cameron JD, Rushing EJ
Hum Pathol 2011 Jan;42(1):120-8. Epub 2010 Nov 5 doi: 10.1016/j.humpath.2010.05.021. PMID: 21056898
Subcutaneous atypical fibrous histiocytoma.
Garrido-Ruiz MC, Ramos P, Enguita AB, Rodriguez Peralto JL
Am J Dermatopathol 2009 Jul;31(5):499-501. doi: 10.1097/DAD.0b013e31819b57ad. PMID: 19542931
Granular cell dermatofibroma.
Soyer HP, Metze D, Kerl H
Am J Dermatopathol 1997 Apr;19(2):168-73. doi: 10.1097/00000372-199704000-00011. PMID: 9129702

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