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Laryngeal Adenosquamous Carcinoma

MedGen UID:
313338
•Concept ID:
C1708649
•
Neoplastic Process

Definition

A rare, aggressive carcinoma that arises from the larynx. It is characterized by the presence of squamous cell carcinoma and adenocarcinoma components. Hoarseness, sore throat, and dysphagia are the presenting symptoms. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLaryngeal Adenosquamous Carcinoma

Professional guidelines

PubMed

How phenotype guides management of non-conventional squamous cell carcinomas of the larynx?
López F, Williams MD, Cardesa A, Hunt JL, Strojan P, Rinaldo A, Nixon IJ, Rodrigo JP, Saba NF, Mendenhall WM, Quer M, Suárez C, Ferlito A
Eur Arch Otorhinolaryngol 2017 Jul;274(7):2709-2726. Epub 2017 Mar 31 doi: 10.1007/s00405-017-4533-8. PMID: 28364287
Adenosquamous carcinoma of the head and neck: criteria for diagnosis in a study of 12 cases.
Alos L, Castillo M, Nadal A, Caballero M, Mallofre C, Palacin A, Cardesa A
Histopathology 2004 Jun;44(6):570-9. doi: 10.1111/j.1365-2559.2004.01881.x. PMID: 15186272

Recent clinical studies

Etiology

How phenotype guides management of non-conventional squamous cell carcinomas of the larynx?
López F, Williams MD, Cardesa A, Hunt JL, Strojan P, Rinaldo A, Nixon IJ, Rodrigo JP, Saba NF, Mendenhall WM, Quer M, Suárez C, Ferlito A
Eur Arch Otorhinolaryngol 2017 Jul;274(7):2709-2726. Epub 2017 Mar 31 doi: 10.1007/s00405-017-4533-8. PMID: 28364287
Laryngeal adenosquamous carcinoma: A population-based perspective.
Dubal PM, Unsal AA, Echanique KA, Vazquez A, Reder LS, Baredes S, Eloy JA
Laryngoscope 2016 Apr;126(4):858-63. Epub 2015 Oct 9 doi: 10.1002/lary.25704. PMID: 26452061
Adenosquamous carcinoma of the head and neck: Molecular analysis using CRTC-MAML FISH and survival comparison with paired conventional squamous cell carcinoma.
Kass JI, Lee SC, Abberbock S, Seethala RR, Duvvuri U
Laryngoscope 2015 Nov;125(11):E371-6. Epub 2015 Aug 8 doi: 10.1002/lary.25519. PMID: 26255977
Immunohistochemical and HPV-related features of laryngeal adenosquamous carcinoma.
Lovato A, Staffieri A, Marino F, Cappellesso R, Barzon L, Marchese-Ragona R, Ottaviano G, Marioni G
Am J Otolaryngol 2015 May-Jun;36(3):442-5. Epub 2014 Dec 24 doi: 10.1016/j.amjoto.2014.12.007. PMID: 25592826
Adenosquamous carcinoma of the head and neck: relationship to human papillomavirus and review of the literature.
Masand RP, El-Mofty SK, Ma XJ, Luo Y, Flanagan JJ, Lewis JS Jr
Head Neck Pathol 2011 Jun;5(2):108-16. Epub 2011 Feb 9 doi: 10.1007/s12105-011-0245-3. PMID: 21305368Free PMC Article

Diagnosis

Systemic therapy in non-conventional cancers of the larynx.
Tan E, Mody MD, Saba NF
Oral Oncol 2018 Jul;82:61-68. Epub 2018 May 26 doi: 10.1016/j.oraloncology.2018.05.005. PMID: 29909903
How phenotype guides management of non-conventional squamous cell carcinomas of the larynx?
López F, Williams MD, Cardesa A, Hunt JL, Strojan P, Rinaldo A, Nixon IJ, Rodrigo JP, Saba NF, Mendenhall WM, Quer M, Suárez C, Ferlito A
Eur Arch Otorhinolaryngol 2017 Jul;274(7):2709-2726. Epub 2017 Mar 31 doi: 10.1007/s00405-017-4533-8. PMID: 28364287
Laryngeal Dysplasia, Squamous Cell Carcinoma, and Variants.
Thompson LD
Surg Pathol Clin 2017 Mar;10(1):15-33. doi: 10.1016/j.path.2016.10.003. PMID: 28153131
Laryngeal adenosquamous carcinoma: A population-based perspective.
Dubal PM, Unsal AA, Echanique KA, Vazquez A, Reder LS, Baredes S, Eloy JA
Laryngoscope 2016 Apr;126(4):858-63. Epub 2015 Oct 9 doi: 10.1002/lary.25704. PMID: 26452061
Adenosquamous carcinoma of the upper aerodigestive tract: a clinicopathologic study of 12 cases and review of the literature.
Keelawat S, Liu CZ, Roehm PC, Barnes L
Am J Otolaryngol 2002 May-Jun;23(3):160-8. doi: 10.1053/ajot.2002.123462. PMID: 12019485

