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Parkinson disease, mitochondrial

MedGen UID:
333199
Concept ID:
C1838867
Disease or Syndrome
Synonym: Parkinson Disease, Mitochondrial
 
Gene (location): MT-TT
 
Monarch Initiative: MONDO:0010796
OMIM®: 556500

Definition

Parkinson's disease is a progressive disorder of the nervous system. The disorder affects several regions of the brain, especially an area called the substantia nigra that controls balance and movement.

Often the first symptom of Parkinson's disease is trembling or shaking (tremor) of a limb, especially when the body is at rest. Typically, the tremor begins on one side of the body, usually in one hand. Tremors can also affect the arms, legs, feet, and face. Other characteristic symptoms of Parkinson's disease include rigidity or stiffness of the limbs and torso, slow movement (bradykinesia) or an inability to move (akinesia), and impaired balance and coordination (postural instability). These symptoms worsen slowly over time.

Generally, Parkinson's disease that begins after age 50 is called late-onset disease. The condition is described as early-onset disease if signs and symptoms begin before age 50. Early-onset cases that begin before age 20 are sometimes referred to as juvenile-onset Parkinson's disease.

Parkinson's disease can also affect emotions and thinking ability (cognition). Some affected individuals develop psychiatric conditions such as depression and visual hallucinations. People with Parkinson's disease also have an increased risk of developing dementia, which is a decline in intellectual functions including judgment and memory. [from MedlinePlus Genetics]

Recent clinical studies

Prognosis

Tsai PI, Course MM, Lovas JR, Hsieh CH, Babic M, Zinsmaier KE, Wang X
Sci Rep 2014 Nov 7;4:6962. doi: 10.1038/srep06962. PMID: 25376463Free PMC Article

Clinical prediction guides

Lixia Z, Wei S, Decheng B
J Tradit Chin Med 2022 Apr;42(2):176-186. doi: 10.19852/j.cnki.jtcm.20220311.002. PMID: 35473337
Inoue N, Ogura S, Kasai A, Nakazawa T, Ikeda K, Higashi S, Isotani A, Baba K, Mochizuki H, Fujimura H, Ago Y, Hayata-Takano A, Seiriki K, Shintani Y, Shintani N, Hashimoto H
EMBO Rep 2018 Mar;19(3) Epub 2018 Jan 25 doi: 10.15252/embr.201744860. PMID: 29371327Free PMC Article
Tsai PI, Course MM, Lovas JR, Hsieh CH, Babic M, Zinsmaier KE, Wang X
Sci Rep 2014 Nov 7;4:6962. doi: 10.1038/srep06962. PMID: 25376463Free PMC Article
Esteves AR, Gozes I, Cardoso SM
Biochim Biophys Acta 2014 Jan;1842(1):7-21. Epub 2013 Oct 11 doi: 10.1016/j.bbadis.2013.10.003. PMID: 24120997

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