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Parkinson disease 10(PARK10; AAOPD)

MedGen UID:
339741
Concept ID:
C1847360
Disease or Syndrome
Synonyms: PARK10; PARKINSON DISEASE, AGE AT ONSET OF
 
Monarch Initiative: MONDO:0011737
OMIM®: 606852

Definition

Parkinson's disease can also affect emotions and thinking ability (cognition). Some affected individuals develop psychiatric conditions such as depression and visual hallucinations. People with Parkinson's disease also have an increased risk of developing dementia, which is a decline in intellectual functions including judgment and memory.

Generally, Parkinson's disease that begins after age 50 is called late-onset disease. The condition is described as early-onset disease if signs and symptoms begin before age 50. Early-onset cases that begin before age 20 are sometimes referred to as juvenile-onset Parkinson's disease.

Often the first symptom of Parkinson's disease is trembling or shaking (tremor) of a limb, especially when the body is at rest. Typically, the tremor begins on one side of the body, usually in one hand. Tremors can also affect the arms, legs, feet, and face. Other characteristic symptoms of Parkinson's disease include rigidity or stiffness of the limbs and torso, slow movement (bradykinesia) or an inability to move (akinesia), and impaired balance and coordination (postural instability). These symptoms worsen slowly over time.

Parkinson's disease is a progressive disorder of the nervous system. The disorder affects several regions of the brain, especially an area called the substantia nigra that controls balance and movement. [from MedlinePlus Genetics]

Professional guidelines

PubMed

Boros FA, Török R, Vágvölgyi-Sümegi E, Pesei ZG, Klivényi P, Vécsei L
Neurosci Lett 2019 Jul 27;706:140-145. Epub 2019 May 11 doi: 10.1016/j.neulet.2019.05.014. PMID: 31085292

Recent clinical studies

Etiology

Milanowski ŁM, Lindemann JA, Hoffman-Zacharska D, Soto-Beasley AI, Barcikowska M, Boczarska-Jedynak M, Deutschlander A, Kłodowska G, Dulski J, Fedoryshyn L, Friedman A, Jamrozik Z, Janik P, Karpinsky K, Koziorowski D, Krygowska-Wajs A, Jasińska-Myga B, Opala G, Potulska-Chromik A, Pulyk A, Rektorova I, Sanotsky Y, Siuda J, Sławek J, Śmiłowska K, Szczechowski L, Rudzińska-Bar M, Walton RL, Ross OA, Wszolek ZK
Parkinsonism Relat Disord 2021 May;86:48-51. Epub 2021 Apr 2 doi: 10.1016/j.parkreldis.2021.03.026. PMID: 33845304Free PMC Article
Chuquilín-Arista F, Álvarez-Avellón T, Menéndez-González M
J Geriatr Psychiatry Neurol 2020 Jul;33(4):207-213. Epub 2019 Oct 9 doi: 10.1177/0891988719874130. PMID: 31597514
Boros FA, Török R, Vágvölgyi-Sümegi E, Pesei ZG, Klivényi P, Vécsei L
Neurosci Lett 2019 Jul 27;706:140-145. Epub 2019 May 11 doi: 10.1016/j.neulet.2019.05.014. PMID: 31085292
Simón-Sánchez J, Heutink P, Gasser T; International Parkinson's Disease Genomics Consortium (IPDGC)
Neurobiol Aging 2015 Oct;36(10):2907.e13-7. Epub 2015 Jul 10 doi: 10.1016/j.neurobiolaging.2015.07.008. PMID: 26260214Free PMC Article
Wan JY, Edwards KL, Hutter CM, Mata IF, Samii A, Roberts JW, Agarwal P, Checkoway H, Farin FM, Yearout D, Zabetian CP
Parkinsonism Relat Disord 2014 Jan;20(1):93-8. Epub 2013 Oct 11 doi: 10.1016/j.parkreldis.2013.10.001. PMID: 24156912Free PMC Article

