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Hereditary sensory and autonomic neuropathy type 1B(HSN1B; HSAN1B)

MedGen UID:
Concept ID:
Disease or Syndrome
Synonyms: Neuropathy, hereditary sensory and autonomic, type I, with cough and gastroesophageal reflux; NEUROPATHY, HEREDITARY SENSORY AND AUTONOMIC, TYPE IB; NEUROPATHY, HEREDITARY SENSORY, TYPE IB
SNOMED CT: Hereditary sensory and autonomic neuropathy type 1B (717825008); Hereditary sensory and autonomic neuropathy type 1 with cough and gastroesophageal reflux (717825008); Hereditary sensory and autonomic neuropathy type 1 with cough and gastrooesophageal reflux (717825008); HSAN1B - hereditary sensory and autonomic neuropathy type 1B (717825008)
Modes of inheritance:
Autosomal dominant inheritance
MedGen UID:
Concept ID:
Intellectual Product
Source: Orphanet
A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele.
Monarch Initiative: MONDO:0011961
OMIM®: 608088
Orphanet: ORPHA139564


The hereditary sensory and autonomic neuropathies (HSAN), which are also referred to as hereditary sensory neuropathies (HSN) in the absence of significant autonomic features, are a genetically and clinically heterogeneous group of disorders associated with sensory dysfunction. For a discussion of genetic heterogeneity of HSAN, see HSAN1A (162400). [from OMIM]

Clinical features

From HPO
MedGen UID:
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Inability to develop or maintain an erection of the penis.
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Sign or Symptom
Syncope is a syndrome in which loss of consciousness is of relatively sudden onset, temporary (usually less than 1 to 2 minutes), self-terminating, and of usually rapid recovery. Syncope leads to a generalized weakness of muscles with loss of postural tone, inability to stand upright, and loss of consciousness. Once the patient is in a horizontal position, blood flow to the brain is no longer hindered by gravitation and consciousness is regained. Unconsciousness usually lasts for seconds to minutes. Headache and drowsiness (which usually follow seizures) do not follow a syncopal attack. Syncope results from a sudden impairment of brain metabolism usually due to a reduction in cerebral blood flow.
Gastroesophageal reflux
MedGen UID:
Concept ID:
A condition in which the stomach contents leak backwards from the stomach into the esophagus through the lower esophageal sphincter.
Sensorineural hearing loss disorder
MedGen UID:
Concept ID:
Disease or Syndrome
A type of hearing impairment in one or both ears related to an abnormal functionality of the cochlear nerve.
Sensory axonal neuropathy
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Concept ID:
An axonal neuropathy of peripheral sensory nerves.
Distal sensory impairment
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Concept ID:
An abnormal reduction in sensation in the distal portions of the extremities.
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Sign or Symptom
A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation.
Hoarse voice
MedGen UID:
Concept ID:
Sign or Symptom
Hoarseness refers to a change in the pitch or quality of the voice, with the voice sounding weak, very breathy, scratchy, or husky.
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Disease or Syndrome
Absence of tear secretion.

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHereditary sensory and autonomic neuropathy type 1B
Follow this link to review classifications for Hereditary sensory and autonomic neuropathy type 1B in Orphanet.

Supplemental Content

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