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Myopia 1, X-linked(MYP1)

MedGen UID:
326540
Concept ID:
C1839612
Disease or Syndrome
Synonyms: Myopia, X-Linked; MYP1
 
Monarch Initiative: MONDO:0010685
OMIM®: 310460

Definition

Myopia, or nearsightedness, is a refractive error of the eye. Light rays from a distant object are focused in front of the retina and those from a near object are focused in the retina; therefore distant objects are blurry and near objects are clear (summary by Kaiser et al., 2004). For a discussion of genetic heterogeneity of myopia, see 160700. [from OMIM]

Clinical features

From HPO
Myopia
MedGen UID:
44558
Concept ID:
C0027092
Disease or Syndrome
Nearsightedness, also known as myopia, is an eye condition that causes blurry distance vision. People who are nearsighted have more trouble seeing things that are far away (such as when driving) than things that are close up (such as when reading or using a computer). If it is not treated with corrective lenses or surgery, nearsightedness can lead to squinting, eyestrain, headaches, and significant visual impairment.\n\nNearsightedness usually begins in childhood or adolescence. It tends to worsen with age until adulthood, when it may stop getting worse (stabilize). In some people, nearsightedness improves in later adulthood.\n\nFor normal vision, light passes through the clear cornea at the front of the eye and is focused by the lens onto the surface of the retina, which is the lining of the back of the eye that contains light-sensing cells. People who are nearsighted typically have eyeballs that are too long from front to back. As a result, light entering the eye is focused too far forward, in front of the retina instead of on its surface. It is this change that causes distant objects to appear blurry. The longer the eyeball is, the farther forward light rays will be focused and the more severely nearsighted a person will be.\n\nNearsightedness is measured by how powerful a lens must be to correct it. The standard unit of lens power is called a diopter. Negative (minus) powered lenses are used to correct nearsightedness. The more severe a person's nearsightedness, the larger the number of diopters required for correction. In an individual with nearsightedness, one eye may be more nearsighted than the other.\n\nEye doctors often refer to nearsightedness less than -5 or -6 diopters as "common myopia." Nearsightedness of -6 diopters or more is commonly called "high myopia." This distinction is important because high myopia increases a person's risk of developing other eye problems that can lead to permanent vision loss or blindness. These problems include tearing and detachment of the retina, clouding of the lens (cataract), and an eye disease called glaucoma that is usually related to increased pressure within the eye. The risk of these other eye problems increases with the severity of the nearsightedness. The term "pathological myopia" is used to describe cases in which high myopia leads to tissue damage within the eye.

Professional guidelines

PubMed

Li Y, Yip M, Ning Y, Chung J, Toh A, Leow C, Liu N, Ting D, Schmetterer L, Saw SM, Jonas JB, Chia A, Ang M
JAMA Ophthalmol 2024 Jan 1;142(1):15-23. doi: 10.1001/jamaophthalmol.2023.5467. PMID: 38019503Free PMC Article

Recent clinical studies

Etiology

Tran M, Kolesnikova M, Kim AH, Kowal T, Ning K, Mahajan VB, Tsang SH, Sun Y
Ophthalmic Genet 2023 Jun;44(3):295-303. Epub 2022 Aug 26 doi: 10.1080/13816810.2022.2113544. PMID: 36017691Free PMC Article

Diagnosis

Huang L, Lai Y, Sun L, Li S, Ding X
Retina 2024 Jan 1;44(1):117-126. doi: 10.1097/IAE.0000000000003934. PMID: 38117582
Tran M, Kolesnikova M, Kim AH, Kowal T, Ning K, Mahajan VB, Tsang SH, Sun Y
Ophthalmic Genet 2023 Jun;44(3):295-303. Epub 2022 Aug 26 doi: 10.1080/13816810.2022.2113544. PMID: 36017691Free PMC Article
Orosz O, Rajta I, Vajas A, Takács L, Csutak A, Fodor M, Kolozsvári B, Resch M, Sényi K, Lesch B, Szabó V, Berta A, Balogh I, Losonczy G
Invest Ophthalmol Vis Sci 2017 Mar 1;58(3):1834-1842. doi: 10.1167/iovs.16-21405. PMID: 28358949

Prognosis

Orosz O, Rajta I, Vajas A, Takács L, Csutak A, Fodor M, Kolozsvári B, Resch M, Sényi K, Lesch B, Szabó V, Berta A, Balogh I, Losonczy G
Invest Ophthalmol Vis Sci 2017 Mar 1;58(3):1834-1842. doi: 10.1167/iovs.16-21405. PMID: 28358949
Zhou L, Li T, Song X, Li Y, Li H, Dan H
Mol Vis 2015;21:213-23. Epub 2015 Mar 5 PMID: 25802485Free PMC Article

Clinical prediction guides

Li J, Gao B, Guan L, Xiao X, Zhang J, Li S, Jiang H, Jia X, Yang J, Guo X, Yin Y, Wang J, Zhang Q
Invest Ophthalmol Vis Sci 2015 Jun;56(6):4150-5. doi: 10.1167/iovs.14-16356. PMID: 26114493
Zhou L, Li T, Song X, Li Y, Li H, Dan H
Mol Vis 2015;21:213-23. Epub 2015 Mar 5 PMID: 25802485Free PMC Article

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