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Non-Neoplastic Pancreatic Disorder

MedGen UID:: 317959
•Concept ID:: C1709252
•: Disease or Syndrome

Definition

A non-neoplastic disorder that affects the pancreas. Representative examples include pancreatitis and pancreatic insufficiency. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVNon-Neoplastic Pancreatic Disorder

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Disorder by Site
      - Disorder of gastrointestinal tract
        Non-Neoplastic Digestive System Disorder
        Non-Neoplastic Pancreatic Disorder
        Acinar Cystic Transformation of the Pancreas
        Exocrine pancreatic insufficiency
        Shwachman syndrome
        Shwachman-Diamond syndrome 1
        Shwachman-Diamond syndrome 2
        Non-Neoplastic Endocrine Pancreas Disorder
        Diabetes mellitus
        Childhood Diabetes Mellitus
        Complication due to diabetes mellitus
        Diabetes mellitus type 1
        Diabetes mellitus without complication
        Gestational diabetes
        Latent autoimmune diabetes in adults
        Leprechaunism syndrome
        Lipoatrophic diabetes
        Maturity onset diabetes mellitus in young
        Mitochondrial Diabetes
        Monogenic diabetes
        New Onset Diabetes After Transplant
        Pre-Gestational Diabetes
        Prediabetes syndrome
        Type 2 diabetes mellitus
        Familial hyperinsulinism
        Adult-onset non-insulinoma persistent hyperinsulinemic hypoglycemia
        Atypical Fanconi syndrome-neonatal hyperinsulinism syndrome
        Exercise-induced hyperinsulinism
        Hyperinsulinemic hypoglycemia, familial, 1
        Hyperinsulinemic hypoglycemia, familial, 2
        Hyperinsulinemic hypoglycemia, familial, 4
        Hyperinsulinism due to glucokinase deficiency
        Hyperinsulinism due to INSR deficiency
        Hyperinsulinism-hyperammonemia syndrome
        Nesidioblastosis
        Hyperinsulinism in the Infant of a Diabetic Mother
        Insulin resistance - type A
        KATP-Associated Hyperinsulinism
        Diffuse KATP-Associated Hyperinsulinism
        Focal KATP-Associated Hyperinsulinism
        Monogenic Hyperinsulinism
        Glucokinase-Associated Hyperinsulinism
        Hepatocyte Nuclear Factor 1-Alpha Hyperinsulinism
        Hepatocyte Nuclear Factor 4-Alpha Hyperinsulinism
        Mitochondrial Hydroxyacyl-Coenzyme A Dehydrogenase Hyperinsulinism
        Mitochondrial Uncoupling Protein 2 Hyperinsulinism
        Obesity-Associated Insulin Resistance
        Perinatal-Stress Induced Hyperinsulinism
        Transient Hyperinsulinism
        Pancreatic Infection
        Pancreatic mucinous ductal ectasia
        Pancreatitis
        Acute hemorrhagic pancreatitis
        Acute necrotizing pancreatitis
        Acute pancreatitis
        Alcoholic pancreatitis
        Chronic calcifying pancreatitis
        Chronic pancreatitis
        Autoimmune pancreatitis
        Hereditary pancreatitis
        Pancreatitis, chronic, susceptibility to
        Tropical pancreatitis
        Pancreatitis, Graft
        Recurrent pancreatitis

Professional guidelines

PubMed

Pancreatic cystic lesions. Differential diagnosis and treatment strategy.

Lira-Treviño A, Carranza Mendoza IG, Borbolla Arizti JP, Soriano-Ríos A, Uscanga-Domínguez L, Peláez-Luna M
Rev Gastroenterol Mex (Engl Ed) 2022 Apr-Jun;87(2):188-197. Epub 2022 May 21 doi: 10.1016/j.rgmxen.2022.05.002. PMID: 35610168

Ultrasound-based scoring system for differential diagnosis of polypoid lesions of the gallbladder.

Liu XS, Chen T, Gu LH, Guo YF, Li CY, Li FH, Wang J
J Gastroenterol Hepatol 2018 Jun;33(6):1295-1299. Epub 2018 Mar 9 doi: 10.1111/jgh.14080. PMID: 29280187

Management of pancreatic cysts: a review of the current guidelines.

Hol L, Signoretti M, Poley JW
Minerva Gastroenterol Dietol 2015 Jun;61(2):87-99. Epub 2015 Feb 5 PMID: 25651835

See all (17)

Recent clinical studies

Etiology

Morphology-guided transcriptomic analysis of human pancreatic cancer organoids reveals microenvironmental signals that enhance invasion.