Therapy

Transoral Laser Surgery for Adenosquamous Carcinoma of the Glottis: First Case Report and Review of the Literature.
Kendall W, Dimitriadis PA, Tahir F, Sionis S
Ear Nose Throat J 2021 Sep;100(8):593-596. Epub 2020 Apr 8 doi: 10.1177/0145561320916576. PMID: 32264709
Pathological evaluation of radiotherapy and concomitant intraarterial cisplatin for maxillary sinus cancer.
Makino T, Tachibana T, Kariya S, Matsui Y, Matsuzaki H, Fujimoto S, Orita Y, Katsui K, Hiraki T, Sato Y, Kanazawa S, Nishizaki K
Auris Nasus Larynx 2020 Oct;47(5):881-886. Epub 2020 Apr 22 doi: 10.1016/j.anl.2020.04.004. PMID: 32359864
Systemic therapy in non-conventional cancers of the larynx.
Tan E, Mody MD, Saba NF
Oral Oncol 2018 Jul;82:61-68. Epub 2018 May 26 doi: 10.1016/j.oraloncology.2018.05.005. PMID: 29909903
Adenosquamous carcinoma of the head and neck: Molecular analysis using CRTC-MAML FISH and survival comparison with paired conventional squamous cell carcinoma.
Kass JI, Lee SC, Abberbock S, Seethala RR, Duvvuri U
Laryngoscope 2015 Nov;125(11):E371-6. Epub 2015 Aug 8 doi: 10.1002/lary.25519. PMID: 26255977
Laryngeal pseudosarcoma.
Giordano AM, Ewing S, Adams G, Maisel R
Laryngoscope 1983 Jun;93(6):735-40. doi: 10.1288/00005537-198306000-00007. PMID: 6855396

Prognosis

Early-stage glottic cancer of rare squamous cell carcinoma variants: a population-based study.
Takenaka Y, Uno A, Tanaka H, Takemoto N, Inohara H
Acta Otolaryngol 2023 Jan;143(1):70-76. Epub 2023 Jan 3 doi: 10.1080/00016489.2022.2161626. PMID: 36595382
Transoral Laser Surgery for Adenosquamous Carcinoma of the Glottis: First Case Report and Review of the Literature.
Kendall W, Dimitriadis PA, Tahir F, Sionis S
Ear Nose Throat J 2021 Sep;100(8):593-596. Epub 2020 Apr 8 doi: 10.1177/0145561320916576. PMID: 32264709
Laryngeal adenosquamous carcinoma: A population-based perspective.
Dubal PM, Unsal AA, Echanique KA, Vazquez A, Reder LS, Baredes S, Eloy JA
Laryngoscope 2016 Apr;126(4):858-63. Epub 2015 Oct 9 doi: 10.1002/lary.25704. PMID: 26452061
Adenosquamous carcinoma of the head and neck: relationship to human papillomavirus and review of the literature.
Masand RP, El-Mofty SK, Ma XJ, Luo Y, Flanagan JJ, Lewis JS Jr
Head Neck Pathol 2011 Jun;5(2):108-16. Epub 2011 Feb 9 doi: 10.1007/s12105-011-0245-3. PMID: 21305368Free PMC Article
Laryngeal pseudosarcoma.
Giordano AM, Ewing S, Adams G, Maisel R
Laryngoscope 1983 Jun;93(6):735-40. doi: 10.1288/00005537-198306000-00007. PMID: 6855396

Clinical prediction guides

Laryngeal adenosquamous carcinoma: A population-based perspective.
Dubal PM, Unsal AA, Echanique KA, Vazquez A, Reder LS, Baredes S, Eloy JA
Laryngoscope 2016 Apr;126(4):858-63. Epub 2015 Oct 9 doi: 10.1002/lary.25704. PMID: 26452061
Fine-needle aspiration of basaloid squamous carcinoma: a case report with review of differential diagnostic considerations.
Gilcrease MZ, Guzman-Paz M
Diagn Cytopathol 1998 Sep;19(3):210-5. doi: 10.1002/(sici)1097-0339(199809)19:3<210::aid-dc12>3.0.co;2-h. PMID: 9740998

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