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Rectal medullary carcinoma

MedGen UID:
364314
•Concept ID:
C1882915
•
Neoplastic Process
Synonyms: Rectal Medullary Carcinoma; rectal medullary carcinoma
 
Monarch Initiative: MONDO:0020801

Definition

A rare, invasive rectal adenocarcinoma characterized by the presence of sheets of malignant epithelial cells with vesicular nuclei, prominent nucleoli, and abundant eosinophilic cytoplasm. It usually has a favorable prognosis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRectal medullary carcinoma

Professional guidelines

PubMed

The value of 11C-5-hydroxy-tryptophan positron emission tomography in neuroendocrine tumor diagnosis and management: experience from one center.
Nikolaou A, Thomas D, Kampanellou C, Alexandraki K, Andersson LG, Sundin A, Kaltsas G
J Endocrinol Invest 2010 Dec;33(11):794-9. Epub 2010 Mar 22 doi: 10.1007/BF03350344. PMID: 20332708

Recent clinical studies

Etiology

Timely diagnosis of multiple endocrine neoplasia 2B by identification of intestinal ganglioneuromatosis: a case series.
van den Broek MFM, Rijks EBG, Nikkels PGJ, Wolters VM, van Es RJJ, van Santen HM, van Nesselrooij BPM, Vriens MR, van Leeuwaarde RS, Valk GD, Verrijn Stuart AA
Endocrine 2021 Jun;72(3):905-914. Epub 2021 Jan 21 doi: 10.1007/s12020-021-02607-2. PMID: 33474713Free PMC Article
Disease-free survival after complete mesocolic excision compared with conventional colon cancer surgery: a retrospective, population-based study.
Bertelsen CA, Neuenschwander AU, Jansen JE, Wilhelmsen M, Kirkegaard-Klitbo A, Tenma JR, Bols B, Ingeholm P, Rasmussen LA, Jepsen LV, Iversen ER, Kristensen B, Gögenur I; Danish Colorectal Cancer Group
Lancet Oncol 2015 Feb;16(2):161-8. Epub 2014 Dec 31 doi: 10.1016/S1470-2045(14)71168-4. PMID: 25555421
Poorly differentiated adenocarcinoma of the colon and rectum: clinical characteristics.
Ogawa M, Watanabe M, Eto K, Kosuge M, Yamagata T, Kobayashi T, Yamazaki K, Anazawa S, Yanaga K
Hepatogastroenterology 2008 May-Jun;55(84):907-11. PMID: 18705295
Prophylactic thyroidectomy in pediatric carriers of multiple endocrine neoplasia type 2A or familial medullary thyroid carcinoma: mutation in C620 is associated with Hirschsprung's disease.
Bütter A, Gagné J, Al-Jazaeri A, Emran MA, Deal C, St-Vil D
J Pediatr Surg 2007 Jan;42(1):203-6. doi: 10.1016/j.jpedsurg.2006.09.019. PMID: 17208566
Visceral neuropathies responsible for chronic intestinal pseudo-obstruction syndrome in pediatric practice: analysis of 26 cases.
Navarro J, Sonsino E, Boige N, Nabarra B, Ferkadji L, Mashako LM, Cezard JP
J Pediatr Gastroenterol Nutr 1990 Aug;11(2):179-95. doi: 10.1097/00005176-199008000-00006. PMID: 2395057

Diagnosis

MULTIPLE NEUROENDOCRINE NEOPLASIA IN A PATIENT WITH TYPE I NEUROFIBROMATOSIS (NF1): REPORT OF A NEW MUTATION (NF1, EXONS 2-30 DELETION) AND LITERATURE REVIEW.
Kanno DT, Mattos RLM, Campos FG, Siqueira RM, Carvalho RB, Real Martinez CA
Arq Bras Cir Dig 2023;35:e1702. Epub 2023 Jan 9 doi: 10.1590/0102-672020220002e1702. PMID: 36629684Free PMC Article
Medullary carcinoma of the colon: A comprehensive analysis of the National Cancer Database.
Jabbal IS, Nagarajan A, Rivera C, Yaghi M, Liang H, Nahleh Z, Bejarano P, Berho M, Wexner S
Surg Oncol 2022 Dec;45:101856. Epub 2022 Sep 29 doi: 10.1016/j.suronc.2022.101856. PMID: 36446307
Timely diagnosis of multiple endocrine neoplasia 2B by identification of intestinal ganglioneuromatosis: a case series.
van den Broek MFM, Rijks EBG, Nikkels PGJ, Wolters VM, van Es RJJ, van Santen HM, van Nesselrooij BPM, Vriens MR, van Leeuwaarde RS, Valk GD, Verrijn Stuart AA
Endocrine 2021 Jun;72(3):905-914. Epub 2021 Jan 21 doi: 10.1007/s12020-021-02607-2. PMID: 33474713Free PMC Article
A rare case of medullary carcinoma of the colon presenting as intussusception in an adult with rectal bleeding.
Jain S, Jain A, Onizuka N, Boukhar SA
Hawaii J Med Public Health 2014 Nov;73(11):348-52. PMID: 25414804Free PMC Article
Multiple endocrine neoplasias type 2B and RET proto-oncogene.
Martucciello G, Lerone M, Bricco L, Tonini GP, Lombardi L, Del Rossi CG, Bernasconi S
Ital J Pediatr 2012 Mar 19;38:9. doi: 10.1186/1824-7288-38-9. PMID: 22429913Free PMC Article

