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Motor neuron disease

MedGen UID:
38785
Concept ID:
C0085084
Disease or Syndrome
Synonyms: Degenerative motor system disease; Motor neuron disorder
SNOMED CT: Motor neurone disease (37340000); MND - Motor neurone disease (37340000); Motor neuron disease (37340000)
 
Monarch Initiative: MONDO:0020128
Orphanet: ORPHA98503

Definition

A disease involving the motor neuron. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMotor neuron disease
Follow this link to review classifications for Motor neuron disease in Orphanet.

Professional guidelines

PubMed

Tao Y, Leng SX, Zhang H
Curr Neuropharmacol 2022 Nov 15;20(12):2303-2319. doi: 10.2174/1570159X20666220830102628. PMID: 36043794Free PMC Article
Foster LA, Salajegheh MK
Am J Med 2019 Jan;132(1):32-37. Epub 2018 Aug 1 doi: 10.1016/j.amjmed.2018.07.012. PMID: 30075105
Mary P, Servais L, Vialle R
Orthop Traumatol Surg Res 2018 Feb;104(1S):S89-S95. Epub 2017 Nov 28 doi: 10.1016/j.otsr.2017.04.019. PMID: 29196274

Recent clinical studies

Etiology

Youn CE, Lu C, Cauchi J, MacGowan D, Morgenstern R, Scelsa S
J Neuromuscul Dis 2023;10(3):405-410. doi: 10.3233/JND-221579. PMID: 36872786
Sorahan T, Nichols L
Occup Med (Lond) 2022 Apr 19;72(3):184-190. doi: 10.1093/occmed/kqab180. PMID: 34940878Free PMC Article
Korb MK, Kimonis VE, Mozaffar T
Muscle Nerve 2021 Apr;63(4):442-454. Epub 2020 Nov 3 doi: 10.1002/mus.27097. PMID: 33145792
Pinto WBVR, Debona R, Nunes PP, Assis ACD, Lopes CG, Bortholin T, Dias RB, Naylor FGM, Chieia MAT, Souza PVS, Oliveira ASB
Rev Neurol (Paris) 2019 Apr;175(4):221-232. Epub 2019 Mar 4 doi: 10.1016/j.neurol.2018.04.016. PMID: 30846210
Kanning KC, Kaplan A, Henderson CE
Annu Rev Neurosci 2010;33:409-40. doi: 10.1146/annurev.neuro.051508.135722. PMID: 20367447

Diagnosis

Kwan J, Vullaganti M
Muscle Nerve 2022 Sep;66(3):240-252. Epub 2022 May 24 doi: 10.1002/mus.27567. PMID: 35607838
Quinn C, Elman L
Continuum (Minneap Minn) 2020 Oct;26(5):1323-1347. doi: 10.1212/CON.0000000000000911. PMID: 33003004
Pinto WBVR, Debona R, Nunes PP, Assis ACD, Lopes CG, Bortholin T, Dias RB, Naylor FGM, Chieia MAT, Souza PVS, Oliveira ASB
Rev Neurol (Paris) 2019 Apr;175(4):221-232. Epub 2019 Mar 4 doi: 10.1016/j.neurol.2018.04.016. PMID: 30846210
Foster LA, Salajegheh MK
Am J Med 2019 Jan;132(1):32-37. Epub 2018 Aug 1 doi: 10.1016/j.amjmed.2018.07.012. PMID: 30075105
Liewluck T, Saperstein DS
Neurol Clin 2015 Nov;33(4):761-73. doi: 10.1016/j.ncl.2015.07.005. PMID: 26515620

Therapy

Turner MR, Barohn RJ, Corcia P, Fink JK, Harms MB, Kiernan MC, Ravits J, Silani V, Simmons Z, Statland J, van den Berg LH; Delegates of the 2nd International PLS Conference, Mitsumoto H
J Neurol Neurosurg Psychiatry 2020 Apr;91(4):373-377. Epub 2020 Feb 6 doi: 10.1136/jnnp-2019-322541. PMID: 32029539Free PMC Article
Gibbons C, Pagnini F, Friede T, Young CA
Cochrane Database Syst Rev 2018 Jan 2;1(1):CD011005. doi: 10.1002/14651858.CD011005.pub2. PMID: 29293261Free PMC Article
Ng L, Khan F, Young CA, Galea M
Cochrane Database Syst Rev 2017 Jan 10;1(1):CD011776. doi: 10.1002/14651858.CD011776.pub2. PMID: 28072907Free PMC Article
Liewluck T, Saperstein DS
Neurol Clin 2015 Nov;33(4):761-73. doi: 10.1016/j.ncl.2015.07.005. PMID: 26515620
Miller RG, Mitchell JD, Moore DH
Cochrane Database Syst Rev 2012 Mar 14;2012(3):CD001447. doi: 10.1002/14651858.CD001447.pub3. PMID: 22419278Free PMC Article

