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Celiac disease, susceptibility to, 6(CELIAC6)

MedGen UID:
369397
Concept ID:
C1969030
Finding
Synonyms: Celiac disease 6; CELIAC6; GLUTEN-SENSITIVE ENTEROPATHY, SUSCEPTIBILITY TO, 6
 
Monarch Initiative: MONDO:0012702
OMIM®: 611598

Definition

Celiac disease, also known as celiac sprue and gluten-sensitive enteropathy, is a multifactorial disorder of the small intestine that is influenced by both environmental and genetic factors. It is characterized by malabsorption resulting from inflammatory injury to the mucosa of the small intestine after the ingestion of wheat gluten or related rye and barley proteins (summary by Farrell and Kelly, 2002). For additional information and a discussion of genetic heterogeneity of celiac disease, see 212750. For a discussion of autoimmunity, see 109100. [from OMIM]

Professional guidelines

PubMed

Rossi RE, Dispinzieri G, Elvevi A, Massironi S
Cells 2023 Mar 7;12(6) doi: 10.3390/cells12060823. PMID: 36980164Free PMC Article
Moisidis-Tesch CM, Shulman LP
Adv Ther 2022 Jun;39(6):2438-2451. Epub 2022 Apr 30 doi: 10.1007/s12325-022-02157-7. PMID: 35488139
Kelly CP, Bai JC, Liu E, Leffler DA
Gastroenterology 2015 May;148(6):1175-86. Epub 2015 Feb 3 doi: 10.1053/j.gastro.2015.01.044. PMID: 25662623Free PMC Article

Recent clinical studies

Etiology

Makharia GK, Chauhan A, Singh P, Ahuja V
Aliment Pharmacol Ther 2022 Jul;56 Suppl 1:S3-S17. doi: 10.1111/apt.16787. PMID: 35815830
Saevarsdottir S, Olafsdottir TA, Ivarsdottir EV, Halldorsson GH, Gunnarsdottir K, Sigurdsson A, Johannesson A, Sigurdsson JK, Juliusdottir T, Lund SH, Arnthorsson AO, Styrmisdottir EL, Gudmundsson J, Grondal GM, Steinsson K, Alfredsson L, Askling J, Benediktsson R, Bjarnason R, Geirsson AJ, Gudbjornsson B, Gudjonsson H, Hjaltason H, Hreidarsson AB, Klareskog L, Kockum I, Kristjansdottir H, Love TJ, Ludviksson BR, Olsson T, Onundarson PT, Orvar KB, Padyukov L, Sigurgeirsson B, Tragante V, Bjarnadottir K, Rafnar T, Masson G, Sulem P, Gudbjartsson DF, Melsted P, Thorleifsson G, Norddahl GL, Thorsteinsdottir U, Jonsdottir I, Stefansson K
Nature 2020 Aug;584(7822):619-623. Epub 2020 Jun 24 doi: 10.1038/s41586-020-2436-0. PMID: 32581359
Guandalini S, Setty M
Curr Opin Gastroenterol 2008 Nov;24(6):707-12. doi: 10.1097/MOG.0b013e32830f4527. PMID: 19122520
Catassi C, Fasano A
Curr Opin Gastroenterol 2008 Nov;24(6):687-91. doi: 10.1097/MOG.0b013e32830edc1e. PMID: 19122516
Bianchi ML, Bardella MT
Calcif Tissue Int 2002 Dec;71(6):465-71. Epub 2002 Sep 18 doi: 10.1007/s00223-001-2131-6. PMID: 12232681

Diagnosis

Moisidis-Tesch CM, Shulman LP
Adv Ther 2022 Jun;39(6):2438-2451. Epub 2022 Apr 30 doi: 10.1007/s12325-022-02157-7. PMID: 35488139
Jimenez J, Loveridge-Lenza B, Horvath K
Pediatr Clin North Am 2021 Dec;68(6):1205-1219. doi: 10.1016/j.pcl.2021.07.007. PMID: 34736585
Cárdenas-Torres FI, Cabrera-Chávez F, Figueroa-Salcido OG, Ontiveros N
Medicina (Kaunas) 2021 May 24;57(6) doi: 10.3390/medicina57060526. PMID: 34073654Free PMC Article
Silvester JA, Therrien A, Kelly CP
Am J Gastroenterol 2021 Jun 1;116(6):1148-1155. doi: 10.14309/ajg.0000000000001218. PMID: 33767109Free PMC Article
Catassi C, Fasano A
Curr Opin Gastroenterol 2008 Nov;24(6):687-91. doi: 10.1097/MOG.0b013e32830edc1e. PMID: 19122516

Therapy

Moisidis-Tesch CM, Shulman LP
Adv Ther 2022 Jun;39(6):2438-2451. Epub 2022 Apr 30 doi: 10.1007/s12325-022-02157-7. PMID: 35488139
Cárdenas-Torres FI, Cabrera-Chávez F, Figueroa-Salcido OG, Ontiveros N
Medicina (Kaunas) 2021 May 24;57(6) doi: 10.3390/medicina57060526. PMID: 34073654Free PMC Article
Silvester JA, Therrien A, Kelly CP
Am J Gastroenterol 2021 Jun 1;116(6):1148-1155. doi: 10.14309/ajg.0000000000001218. PMID: 33767109Free PMC Article
Guandalini S, Setty M
Curr Opin Gastroenterol 2008 Nov;24(6):707-12. doi: 10.1097/MOG.0b013e32830f4527. PMID: 19122520
Catassi C, Fasano A
Curr Opin Gastroenterol 2008 Nov;24(6):687-91. doi: 10.1097/MOG.0b013e32830edc1e. PMID: 19122516

