U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Optic atrophy with demyelinating disease of CNS

MedGen UID:
322290
•Concept ID:
C1833830
•
Disease or Syndrome
Synonym: Optic Atrophy with Demyelinating Disease of CNS
 
Monarch Initiative: MONDO:0008132
OMIM®: 165200

Professional guidelines

PubMed

Statin treatment in multiple sclerosis: a systematic review and meta-analysis.
Pihl-Jensen G, Tsakiri A, Frederiksen JL
CNS Drugs 2015 Apr;29(4):277-91. doi: 10.1007/s40263-015-0239-x. PMID: 25795002

Recent clinical studies

Etiology

Modeling MOG Antibody-Associated Disorder and Neuromyelitis Optica Spectrum Disorder in Animal Models: Visual System Manifestations.
Remlinger J, Bagnoud M, Meli I, Massy M, Hoepner R, Linington C, Chan A, Bennett JL, Enzmann V, Salmen A
Neurol Neuroimmunol Neuroinflamm 2023 Sep;10(5) Epub 2023 Jul 10 doi: 10.1212/NXI.0000000000200141. PMID: 37429715Free PMC Article
Clinical characteristics and clinical course of myelin oligodendrocyte glycoprotein antibody-seropositive pediatric optic neuritis.
Moon Y, Lim BC, Chae JH, Jung JH
Mult Scler Relat Disord 2022 Apr;60:103709. Epub 2022 Feb 22 doi: 10.1016/j.msard.2022.103709. PMID: 35220001
Optical coherence tomography in multiple sclerosis: A 3-year prospective multicenter study.
Paul F, Calabresi PA, Barkhof F, Green AJ, Kardon R, Sastre-Garriga J, Schippling S, Vermersch P, Saidha S, Gerendas BS, Schmidt-Erfurth U, Agoropoulou C, Zhang Y, Seifer G, Petzold A
Ann Clin Transl Neurol 2021 Dec;8(12):2235-2251. Epub 2021 Nov 18 doi: 10.1002/acn3.51473. PMID: 34792863Free PMC Article
Mutations in NKX6-2 Cause Progressive Spastic Ataxia and Hypomyelination.
Chelban V, Patel N, Vandrovcova J, Zanetti MN, Lynch DS, Ryten M, Botía JA, Bello O, Tribollet E, Efthymiou S, Davagnanam I; SYNAPSE Study Group, Bashiri FA, Wood NW, Rothman JE, Alkuraya FS, Houlden H
Am J Hum Genet 2017 Jun 1;100(6):969-977. doi: 10.1016/j.ajhg.2017.05.009. PMID: 28575651Free PMC Article
Statin treatment in multiple sclerosis: a systematic review and meta-analysis.
Pihl-Jensen G, Tsakiri A, Frederiksen JL
CNS Drugs 2015 Apr;29(4):277-91. doi: 10.1007/s40263-015-0239-x. PMID: 25795002

Diagnosis

Asymptomatic MRI lesions in pediatric-onset AQP4-IgG positive NMOSD.
Paolilo RB, Rimkus CM, da Paz JA, Apostolos-Pereira SL, Callegaro D, Sato DK
Mult Scler Relat Disord 2022 Dec;68:104215. Epub 2022 Oct 4 doi: 10.1016/j.msard.2022.104215. PMID: 36257150
Clinical characteristics and clinical course of myelin oligodendrocyte glycoprotein antibody-seropositive pediatric optic neuritis.
Moon Y, Lim BC, Chae JH, Jung JH
Mult Scler Relat Disord 2022 Apr;60:103709. Epub 2022 Feb 22 doi: 10.1016/j.msard.2022.103709. PMID: 35220001
Current and future potential of retinal optical coherence tomography in multiple sclerosis with and without optic neuritis.
Balk LJ, Petzold A
Neurodegener Dis Manag 2014;4(2):165-76. doi: 10.2217/nmt.14.10. PMID: 24832034
Optic nerve imaging in multiple sclerosis.
Hickman SJ
J Neuroimaging 2007 Apr;17 Suppl 1:42S-45S. doi: 10.1111/j.1552-6569.2007.00136.x. PMID: 17425734
Sensory evoked potentials: PERG, VEP, and SEP.
Bodis-Wollner I
Curr Opin Neurol Neurosurg 1992 Oct;5(5):716-26. PMID: 1392145

Therapy

Statin treatment in multiple sclerosis: a systematic review and meta-analysis.
Pihl-Jensen G, Tsakiri A, Frederiksen JL
CNS Drugs 2015 Apr;29(4):277-91. doi: 10.1007/s40263-015-0239-x. PMID: 25795002
Devic's neuromyelitis optica in an infant case.
Yuksel D, Senbil N, Yilmaz D, Yavuz Gurer YK
J Child Neurol 2007 Sep;22(9):1143-6. doi: 10.1177/0883073807306270. PMID: 17890418

