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Narrowing of medullary canal

MedGen UID:
377067
•Concept ID:
C1851612
•
Finding
Synonyms: Medullary cavity obliteration; Narrowing of bone marrow canal; Narrowing of bone medullary canal; Narrowing of the marrow cavity
 
HPO: HP:0032458

Definition

A reduction in diameter and volume of the central cavity of bone where red or yellow bone marrow is located. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNarrowing of medullary canal

Conditions with this feature

Diaphyseal dysplasia
MedGen UID:
4268
•Concept ID:
C0011989
•
Finding
Camurati-Engelmann disease (CED) is characterized by hyperostosis of the long bones and the skull, proximal muscle weakness, limb pain, a wide-based, waddling gait, and joint contractures. Facial features such as macrocephaly, frontal bossing, enlargement of the mandible, proptosis, and cranial nerve impingement resulting in facial palsy are seen in severely affected individuals later in life.
See: Condition Record
Diaphyseal dysplasia

Professional guidelines

PubMed

The use of anterolateral bowing of the lower leg in the diagnostic criteria for neurofibromatosis type 1.
Stevenson DA, Viskochil DH, Schorry EK, Crawford AH, D'Astous J, Murray KA, Friedman JM, Armstrong L, Carey JC
Genet Med 2007 Jul;9(7):409-12. doi: 10.1097/gim.0b013e3180986e05. PMID: 17666887Free PMC Article
Jones fracture. Surgical versus nonsurgical treatment.
Josefsson PO, Karlsson M, Redlund-Johnell I, Wendeberg B
Clin Orthop Relat Res 1994 Feb;(299):252-5. PMID: 8119027
Fractures of the base of the fifth metatarsal distal to the tuberosity. Classification and guidelines for non-surgical and surgical management.
Torg JS, Balduini FC, Zelko RR, Pavlov H, Peff TC, Das M
J Bone Joint Surg Am 1984 Feb;66(2):209-14. PMID: 6693447

Recent clinical studies

Etiology

Can CT-based assessment of lateral malleolus anatomy indicate when and how to perform an intramedullary fixation in distal fibula fractures? An analysis of 150 ankles.
Giordano V, Azevedo PH, Peres C, Perucci M, Rodrigues M, Meireles R, Pires RE, Godoy-Santos A, Giannoudis PV
Eur J Orthop Surg Traumatol 2023 Apr;33(3):601-609. Epub 2022 Aug 19 doi: 10.1007/s00590-022-03360-6. PMID: 35984518
A novel radiological classification system of the distal femur.
Citak M, Levent A, Suero EM, Rademacher K, Busch SM, Gehrke T
Arch Orthop Trauma Surg 2022 Feb;142(2):315-322. Epub 2021 Feb 27 doi: 10.1007/s00402-021-03828-w. PMID: 33638676
Interlocking nailing of femoral shaft fractures with an extremely narrow medullary canal is associated with iatrogenic fractures.
Hsu KL, Kuan FC, Chang WL, Liu YF, Hong CK, Yeh ML, Su WR
Injury 2019 Dec;50(12):2306-2311. Epub 2019 Oct 4 doi: 10.1016/j.injury.2019.10.010. PMID: 31610947
Quantitative Ultrasound and Tibial Dysplasia in Neurofibromatosis Type 1.
Stevenson DA, Hanson H, Stevens A, Carey J, Viskochil D, Sheng X, Wheeler K, Slater H
J Clin Densitom 2018 Apr-Jun;21(2):179-184. Epub 2017 Apr 21 doi: 10.1016/j.jocd.2017.03.004. PMID: 28438404
The orthopedic manifestation of neurofibromatosis. A clinical experience and review of the literature.
DiSimone RE, Berman AT, Schwentker EP
Clin Orthop Relat Res 1988 May;(230):277-83. PMID: 3130209

Diagnosis

Surgical treatment of pycnodysostosis associated with pathological tibial fracture : Case report and review of the literature.
Mariscal G, Domenech P, Salom M
Orthopadie (Heidelb) 2022 Dec;51(12):1010-1014. Epub 2022 Sep 26 doi: 10.1007/s00132-022-04309-7. PMID: 36161513
Interlocking nailing of femoral shaft fractures with an extremely narrow medullary canal is associated with iatrogenic fractures.
Hsu KL, Kuan FC, Chang WL, Liu YF, Hong CK, Yeh ML, Su WR
Injury 2019 Dec;50(12):2306-2311. Epub 2019 Oct 4 doi: 10.1016/j.injury.2019.10.010. PMID: 31610947
Quantitative Ultrasound and Tibial Dysplasia in Neurofibromatosis Type 1.
Stevenson DA, Hanson H, Stevens A, Carey J, Viskochil D, Sheng X, Wheeler K, Slater H
J Clin Densitom 2018 Apr-Jun;21(2):179-184. Epub 2017 Apr 21 doi: 10.1016/j.jocd.2017.03.004. PMID: 28438404
Acute traumatic central cord syndrome: a comprehensive review.
Molliqaj G, Payer M, Schaller K, Tessitore E
Neurochirurgie 2014 Feb-Apr;60(1-2):5-11. Epub 2014 Mar 7 doi: 10.1016/j.neuchi.2013.12.002. PMID: 24613283
The use of anterolateral bowing of the lower leg in the diagnostic criteria for neurofibromatosis type 1.
Stevenson DA, Viskochil DH, Schorry EK, Crawford AH, D'Astous J, Murray KA, Friedman JM, Armstrong L, Carey JC
Genet Med 2007 Jul;9(7):409-12. doi: 10.1097/gim.0b013e3180986e05. PMID: 17666887Free PMC Article

