Webbing or fusion of the fingers or toes, involving soft parts only or including bone structure. Bony fusions are referred to as "bony" syndactyly if the fusion occurs in a radio-ulnar axis. Fusions of bones of the fingers or toes in a proximo-distal axis are referred to as "symphalangism".

A toe that appears disproportionately short compared to the foot.

Severe mental retardation is defined as an intelligence quotient (IQ) in the range of 20-34.

Intellectual disability, previously referred to as mental retardation, is characterized by subnormal intellectual functioning that occurs during the developmental period. It is defined by an IQ score below 70.

Posterior positions and/or vertical shortening of the infraorbital and perialar regions, or increased concavity of the face and/or reduced nasolabial angle.

Decreased vertical distance from the vermilion border of the lower lip to the inferior-most point of the chin.

A form of strabismus with one or both eyes deviated outward.