Prognosis

Asymptomatic MRI lesions in pediatric-onset AQP4-IgG positive NMOSD.
Paolilo RB, Rimkus CM, da Paz JA, Apostolos-Pereira SL, Callegaro D, Sato DK
Mult Scler Relat Disord 2022 Dec;68:104215. Epub 2022 Oct 4 doi: 10.1016/j.msard.2022.104215. PMID: 36257150
Clinical characteristics and clinical course of myelin oligodendrocyte glycoprotein antibody-seropositive pediatric optic neuritis.
Moon Y, Lim BC, Chae JH, Jung JH
Mult Scler Relat Disord 2022 Apr;60:103709. Epub 2022 Feb 22 doi: 10.1016/j.msard.2022.103709. PMID: 35220001
Evidence of retinal anterograde neurodegeneration in the very early stages of multiple sclerosis: a longitudinal OCT study.
Pietroboni AM, Carandini T, Dell'Arti L, Bovis F, Colombi A, De Riz MA, Casazza E, Scola E, Fenoglio C, Arighi A, Fumagalli GG, Triulzi F, Galimberti D, Viola F, Scarpini E
Neurol Sci 2020 Nov;41(11):3175-3183. Epub 2020 Apr 30 doi: 10.1007/s10072-020-04431-4. PMID: 32356126
Clinical outcomes and predictive factors related to good outcomes in plasma exchange in severe attack of NMOSD and long extensive transverse myelitis: Case series and review of the literature.
Aungsumart S, Apiwattanakul M
Mult Scler Relat Disord 2017 Apr;13:93-97. Epub 2017 Feb 20 doi: 10.1016/j.msard.2017.02.015. PMID: 28427710
Optic nerve diffusion changes and atrophy jointly predict visual dysfunction after optic neuritis.
Kolbe S, Chapman C, Nguyen T, Bajraszewski C, Johnston L, Kean M, Mitchell P, Paine M, Butzkueven H, Kilpatrick T, Egan G
Neuroimage 2009 Apr 15;45(3):679-86. Epub 2009 Jan 7 doi: 10.1016/j.neuroimage.2008.12.047. PMID: 19162205

Clinical prediction guides

Modeling MOG Antibody-Associated Disorder and Neuromyelitis Optica Spectrum Disorder in Animal Models: Visual System Manifestations.
Remlinger J, Bagnoud M, Meli I, Massy M, Hoepner R, Linington C, Chan A, Bennett JL, Enzmann V, Salmen A
Neurol Neuroimmunol Neuroinflamm 2023 Sep;10(5) Epub 2023 Jul 10 doi: 10.1212/NXI.0000000000200141. PMID: 37429715Free PMC Article
Clinical characteristics and clinical course of myelin oligodendrocyte glycoprotein antibody-seropositive pediatric optic neuritis.
Moon Y, Lim BC, Chae JH, Jung JH
Mult Scler Relat Disord 2022 Apr;60:103709. Epub 2022 Feb 22 doi: 10.1016/j.msard.2022.103709. PMID: 35220001
Optical coherence tomography in multiple sclerosis: A 3-year prospective multicenter study.
Paul F, Calabresi PA, Barkhof F, Green AJ, Kardon R, Sastre-Garriga J, Schippling S, Vermersch P, Saidha S, Gerendas BS, Schmidt-Erfurth U, Agoropoulou C, Zhang Y, Seifer G, Petzold A
Ann Clin Transl Neurol 2021 Dec;8(12):2235-2251. Epub 2021 Nov 18 doi: 10.1002/acn3.51473. PMID: 34792863Free PMC Article
Mutations in NKX6-2 Cause Progressive Spastic Ataxia and Hypomyelination.
Chelban V, Patel N, Vandrovcova J, Zanetti MN, Lynch DS, Ryten M, Botía JA, Bello O, Tribollet E, Efthymiou S, Davagnanam I; SYNAPSE Study Group, Bashiri FA, Wood NW, Rothman JE, Alkuraya FS, Houlden H
Am J Hum Genet 2017 Jun 1;100(6):969-977. doi: 10.1016/j.ajhg.2017.05.009. PMID: 28575651Free PMC Article
Optic nerve diffusion changes and atrophy jointly predict visual dysfunction after optic neuritis.
Kolbe S, Chapman C, Nguyen T, Bajraszewski C, Johnston L, Kean M, Mitchell P, Paine M, Butzkueven H, Kilpatrick T, Egan G
Neuroimage 2009 Apr 15;45(3):679-86. Epub 2009 Jan 7 doi: 10.1016/j.neuroimage.2008.12.047. PMID: 19162205

Recent systematic reviews

Statin treatment in multiple sclerosis: a systematic review and meta-analysis.
Pihl-Jensen G, Tsakiri A, Frederiksen JL
CNS Drugs 2015 Apr;29(4):277-91. doi: 10.1007/s40263-015-0239-x. PMID: 25795002

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Reviews

    Related information

    • MeSH
      Related Medical Subject Headings
    • OMIM
      Related records in OMIM
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed
    • PubMed (OMIM)
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...