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Cryoglobulinemia

MedGen UID:
3673
•Concept ID:
C0010403
•
Disease or Syndrome
Synonym: Cryoglobulinemias
SNOMED CT: Cryoglobulinemia (30911005); Cryoimmunoglobulinemia (30911005)
 
HPO: HP:0100778
Monarch Initiative: MONDO:0005576

Definition

Increased level of cryoglobulins in the blood. Cryoglobulins are abnormal immunoglobulins, especially IGG or IGM, that precipitate spontaneously when serum is cooled below 37 degrees Celsius. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCryoglobulinemia

Conditions with this feature

Cryoglobulinemic vasculitis
MedGen UID:
343814
•Concept ID:
C1852456
•
Disease or Syndrome
A rare immune complex-mediated vasculitis characterized by the presence of circulating cryoprecipitable immune complexes in the serum, manifesting clinically with the classical triad of purpura, weakness and arthralgia.
See: Condition Record
Cryoglobulinemic vasculitis

Professional guidelines

PubMed

Recent updates in the diagnosis and management of cryoglobulinemic vasculitis.
Treppo E, Quartuccio L, De Vita S
Expert Rev Clin Immunol 2023 Jul-Dec;19(12):1457-1467. Epub 2023 Sep 12 doi: 10.1080/1744666X.2023.2249609. PMID: 37698547
Executive Summary of the KDIGO 2022 Clinical Practice Guideline for the Prevention, Diagnosis, Evaluation, and Treatment of Hepatitis C in Chronic Kidney Disease.
Martin P, Awan AA, Berenguer MC, Bruchfeld A, Fabrizi F, Goldberg DS, Jia J, Kamar N, Mohamed R, Pessôa MG, Pol S, Sise ME, Balk EM, Gordon CE, Adam G, Cheung M, Earley A, Jadoul M
Kidney Int 2022 Dec;102(6):1228-1237. doi: 10.1016/j.kint.2022.07.012. PMID: 36411019
IgM monoclonal gammopathies of clinical significance: diagnosis and management.
Khwaja J, D'Sa S, Minnema MC, Kersten MJ, Wechalekar A, Vos JM
Haematologica 2022 Sep 1;107(9):2037-2050. doi: 10.3324/haematol.2022.280953. PMID: 35770530Free PMC Article

Recent clinical studies

Etiology

A Review on Extrahepatic Manifestations of Chronic Hepatitis C Virus Infection and the Impact of Direct-Acting Antiviral Therapy.
Mazzaro C, Quartuccio L, Adinolfi LE, Roccatello D, Pozzato G, Nevola R, Tonizzo M, Gitto S, Andreone P, Gattei V
Viruses 2021 Nov 9;13(11) doi: 10.3390/v13112249. PMID: 34835054Free PMC Article
Cryoglobulinemia: An update in 2019.
Desbois AC, Cacoub P, Saadoun D
Joint Bone Spine 2019 Nov;86(6):707-713. Epub 2019 Feb 4 doi: 10.1016/j.jbspin.2019.01.016. PMID: 30731128
Cryoglobulinemia Vasculitis.
Cacoub P, Comarmond C, Domont F, Savey L, Saadoun D
Am J Med 2015 Sep;128(9):950-5. Epub 2015 Mar 30 doi: 10.1016/j.amjmed.2015.02.017. PMID: 25837517
Cryofibrinogenemia.
Michaud M, Pourrat J
J Clin Rheumatol 2013 Apr;19(3):142-8. doi: 10.1097/RHU.0b013e318289e06e. PMID: 23519183
The cryoglobulinaemias.
Ramos-Casals M, Stone JH, Cid MC, Bosch X
Lancet 2012 Jan 28;379(9813):348-60. Epub 2011 Aug 23 doi: 10.1016/S0140-6736(11)60242-0. PMID: 21868085

