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Ectopic tissue

MedGen UID:
40280
•Concept ID:
C0008519
•
Pathologic Function
Synonym: Heterotopia
SNOMED CT: Heterotopic tissue (128490007); Heterotopia (128490007); Choristoma (417338002); Heterotopic structure, either congenital or acquired (128490007); Ectopic tissue (719446000); Aberrant tissue (719446000); Ectopia (719446000)

Definition

Proliferation of normal tissue in an anatomic site in which this particular type of tissue is not normally present. [from NCI]

Professional guidelines

PubMed

Mesenchymal stromal cells as treatment or prophylaxis for acute or chronic graft-versus-host disease in haematopoietic stem cell transplant (HSCT) recipients with a haematological condition.
Fisher SA, Cutler A, Doree C, Brunskill SJ, Stanworth SJ, Navarrete C, Girdlestone J
Cochrane Database Syst Rev 2019 Jan 30;1(1):CD009768. doi: 10.1002/14651858.CD009768.pub2. PMID: 30697701Free PMC Article
Safety of treatment with DLA-identical or unrelated mesenchymal stromal cells in DLA-identical canine bone marrow transplantation.
Kornblit B, Leisenring WM, Santos EB, Storb R, Sandmaier BM
Chimerism 2013 Jul-Sep;4(3):95-101. Epub 2013 May 29 doi: 10.4161/chim.25110. PMID: 23723082Free PMC Article
Mesenchymal stem cells for treatment of acute and chronic graft-versus-host disease, tissue toxicity and hemorrhages.
Ringden O, Le Blanc K
Best Pract Res Clin Haematol 2011 Mar;24(1):65-72. Epub 2011 Feb 25 doi: 10.1016/j.beha.2011.01.003. PMID: 21396594

Recent clinical studies

Etiology

Assessment of BMP7, SMAD4, and CDH1 Expression Profile and Regulatory miRNA-542-3p in Eutopic and Ectopic Endometrium of Women with Endometriosis.
Zubrzycka A, Migdalska-Sęk M, Jędrzejczyk S, Brzeziańska-Lasota E
Int J Mol Sci 2023 Apr 2;24(7) doi: 10.3390/ijms24076637. PMID: 37047609Free PMC Article
Overview of the 2022 WHO Classification of Adrenal Cortical Tumors.
Mete O, Erickson LA, Juhlin CC, de Krijger RR, Sasano H, Volante M, Papotti MG
Endocr Pathol 2022 Mar;33(1):155-196. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09710-8. PMID: 35288842Free PMC Article
Complications Following Stem Cell Therapy in Inflammatory Bowel Disease.
Wei H, Liu X, Ouyang C, Zhang J, Chen S, Lu F, Chen L
Curr Stem Cell Res Ther 2017;12(6):471-475. doi: 10.2174/1574888X12666170315105556. PMID: 28302045
Uterine Leukocyte Function and Dysfunction: A Hypothesis on the Impact of Endometriosis.
Parkin KL, Fazleabas AT
Am J Reprod Immunol 2016 Mar;75(3):411-7. Epub 2016 Jan 19 doi: 10.1111/aji.12487. PMID: 26782366Free PMC Article
Pancreatic and gastric heterotopy in the gastrointestinal tract.
Wlaź J, Mądro A, Kaźmierak W, Celiński K, Słomka M
Postepy Hig Med Dosw (Online) 2014 Sep 3;68:1069-75. doi: 10.5604/17322693.1119720. PMID: 25228515

Diagnosis

Biomarkers of endometriosis.
Pant A, Moar K, K Arora T, Maurya PK
Clin Chim Acta 2023 Sep 1;549:117563. Epub 2023 Sep 20 doi: 10.1016/j.cca.2023.117563. PMID: 37739024
Imaging Features of Ectopic Tissues and Their Complications: Embryologic and Anatomic Approach.
Kurokawa M, Kurokawa R, Tamura K, Baba A, Ota Y, Nakaya M, Yokoyama K, Kim J, Moritani T, Abe O
Radiographics 2023 Jun;43(6):e220111. doi: 10.1148/rg.220111. PMID: 37141139
Overview of the 2022 WHO Classification of Adrenal Cortical Tumors.
Mete O, Erickson LA, Juhlin CC, de Krijger RR, Sasano H, Volante M, Papotti MG
Endocr Pathol 2022 Mar;33(1):155-196. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09710-8. PMID: 35288842Free PMC Article
The Origin and Pathogenesis of Endometriosis.
Wang Y, Nicholes K, Shih IM
Annu Rev Pathol 2020 Jan 24;15:71-95. Epub 2019 Sep 3 doi: 10.1146/annurev-pathmechdis-012419-032654. PMID: 31479615Free PMC Article
Meckel's diverticulum.
Martin JP, Connor PD, Charles K
Am Fam Physician 2000 Feb 15;61(4):1037-42, 1044. PMID: 10706156