Prognosis

Medullary carcinoma of the colon: A comprehensive analysis of the National Cancer Database.
Jabbal IS, Nagarajan A, Rivera C, Yaghi M, Liang H, Nahleh Z, Bejarano P, Berho M, Wexner S
Surg Oncol 2022 Dec;45:101856. Epub 2022 Sep 29 doi: 10.1016/j.suronc.2022.101856. PMID: 36446307
Timely diagnosis of multiple endocrine neoplasia 2B by identification of intestinal ganglioneuromatosis: a case series.
van den Broek MFM, Rijks EBG, Nikkels PGJ, Wolters VM, van Es RJJ, van Santen HM, van Nesselrooij BPM, Vriens MR, van Leeuwaarde RS, Valk GD, Verrijn Stuart AA
Endocrine 2021 Jun;72(3):905-914. Epub 2021 Jan 21 doi: 10.1007/s12020-021-02607-2. PMID: 33474713Free PMC Article
TNM staging of colorectal carcinoma: issues and caveats.
Shia J, Klimstra DS, Bagci P, Basturk O, Adsay NV
Semin Diagn Pathol 2012 Aug;29(3):142-53. doi: 10.1053/j.semdp.2012.02.001. PMID: 23062421
Multiple endocrine neoplasias type 2B and RET proto-oncogene.
Martucciello G, Lerone M, Bricco L, Tonini GP, Lombardi L, Del Rossi CG, Bernasconi S
Ital J Pediatr 2012 Mar 19;38:9. doi: 10.1186/1824-7288-38-9. PMID: 22429913Free PMC Article
Poorly differentiated adenocarcinoma of the colon and rectum: clinical characteristics.
Ogawa M, Watanabe M, Eto K, Kosuge M, Yamagata T, Kobayashi T, Yamazaki K, Anazawa S, Yanaga K
Hepatogastroenterology 2008 May-Jun;55(84):907-11. PMID: 18705295

Clinical prediction guides

Disease-free survival after complete mesocolic excision compared with conventional colon cancer surgery: a retrospective, population-based study.
Bertelsen CA, Neuenschwander AU, Jansen JE, Wilhelmsen M, Kirkegaard-Klitbo A, Tenma JR, Bols B, Ingeholm P, Rasmussen LA, Jepsen LV, Iversen ER, Kristensen B, Gögenur I; Danish Colorectal Cancer Group
Lancet Oncol 2015 Feb;16(2):161-8. Epub 2014 Dec 31 doi: 10.1016/S1470-2045(14)71168-4. PMID: 25555421
Visceral neuropathies responsible for chronic intestinal pseudo-obstruction syndrome in pediatric practice: analysis of 26 cases.
Navarro J, Sonsino E, Boige N, Nabarra B, Ferkadji L, Mashako LM, Cezard JP
J Pediatr Gastroenterol Nutr 1990 Aug;11(2):179-95. doi: 10.1097/00005176-199008000-00006. PMID: 2395057
Patterns of reactivity of the monoclonal antibody 791T/36 with different tumour metastases in the liver.
Hawkey CJ, Holmes CH, Smith PG, Austin EB, Baldwin RW
Br J Cancer 1986 Dec;54(6):871-5. doi: 10.1038/bjc.1986.255. PMID: 3026425Free PMC Article
Prostate-specific acid phosphatase in carcinoid tumors.
Kimura N, Sasano N
Virchows Arch A Pathol Anat Histopathol 1986;410(3):247-51. doi: 10.1007/BF00710831. PMID: 3026083

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