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Accelerated atherosclerosis

MedGen UID:
376623
Concept ID:
C1849618
Finding
Synonym: Accelerated plaque build-up in arteries
 
HPO: HP:0004943

Definition

Atherosclerosis which occurs in a person with certain risk factors (e.g., SLE, diabetes, smoking, hypertension, hypercholesterolaemia, family history of early heart disease) at an earlier age than would occur in another person without those risk factors. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAccelerated atherosclerosis

Conditions with this feature

Autosomal recessive inherited pseudoxanthoma elasticum
MedGen UID:
698415
Concept ID:
C1275116
Disease or Syndrome
Pseudoxanthoma elasticum (PXE) is a systemic disorder that affects the elastic tissue of the skin, the eye, and vascular system. Individuals most commonly present with angioid streaks of the retina found on routine eye examination or associated with retinal hemorrhage and/or characteristic papules in the skin. The most frequent cause of morbidity and disability in PXE is reduced vision due to complications of subretinal neovascularizations and macular atrophy. Other manifestations include premature gastrointestinal angina and/or bleeding, intermittent claudication of arm and leg muscles, stroke, renovascular hypertension, and cardiovascular complications (angina/myocardial infarction). Most affected individuals live a normal life span.
Abdominal obesity-metabolic syndrome 4
MedGen UID:
1704861
Concept ID:
C5231430
Disease or Syndrome
Abdominal obesity-metabolic syndrome-4 (AOMS4) is characterized by obesity, hypertension, and early-onset coronary artery disease. Most affected individuals meet the criteria for metabolic syndrome, including elevated triglyceride and low high-density lipoprotein levels, and type 2 diabetes (Esteghamat et al., 2019). For a discussion of the genetic heterogeneity of abdominal obesity-metabolic syndrome, see AOMS1 (605552).

Professional guidelines

PubMed

Koutroumpakis E, Deswal A, Yusuf SW, Abe JI, Nead KT, Potter AS, Liao Z, Lin SH, Palaskas NL
Curr Oncol Rep 2022 May;24(5):543-553. Epub 2022 Feb 22 doi: 10.1007/s11912-022-01238-8. PMID: 35192118
Gillespie J
Clin Radiol 2020 Oct;75(10):794.e7-794.e17. Epub 2020 Jul 18 doi: 10.1016/j.crad.2020.06.011. PMID: 32690240
Reiss AB, Silverman A, Khalfan M, Vernice NA, Kasselman LJ, Carsons SE, De Leon J
Curr Pharm Des 2019;25(9):969-986. doi: 10.2174/1381612825666190430113212. PMID: 31208307

Recent clinical studies

Etiology

Galicia-Garcia U, Benito-Vicente A, Jebari S, Larrea-Sebal A, Siddiqi H, Uribe KB, Ostolaza H, Martín C
Int J Mol Sci 2020 Aug 30;21(17) doi: 10.3390/ijms21176275. PMID: 32872570Free PMC Article
Tselios K, Urowitz MB
Curr Rheumatol Rev 2017;13(3):206-218. doi: 10.2174/1573397113666170704102444. PMID: 28675998
Tobaldini E, Costantino G, Solbiati M, Cogliati C, Kara T, Nobili L, Montano N
Neurosci Biobehav Rev 2017 Mar;74(Pt B):321-329. Epub 2016 Jul 7 doi: 10.1016/j.neubiorev.2016.07.004. PMID: 27397854
Virdis A, Giannarelli C, Neves MF, Taddei S, Ghiadoni L
Curr Pharm Des 2010;16(23):2518-25. doi: 10.2174/138161210792062920. PMID: 20550499
Brownlee M
Nature 2001 Dec 13;414(6865):813-20. doi: 10.1038/414813a. PMID: 11742414

Diagnosis

Thuny F, Naidoo J, Neilan TG
Eur Heart J 2022 Nov 7;43(42):4458-4468. doi: 10.1093/eurheartj/ehac456. PMID: 36040835Free PMC Article
Drobni ZD, Alvi RM, Taron J, Zafar A, Murphy SP, Rambarat PK, Mosarla RC, Lee C, Zlotoff DA, Raghu VK, Hartmann SE, Gilman HK, Gong J, Zubiri L, Sullivan RJ, Reynolds KL, Mayrhofer T, Zhang L, Hoffmann U, Neilan TG
Circulation 2020 Dec 15;142(24):2299-2311. Epub 2020 Oct 2 doi: 10.1161/CIRCULATIONAHA.120.049981. PMID: 33003973Free PMC Article
Galicia-Garcia U, Benito-Vicente A, Jebari S, Larrea-Sebal A, Siddiqi H, Uribe KB, Ostolaza H, Martín C
Int J Mol Sci 2020 Aug 30;21(17) doi: 10.3390/ijms21176275. PMID: 32872570Free PMC Article
Tselios K, Urowitz MB
Curr Rheumatol Rev 2017;13(3):206-218. doi: 10.2174/1573397113666170704102444. PMID: 28675998
Lebovitz HE
Exp Clin Endocrinol Diabetes 2001;109 Suppl 2:S135-48. doi: 10.1055/s-2001-18576. PMID: 11460565

