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Joint laxity

MedGen UID:
39439
•Concept ID:
C0086437
•
Finding
Synonyms: Hypermobilities, Joint; Hypermobility, Joint; Joint Hypermobilities; Joint Hypermobility; Joint Laxities; Joint Laxity; Laxities, Joint; Laxity, Joint
SNOMED CT: Joint laxity (298203008)

Definition

Looseness or instability of a joint. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVJoint laxity

Professional guidelines

PubMed

CUX1-related neurodevelopmental disorder: deep insights into phenotype-genotype spectrum and underlying pathology.
Oppermann H, Marcos-Grañeda E, Weiss LA, Gurnett CA, Jelsig AM, Vineke SH, Isidor B, Mercier S, Magnussen K, Zacher P, Hashim M, Pagnamenta AT, Race S, Srivastava S, Frazier Z, Maiwald R, Pergande M, Milani D, Rinelli M, Levy J, Krey I, Fontana P, Lonardo F, Riley S, Kretzer J, Rankin J, Reis LM, Semina EV, Reuter MS, Scherer SW, Iascone M, Weis D, Fagerberg CR, Brasch-Andersen C, Hansen LK, Kuechler A, Noble N, Gardham A, Tenney J, Rathore G, Beck-Woedl S, Haack TB, Pavlidou DC, Atallah I, Vodopiutz J, Janecke AR, Hsieh TC, Lesmann H, Klinkhammer H, Krawitz PM, Lemke JR, Jamra RA, Nieto M, Tümer Z, Platzer K
Eur J Hum Genet 2023 Nov;31(11):1251-1260. Epub 2023 Aug 30 doi: 10.1038/s41431-023-01445-2. PMID: 37644171Free PMC Article
Pseudoachondroplasia: Phenotype and genotype in 11 Indian patients.
Jacob P, Bhavani GSL, Shah H, Galada C, Nampoothiri S, Kamath N, Phadke SR, Muranjan M, Datar CA, Shukla A, Girisha KM
Am J Med Genet A 2022 Mar;188(3):751-759. Epub 2021 Nov 9 doi: 10.1002/ajmg.a.62566. PMID: 34750995
Quadriceps arthrogenic muscle inhibition: neural mechanisms and treatment perspectives.
Rice DA, McNair PJ
Semin Arthritis Rheum 2010 Dec;40(3):250-66. Epub 2009 Dec 2 doi: 10.1016/j.semarthrit.2009.10.001. PMID: 19954822

Recent clinical studies

Etiology

Diagnosis and Management of Hypermobility Spectrum Disorders in Primary Care.
Atwell K, Michael W, Dubey J, James S, Martonffy A, Anderson S, Rudin N, Schrager S
J Am Board Fam Med 2021 Jul-Aug;34(4):838-848. doi: 10.3122/jabfm.2021.04.200374. PMID: 34312277
Sex Hormones and Tendon.
Hansen M, Kjaer M
Adv Exp Med Biol 2016;920:139-49. doi: 10.1007/978-3-319-33943-6_13. PMID: 27535256
Epidemiology of osteoarthritis.
Zhang Y, Jordan JM
Clin Geriatr Med 2010 Aug;26(3):355-69. doi: 10.1016/j.cger.2010.03.001. PMID: 20699159Free PMC Article
Quadriceps arthrogenic muscle inhibition: neural mechanisms and treatment perspectives.
Rice DA, McNair PJ
Semin Arthritis Rheum 2010 Dec;40(3):250-66. Epub 2009 Dec 2 doi: 10.1016/j.semarthrit.2009.10.001. PMID: 19954822
Osteoarthritis: new insights. Part 1: the disease and its risk factors.
Felson DT, Lawrence RC, Dieppe PA, Hirsch R, Helmick CG, Jordan JM, Kington RS, Lane NE, Nevitt MC, Zhang Y, Sowers M, McAlindon T, Spector TD, Poole AR, Yanovski SZ, Ateshian G, Sharma L, Buckwalter JA, Brandt KD, Fries JF
Ann Intern Med 2000 Oct 17;133(8):635-46. doi: 10.7326/0003-4819-133-8-200010170-00016. PMID: 11033593

