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Dohle bodies and leukemia

MedGen UID:
346548
Concept ID:
C1857225
Neoplastic Process
Synonym: Dohle Bodies and Leukemia
 
Monarch Initiative: MONDO:0009122
OMIM®: 223350

Clinical features

From HPO
Acute myeloid leukemia
MedGen UID:
9730
Concept ID:
C0023467
Neoplastic Process
A clonal expansion of myeloid blasts in the bone marrow, blood or other tissues. The classification of acute myeloid leukemias (AMLs) encompasses four major categories: 1) AML with recurrent genetic abnormalities; 2) AML with multilineage dysplasia; 3) Therapy-related AML; 4) AML not otherwise specified. The required bone marrow or peripheral blood blast percentage for the diagnosis of AML is 20% (WHO classification)
Atrial septal defect, ostium secundum type
MedGen UID:
91034
Concept ID:
C0344724
Congenital Abnormality
A kind of atrial septum defect arising from an enlarged foramen ovale, inadequate growth of the septum secundum, or excessive absorption of the septum primum.
Anemia
MedGen UID:
1526
Concept ID:
C0002871
Disease or Syndrome
A reduction in erythrocytes volume or hemoglobin concentration.
Leukocyte inclusion bodies
MedGen UID:
908819
Concept ID:
C4280711
Finding
The presence of intraceullar inclusion bodies (aggregates of stainable substances, usually proteins) in leukocytes.
Lymphedema
MedGen UID:
6155
Concept ID:
C0024236
Disease or Syndrome
Localized fluid retention and tissue swelling caused by a compromised lymphatic system.
Recurrent fever
MedGen UID:
811468
Concept ID:
C3714772
Sign or Symptom
Periodic (episodic or recurrent) bouts of fever.

Recent clinical studies

Diagnosis

Bain BJ, Ahmad S
Br J Haematol 2015 Nov;171(3):400-10. Epub 2015 Jul 27 doi: 10.1111/bjh.13600. PMID: 26218186

Clinical prediction guides

Bain BJ, Ahmad S
Br J Haematol 2015 Nov;171(3):400-10. Epub 2015 Jul 27 doi: 10.1111/bjh.13600. PMID: 26218186

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