Diagnosis

Cryoglobulinemia.
Retamozo S, Quartuccio L, Ramos-Casals M
Med Clin (Barc) 2022 May 27;158(10):478-487. Epub 2022 Feb 22 doi: 10.1016/j.medcli.2021.11.017. PMID: 35216803
Cryoglobulinemic vasculitis: pathophysiological mechanisms and diagnosis.
Kolopp-Sarda MN, Miossec P
Curr Opin Rheumatol 2021 Jan;33(1):1-7. doi: 10.1097/BOR.0000000000000757. PMID: 33186245
New insights in cryoglobulinemic vasculitis.
Silva F, Pinto C, Barbosa A, Borges T, Dias C, Almeida J
J Autoimmun 2019 Dec;105:102313. Epub 2019 Aug 2 doi: 10.1016/j.jaut.2019.102313. PMID: 31383568
Cryoglobulinemia: An update in 2019.
Desbois AC, Cacoub P, Saadoun D
Joint Bone Spine 2019 Nov;86(6):707-713. Epub 2019 Feb 4 doi: 10.1016/j.jbspin.2019.01.016. PMID: 30731128
Acute hyperviscosity: syndromes and management.
Gertz MA
Blood 2018 Sep 27;132(13):1379-1385. Epub 2018 Aug 13 doi: 10.1182/blood-2018-06-846816. PMID: 30104220Free PMC Article

Therapy

Cryoglobulinemia.
Retamozo S, Quartuccio L, Ramos-Casals M
Med Clin (Barc) 2022 May 27;158(10):478-487. Epub 2022 Feb 22 doi: 10.1016/j.medcli.2021.11.017. PMID: 35216803
New insights in cryoglobulinemic vasculitis.
Silva F, Pinto C, Barbosa A, Borges T, Dias C, Almeida J
J Autoimmun 2019 Dec;105:102313. Epub 2019 Aug 2 doi: 10.1016/j.jaut.2019.102313. PMID: 31383568
Cryoglobulinaemia.
Roccatello D, Saadoun D, Ramos-Casals M, Tzioufas AG, Fervenza FC, Cacoub P, Zignego AL, Ferri C
Nat Rev Dis Primers 2018 Aug 2;4(1):11. doi: 10.1038/s41572-018-0009-4. PMID: 30072738
Cryoglobulinemic disease.
Retamozo S, Brito-Zerón P, Bosch X, Stone JH, Ramos-Casals M
Oncology (Williston Park) 2013 Nov;27(11):1098-1105, 1110-6. PMID: 24575538
Cryofibrinogenemia.
Michaud M, Pourrat J
J Clin Rheumatol 2013 Apr;19(3):142-8. doi: 10.1097/RHU.0b013e318289e06e. PMID: 23519183

Prognosis

Clinical impact and prognosis of cryoglobulinemia and cryofibrinogenemia in systemic sclerosis.
De Almeida Chaves S, Puissant B, Porel T, Bories E, Adoue D, Alric L, Astudillo L, Huart A, Lairez O, Michaud M, Ribes D, Prévot G, Sailler L, Gaches F, Pugnet G
Autoimmun Rev 2022 Aug;21(8):103133. Epub 2022 Jun 22 doi: 10.1016/j.autrev.2022.103133. PMID: 35752439
Cryoglobulinaemia.
Roccatello D, Saadoun D, Ramos-Casals M, Tzioufas AG, Fervenza FC, Cacoub P, Zignego AL, Ferri C
Nat Rev Dis Primers 2018 Aug 2;4(1):11. doi: 10.1038/s41572-018-0009-4. PMID: 30072738
Cryoglobulinemia Vasculitis.
Cacoub P, Comarmond C, Domont F, Savey L, Saadoun D
Am J Med 2015 Sep;128(9):950-5. Epub 2015 Mar 30 doi: 10.1016/j.amjmed.2015.02.017. PMID: 25837517
Cryoglobulinemia (review).
Takada S, Shimizu T, Hadano Y, Matsumoto K, Kataoka Y, Arima Y, Inoue T, Sorano S
Mol Med Rep 2012 Jul;6(1):3-8. Epub 2012 Apr 6 doi: 10.3892/mmr.2012.861. PMID: 22484457
The cryoglobulinaemias.
Ramos-Casals M, Stone JH, Cid MC, Bosch X
Lancet 2012 Jan 28;379(9813):348-60. Epub 2011 Aug 23 doi: 10.1016/S0140-6736(11)60242-0. PMID: 21868085

