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Lack of T cell function

MedGen UID:
336597
•Concept ID:
C1849426
•
Finding
Synonym: Absent cellular immunity
 
HPO: HP:0005354

Definition

Complete inability of T cells to perform their functions in cell-mediated immunity. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLack of T cell function

Conditions with this feature

Reticular dysgenesis
MedGen UID:
124417
•Concept ID:
C0272167
•
Disease or Syndrome
Reticular dysgenesis, the most severe form of inborn severe combined immunodeficiency (SCID), is characterized by absence of granulocytes and almost complete deficiency of lymphocytes in peripheral blood, hypoplasia of the thymus and secondary lymphoid organs, and lack of innate and adaptive humoral and cellular immune functions, leading to fatal septicemia within days after birth (summary by Pannicke et al., 2009).
See: Condition Record
Reticular dysgenesis

Professional guidelines

PubMed

T-helper cells and their cytokines in pathogenesis and treatment of asthma.
Ji T, Li H
Front Immunol 2023;14:1149203. Epub 2023 Jun 12 doi: 10.3389/fimmu.2023.1149203. PMID: 37377958Free PMC Article
Single-cell transcriptomic atlas-guided development of CAR-T cells for the treatment of acute myeloid leukemia.
Gottschlich A, Thomas M, Grünmeier R, Lesch S, Rohrbacher L, Igl V, Briukhovetska D, Benmebarek MR, Vick B, Dede S, Müller K, Xu T, Dhoqina D, Märkl F, Robinson S, Sendelhofert A, Schulz H, Umut Ö, Kavaka V, Tsiverioti CA, Carlini E, Nandi S, Strzalkowski T, Lorenzini T, Stock S, Müller PJ, Dörr J, Seifert M, Cadilha BL, Brabenec R, Röder N, Rataj F, Nüesch M, Modemann F, Wellbrock J, Fiedler W, Kellner C, Beltrán E, Herold T, Paquet D, Jeremias I, von Baumgarten L, Endres S, Subklewe M, Marr C, Kobold S
Nat Biotechnol 2023 Nov;41(11):1618-1632. Epub 2023 Mar 13 doi: 10.1038/s41587-023-01684-0. PMID: 36914885Free PMC Article
Treatment of Richter's syndrome.
Thompson PA, Siddiqi T
Hematology Am Soc Hematol Educ Program 2022 Dec 9;2022(1):329-336. doi: 10.1182/hematology.2022000345. PMID: 36485138Free PMC Article

Recent clinical studies

Etiology

Pan-cancer single-cell landscape of tumor-infiltrating T cells.
Zheng L, Qin S, Si W, Wang A, Xing B, Gao R, Ren X, Wang L, Wu X, Zhang J, Wu N, Zhang N, Zheng H, Ouyang H, Chen K, Bu Z, Hu X, Ji J, Zhang Z
Science 2021 Dec 17;374(6574):abe6474. doi: 10.1126/science.abe6474. PMID: 34914499
Bifidobacteria-mediated immune system imprinting early in life.
Henrick BM, Rodriguez L, Lakshmikanth T, Pou C, Henckel E, Arzoomand A, Olin A, Wang J, Mikes J, Tan Z, Chen Y, Ehrlich AM, Bernhardsson AK, Mugabo CH, Ambrosiani Y, Gustafsson A, Chew S, Brown HK, Prambs J, Bohlin K, Mitchell RD, Underwood MA, Smilowitz JT, German JB, Frese SA, Brodin P
Cell 2021 Jul 22;184(15):3884-3898.e11. Epub 2021 Jun 17 doi: 10.1016/j.cell.2021.05.030. PMID: 34143954
Hallmarks of T cell aging.
Mittelbrunn M, Kroemer G
Nat Immunol 2021 Jun;22(6):687-698. Epub 2021 May 13 doi: 10.1038/s41590-021-00927-z. PMID: 33986548
Stress-Induced Metabolic Disorder in Peripheral CD4(+) T Cells Leads to Anxiety-like Behavior.
Fan KQ, Li YY, Wang HL, Mao XT, Guo JX, Wang F, Huang LJ, Li YN, Ma XY, Gao ZJ, Chen W, Qian DD, Xue WJ, Cao Q, Zhang L, Shen L, Zhang L, Tong C, Zhong JY, Lu W, Lu L, Ren KM, Zhong G, Wang Y, Tang M, Feng XH, Chai RJ, Jin J
Cell 2019 Oct 31;179(4):864-879.e19. doi: 10.1016/j.cell.2019.10.001. PMID: 31675497
Defining 'T cell exhaustion'.
Blank CU, Haining WN, Held W, Hogan PG, Kallies A, Lugli E, Lynn RC, Philip M, Rao A, Restifo NP, Schietinger A, Schumacher TN, Schwartzberg PL, Sharpe AH, Speiser DE, Wherry EJ, Youngblood BA, Zehn D
Nat Rev Immunol 2019 Nov;19(11):665-674. Epub 2019 Sep 30 doi: 10.1038/s41577-019-0221-9. PMID: 31570879Free PMC Article

