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Uterine corpus myxoid leiomyosarcoma

MedGen UID:
311426
•Concept ID:
C1519861
•
Neoplastic Process
Synonyms: body of uterus myxoid leiomyosarcoma; myxoid leiomyosarcoma of body of uterus; Uterine Corpus Myxoid Leiomyosarcoma; uterine corpus myxoid leiomyosarcoma; uterine myxoid leiomyosarcoma
 
Monarch Initiative: MONDO:0003928

Definition

A morphologic variant of leiomyosarcoma arising from the uterus corpus. It is characterized by the presence of cellular pleomorphism, malignant cells with large nuclei, and a myxoid stroma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUterine corpus myxoid leiomyosarcoma

Professional guidelines

PubMed

Uterine Morcellation for Presumed Leiomyomas: ACOG Committee Opinion, Number 822.
Obstet Gynecol 2021 Mar 1;137(3):e63-e74. doi: 10.1097/AOG.0000000000004291. PMID: 33595252
ACOG Committee Opinion No. 770: Uterine Morcellation for Presumed Leiomyomas.
Obstet Gynecol 2019 Mar;133(3):e238-e248. doi: 10.1097/AOG.0000000000003126. PMID: 30801477
Treatment, results and prognostic factors in stage I and II sarcomas of the corpus uteri.
Vongtama V, Karlen JR, Piver SM, Tsukada Y, Moore RH
AJR Am J Roentgenol 1976 Jan;126(1):139-47. doi: 10.2214/ajr.126.1.139. PMID: 175673

Recent clinical studies

Etiology

Recent Developments in Surgical Pathology of the Uterine Corpus.
Hanley KZ, Birdsong GG, Mosunjac MB
Arch Pathol Lab Med 2017 Apr;141(4):528-541. Epub 2017 Feb 28 doi: 10.5858/arpa.2016-0284-SA. PMID: 28353387
Major clinical research advances in gynecologic cancer in 2015.
Suh DH, Kim M, Kim HJ, Lee KH, Kim JW
J Gynecol Oncol 2016 Nov;27(6):e53. doi: 10.3802/jgo.2016.27.e53. PMID: 27775259Free PMC Article
Malignant tumors of the uterine corpus: molecular background of their origin.
Brany D, Dvorska D, Nachajova M, Slavik P, Burjanivova T
Tumour Biol 2015 Sep;36(9):6615-21. Epub 2015 Aug 26 doi: 10.1007/s13277-015-3824-1. PMID: 26307392
Major clinical research advances in gynecologic cancer in 2014.
Suh DH, Lee KH, Kim K, Kang S, Kim JW
J Gynecol Oncol 2015 Apr;26(2):156-67. doi: 10.3802/jgo.2015.26.2.156. PMID: 25872896Free PMC Article
Heterologous and rare homologous sarcomas of the uterine corpus: a clinicopathologic review.
Fadare O
Adv Anat Pathol 2011 Jan;18(1):60-74. doi: 10.1097/PAP.0b013e3182026be7. PMID: 21169739

Diagnosis

Prevalence, characteristics, and risk factors of occult uterine cancer in presumed benign hysterectomy.
Desai VB, Wright JD, Gross CP, Lin H, Boscoe FP, Hutchison LM, Schwartz PE, Xu X
Am J Obstet Gynecol 2019 Jul;221(1):39.e1-39.e14. Epub 2019 Mar 7 doi: 10.1016/j.ajog.2019.02.051. PMID: 30853364Free PMC Article
Recent Developments in Surgical Pathology of the Uterine Corpus.
Hanley KZ, Birdsong GG, Mosunjac MB
Arch Pathol Lab Med 2017 Apr;141(4):528-541. Epub 2017 Feb 28 doi: 10.5858/arpa.2016-0284-SA. PMID: 28353387
Major clinical research advances in gynecologic cancer in 2014.
Suh DH, Lee KH, Kim K, Kang S, Kim JW
J Gynecol Oncol 2015 Apr;26(2):156-67. doi: 10.3802/jgo.2015.26.2.156. PMID: 25872896Free PMC Article
Uterine leiomyosarcoma: a review article.
Gockley AA, Rauh-Hain JA, del Carmen MG
Int J Gynecol Cancer 2014 Nov;24(9):1538-42. doi: 10.1097/IGC.0000000000000290. PMID: 25304676
Heterologous and rare homologous sarcomas of the uterine corpus: a clinicopathologic review.
Fadare O
Adv Anat Pathol 2011 Jan;18(1):60-74. doi: 10.1097/PAP.0b013e3182026be7. PMID: 21169739

