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Skin Fibrous Histiocytoma, Histiocytic Variant

MedGen UID:
313068
•Concept ID:
C1707546
•
Neoplastic Process
Synonym: Cutaneous Fibrous Histiocytoma, Histiocytic Variant

Definition

A morphologic variant of fibrous histiocytoma of the skin. It is characterized by the presence of xanthomatous fibrohistiocytic cells, giant cells, and hemosiderin deposition. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSkin Fibrous Histiocytoma, Histiocytic Variant

Professional guidelines

PubMed

High proliferative activity excludes dermatofibroma: report of the utility of MIB-1 in the differential diagnosis of selected fibrohistiocytic tumors.
Hanly AJ, Jordà M, Elgart GW, Badiavas E, Nassiri M, Nadji M
Arch Pathol Lab Med 2006 Jun;130(6):831-4. doi: 10.5858/2006-130-831-HPAEDR. PMID: 16740036

Recent clinical studies

Etiology

Fibrohistiocytic Tumors.
Romano RC, Fritchie KJ
Clin Lab Med 2017 Sep;37(3):603-631. Epub 2017 Jun 15 doi: 10.1016/j.cll.2017.05.007. PMID: 28802503
Cutaneous fibrohistiocytic tumours - an update.
Luzar B, Calonje E
Histopathology 2010 Jan;56(1):148-65. doi: 10.1111/j.1365-2559.2009.03447.x. PMID: 20055912
Fine-needle aspiration of primary and recurrent benign fibrous histiocytoma: classic, aneurysmal, and myxoid variants.
Klijanienko J, Caillaud JM, Lagacé R
Diagn Cytopathol 2004 Dec;31(6):387-91. doi: 10.1002/dc.20140. PMID: 15540171
Malignant fibrous histiocytoma: morphologic pattern or pathologic entity?
Hollowood K, Fletcher CD
Semin Diagn Pathol 1995 Aug;12(3):210-20. PMID: 8545588
Benign fibrous histiocytoma of the skin. An immunohistochemical analysis of 30 cases.
Gonzalez S
Pathol Res Pract 1985 Nov;180(5):486-9. doi: 10.1016/s0344-0338(85)80009-1. PMID: 3001679

Diagnosis

Epithelioid Fibrous Histiocytoma: A Concise Review.
Felty CC, Linos K
Am J Dermatopathol 2019 Dec;41(12):879-883. doi: 10.1097/DAD.0000000000001272. PMID: 30289773
Langerhans Cell Histiocytoma: A Benign Histiocytic Neoplasm of Diverse Lines of Terminal Differentiation.
Dupeux M, Boccara O, Frassati-Biaggi A, Hélias-Rodzewicz Z, Leclerc-Mercier S, Bodemer C, Molina TJ, Emile JF, Fraitag S
Am J Dermatopathol 2019 Jan;41(1):29-36. doi: 10.1097/DAD.0000000000001255. PMID: 30252693
Fibrohistiocytic Tumors.
Romano RC, Fritchie KJ
Clin Lab Med 2017 Sep;37(3):603-631. Epub 2017 Jun 15 doi: 10.1016/j.cll.2017.05.007. PMID: 28802503
Cutaneous fibrohistiocytic tumours - an update.
Luzar B, Calonje E
Histopathology 2010 Jan;56(1):148-65. doi: 10.1111/j.1365-2559.2009.03447.x. PMID: 20055912
The rise and fall of malignant fibrous histiocytoma.
Erlandson RA, Antonescu CR
Ultrastruct Pathol 2004 Sep-Dec;28(5-6):283-9. doi: 10.1080/019131290882150. PMID: 15764577

Therapy

The pathology of malignant fibrous histiocytoma of bone. A study of 130 patients.
Huvos AG, Heilweil M, Bretsky SS
Am J Surg Pathol 1985 Dec;9(12):853-71. doi: 10.1097/00000478-198512000-00002. PMID: 3000204

Prognosis

Epithelioid Fibrous Histiocytoma: A Concise Review.
Felty CC, Linos K
Am J Dermatopathol 2019 Dec;41(12):879-883. doi: 10.1097/DAD.0000000000001272. PMID: 30289773
Prominent myofibroblastic differentiation. A pitfall in the diagnosis of dermatofibroma.
Zelger BW, Zelger BG, Rappersberger K
Am J Dermatopathol 1997 Apr;19(2):138-46. doi: 10.1097/00000372-199704000-00007. PMID: 9129698
The pathology of malignant fibrous histiocytoma of bone. A study of 130 patients.
Huvos AG, Heilweil M, Bretsky SS
Am J Surg Pathol 1985 Dec;9(12):853-71. doi: 10.1097/00000478-198512000-00002. PMID: 3000204
Malignant histiocytosis and related tumors. A clinicopathologic study of 42 cases using cytological, histochemical and ultrastructural parameters.
van Heerde P, Feltkamp CA, Hart AA, Somers R, van Unnik JA, Vroom TM
Hematol Oncol 1984 Jan-Mar;2(1):13-32. doi: 10.1002/hon.2900020104. PMID: 6329939
Myxoid variant of malignant fibrous histiocytoma: ultrastructural observations.
Lagacé R, Delage C, Seemayer TA
Cancer 1979 Feb;43(2):526-34. doi: 10.1002/1097-0142(197902)43:2<526::aid-cncr2820430218>3.0.co;2-1. PMID: 217521

Clinical prediction guides

Epithelioid Fibrous Histiocytoma: A Concise Review.
Felty CC, Linos K
Am J Dermatopathol 2019 Dec;41(12):879-883. doi: 10.1097/DAD.0000000000001272. PMID: 30289773
Subcutaneous atypical fibrous histiocytoma.
Garrido-Ruiz MC, Ramos P, Enguita AB, Rodriguez Peralto JL
Am J Dermatopathol 2009 Jul;31(5):499-501. doi: 10.1097/DAD.0b013e31819b57ad. PMID: 19542931
Granular cell dermatofibroma.
Soyer HP, Metze D, Kerl H
Am J Dermatopathol 1997 Apr;19(2):168-73. doi: 10.1097/00000372-199704000-00011. PMID: 9129702
Benign cutaneous histiocytic tumors in childhood and adolescence, excluding Langerhans' cell proliferations. A clinicopathologic and immunohistochemical analysis.
Marrogi AJ, Dehner LP, Coffin CM, Wick MR
Am J Dermatopathol 1992 Feb;14(1):8-18. doi: 10.1097/00000372-199202000-00002. PMID: 1324624
Immunohistochemical investigations of tumors of supposed fibroblastic-histiocytic origin.
Kindblom LG, Jacobsen GK, Jacobsen M
Hum Pathol 1982 Sep;13(9):834-40. doi: 10.1016/s0046-8177(82)80080-4. PMID: 6286459

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