Diagnosis

Repeated peripheral infusions of anti-EGFRvIII CAR T cells in combination with pembrolizumab show no efficacy in glioblastoma: a phase 1 trial.
Bagley SJ, Binder ZA, Lamrani L, Marinari E, Desai AS, Nasrallah MP, Maloney E, Brem S, Lustig RA, Kurtz G, Alonso-Basanta M, Bonté PE, Goudot C, Richer W, Piaggio E, Kothari S, Guyonnet L, Guerin CL, Waterfall JJ, Mohan S, Hwang WT, Tang OY, Logun M, Bhattacharyya M, Markowitz K, Delman D, Marshall A, Wherry EJ, Amigorena S, Beatty GL, Brogdon JL, Hexner E, Migliorini D, Alanio C, O'Rourke DM
Nat Cancer 2024 Mar;5(3):517-531. Epub 2024 Jan 12 doi: 10.1038/s43018-023-00709-6. PMID: 38216766
Tackling Chronic Kidney Transplant Rejection: Challenges and Promises.
Lai X, Zheng X, Mathew JM, Gallon L, Leventhal JR, Zhang ZJ
Front Immunol 2021;12:661643. Epub 2021 May 20 doi: 10.3389/fimmu.2021.661643. PMID: 34093552Free PMC Article
Emerging Role of T-cell Receptor Constant β Chain-1 (TRBC1) Expression in the Flow Cytometric Diagnosis of T-cell Malignancies.
Horna P, Shi M, Olteanu H, Johansson U
Int J Mol Sci 2021 Feb 12;22(4) doi: 10.3390/ijms22041817. PMID: 33673033Free PMC Article
Reversible ON- and OFF-switch chimeric antigen receptors controlled by lenalidomide.
Jan M, Scarfò I, Larson RC, Walker A, Schmidts A, Guirguis AA, Gasser JA, Słabicki M, Bouffard AA, Castano AP, Kann MC, Cabral ML, Tepper A, Grinshpun DE, Sperling AS, Kyung T, Sievers QL, Birnbaum ME, Maus MV, Ebert BL
Sci Transl Med 2021 Jan 6;13(575) doi: 10.1126/scitranslmed.abb6295. PMID: 33408186Free PMC Article
Immune-resistant mechanisms in cancer immunotherapy.
Kawakami Y, Ohta S, Sayem MA, Tsukamoto N, Yaguchi T
Int J Clin Oncol 2020 May;25(5):810-817. Epub 2020 Jan 9 doi: 10.1007/s10147-019-01611-x. PMID: 31919690