Prognosis

Kwan J, Vullaganti M
Muscle Nerve 2022 Sep;66(3):240-252. Epub 2022 May 24 doi: 10.1002/mus.27567. PMID: 35607838
Blacher E, Bashiardes S, Shapiro H, Rothschild D, Mor U, Dori-Bachash M, Kleimeyer C, Moresi C, Harnik Y, Zur M, Zabari M, Brik RB, Kviatcovsky D, Zmora N, Cohen Y, Bar N, Levi I, Amar N, Mehlman T, Brandis A, Biton I, Kuperman Y, Tsoory M, Alfahel L, Harmelin A, Schwartz M, Israelson A, Arike L, Johansson MEV, Hansson GC, Gotkine M, Segal E, Elinav E
Nature 2019 Aug;572(7770):474-480. Epub 2019 Jul 22 doi: 10.1038/s41586-019-1443-5. PMID: 31330533
Foster LA, Salajegheh MK
Am J Med 2019 Jan;132(1):32-37. Epub 2018 Aug 1 doi: 10.1016/j.amjmed.2018.07.012. PMID: 30075105
Westeneng HJ, Debray TPA, Visser AE, van Eijk RPA, Rooney JPK, Calvo A, Martin S, McDermott CJ, Thompson AG, Pinto S, Kobeleva X, Rosenbohm A, Stubendorff B, Sommer H, Middelkoop BM, Dekker AM, van Vugt JJFA, van Rheenen W, Vajda A, Heverin M, Kazoka M, Hollinger H, Gromicho M, Körner S, Ringer TM, Rödiger A, Gunkel A, Shaw CE, Bredenoord AL, van Es MA, Corcia P, Couratier P, Weber M, Grosskreutz J, Ludolph AC, Petri S, de Carvalho M, Van Damme P, Talbot K, Turner MR, Shaw PJ, Al-Chalabi A, Chiò A, Hardiman O, Moons KGM, Veldink JH, van den Berg LH
Lancet Neurol 2018 May;17(5):423-433. Epub 2018 Mar 26 doi: 10.1016/S1474-4422(18)30089-9. PMID: 29598923
Bensimon G, Lacomblez L, Meininger V
N Engl J Med 1994 Mar 3;330(9):585-91. doi: 10.1056/NEJM199403033300901. PMID: 8302340

Clinical prediction guides

Youn CE, Lu C, Cauchi J, MacGowan D, Morgenstern R, Scelsa S
J Neuromuscul Dis 2023;10(3):405-410. doi: 10.3233/JND-221579. PMID: 36872786
Ashford BA, Boche D, Cooper-Knock J, Heath PR, Simpson JE, Highley JR
Neuropathol Appl Neurobiol 2021 Feb;47(2):179-197. Epub 2020 Jul 21 doi: 10.1111/nan.12640. PMID: 32594542
Pinto WBVR, Debona R, Nunes PP, Assis ACD, Lopes CG, Bortholin T, Dias RB, Naylor FGM, Chieia MAT, Souza PVS, Oliveira ASB
Rev Neurol (Paris) 2019 Apr;175(4):221-232. Epub 2019 Mar 4 doi: 10.1016/j.neurol.2018.04.016. PMID: 30846210
Ruffoli R, Biagioni F, Busceti CL, Gaglione A, Ryskalin L, Gambardella S, Frati A, Fornai F
Histol Histopathol 2017 Nov;32(11):1115-1123. Epub 2017 Apr 11 doi: 10.14670/HH-11-895. PMID: 28397197
Cedarbaum JM, Stambler N, Malta E, Fuller C, Hilt D, Thurmond B, Nakanishi A
J Neurol Sci 1999 Oct 31;169(1-2):13-21. doi: 10.1016/s0022-510x(99)00210-5. PMID: 10540002

Recent systematic reviews

Gibbons C, Pagnini F, Friede T, Young CA
Cochrane Database Syst Rev 2018 Jan 2;1(1):CD011005. doi: 10.1002/14651858.CD011005.pub2. PMID: 29293261Free PMC Article
Ng L, Khan F, Young CA, Galea M
Cochrane Database Syst Rev 2017 Jan 10;1(1):CD011776. doi: 10.1002/14651858.CD011776.pub2. PMID: 28072907Free PMC Article
Dal Bello-Haas V, Florence JM
Cochrane Database Syst Rev 2013 May 31;2013(5):CD005229. doi: 10.1002/14651858.CD005229.pub3. PMID: 23728653Free PMC Article
Miller RG, Mitchell JD, Moore DH
Cochrane Database Syst Rev 2012 Mar 14;2012(3):CD001447. doi: 10.1002/14651858.CD001447.pub3. PMID: 22419278Free PMC Article
Chou R, Peterson K, Helfand M
J Pain Symptom Manage 2004 Aug;28(2):140-75. doi: 10.1016/j.jpainsymman.2004.05.002. PMID: 15276195

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