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Fasting hyperinsulinemia

MedGen UID:
351259
Concept ID:
C1864954
Finding
Synonym: Hyperinsulinemia, fasting
 
HPO: HP:0008283

Definition

An increased concentration of insulin in the blood in the fasting state, i.e., not as the response to food intake. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFasting hyperinsulinemia

Conditions with this feature

Hyperinsulinism due to INSR deficiency
MedGen UID:
355335
Concept ID:
C1864952
Disease or Syndrome
The severity of congenital hyperinsulinism varies widely among affected individuals, even among members of the same family. About 60 percent of infants with this condition experience a hypoglycemic episode within the first month of life. Other affected children develop hypoglycemia by early childhood. Unlike typical episodes of hypoglycemia, which occur most often after periods without food (fasting) or after exercising, episodes of hypoglycemia in people with congenital hyperinsulinism can also occur after eating.\n\nCongenital hyperinsulinism is a condition that causes individuals to have abnormally high levels of insulin. Insulin is a hormone that helps control levels of blood glucose, also called blood sugar. People with this condition have frequent episodes of low blood glucose (hypoglycemia). In infants and young children, these episodes are characterized by a lack of energy (lethargy), irritability, or difficulty feeding. Repeated episodes of low blood glucose increase the risk for serious complications such as breathing difficulties, seizures, intellectual disability, vision loss, brain damage, and coma.
Short stature, Dauber-Argente type
MedGen UID:
1794178
Concept ID:
C5561968
Disease or Syndrome
Short stature of the Dauber-Argente type (SSDA) is characterized by progressive postnatal growth failure, moderate microcephaly, thin long bones, and mildly decreased bone density. Patients have elevated circulating levels of total IGF1 (147440) due to impaired proteolysis of IGFBP3 (146732) and IGFBP5 (146734), resulting in reduced free IGF1 (Dauber et al., 2016).

Professional guidelines

PubMed

Michalsky MP, Inge TH, Simmons M, Jenkins TM, Buncher R, Helmrath M, Brandt ML, Harmon CM, Courcoulas A, Chen M, Horlick M, Daniels SR, Urbina EM; Teen-LABS Consortium
JAMA Pediatr 2015 May;169(5):438-44. doi: 10.1001/jamapediatrics.2014.3690. PMID: 25730293Free PMC Article
Hansen JB, Arkhammar PO, Bodvarsdottir TB, Wahl P
Curr Med Chem 2004 Jun;11(12):1595-615. doi: 10.2174/0929867043365026. PMID: 15180566
Decsi T, Molnár D
Paediatr Drugs 2003;5(5):291-9. doi: 10.2165/00128072-200305050-00002. PMID: 12716216

Recent clinical studies

Etiology

Tricò D, Moriconi D, Berta R, Baldi S, Quinones-Galvan A, Guiducci L, Taddei S, Mari A, Nannipieri M
Nutrients 2021 Apr 18;13(4) doi: 10.3390/nu13041345. PMID: 33919503Free PMC Article
Fryk E, Olausson J, Mossberg K, Strindberg L, Schmelz M, Brogren H, Gan LM, Piazza S, Provenzani A, Becattini B, Lind L, Solinas G, Jansson PA
EBioMedicine 2021 Mar;65:103264. Epub 2021 Mar 9 doi: 10.1016/j.ebiom.2021.103264. PMID: 33712379Free PMC Article
De Pergola G, Nardecchia A, Cirillo M, Boninfante B, Sciaraffia M, Giagulli VA, Triggiani V, Silvestris F
Endocr Metab Immune Disord Drug Targets 2015;15(4):297-301. doi: 10.2174/1871530315666150506125651. PMID: 25944063
Afonso LC, Edelson GW, Sowers JR
Curr Opin Nephrol Hypertens 1997 May;6(3):219-23. doi: 10.1097/00041552-199705000-00004. PMID: 9263663
Hall JE, Summers RL, Brands MW, Keen H, Alonso-Galicia M
Am J Hypertens 1994 Aug;7(8):772-88. doi: 10.1093/ajh/7.8.772. PMID: 7986471