Therapy

Tackling Chronic Kidney Transplant Rejection: Challenges and Promises.
Lai X, Zheng X, Mathew JM, Gallon L, Leventhal JR, Zhang ZJ
Front Immunol 2021;12:661643. Epub 2021 May 20 doi: 10.3389/fimmu.2021.661643. PMID: 34093552Free PMC Article
Emerging Therapeutics for Immune Tolerance: Tolerogenic Vaccines, T cell Therapy, and IL-2 Therapy.
Moorman CD, Sohn SJ, Phee H
Front Immunol 2021;12:657768. Epub 2021 Mar 29 doi: 10.3389/fimmu.2021.657768. PMID: 33854514Free PMC Article
Peripheral T cell expansion predicts tumour infiltration and clinical response.
Wu TD, Madireddi S, de Almeida PE, Banchereau R, Chen YJ, Chitre AS, Chiang EY, Iftikhar H, O'Gorman WE, Au-Yeung A, Takahashi C, Goldstein LD, Poon C, Keerthivasan S, de Almeida Nagata DE, Du X, Lee HM, Banta KL, Mariathasan S, Das Thakur M, Huseni MA, Ballinger M, Estay I, Caplazi P, Modrusan Z, Delamarre L, Mellman I, Bourgon R, Grogan JL
Nature 2020 Mar;579(7798):274-278. Epub 2020 Feb 26 doi: 10.1038/s41586-020-2056-8. PMID: 32103181
TIM3 comes of age as an inhibitory receptor.
Wolf Y, Anderson AC, Kuchroo VK
Nat Rev Immunol 2020 Mar;20(3):173-185. Epub 2019 Nov 1 doi: 10.1038/s41577-019-0224-6. PMID: 31676858Free PMC Article
Targeting the T cell receptor β-chain constant region for immunotherapy of T cell malignancies.
Maciocia PM, Wawrzyniecka PA, Philip B, Ricciardelli I, Akarca AU, Onuoha SC, Legut M, Cole DK, Sewell AK, Gritti G, Somja J, Piris MA, Peggs KS, Linch DC, Marafioti T, Pule MA
Nat Med 2017 Dec;23(12):1416-1423. Epub 2017 Nov 13 doi: 10.1038/nm.4444. PMID: 29131157

Prognosis

High endothelial venules in cancer: Regulation, function, and therapeutic implication.
Vella G, Hua Y, Bergers G
Cancer Cell 2023 Mar 13;41(3):527-545. Epub 2023 Feb 23 doi: 10.1016/j.ccell.2023.02.002. PMID: 36827979
Peripheral T cell expansion predicts tumour infiltration and clinical response.
Wu TD, Madireddi S, de Almeida PE, Banchereau R, Chen YJ, Chitre AS, Chiang EY, Iftikhar H, O'Gorman WE, Au-Yeung A, Takahashi C, Goldstein LD, Poon C, Keerthivasan S, de Almeida Nagata DE, Du X, Lee HM, Banta KL, Mariathasan S, Das Thakur M, Huseni MA, Ballinger M, Estay I, Caplazi P, Modrusan Z, Delamarre L, Mellman I, Bourgon R, Grogan JL
Nature 2020 Mar;579(7798):274-278. Epub 2020 Feb 26 doi: 10.1038/s41586-020-2056-8. PMID: 32103181
TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis.
Tauriello DVF, Palomo-Ponce S, Stork D, Berenguer-Llergo A, Badia-Ramentol J, Iglesias M, Sevillano M, Ibiza S, Cañellas A, Hernando-Momblona X, Byrom D, Matarin JA, Calon A, Rivas EI, Nebreda AR, Riera A, Attolini CS, Batlle E
Nature 2018 Feb 22;554(7693):538-543. Epub 2018 Feb 14 doi: 10.1038/nature25492. PMID: 29443964
Targeting the T cell receptor β-chain constant region for immunotherapy of T cell malignancies.
Maciocia PM, Wawrzyniecka PA, Philip B, Ricciardelli I, Akarca AU, Onuoha SC, Legut M, Cole DK, Sewell AK, Gritti G, Somja J, Piris MA, Peggs KS, Linch DC, Marafioti T, Pule MA
Nat Med 2017 Dec;23(12):1416-1423. Epub 2017 Nov 13 doi: 10.1038/nm.4444. PMID: 29131157
T-cell exhaustion, co-stimulation and clinical outcome in autoimmunity and infection.
McKinney EF, Lee JC, Jayne DR, Lyons PA, Smith KG
Nature 2015 Jul 30;523(7562):612-6. Epub 2015 Jun 29 doi: 10.1038/nature14468. PMID: 26123020Free PMC Article