Clinical prediction guides

Cryofibrinogenemia: What Rheumatologists Should Know.
Santiago MB, Melo BS
Curr Rheumatol Rev 2022;18(3):186-194. doi: 10.2174/1573397118666220325110737. PMID: 35339184
Cryoglobulinemic disease.
Retamozo S, Brito-Zerón P, Bosch X, Stone JH, Ramos-Casals M
Oncology (Williston Park) 2013 Nov;27(11):1098-1105, 1110-6. PMID: 24575538
Infections in vasculitis.
Guillevin L
Best Pract Res Clin Rheumatol 2013 Feb;27(1):19-31. doi: 10.1016/j.berh.2013.01.004. PMID: 23507054
Cryoglobulinemia vasculitis.
Cacoub P, Costedoat-Chalumeau N, Lidove O, Alric L
Curr Opin Rheumatol 2002 Jan;14(1):29-35. doi: 10.1097/00002281-200201000-00006. PMID: 11790993
Chronic hepatitis C.
Sharara AI
South Med J 1997 Sep;90(9):872-7. doi: 10.1097/00007611-199709000-00002. PMID: 9305294

Recent systematic reviews

Regulatory T cells and systemic vasculitis.
Mirouse A, Cacoub P, Saadoun D
Curr Opin Rheumatol 2023 Jan 1;35(1):25-30. Epub 2022 Oct 20 doi: 10.1097/BOR.0000000000000915. PMID: 36508306
Management of mixed cryoglobulinemia with rituximab: evidence and consensus-based recommendations from the Italian Study Group of Cryoglobulinemia (GISC).
Quartuccio L, Bortoluzzi A, Scirè CA, Marangoni A, Del Frate G, Treppo E, Castelnovo L, Saccardo F, Zani R, Candela M, Fraticelli P, Mazzaro C, Renoldi P, Scaini P, Filippini DA, Visentini M, Scarpato S, Giuggioli D, Mascia MT, Sebastiani M, Zignego AL, Lauletta G, Fiorilli M, Casato M, Ferri C, Pietrogrande M, Pioltelli PE, De Vita S, Monti G, Galli M
Clin Rheumatol 2023 Feb;42(2):359-370. Epub 2022 Sep 28 doi: 10.1007/s10067-022-06391-w. PMID: 36169798Free PMC Article
Systematic Review of Safety and Efficacy of Rituximab in Treating Immune-Mediated Disorders.
Kaegi C, Wuest B, Schreiner J, Steiner UC, Vultaggio A, Matucci A, Crowley C, Boyman O
Front Immunol 2019;10:1990. Epub 2019 Sep 6 doi: 10.3389/fimmu.2019.01990. PMID: 31555262Free PMC Article
Efficacy and safety of Rituximab in vasculitic neuropathy: a systematic review of the literature.
Mena-Vázquez N, Cabezudo-García P, Fuego Varela C, Manrique-Arija S, Fernandez-Nebro A
Reumatol Clin (Engl Ed) 2019 May-Jun;15(3):173-178. Epub 2019 Jan 25 doi: 10.1016/j.reuma.2018.10.007. PMID: 30691946
Biologic therapy in ANCA-negative vasculitis.
Loricera J, Blanco R, Hernández JL, Pina T, González-Vela MC, González-Gay MA
Int Immunopharmacol 2015 Aug;27(2):213-9. Epub 2015 Mar 28 doi: 10.1016/j.intimp.2015.03.020. PMID: 25828585

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