Diagnosis

Milanowski ŁM, Lindemann JA, Hoffman-Zacharska D, Soto-Beasley AI, Barcikowska M, Boczarska-Jedynak M, Deutschlander A, Kłodowska G, Dulski J, Fedoryshyn L, Friedman A, Jamrozik Z, Janik P, Karpinsky K, Koziorowski D, Krygowska-Wajs A, Jasińska-Myga B, Opala G, Potulska-Chromik A, Pulyk A, Rektorova I, Sanotsky Y, Siuda J, Sławek J, Śmiłowska K, Szczechowski L, Rudzińska-Bar M, Walton RL, Ross OA, Wszolek ZK
Parkinsonism Relat Disord 2021 May;86:48-51. Epub 2021 Apr 2 doi: 10.1016/j.parkreldis.2021.03.026. PMID: 33845304Free PMC Article
Chuquilín-Arista F, Álvarez-Avellón T, Menéndez-González M
J Geriatr Psychiatry Neurol 2020 Jul;33(4):207-213. Epub 2019 Oct 9 doi: 10.1177/0891988719874130. PMID: 31597514
Beecham GW, Dickson DW, Scott WK, Martin ER, Schellenberg G, Nuytemans K, Larson EB, Buxbaum JD, Trojanowski JQ, Van Deerlin VM, Hurtig HI, Mash DC, Beach TG, Troncoso JC, Pletnikova O, Frosch MP, Ghetti B, Foroud TM, Honig LS, Marder K, Vonsattel JP, Goldman SM, Vinters HV, Ross OA, Wszolek ZK, Wang L, Dykxhoorn DM, Pericak-Vance MA, Montine TJ, Leverenz JB, Dawson TM, Vance JM
Neurology 2015 Mar 10;84(10):972-80. Epub 2015 Feb 6 doi: 10.1212/WNL.0000000000001332. PMID: 25663231Free PMC Article
Klein C, Schlossmacher MG
Neurology 2007 Nov 27;69(22):2093-104. Epub 2007 Aug 29 doi: 10.1212/01.wnl.0000271880.27321.a7. PMID: 17761553
Arnulf I, Merino-Andreu M, Bloch F, Konofal E, Vidailhet M, Cochen V, Derenne JP, Agid Y
Sleep 2005 Mar;28(3):349-54. PMID: 16173657

Therapy

Klein C, Schlossmacher MG
Neurology 2007 Nov 27;69(22):2093-104. Epub 2007 Aug 29 doi: 10.1212/01.wnl.0000271880.27321.a7. PMID: 17761553

Clinical prediction guides

Milanowski ŁM, Lindemann JA, Hoffman-Zacharska D, Soto-Beasley AI, Barcikowska M, Boczarska-Jedynak M, Deutschlander A, Kłodowska G, Dulski J, Fedoryshyn L, Friedman A, Jamrozik Z, Janik P, Karpinsky K, Koziorowski D, Krygowska-Wajs A, Jasińska-Myga B, Opala G, Potulska-Chromik A, Pulyk A, Rektorova I, Sanotsky Y, Siuda J, Sławek J, Śmiłowska K, Szczechowski L, Rudzińska-Bar M, Walton RL, Ross OA, Wszolek ZK
Parkinsonism Relat Disord 2021 May;86:48-51. Epub 2021 Apr 2 doi: 10.1016/j.parkreldis.2021.03.026. PMID: 33845304Free PMC Article
Chuquilín-Arista F, Álvarez-Avellón T, Menéndez-González M
J Geriatr Psychiatry Neurol 2020 Jul;33(4):207-213. Epub 2019 Oct 9 doi: 10.1177/0891988719874130. PMID: 31597514
Thayer JA, Awad O, Hegdekar N, Sarkar C, Tesfay H, Burt C, Zeng X, Feldman RA, Lipinski MM
Autophagy 2020 Jan;16(1):140-153. Epub 2019 Apr 7 doi: 10.1080/15548627.2019.1598754. PMID: 30957634Free PMC Article

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