Clinical prediction guides

Exhausted intratumoral Vδ2(-) γδ T cells in human kidney cancer retain effector function.
Rancan C, Arias-Badia M, Dogra P, Chen B, Aran D, Yang H, Luong D, Ilano A, Li J, Chang H, Kwek SS, Zhang L, Lanier LL, Meng MV, Farber DL, Fong L
Nat Immunol 2023 Apr;24(4):612-624. Epub 2023 Mar 16 doi: 10.1038/s41590-023-01448-7. PMID: 36928415Free PMC Article
High endothelial venules in cancer: Regulation, function, and therapeutic implication.
Vella G, Hua Y, Bergers G
Cancer Cell 2023 Mar 13;41(3):527-545. Epub 2023 Feb 23 doi: 10.1016/j.ccell.2023.02.002. PMID: 36827979
Peripheral T cell expansion predicts tumour infiltration and clinical response.
Wu TD, Madireddi S, de Almeida PE, Banchereau R, Chen YJ, Chitre AS, Chiang EY, Iftikhar H, O'Gorman WE, Au-Yeung A, Takahashi C, Goldstein LD, Poon C, Keerthivasan S, de Almeida Nagata DE, Du X, Lee HM, Banta KL, Mariathasan S, Das Thakur M, Huseni MA, Ballinger M, Estay I, Caplazi P, Modrusan Z, Delamarre L, Mellman I, Bourgon R, Grogan JL
Nature 2020 Mar;579(7798):274-278. Epub 2020 Feb 26 doi: 10.1038/s41586-020-2056-8. PMID: 32103181
Lack of acute xenogeneic graft- versus-host disease, but retention of T-cell function following engraftment of human peripheral blood mononuclear cells in NSG mice deficient in MHC class I and II expression.
Brehm MA, Kenney LL, Wiles MV, Low BE, Tisch RM, Burzenski L, Mueller C, Greiner DL, Shultz LD
FASEB J 2019 Mar;33(3):3137-3151. Epub 2018 Nov 1 doi: 10.1096/fj.201800636R. PMID: 30383447Free PMC Article
Histiocytosis-X.
Osband ME, Lipton JM, Lavin P, Levey R, Vawter G, Greenberger JS, McCaffrey RP, Parkman R
N Engl J Med 1981 Jan 15;304(3):146-53. doi: 10.1056/NEJM198101153040304. PMID: 6449667

Recent systematic reviews

Real-World Outcomes with Chimeric Antigen Receptor T Cell Therapies in Large B Cell Lymphoma: A Systematic Review and Meta-Analysis.
Jacobson CA, Munoz J, Sun F, Kanters S, Limbrick-Oldfield EH, Spooner C, Mignone K, Ayuk F, Sanderson R, Whitmore J, Wang Y, Xu H, Dickinson M
Transplant Cell Ther 2024 Jan;30(1):77.e1-77.e15. Epub 2023 Oct 27 doi: 10.1016/j.jtct.2023.10.017. PMID: 37890589
Obesity in HIV infection: host-pathogen interaction.
Savinelli S, Wrigley Kelly NE, Feeney ER, O'Shea DB, Hogan AE, Overton ET, Landay AL, Mallon PW
AIDS 2022 Sep 1;36(11):1477-1491. Epub 2022 Jun 21 doi: 10.1097/QAD.0000000000003281. PMID: 35979828
T cell response to SARS-CoV-2 infection in humans: A systematic review.
Shrotri M, van Schalkwyk MCI, Post N, Eddy D, Huntley C, Leeman D, Rigby S, Williams SV, Bermingham WH, Kellam P, Maher J, Shields AM, Amirthalingam G, Peacock SJ, Ismail SA
PLoS One 2021;16(1):e0245532. Epub 2021 Jan 25 doi: 10.1371/journal.pone.0245532. PMID: 33493185Free PMC Article
Adult T-cell leukemia/lymphoma in South and Central America and the Caribbean: systematic search and review.
Oliveira PD, de Carvalho RF, Bittencourt AL
Int J STD AIDS 2017 Mar;28(3):217-228. Epub 2016 Dec 14 doi: 10.1177/0956462416684461. PMID: 28178905
Effects of exercise on immune function in patients with cancer: a systematic review.
Kruijsen-Jaarsma M, Révész D, Bierings MB, Buffart LM, Takken T
Exerc Immunol Rev 2013;19:120-43. PMID: 23977724

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