Therapy

Three-dimensional femoral morphology in Hartofilakidis type C developmental dysplastic hips and the implications for total hip arthroplasty.
Wang Z, Li H, Zhou Y, Deng W
Int Orthop 2020 Oct;44(10):1935-1942. Epub 2020 Jun 17 doi: 10.1007/s00264-020-04661-3. PMID: 32556383
Interlocking nailing of femoral shaft fractures with an extremely narrow medullary canal is associated with iatrogenic fractures.
Hsu KL, Kuan FC, Chang WL, Liu YF, Hong CK, Yeh ML, Su WR
Injury 2019 Dec;50(12):2306-2311. Epub 2019 Oct 4 doi: 10.1016/j.injury.2019.10.010. PMID: 31610947
Acute traumatic central cord syndrome: a comprehensive review.
Molliqaj G, Payer M, Schaller K, Tessitore E
Neurochirurgie 2014 Feb-Apr;60(1-2):5-11. Epub 2014 Mar 7 doi: 10.1016/j.neuchi.2013.12.002. PMID: 24613283
Treatment of long bone intramedullary infection using the RIA for removal of infected tissue: indications, method and clinical results.
Zalavras CG, Sirkin M
Injury 2010 Nov;41 Suppl 2:S43-7. doi: 10.1016/S0020-1383(10)70008-5. PMID: 21144927
The ANK device: a new approach in the treatment of the fractures of the lateral malleolus associated with the rupture of the syndesmosis.
Kabukcuoglu Y, Kucukkaya M, Eren T, Gorgec M, Kuzgun U
Foot Ankle Int 2000 Sep;21(9):753-8. doi: 10.1177/107110070002100907. PMID: 11023223

Prognosis

A novel radiological classification system of the distal femur.
Citak M, Levent A, Suero EM, Rademacher K, Busch SM, Gehrke T
Arch Orthop Trauma Surg 2022 Feb;142(2):315-322. Epub 2021 Feb 27 doi: 10.1007/s00402-021-03828-w. PMID: 33638676
Quantitative Ultrasound and Tibial Dysplasia in Neurofibromatosis Type 1.
Stevenson DA, Hanson H, Stevens A, Carey J, Viskochil D, Sheng X, Wheeler K, Slater H
J Clin Densitom 2018 Apr-Jun;21(2):179-184. Epub 2017 Apr 21 doi: 10.1016/j.jocd.2017.03.004. PMID: 28438404
Pitfalls of femoral titanium elastic nailing.
Salonen A, Lahdes-Vasama T, Mattila VM, Välipakka J, Pajulo O
Scand J Surg 2015 Jun;104(2):121-6. Epub 2014 Apr 15 doi: 10.1177/1457496914529275. PMID: 24737849
Jones fracture. Surgical versus nonsurgical treatment.
Josefsson PO, Karlsson M, Redlund-Johnell I, Wendeberg B
Clin Orthop Relat Res 1994 Feb;(299):252-5. PMID: 8119027
Fractures of the base of the fifth metatarsal distal to the tuberosity. Classification and guidelines for non-surgical and surgical management.
Torg JS, Balduini FC, Zelko RR, Pavlov H, Peff TC, Das M
J Bone Joint Surg Am 1984 Feb;66(2):209-14. PMID: 6693447

Clinical prediction guides

A novel radiological classification system of the distal femur.
Citak M, Levent A, Suero EM, Rademacher K, Busch SM, Gehrke T
Arch Orthop Trauma Surg 2022 Feb;142(2):315-322. Epub 2021 Feb 27 doi: 10.1007/s00402-021-03828-w. PMID: 33638676
Bilateral congenital pseudarthrosis of the tibia with neurofibromatosis type 1.
Ari B, Kuyubasi SN
J Pak Med Assoc 2021 May;71(5):1499-1502. doi: 10.47391/JPMA.504. PMID: 34091645
'In-Out-In' K-wires sliding in severe tibial deformities of osteogenesis imperfecta: a technical note.
Langlais T, Pannier S, De Tienda M, Dukan R, Finidori G, Glorion C, Péjin Z
J Pediatr Orthop B 2021 May 1;30(3):257-263. doi: 10.1097/BPB.0000000000000785. PMID: 33767124
Quantitative Ultrasound and Tibial Dysplasia in Neurofibromatosis Type 1.
Stevenson DA, Hanson H, Stevens A, Carey J, Viskochil D, Sheng X, Wheeler K, Slater H
J Clin Densitom 2018 Apr-Jun;21(2):179-184. Epub 2017 Apr 21 doi: 10.1016/j.jocd.2017.03.004. PMID: 28438404
A morphometric study on the humerus for intramedullary fixation.
Akpinar F, Aydinlioğlu A, Tosun N, Doğan A, Tuncay I, Unal O
Tohoku J Exp Med 2003 Jan;199(1):35-42. doi: 10.1620/tjem.199.35. PMID: 12688558

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