Diagnosis

Loeys-Dietz Syndrome.
Velchev JD, Van Laer L, Luyckx I, Dietz H, Loeys B
Adv Exp Med Biol 2021;1348:251-264. doi: 10.1007/978-3-030-80614-9_11. PMID: 34807423
Diagnosis and Management of Hypermobility Spectrum Disorders in Primary Care.
Atwell K, Michael W, Dubey J, James S, Martonffy A, Anderson S, Rudin N, Schrager S
J Am Board Fam Med 2021 Jul-Aug;34(4):838-848. doi: 10.3122/jabfm.2021.04.200374. PMID: 34312277
Low Back Pain and Pelvic Girdle Pain in Pregnancy.
Casagrande D, Gugala Z, Clark SM, Lindsey RW
J Am Acad Orthop Surg 2015 Sep;23(9):539-49. Epub 2015 Aug 13 doi: 10.5435/JAAOS-D-14-00248. PMID: 26271756
Which screening tools can predict injury to the lower extremities in team sports?: a systematic review.
Dallinga JM, Benjaminse A, Lemmink KA
Sports Med 2012 Sep 1;42(9):791-815. doi: 10.1007/BF03262295. PMID: 22909185
Impact of joint laxity and hypermobility on the musculoskeletal system.
Wolf JM, Cameron KL, Owens BD
J Am Acad Orthop Surg 2011 Aug;19(8):463-71. doi: 10.5435/00124635-201108000-00002. PMID: 21807914

Therapy

Knee osteoarthritis, joint laxity and PROMs following conservative management versus surgical reconstruction for ACL rupture: a meta-analysis.
Migliorini F, Oliva F, Eschweiler J, Torsiello E, Hildebrand F, Maffulli N
Br Med Bull 2023 Apr 5;145(1):72-87. doi: 10.1093/bmb/ldac029. PMID: 36412118
Functional somatic syndromes and joint hypermobility: A systematic review and meta-analysis.
Chen G, Olver JS, Kanaan RA
J Psychosom Res 2021 Sep;148:110556. Epub 2021 Jun 24 doi: 10.1016/j.jpsychores.2021.110556. PMID: 34237584
Do External Supports Improve Dynamic Balance in Patients with Chronic Ankle Instability? A Network Meta-analysis.
Tsikopoulos K, Sidiropoulos K, Kitridis D, Cain Atc SM, Metaxiotis D, Ali A
Clin Orthop Relat Res 2020 Feb;478(2):359-377. doi: 10.1097/CORR.0000000000000946. PMID: 31625960Free PMC Article
Comparing the Effectiveness of Blood Flow Restriction and Traditional Heavy Load Resistance Training in the Post-Surgery Rehabilitation of Anterior Cruciate Ligament Reconstruction Patients: A UK National Health Service Randomised Controlled Trial.
Hughes L, Rosenblatt B, Haddad F, Gissane C, McCarthy D, Clarke T, Ferris G, Dawes J, Paton B, Patterson SD
Sports Med 2019 Nov;49(11):1787-1805. doi: 10.1007/s40279-019-01137-2. PMID: 31301034
Quadriceps arthrogenic muscle inhibition: neural mechanisms and treatment perspectives.
Rice DA, McNair PJ
Semin Arthritis Rheum 2010 Dec;40(3):250-66. Epub 2009 Dec 2 doi: 10.1016/j.semarthrit.2009.10.001. PMID: 19954822

Prognosis

CUX1-related neurodevelopmental disorder: deep insights into phenotype-genotype spectrum and underlying pathology.
Oppermann H, Marcos-Grañeda E, Weiss LA, Gurnett CA, Jelsig AM, Vineke SH, Isidor B, Mercier S, Magnussen K, Zacher P, Hashim M, Pagnamenta AT, Race S, Srivastava S, Frazier Z, Maiwald R, Pergande M, Milani D, Rinelli M, Levy J, Krey I, Fontana P, Lonardo F, Riley S, Kretzer J, Rankin J, Reis LM, Semina EV, Reuter MS, Scherer SW, Iascone M, Weis D, Fagerberg CR, Brasch-Andersen C, Hansen LK, Kuechler A, Noble N, Gardham A, Tenney J, Rathore G, Beck-Woedl S, Haack TB, Pavlidou DC, Atallah I, Vodopiutz J, Janecke AR, Hsieh TC, Lesmann H, Klinkhammer H, Krawitz PM, Lemke JR, Jamra RA, Nieto M, Tümer Z, Platzer K
Eur J Hum Genet 2023 Nov;31(11):1251-1260. Epub 2023 Aug 30 doi: 10.1038/s41431-023-01445-2. PMID: 37644171Free PMC Article
Which screening tools can predict injury to the lower extremities in team sports?: a systematic review.
Dallinga JM, Benjaminse A, Lemmink KA
Sports Med 2012 Sep 1;42(9):791-815. doi: 10.1007/BF03262295. PMID: 22909185
Epidemiology of osteoarthritis.
Zhang Y, Jordan JM
Clin Geriatr Med 2010 Aug;26(3):355-69. doi: 10.1016/j.cger.2010.03.001. PMID: 20699159Free PMC Article
Osteoarthritis: new insights. Part 1: the disease and its risk factors.
Felson DT, Lawrence RC, Dieppe PA, Hirsch R, Helmick CG, Jordan JM, Kington RS, Lane NE, Nevitt MC, Zhang Y, Sowers M, McAlindon T, Spector TD, Poole AR, Yanovski SZ, Ateshian G, Sharma L, Buckwalter JA, Brandt KD, Fries JF
Ann Intern Med 2000 Oct 17;133(8):635-46. doi: 10.7326/0003-4819-133-8-200010170-00016. PMID: 11033593
Knee injury patterns among men and women in collegiate basketball and soccer. NCAA data and review of literature.
Arendt E, Dick R
Am J Sports Med 1995 Nov-Dec;23(6):694-701. doi: 10.1177/036354659502300611. PMID: 8600737