Therapy

Thuny F, Naidoo J, Neilan TG
Eur Heart J 2022 Nov 7;43(42):4458-4468. doi: 10.1093/eurheartj/ehac456. PMID: 36040835Free PMC Article
Gillespie J
Clin Radiol 2020 Oct;75(10):794.e7-794.e17. Epub 2020 Jul 18 doi: 10.1016/j.crad.2020.06.011. PMID: 32690240
Kostopoulou M, Nikolopoulos D, Parodis I, Bertsias G
Curr Vasc Pharmacol 2020;18(6):549-565. doi: 10.2174/1570161118666191227101636. PMID: 31880245
Aguiar C, Duarte R, Carvalho D
Rev Port Cardiol (Engl Ed) 2019 Jan;38(1):53-63. Epub 2019 Jan 23 doi: 10.1016/j.repc.2018.03.013. PMID: 30685291
Virdis A, Giannarelli C, Neves MF, Taddei S, Ghiadoni L
Curr Pharm Des 2010;16(23):2518-25. doi: 10.2174/138161210792062920. PMID: 20550499

Prognosis

Dong Z, Hou L, Luo W, Pan LH, Li X, Tan HP, Wu RD, Lu H, Yao K, Mu MD, Gao CS, Weng XY, Ge JB
Eur Heart J 2024 Mar 1;45(9):669-684. doi: 10.1093/eurheartj/ehad787. PMID: 38085922
Kronbichler A, Leierer J, Gauckler P, Shin JI
Rheumatology (Oxford) 2020 May 1;59(Suppl 3):iii79-iii83. doi: 10.1093/rheumatology/kez617. PMID: 32348518Free PMC Article
Kostopoulou M, Nikolopoulos D, Parodis I, Bertsias G
Curr Vasc Pharmacol 2020;18(6):549-565. doi: 10.2174/1570161118666191227101636. PMID: 31880245
Aguiar C, Duarte R, Carvalho D
Rev Port Cardiol (Engl Ed) 2019 Jan;38(1):53-63. Epub 2019 Jan 23 doi: 10.1016/j.repc.2018.03.013. PMID: 30685291
Tselios K, Urowitz MB
Curr Rheumatol Rev 2017;13(3):206-218. doi: 10.2174/1573397113666170704102444. PMID: 28675998

Clinical prediction guides

Dong Z, Hou L, Luo W, Pan LH, Li X, Tan HP, Wu RD, Lu H, Yao K, Mu MD, Gao CS, Weng XY, Ge JB
Eur Heart J 2024 Mar 1;45(9):669-684. doi: 10.1093/eurheartj/ehad787. PMID: 38085922
Thuny F, Naidoo J, Neilan TG
Eur Heart J 2022 Nov 7;43(42):4458-4468. doi: 10.1093/eurheartj/ehac456. PMID: 36040835Free PMC Article
Maida CD, Daidone M, Pacinella G, Norrito RL, Pinto A, Tuttolomondo A
Int J Mol Sci 2022 Feb 21;23(4) doi: 10.3390/ijms23042397. PMID: 35216512Free PMC Article
Chen HJ, Tas SW, de Winther MPJ
J Exp Med 2020 Jan 6;217(1) doi: 10.1084/jem.20190459. PMID: 31821440Free PMC Article
Virdis A, Giannarelli C, Neves MF, Taddei S, Ghiadoni L
Curr Pharm Des 2010;16(23):2518-25. doi: 10.2174/138161210792062920. PMID: 20550499

Recent systematic reviews

Raj R, Thomas S, Gorantla V
F1000Res 2022;11:466. Epub 2022 Apr 27 doi: 10.12688/f1000research.112921.2. PMID: 36249997Free PMC Article
Restivo V, Candiloro S, Daidone M, Norrito R, Cataldi M, Minutolo G, Caracci F, Fasano S, Ciccia F, Casuccio A, Tuttolomondo A
Autoimmun Rev 2022 Jan;21(1):102925. Epub 2021 Aug 26 doi: 10.1016/j.autrev.2021.102925. PMID: 34454117
Andrades C, Fuego C, Manrique-Arija S, Fernández-Nebro A
Lupus 2017 Nov;26(13):1407-1419. Epub 2017 Apr 29 doi: 10.1177/0961203317704710. PMID: 28457197
Ungprasert P, Koster MJ, Warrington KJ, Matteson EL
Rheumatol Int 2017 Jan;37(1):143-149. Epub 2016 Aug 30 doi: 10.1007/s00296-016-3557-5. PMID: 27577940
Tyrrell PN, Beyene J, Feldman BM, McCrindle BW, Silverman ED, Bradley TJ
Arterioscler Thromb Vasc Biol 2010 May;30(5):1014-26. Epub 2010 Feb 11 doi: 10.1161/ATVBAHA.109.198424. PMID: 20150560

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