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Breast Columnar Cell Lesion

MedGen UID:
317529
Concept ID:
C1707448
Neoplastic Process
Synonyms: Columnar Cell Lesion of Breast; Columnar Cell Lesion of the Breast

Definition

A morphologic spectrum of lesions that arise in the terminal ductal lobular units of the breast parenchyma. These lesions are characterized by the presence of columnar epithelial cells that line dilated terminal ductal lobular units. Cytological and architectural atypia may be absent or minimal, or significant enough to raise the possibility of atypical ductal hyperplasia or ductal carcinoma in situ. Columnar cell lesions are frequently found in breast biopsies but their biologic significance is not known. [from NCI]

Professional guidelines

PubMed

Kim WG, Cummings MC, Lakhani SR
Expert Rev Anticancer Ther 2020 Mar;20(3):205-219. Epub 2020 Mar 14 doi: 10.1080/14737140.2020.1738222. PMID: 32174198
Neal L, Sandhu NP, Hieken TJ, Glazebrook KN, Mac Bride MB, Dilaveri CA, Wahner-Roedler DL, Ghosh K, Visscher DW
Mayo Clin Proc 2014 Apr;89(4):536-47. doi: 10.1016/j.mayocp.2014.02.004. PMID: 24684875
Moinfar F
Arch Pathol Lab Med 2009 Jun;133(6):879-92. doi: 10.5858/133.6.879. PMID: 19492880

Recent clinical studies

Etiology

Strickland S, Turashvili G
Curr Oncol 2022 Aug 11;29(8):5664-5681. doi: 10.3390/curroncol29080447. PMID: 36005185Free PMC Article
Collins LC
Surg Pathol Clin 2018 Mar;11(1):177-197. Epub 2017 Dec 8 doi: 10.1016/j.path.2017.09.007. PMID: 29413656
Dion L, Racin A, Brousse S, Beltjens F, Cauchois A, Levêque J, Coutant C, Lavoué V
Expert Rev Anticancer Ther 2016 Sep;16(9):943-53. Epub 2016 Jul 5 doi: 10.1080/14737140.2016.1204916. PMID: 27367571
Neal L, Sandhu NP, Hieken TJ, Glazebrook KN, Mac Bride MB, Dilaveri CA, Wahner-Roedler DL, Ghosh K, Visscher DW
Mayo Clin Proc 2014 Apr;89(4):536-47. doi: 10.1016/j.mayocp.2014.02.004. PMID: 24684875
Jara-Lazaro AR, Tse GM, Tan PH
Pathology 2009 Jan;41(1):18-27. doi: 10.1080/00313020802563486. PMID: 19089736

Diagnosis

de Boer M, Verschuur-Maes AHJ, Moelans C, van Diest PJ
J Clin Pathol 2023 Apr;76(4):228-233. Epub 2023 Jan 24 doi: 10.1136/jcp-2022-208389. PMID: 36693714
Strickland S, Turashvili G
Curr Oncol 2022 Aug 11;29(8):5664-5681. doi: 10.3390/curroncol29080447. PMID: 36005185Free PMC Article
de Boer M, van Diest PJ
J Clin Pathol 2022 Jan;75(1):5-9. Epub 2021 Apr 15 doi: 10.1136/jclinpath-2020-207359. PMID: 33858936Free PMC Article
Kim WG, Cummings MC, Lakhani SR
Expert Rev Anticancer Ther 2020 Mar;20(3):205-219. Epub 2020 Mar 14 doi: 10.1080/14737140.2020.1738222. PMID: 32174198
Jara-Lazaro AR, Tse GM, Tan PH
Pathology 2009 Jan;41(1):18-27. doi: 10.1080/00313020802563486. PMID: 19089736