Diagnosis

Tricò D, Moriconi D, Berta R, Baldi S, Quinones-Galvan A, Guiducci L, Taddei S, Mari A, Nannipieri M
Nutrients 2021 Apr 18;13(4) doi: 10.3390/nu13041345. PMID: 33919503Free PMC Article
Melvin A, O'Rahilly S, Savage DB
Curr Opin Genet Dev 2018 Jun;50:60-67. Epub 2018 Feb 22 doi: 10.1016/j.gde.2018.02.002. PMID: 29477938
Lautt WW, Ming Z, Legare DJ
Can J Physiol Pharmacol 2010 Mar;88(3):313-23. doi: 10.1139/Y09-130. PMID: 20393596Free PMC Article
Hansen JB, Arkhammar PO, Bodvarsdottir TB, Wahl P
Curr Med Chem 2004 Jun;11(12):1595-615. doi: 10.2174/0929867043365026. PMID: 15180566
Odeleye OE, de Courten M, Pettitt DJ, Ravussin E
Diabetes 1997 Aug;46(8):1341-5. doi: 10.2337/diab.46.8.1341. PMID: 9231660

Therapy

Larsen IS, Jensen BAH, Bonazzi E, Choi BSY, Kristensen NN, Schmidt EGW, Süenderhauf A, Morin L, Olsen PB, Hansen LBS, Schröder T, Sina C, Chassaing B, Marette A
Gut Microbes 2021 Jan-Dec;13(1):1988836. doi: 10.1080/19490976.2021.1988836. PMID: 34693864Free PMC Article
Tricò D, Moriconi D, Berta R, Baldi S, Quinones-Galvan A, Guiducci L, Taddei S, Mari A, Nannipieri M
Nutrients 2021 Apr 18;13(4) doi: 10.3390/nu13041345. PMID: 33919503Free PMC Article
De Pergola G, Nardecchia A, Cirillo M, Boninfante B, Sciaraffia M, Giagulli VA, Triggiani V, Silvestris F
Endocr Metab Immune Disord Drug Targets 2015;15(4):297-301. doi: 10.2174/1871530315666150506125651. PMID: 25944063
Lautt WW, Ming Z, Legare DJ
Can J Physiol Pharmacol 2010 Mar;88(3):313-23. doi: 10.1139/Y09-130. PMID: 20393596Free PMC Article
Kolodziejczyk B, Duleba AJ, Spaczynski RZ, Pawelczyk L
Fertil Steril 2000 Jun;73(6):1149-54. doi: 10.1016/s0015-0282(00)00501-x. PMID: 10856473

Prognosis

Hou L, Liang Y, Wu W, Lin HH, Luo XP, Ying YQ
Growth Horm IGF Res 2020 Aug-Oct;53-54:101331. Epub 2020 Jul 17 doi: 10.1016/j.ghir.2020.101331. PMID: 32777706
Lautt WW, Ming Z, Legare DJ
Can J Physiol Pharmacol 2010 Mar;88(3):313-23. doi: 10.1139/Y09-130. PMID: 20393596Free PMC Article
Miuma S, Ichikawa T, Taura N, Shibata H, Takeshita S, Akiyama M, Motoyoshi Y, Ozawa E, Fujimoto M, Kawashimo H, Miyaaki H, Eguchi K, Nakao K
Oncol Rep 2009 Dec;22(6):1415-24. doi: 10.3892/or_00000583. PMID: 19885595
Afonso LC, Edelson GW, Sowers JR
Curr Opin Nephrol Hypertens 1997 May;6(3):219-23. doi: 10.1097/00041552-199705000-00004. PMID: 9263663
Odeleye OE, de Courten M, Pettitt DJ, Ravussin E
Diabetes 1997 Aug;46(8):1341-5. doi: 10.2337/diab.46.8.1341. PMID: 9231660

Clinical prediction guides

Truong CD, Ton TT
Perfusion 2023 Oct;38(7):1428-1435. Epub 2022 Jul 11 doi: 10.1177/02676591221113970. PMID: 35817752
Larsen IS, Jensen BAH, Bonazzi E, Choi BSY, Kristensen NN, Schmidt EGW, Süenderhauf A, Morin L, Olsen PB, Hansen LBS, Schröder T, Sina C, Chassaing B, Marette A
Gut Microbes 2021 Jan-Dec;13(1):1988836. doi: 10.1080/19490976.2021.1988836. PMID: 34693864Free PMC Article
Fryk E, Olausson J, Mossberg K, Strindberg L, Schmelz M, Brogren H, Gan LM, Piazza S, Provenzani A, Becattini B, Lind L, Solinas G, Jansson PA
EBioMedicine 2021 Mar;65:103264. Epub 2021 Mar 9 doi: 10.1016/j.ebiom.2021.103264. PMID: 33712379Free PMC Article
Lautt WW, Ming Z, Legare DJ
Can J Physiol Pharmacol 2010 Mar;88(3):313-23. doi: 10.1139/Y09-130. PMID: 20393596Free PMC Article
Afonso LC, Edelson GW, Sowers JR
Curr Opin Nephrol Hypertens 1997 May;6(3):219-23. doi: 10.1097/00041552-199705000-00004. PMID: 9263663

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