Therapy

Phase II study of niraparib in recurrent or persistent rare fraction of gynecologic malignancies with homologous recombination deficiency (JGOG2052).
Asano H, Oda K, Yoshihara K, Ito YM, Matsumura N, Shimada M, Watari H, Enomoto T
J Gynecol Oncol 2022 Jul;33(4):e55. Epub 2022 May 3 doi: 10.3802/jgo.2022.33.e55. PMID: 35557035Free PMC Article
CD70 antibody-drug conjugate as a potential therapeutic agent for uterine leiomyosarcoma.
Nakae R, Matsuzaki S, Serada S, Matsuo K, Shiomi M, Sato K, Nagase Y, Matsuzaki S, Nakagawa S, Hiramatsu K, Okazawa A, Kimura T, Egawa-Takata T, Kobayashi E, Ueda Y, Yoshino K, Naka T, Kimura T
Am J Obstet Gynecol 2021 Feb;224(2):197.e1-197.e23. Epub 2020 Aug 19 doi: 10.1016/j.ajog.2020.08.028. PMID: 32822640
Prevalence, characteristics, and risk factors of occult uterine cancer in presumed benign hysterectomy.
Desai VB, Wright JD, Gross CP, Lin H, Boscoe FP, Hutchison LM, Schwartz PE, Xu X
Am J Obstet Gynecol 2019 Jul;221(1):39.e1-39.e14. Epub 2019 Mar 7 doi: 10.1016/j.ajog.2019.02.051. PMID: 30853364Free PMC Article
Major clinical research advances in gynecologic cancer in 2015.
Suh DH, Kim M, Kim HJ, Lee KH, Kim JW
J Gynecol Oncol 2016 Nov;27(6):e53. doi: 10.3802/jgo.2016.27.e53. PMID: 27775259Free PMC Article
Major clinical research advances in gynecologic cancer in 2014.
Suh DH, Lee KH, Kim K, Kang S, Kim JW
J Gynecol Oncol 2015 Apr;26(2):156-67. doi: 10.3802/jgo.2015.26.2.156. PMID: 25872896Free PMC Article

Prognosis

Recent Developments in Surgical Pathology of the Uterine Corpus.
Hanley KZ, Birdsong GG, Mosunjac MB
Arch Pathol Lab Med 2017 Apr;141(4):528-541. Epub 2017 Feb 28 doi: 10.5858/arpa.2016-0284-SA. PMID: 28353387
Malignant tumors of the uterine corpus: molecular background of their origin.
Brany D, Dvorska D, Nachajova M, Slavik P, Burjanivova T
Tumour Biol 2015 Sep;36(9):6615-21. Epub 2015 Aug 26 doi: 10.1007/s13277-015-3824-1. PMID: 26307392
Uterine leiomyosarcoma: a review article.
Gockley AA, Rauh-Hain JA, del Carmen MG
Int J Gynecol Cancer 2014 Nov;24(9):1538-42. doi: 10.1097/IGC.0000000000000290. PMID: 25304676
Heterologous and rare homologous sarcomas of the uterine corpus: a clinicopathologic review.
Fadare O
Adv Anat Pathol 2011 Jan;18(1):60-74. doi: 10.1097/PAP.0b013e3182026be7. PMID: 21169739
Gynecological sarcomas.
DiSaia PJ, Pecorelli S
Semin Surg Oncol 1994 Sep-Oct;10(5):369-73. doi: 10.1002/ssu.2980100510. PMID: 7997731

Clinical prediction guides

CD70 antibody-drug conjugate as a potential therapeutic agent for uterine leiomyosarcoma.
Nakae R, Matsuzaki S, Serada S, Matsuo K, Shiomi M, Sato K, Nagase Y, Matsuzaki S, Nakagawa S, Hiramatsu K, Okazawa A, Kimura T, Egawa-Takata T, Kobayashi E, Ueda Y, Yoshino K, Naka T, Kimura T
Am J Obstet Gynecol 2021 Feb;224(2):197.e1-197.e23. Epub 2020 Aug 19 doi: 10.1016/j.ajog.2020.08.028. PMID: 32822640
Prevalence, characteristics, and risk factors of occult uterine cancer in presumed benign hysterectomy.
Desai VB, Wright JD, Gross CP, Lin H, Boscoe FP, Hutchison LM, Schwartz PE, Xu X
Am J Obstet Gynecol 2019 Jul;221(1):39.e1-39.e14. Epub 2019 Mar 7 doi: 10.1016/j.ajog.2019.02.051. PMID: 30853364Free PMC Article
Major clinical research advances in gynecologic cancer in 2015.
Suh DH, Kim M, Kim HJ, Lee KH, Kim JW
J Gynecol Oncol 2016 Nov;27(6):e53. doi: 10.3802/jgo.2016.27.e53. PMID: 27775259Free PMC Article
Major clinical research advances in gynecologic cancer in 2014.
Suh DH, Lee KH, Kim K, Kang S, Kim JW
J Gynecol Oncol 2015 Apr;26(2):156-67. doi: 10.3802/jgo.2015.26.2.156. PMID: 25872896Free PMC Article
Heterologous and rare homologous sarcomas of the uterine corpus: a clinicopathologic review.
Fadare O
Adv Anat Pathol 2011 Jan;18(1):60-74. doi: 10.1097/PAP.0b013e3182026be7. PMID: 21169739

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