Clinical prediction guides

Does Generalized Joint Laxity Affect Postoperative Alignment and Clinical Outcomes Following Medial Opening-Wedge High Tibial Osteotomy?
Kim MS, Kim JJ, Kang KH, Sin KJ, In Y
J Arthroplasty 2023 Apr;38(4):662-667. Epub 2022 Oct 27 doi: 10.1016/j.arth.2022.10.033. PMID: 36309143
Association Between Excessive Joint Laxity and a Wider Hill-Sachs Lesion in Anterior Shoulder Instability.
Lim JR, Lee HM, Yoon TH, Lee HM, Chun YM
Am J Sports Med 2021 Dec;49(14):3981-3987. Epub 2021 Oct 25 doi: 10.1177/03635465211049221. PMID: 34694163
Do External Supports Improve Dynamic Balance in Patients with Chronic Ankle Instability? A Network Meta-analysis.
Tsikopoulos K, Sidiropoulos K, Kitridis D, Cain Atc SM, Metaxiotis D, Ali A
Clin Orthop Relat Res 2020 Feb;478(2):359-377. doi: 10.1097/CORR.0000000000000946. PMID: 31625960Free PMC Article
Assessment of joint laxity in children and adolescents: a review of methods.
Czaprowski D, Kotwicki T, Stoliński L
Ortop Traumatol Rehabil 2012 Sep-Oct;14(5):407-20. doi: 10.5604/15093492.1016368. PMID: 23208932
Which screening tools can predict injury to the lower extremities in team sports?: a systematic review.
Dallinga JM, Benjaminse A, Lemmink KA
Sports Med 2012 Sep 1;42(9):791-815. doi: 10.1007/BF03262295. PMID: 22909185

Recent systematic reviews

Functional somatic syndromes and joint hypermobility: A systematic review and meta-analysis.
Chen G, Olver JS, Kanaan RA
J Psychosom Res 2021 Sep;148:110556. Epub 2021 Jun 24 doi: 10.1016/j.jpsychores.2021.110556. PMID: 34237584
Generalized Joint Laxity Is Associated With Increased Failure Rates of Primary Anterior Cruciate Ligament Reconstructions: A Systematic Review.
Krebs NM, Barber-Westin S, Noyes FR
Arthroscopy 2021 Jul;37(7):2337-2347. Epub 2021 Feb 20 doi: 10.1016/j.arthro.2021.02.021. PMID: 33621648
Do External Supports Improve Dynamic Balance in Patients with Chronic Ankle Instability? A Network Meta-analysis.
Tsikopoulos K, Sidiropoulos K, Kitridis D, Cain Atc SM, Metaxiotis D, Ali A
Clin Orthop Relat Res 2020 Feb;478(2):359-377. doi: 10.1097/CORR.0000000000000946. PMID: 31625960Free PMC Article
Risk factors for shoulder pain and injury in swimmers: A critical systematic review.
Hill L, Collins M, Posthumus M
Phys Sportsmed 2015 Nov;43(4):412-20. Epub 2015 Sep 14 doi: 10.1080/00913847.2015.1077097. PMID: 26366502
Which screening tools can predict injury to the lower extremities in team sports?: a systematic review.
Dallinga JM, Benjaminse A, Lemmink KA
Sports Med 2012 Sep 1;42(9):791-815. doi: 10.1007/BF03262295. PMID: 22909185

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    Related information

    • ClinVar
      Related medical variations
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      Related information in GTR
    • GTR(Clinical)
      Clinical tests in GTR
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