Therapy

Baker GM, Guzman-Arocho YD, Bret-Mounet VC, Torous VF, Schnitt SJ, Tobias AM, Bartlett RA, Fein-Zachary VJ, Collins LC, Wulf GM, Heng YJ
Mod Pathol 2021 Jan;34(1):85-94. Epub 2020 Sep 16 doi: 10.1038/s41379-020-00675-9. PMID: 32939016Free PMC Article
Sciarra A, Lopez G, Corti C, Runza L, Ercoli G, Bonometti A, Despini L, Blundo C, Gambini D, Fusco N
Appl Immunohistochem Mol Morphol 2019 Aug;27(7):508-514. doi: 10.1097/PAI.0000000000000604. PMID: 29084054
Petry KU
Scand J Clin Lab Invest Suppl 2014;244:59-62; discussion 62. doi: 10.3109/00365513.2014.936683. PMID: 25083895
Kabat GC, Jones JG, Olson N, Negassa A, Duggan C, Ginsberg M, Kandel RA, Glass AG, Rohan TE
Cancer Causes Control 2010 Jun;21(6):821-8. Epub 2010 Jan 19 doi: 10.1007/s10552-010-9508-7. PMID: 20084540Free PMC Article
Turashvili G, McKinney S, Martin L, Gelmon KA, Watson P, Boyd N, Aparicio S
Breast Cancer Res Treat 2009 Jun;115(3):561-71. Epub 2008 Jun 28 doi: 10.1007/s10549-008-0099-x. PMID: 18587641

Prognosis

Strickland S, Turashvili G
Curr Oncol 2022 Aug 11;29(8):5664-5681. doi: 10.3390/curroncol29080447. PMID: 36005185Free PMC Article
Kim WG, Cummings MC, Lakhani SR
Expert Rev Anticancer Ther 2020 Mar;20(3):205-219. Epub 2020 Mar 14 doi: 10.1080/14737140.2020.1738222. PMID: 32174198
Sciarra A, Lopez G, Corti C, Runza L, Ercoli G, Bonometti A, Despini L, Blundo C, Gambini D, Fusco N
Appl Immunohistochem Mol Morphol 2019 Aug;27(7):508-514. doi: 10.1097/PAI.0000000000000604. PMID: 29084054
Walker RA, Hanby A, Pinder SE, Thomas J, Ellis IO; National Coordinating Committee for Breast Pathology Research Subgroup
J Clin Pathol 2012 Sep;65(9):771-85. Epub 2012 Jul 19 doi: 10.1136/jclinpath-2012-200733. PMID: 22813732
Kim MJ, Kim EK, Oh KK, Park BW, Kim H
Eur J Radiol 2006 Nov;60(2):264-9. Epub 2006 Aug 7 doi: 10.1016/j.ejrad.2006.06.013. PMID: 16891081

Clinical prediction guides

Katayama A, Toss MS, Parkin M, Sano T, Oyama T, Quinn CM, Ellis IO, Rakha EA
Histopathology 2022 Feb;80(3):515-528. Epub 2021 Dec 2 doi: 10.1111/his.14577. PMID: 34605058
Kim WG, Cummings MC, Lakhani SR
Expert Rev Anticancer Ther 2020 Mar;20(3):205-219. Epub 2020 Mar 14 doi: 10.1080/14737140.2020.1738222. PMID: 32174198
Masood S, Rosa M
Adv Anat Pathol 2011 May;18(3):190-8. doi: 10.1097/PAP.0b013e31821698cc. PMID: 21490436
Brandt SM, Young GQ, Hoda SA
Adv Anat Pathol 2008 May;15(3):140-6. doi: 10.1097/PAP.0b013e31816ff313. PMID: 18434766
Pinder SE, Reis-Filho JS
J Clin Pathol 2007 Dec;60(12):1307-12. Epub 2006 Dec 20 doi: 10.1136/jcp.2006.040634. PMID: 17182657Free PMC Article

Recent systematic reviews

Verschuur-Maes AH, van Deurzen CH, Monninkhof EM, van Diest PJ
Ann Surg 2012 Feb;255(2):259-65. doi: 10.1097/SLA.0b013e318233523f. PMID: 21989373

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