Jeong YJ, Knutsdottir H, Shojaeian F, Lerner MG, Wissler MF, Henriet E, Ng T, Datta S, Navarro-Serer B, Chianchiano P, Kinny-Köster B, Zimmerman JW, Stein-O'Brien G, Gaida MM, Eshleman JR, Lin MT, Fertig EJ, Ewald AJ, Bader JS, Wood LD
J Clin Invest 2023 Apr 17;133(8) doi: 10.1172/JCI162054. PMID: 36881486 Free PMC Article

Pancreatic cystic lesions. Differential diagnosis and treatment strategy.

Pancreatic cystic lesions and the role of contrast enhanced endoscopic ultrasound.

Hickman K, Sadler TJ, Zhang TT, Boninsegna E, Majcher V, Godfrey E
Clin Radiol 2022 Jun;77(6):418-427. Epub 2022 Apr 3 doi: 10.1016/j.crad.2022.02.017. PMID: 35387743

Cutaneous paraneoplastic syndromes.

Wick MR, Patterson JW
Semin Diagn Pathol 2019 Jul;36(4):211-228. Epub 2019 Jan 31 doi: 10.1053/j.semdp.2019.01.001. PMID: 30736994

Uncommon pancreatic tumors and pseudotumors.

Lalwani N, Mannelli L, Ganeshan DM, Shanbhogue AK, Dighe MK, Tiwari HA, Maximin S, Monti S, Ragucci M, Prasad SR
Abdom Imaging 2015 Jan;40(1):167-80. doi: 10.1007/s00261-014-0189-7. PMID: 25063236

See all (116)

Diagnosis

Pathological features in non-neoplastic congenital and adult hyperinsulinism: from nesidioblastosis to current terminology and understanding.

Sempoux C, Klöppel G
Endocr Relat Cancer 2023 Sep 1;30(9) Epub 2023 Jul 26 doi: 10.1530/ERC-23-0034. PMID: 37279235

Pancreatic cystic lesions. Differential diagnosis and treatment strategy.

Non-Neoplastic Masses of the Pancreas.

Centeno BA, Thomas SC
Monogr Clin Cytol 2020;26:42-52. Epub 2020 Sep 28 doi: 10.1159/000455734. PMID: 32987396

Non-Neoplastic and Neoplastic Cysts of the Pancreas.

Centeno BA, Thomas SC
Monogr Clin Cytol 2020;26:53-73. Epub 2020 Sep 28 doi: 10.1159/000455735. PMID: 32987387

Common and uncommon pitfalls in pancreatic imaging: it is not always cancer.

Vernuccio F, Borhani AA, Dioguardi Burgio M, Midiri M, Furlan A, Brancatelli G
Abdom Radiol (NY) 2016 Feb;41(2):283-94. doi: 10.1007/s00261-015-0557-y. PMID: 26867910

See all (181)

Therapy

The tumor microenvironment in pancreatic ductal adenocarcinoma: current perspectives and future directions.

Herting CJ, Karpovsky I, Lesinski GB
Cancer Metastasis Rev 2021 Sep;40(3):675-689. doi: 10.1007/s10555-021-09988-w. PMID: 34591240

Snus: a compelling harm reduction alternative to cigarettes.

Clarke E, Thompson K, Weaver S, Thompson J, O'Connell G
Harm Reduct J 2019 Nov 27;16(1):62. doi: 10.1186/s12954-019-0335-1. PMID: 31775744 Free PMC Article

Non-neoplastic epithelial cysts of the pancreas: a rare, benign entity.

Assifi MM, Nguyen PD, Agrawal N, Dedania N, Kennedy EP, Sauter PK, Prestipino A, Winter JM, Yeo CJ, Lavu H
J Gastrointest Surg 2014 Mar;18(3):523-31. Epub 2014 Jan 22 doi: 10.1007/s11605-014-2459-7. PMID: 24449000

Metabolic syndrome and pancreatic cancer risk: a case-control study in Italy and meta-analysis.

Rosato V, Tavani A, Bosetti C, Pelucchi C, Talamini R, Polesel J, Serraino D, Negri E, La Vecchia C
Metabolism 2011 Oct;60(10):1372-8. Epub 2011 May 6 doi: 10.1016/j.metabol.2011.03.005. PMID: 21550085

Artificial sweeteners and the risk of gastric, pancreatic, and endometrial cancers in Italy.

Bosetti C, Gallus S, Talamini R, Montella M, Franceschi S, Negri E, La Vecchia C
Cancer Epidemiol Biomarkers Prev 2009 Aug;18(8):2235-8. doi: 10.1158/1055-9965.EPI-09-0365. PMID: 19661082

See all (34)

Prognosis

Microenvironmental Determinants of Pancreatic Cancer.

