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Skin Fibrous Histiocytoma, Cellular Variant

MedGen UID:: 353574
•Concept ID:: C1707543
•: Neoplastic Process

Synonym:

Cutaneous Fibrous Histiocytoma, Cellular Variant

Definition

A morphologic variant of fibrous histiocytoma of the skin. It is characterized by the presence of spindle-shaped fibrohistiocytic cells and increased cellularity. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVSkin Fibrous Histiocytoma, Cellular Variant

Benign neoplasm of skin
- Benign Dermal Neoplasm
  - Benign Skin Fibrohistiocytic Neoplasm
    - Dermatofibroma
      - Skin Fibrous Histiocytoma, Cellular Variant

Professional guidelines

PubMed

Diagnosis and differential diagnosis of dermatofibrosarcoma protuberans: Utility of high-resolution dynamic contrast-enhanced (DCE) MRI.

Yu Q, Zhu Y, Huang R, Li Y, Song L, Zhang X, Tang M, Gu Q, Li P, Zhou N, Li Y
Skin Res Technol 2022 Sep;28(5):651-663. Epub 2022 May 31 doi: 10.1111/srt.13164. PMID: 35639715 Free PMC Article

High proliferative activity excludes dermatofibroma: report of the utility of MIB-1 in the differential diagnosis of selected fibrohistiocytic tumors.

Hanly AJ, Jordà M, Elgart GW, Badiavas E, Nassiri M, Nadji M
Arch Pathol Lab Med 2006 Jun;130(6):831-4. doi: 10.5858/2006-130-831-HPAEDR. PMID: 16740036

CD44 and hyaluronate in the differential diagnosis of dermatofibroma and dermatofibrosarcoma protuberans.

Calikoglu E, Augsburger E, Chavaz P, Saurat JH, Kaya G
J Cutan Pathol 2003 Mar;30(3):185-9. doi: 10.1034/j.1600-0560.2003.300304.x. PMID: 12641778

See all (3)

Recent clinical studies

Etiology

Recurrent and metastatic cellular cutaneous fibrous histiocytoma: A case report and literature review.

Fuentes-Sánchez J, Pena-Burgos EM, Tapia-Viñe M, Ortiz-Cruz EJ, Pozo-Kreilinger JJ
J Cutan Pathol 2024 Mar;51(3):214-220. Epub 2023 Dec 12 doi: 10.1111/cup.14574. PMID: 38084789

Cutaneous soft tissue tumors: how do we make sense of fibrous and "fibrohistiocytic" tumors with confusing names and similar appearances?

Hornick JL
Mod Pathol 2020 Jan;33(Suppl 1):56-65. Epub 2019 Oct 25 doi: 10.1038/s41379-019-0388-4. PMID: 31653978

Pleomorphic dermal neoplasms: a review.

Brenn T
Adv Anat Pathol 2014 Mar;21(2):108-30. doi: 10.1097/PAP.0000000000000009. PMID: 24508694

Cutaneous fibrohistiocytic tumours - an update.

Luzar B, Calonje E
Histopathology 2010 Jan;56(1):148-65. doi: 10.1111/j.1365-2559.2009.03447.x. PMID: 20055912

Lipomatous tumors.

Weiss SW
Monogr Pathol 1996;38:207-39. PMID: 8744279

See all (49)

Diagnosis

Adenodermatofibroma: a rare variant.

Russomanno K, Deng M, Cardis M
Dermatol Online J 2021 Aug 15;27(8) doi: 10.5070/D327854711. PMID: 34755965

Epithelioid Fibrous Histiocytoma: A Concise Review.

Felty CC, Linos K
Am J Dermatopathol 2019 Dec;41(12):879-883. doi: 10.1097/DAD.0000000000001272. PMID: 30289773

Mixofibrossarcoma--case report.

Tupinambá WL, Schettini RA, Souza Júnior Jd, Schettini AP, Rodrigues CA, Oliveira Fda S
An Bras Dermatol 2011 Jul-Aug;86(4 Suppl 1):S110-3. doi: 10.1590/s0365-05962011000700029. PMID: 22068787

Myofibroblastic malignancies.

Fisher C
Adv Anat Pathol 2004 Jul;11(4):190-201. doi: 10.1097/01.pap.0000131773.16130.aa. PMID: 15220822

Myofibrosarcoma.

Fisher C
Virchows Arch 2004 Sep;445(3):215-23. Epub 2004 Jun 2 doi: 10.1007/s00428-004-1038-9. PMID: 15173943

See all (156)

Therapy

Morphometric analyses of elastic tissue fibers in dermatofibroma: clues to etiopathogenesis?

Pongpudpunth M, Keady M, Mahalingam M
J Cutan Pathol 2009 Oct;36(10):1083-8. Epub 2009 Jul 10 doi: 10.1111/j.1600-0560.2009.01237.x. PMID: 19615002

Giant dermatofibroma with granular cell changes: side-effect of bee-venom acupuncture?

Rhee DY, Lee HW, Chung WK, Chang SE, Lee MW, Choi JH, Moon KC, Koh JK
Clin Exp Dermatol 2009 Jul;34(5):e18-20. Epub 2009 May 26 doi: 10.1111/j.1365-2230.2008.03149.x. PMID: 19486038

Clear cell atypical fibroxanthoma:a clinicopathologic study.

Crowson AN, Carlson-Sweet K, Macinnis C, Taylor JR, Battaglia T, LaMar WL, Minor D, Sutter S, Hill T
J Cutan Pathol 2002 Jul;29(6):374-81. doi: 10.1034/j.1600-0560.2002.290609.x. PMID: 12135470

The pathology of malignant fibrous histiocytoma of bone. A study of 130 patients.

Huvos AG, Heilweil M, Bretsky SS
Am J Surg Pathol 1985 Dec;9(12):853-71. doi: 10.1097/00000478-198512000-00002. PMID: 3000204

See all (4)

Prognosis

Fibrous histiocytoma/dermatofibroma in children: the same as adults?

Berklite L, Ranganathan S, John I, Picarsic J, Santoro L, Alaggio R
Hum Pathol 2020 May;99:107-115. Epub 2020 Apr 1 doi: 10.1016/j.humpath.2020.03.012. PMID: 32246988

Epithelioid Fibrous Histiocytoma: A Concise Review.

Felty CC, Linos K
Am J Dermatopathol 2019 Dec;41(12):879-883. doi: 10.1097/DAD.0000000000001272. PMID: 30289773

Pleomorphic dermal neoplasms: a review.

Brenn T
Adv Anat Pathol 2014 Mar;21(2):108-30. doi: 10.1097/PAP.0000000000000009. PMID: 24508694

Fatal case of metastatic cellular fibrous histiocytoma: case report and review of literature.

Lodewick E, Avermaete A, Blom WA, Lelie B, Block R, Keuppens M
Am J Dermatopathol 2014 Sep;36(9):e156-62. doi: 10.1097/DAD.0b013e318299f28c. PMID: 24067802

Lipomatous tumors.

Weiss SW
Monogr Pathol 1996;38:207-39. PMID: 8744279

See all (48)