From HPO
Polydactyly- MedGen UID:
- 57774
- •Concept ID:
- C0152427
- •
- Congenital Abnormality
A congenital anomaly characterized by the presence of supernumerary fingers or toes.
Postaxial polydactyly- MedGen UID:
- 67394
- •Concept ID:
- C0220697
- •
- Disease or Syndrome
Polydactyly refers to the occurrence of supernumerary digits and is the most frequent of congenital hand and foot deformities. Based on the location of the extra digits, polydactyly can be classified into preaxial, involving the thumb or great toe; postaxial, affecting the fifth digit; and central, involving the 3 central digits. Postaxial polydactyly (PAP) is further subclassified into 2 types: in type A, a well-formed extra digit articulates with the fifth or a sixth metacarpal, whereas in type B, a rudimentary, poorly developed extra digit is present (summary by Umm-e-Kalsoom et al., 2012).
Genetic Heterogeneity of Postaxial Polydactyly
Other forms of postaxial polydactyly type A include PAPA2 (602085) on chromosome 13q21; PAPA3 (607324) on chromosome 19p13; PAPA4 (608562) on chromosome 7q22; PAPA5 (263450) on chromosome 13q13; PAPA6 (615226), caused by mutation in the ZNF141 gene (194648) on chromosome 4p16; PAPA7 (617642), caused by mutation in the IQCE gene (617631) on chromosome 7p22; PAPA8 (618123), caused by mutation in the GLI1 gene (165220) on chromosome 12q13; PAPA9 (618219), caused by mutation in the FAM98A gene (617273) on chromosome 8q22; and PAPA10 (618498), caused by mutation in the KIAA0825 gene (617266) on chromosome 5q15.
Triphalangeal thumb- MedGen UID:
- 66029
- •Concept ID:
- C0241397
- •
- Congenital Abnormality
A thumb with three phalanges in a single, proximo-distal axis. Thus, this term applies if the thumb has an accessory phalanx, leading to a digit like appearance of the thumb.
Supernumerary metacarpal bones- MedGen UID:
- 639615
- •Concept ID:
- C0545617
- •
- Congenital Abnormality
The presence of more than the normal number of metacarpal bones.
1-5 finger complete cutaneous syndactyly- MedGen UID:
- 350015
- •Concept ID:
- C1861357
- •
- Finding
6 metacarpals- MedGen UID:
- 348337
- •Concept ID:
- C1861360
- •
- Finding
1-5 finger syndactyly- MedGen UID:
- 869302
- •Concept ID:
- C4023728
- •
- Congenital Abnormality
Syndactyly with fusion of fingers one to five (complete syndactyly of all fingers of the hand).
2-3 toe syndactyly- MedGen UID:
- 1645640
- •Concept ID:
- C4551570
- •
- Congenital Abnormality
Syndactyly with fusion of toes two and three.