Hessmann E, Buchholz SM, Demir IE, Singh SK, Gress TM, Ellenrieder V, Neesse A
Physiol Rev 2020 Oct 1;100(4):1707-1751. Epub 2020 Apr 16 doi: 10.1152/physrev.00042.2019. PMID: 32297835

Snus: a compelling harm reduction alternative to cigarettes.

Clarke E, Thompson K, Weaver S, Thompson J, O'Connell G
Harm Reduct J 2019 Nov 27;16(1):62. doi: 10.1186/s12954-019-0335-1. PMID: 31775744 Free PMC Article

Ki67 labeling index: assessment and prognostic role in gastroenteropancreatic neuroendocrine neoplasms.

Klöppel G, La Rosa S
Virchows Arch 2018 Mar;472(3):341-349. Epub 2017 Nov 13 doi: 10.1007/s00428-017-2258-0. PMID: 29134440

Obesity and metabolic syndrome: pathological effects on the gastrointestinal tract.

Feakins RM
Histopathology 2016 Apr;68(5):630-40. Epub 2016 Jan 19 doi: 10.1111/his.12907. PMID: 26599607

Pseudocysts and other non-neoplastic cysts of the pancreas.

Klöppel G
Semin Diagn Pathol 2000 Feb;17(1):7-15. PMID: 10721803

See all (94)

Clinical prediction guides

Implementation of deep learning in liver pathology optimizes diagnosis of benign lesions and adenocarcinoma metastasis.

Kriegsmann M, Kriegsmann K, Steinbuss G, Zgorzelski C, Albrecht T, Heinrich S, Farkas S, Roth W, Dang H, Hausen A, Gaida MM
Clin Transl Med 2023 Jul;13(7):e1299. doi: 10.1002/ctm2.1299. PMID: 37415390 Free PMC Article

Pancreatic cystic lesions and the role of contrast enhanced endoscopic ultrasound.

Hickman K, Sadler TJ, Zhang TT, Boninsegna E, Majcher V, Godfrey E
Clin Radiol 2022 Jun;77(6):418-427. Epub 2022 Apr 3 doi: 10.1016/j.crad.2022.02.017. PMID: 35387743

Matsuda Y
Pathol Int 2019 Aug;69(8):450-462. Epub 2019 Jul 24 doi: 10.1111/pin.12837. PMID: 31339204

Obesity and metabolic syndrome: pathological effects on the gastrointestinal tract.

Feakins RM
Histopathology 2016 Apr;68(5):630-40. Epub 2016 Jan 19 doi: 10.1111/his.12907. PMID: 26599607

Expression of urocortin in pancreatic ductal adenocarcinoma and pancreatic intraepithelial neoplasia.

Cheng MF, Tsai WC, Hsia KT, Yang YS, Jin JS
APMIS 2014 Feb;122(2):147-54. Epub 2013 Jun 12 doi: 10.1111/apm.12117. PMID: 23755913

See all (104)

Recent systematic reviews

Ki-67 assessment of pancreatic neuroendocrine neoplasms: Systematic review and meta-analysis of manual vs. digital pathology scoring.

Luchini C, Pantanowitz L, Adsay V, Asa SL, Antonini P, Girolami I, Veronese N, Nottegar A, Cingarlini S, Landoni L, Brosens LA, Verschuur AV, Mattiolo P, Pea A, Mafficini A, Milella M, Niazi MK, Gurcan MN, Eccher A, Cree IA, Scarpa A
Mod Pathol 2022 Jun;35(6):712-720. Epub 2022 Mar 5 doi: 10.1038/s41379-022-01055-1. PMID: 35249100 Free PMC Article

Value of contrast-enhanced harmonic endoscopic ultrasonography with enhancement pattern for diagnosis of pancreatic cancer: A meta-analysis.

Yamashita Y, Shimokawa T, Napoléon B, Fusaroli P, Gincul R, Kudo M, Kitano M
Dig Endosc 2019 Mar;31(2):125-133. Epub 2019 Jan 15 doi: 10.1111/den.13290. PMID: 30338569

Diagnostic performance of contrast-enhanced ultrasound (CEUS) and contrast-enhanced endoscopic ultrasound (ECEUS) for the differentiation of pancreatic lesions: a systematic review and meta-analysis.

D'Onofrio M, Biagioli E, Gerardi C, Canestrini S, Rulli E, Crosara S, De Robertis R, Floriani I
Ultraschall Med 2014 Dec;35(6):515-21. Epub 2014 Sep 16 doi: 10.1055/s-0034-1385068. PMID: 25226455

See all (3)

MedGen

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Non-Neoplastic Pancreatic Disorder

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Practice guidelines

Related information

Recent activity