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Chloramphenicol toxicity

MedGen UID:
374104
Concept ID:
C1838989
Injury or Poisoning
Synonym: ANEMIA, CHLORAMPHENICOL-INDUCED
 
Monarch Initiative: MONDO:0010784
OMIM®: 515000

Clinical features

From HPO
Aplastic anemia
MedGen UID:
8063
Concept ID:
C0002874
Disease or Syndrome
Aplastic anemia is a serious disorder of the bone marrow that affects between 2 and 5 persons per million per year. About 75% of these cases are classified as idiopathic (Young, 2000). In about 15% of cases a drug or infection can be identified that precipitates the aplasia, although why only some individuals are susceptible is unclear. In about 5 to 10% of patients, the aplastic anemia is constitutional--i.e., is familial or presents with one or more associated somatic abnormalities (summary by Vulliamy et al., 2002).

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  

Professional guidelines

PubMed

Sah SP, Raj GA, Rijal S, Karki P
Singapore Med J 1999 Jul;40(7):451-4. PMID: 10560270
Mulhall A, de Louvois J, Hurley R
Lancet 1983 Feb 5;1(8319):284-7. doi: 10.1016/s0140-6736(83)91697-5. PMID: 6130304

Recent systematic reviews

Lazzerini M, Tickell D
Bull World Health Organ 2011 Aug 1;89(8):594-607. Epub 2011 May 20 doi: 10.2471/BLT.10.084715. PMID: 21836758Free PMC Article

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