Prognosis

Saevarsdottir S, Olafsdottir TA, Ivarsdottir EV, Halldorsson GH, Gunnarsdottir K, Sigurdsson A, Johannesson A, Sigurdsson JK, Juliusdottir T, Lund SH, Arnthorsson AO, Styrmisdottir EL, Gudmundsson J, Grondal GM, Steinsson K, Alfredsson L, Askling J, Benediktsson R, Bjarnason R, Geirsson AJ, Gudbjornsson B, Gudjonsson H, Hjaltason H, Hreidarsson AB, Klareskog L, Kockum I, Kristjansdottir H, Love TJ, Ludviksson BR, Olsson T, Onundarson PT, Orvar KB, Padyukov L, Sigurgeirsson B, Tragante V, Bjarnadottir K, Rafnar T, Masson G, Sulem P, Gudbjartsson DF, Melsted P, Thorleifsson G, Norddahl GL, Thorsteinsdottir U, Jonsdottir I, Stefansson K
Nature 2020 Aug;584(7822):619-623. Epub 2020 Jun 24 doi: 10.1038/s41586-020-2436-0. PMID: 32581359
Kaur N, Bhadada SK, Minz RW, Dayal D, Kochhar R
Dig Dis 2018;36(6):399-408. Epub 2018 Jul 25 doi: 10.1159/000488670. PMID: 30045024
Lee GJ, Kao JY
Expert Rev Gastroenterol Hepatol 2017 Jun;11(6):583-592. Epub 2017 Mar 28 doi: 10.1080/17474124.2017.1309288. PMID: 28317399
Guandalini S, Setty M
Curr Opin Gastroenterol 2008 Nov;24(6):707-12. doi: 10.1097/MOG.0b013e32830f4527. PMID: 19122520
Catassi C, Fasano A
Curr Opin Gastroenterol 2008 Nov;24(6):687-91. doi: 10.1097/MOG.0b013e32830edc1e. PMID: 19122516

Clinical prediction guides

Emiralioglu N, Ademhan Tural D, Hizarcioglu Gulsen H, Ergen YM, Ozsezen B, Sunman B, Saltık Temizel İ, Yalcin E, Dogru D, Ozcelik U, Kiper N
Eur J Pediatr 2021 Sep;180(9):2807-2813. Epub 2021 Mar 25 doi: 10.1007/s00431-021-04011-4. PMID: 33765186
Saevarsdottir S, Olafsdottir TA, Ivarsdottir EV, Halldorsson GH, Gunnarsdottir K, Sigurdsson A, Johannesson A, Sigurdsson JK, Juliusdottir T, Lund SH, Arnthorsson AO, Styrmisdottir EL, Gudmundsson J, Grondal GM, Steinsson K, Alfredsson L, Askling J, Benediktsson R, Bjarnason R, Geirsson AJ, Gudbjornsson B, Gudjonsson H, Hjaltason H, Hreidarsson AB, Klareskog L, Kockum I, Kristjansdottir H, Love TJ, Ludviksson BR, Olsson T, Onundarson PT, Orvar KB, Padyukov L, Sigurgeirsson B, Tragante V, Bjarnadottir K, Rafnar T, Masson G, Sulem P, Gudbjartsson DF, Melsted P, Thorleifsson G, Norddahl GL, Thorsteinsdottir U, Jonsdottir I, Stefansson K
Nature 2020 Aug;584(7822):619-623. Epub 2020 Jun 24 doi: 10.1038/s41586-020-2436-0. PMID: 32581359
Lee GJ, Kao JY
Expert Rev Gastroenterol Hepatol 2017 Jun;11(6):583-592. Epub 2017 Mar 28 doi: 10.1080/17474124.2017.1309288. PMID: 28317399
Parra-Medina R, Molano-Gonzalez N, Rojas-Villarraga A, Agmon-Levin N, Arango MT, Shoenfeld Y, Anaya JM
PLoS One 2015;10(5):e0124040. Epub 2015 May 5 doi: 10.1371/journal.pone.0124040. PMID: 25942408Free PMC Article
Kelly CP, Bai JC, Liu E, Leffler DA
Gastroenterology 2015 May;148(6):1175-86. Epub 2015 Feb 3 doi: 10.1053/j.gastro.2015.01.044. PMID: 25662623Free PMC Article

Recent systematic reviews

Yang G, Zhang B, Huang W, Zhang N, Dong F, Jing L, Wang M, Liu Y, Guo C, Pan H, Wei X, Jing C
Expert Rev Gastroenterol Hepatol 2015;9(10):1327-38. Epub 2015 Aug 8 doi: 10.1586/17474124.2015.1075880. PMID: 26289103
Parra-Medina R, Molano-Gonzalez N, Rojas-Villarraga A, Agmon-Levin N, Arango MT, Shoenfeld Y, Anaya JM
PLoS One 2015;10(5):e0124040. Epub 2015 May 5 doi: 10.1371/journal.pone.0124040. PMID: 25942408Free PMC Article

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