Therapy

Implication of biosignatures in the progression of endometriosis.
Pant A, Moar K, Arora TK, Maurya PK
Pathol Res Pract 2024 Feb;254:155103. Epub 2024 Jan 9 doi: 10.1016/j.prp.2024.155103. PMID: 38237401
INSPECT: A Retrospective Study to Evaluate Long-term Effectiveness and Safety of Darvadstrocel in Patients With Perianal Fistulizing Crohn's Disease Treated in the ADMIRE-CD Trial.
Panés J, Bouma G, Ferrante M, Kucharzik T, Nachury M, de la Portilla de Juan F, Reinisch W, Selvaggi F, Tschmelitsch J, Brett NR, Ladouceur M, Binek M, Hantsbarger G, Campbell-Hill S, Karki C, Buskens C
Inflamm Bowel Dis 2022 Nov 2;28(11):1737-1745. doi: 10.1093/ibd/izab361. PMID: 35099555Free PMC Article
Immune Regulation of the Metastatic Process: Implications for Therapy.
de Mingo Pulido A, Ruffell B
Adv Cancer Res 2016;132:139-63. Epub 2016 Jun 17 doi: 10.1016/bs.acr.2016.05.004. PMID: 27613132Free PMC Article
Medical treatments for endometriosis.
Kappou D, Matalliotakis M, Matalliotakis I
Minerva Ginecol 2010 Oct;62(5):415-32. PMID: 20938427
Vascular endothelial growth factor and endometriotic angiogenesis.
McLaren J
Hum Reprod Update 2000 Jan-Feb;6(1):45-55. doi: 10.1093/humupd/6.1.45. PMID: 10711829

Prognosis

Overview of the 2022 WHO Classification of Adrenal Cortical Tumors.
Mete O, Erickson LA, Juhlin CC, de Krijger RR, Sasano H, Volante M, Papotti MG
Endocr Pathol 2022 Mar;33(1):155-196. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09710-8. PMID: 35288842Free PMC Article
Ectopic mammary tissue in vulva: case report and systematic literature review.
Buitrago-Flechas SM, Barrera-Latorre SJ, Morante-Caicedo C
Rev Colomb Obstet Ginecol 2021 Sep 30;72(3):271-290. doi: 10.18597/rcog.3593. PMID: 34851570Free PMC Article
Mouse model for endometriosis is characterized by proliferation and inflammation but not epithelial-to-mesenchymal transition and fibrosis.
Mishra A, Galvankar M, Vaidya S, Chaudhari U, Modi D
J Biosci 2020;45 PMID: 32975232
Review of Endometriosis Diagnosis through Advances in Biomedical Engineering.
Shah R, Jagani RP
Crit Rev Biomed Eng 2018;46(3):277-288. doi: 10.1615/CritRevBiomedEng.2018027414. PMID: 30311558
Role of Epicardial Adipose Tissue in Health and Disease: A Matter of Fat?
Gaborit B, Sengenes C, Ancel P, Jacquier A, Dutour A
Compr Physiol 2017 Jun 18;7(3):1051-1082. doi: 10.1002/cphy.c160034. PMID: 28640452

Clinical prediction guides

Overview of the 2022 WHO Classification of Adrenal Cortical Tumors.
Mete O, Erickson LA, Juhlin CC, de Krijger RR, Sasano H, Volante M, Papotti MG
Endocr Pathol 2022 Mar;33(1):155-196. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09710-8. PMID: 35288842Free PMC Article
Immunological Basis of the Endometriosis: The Complement System as a Potential Therapeutic Target.
Agostinis C, Balduit A, Mangogna A, Zito G, Romano F, Ricci G, Kishore U, Bulla R
Front Immunol 2020;11:599117. Epub 2021 Jan 11 doi: 10.3389/fimmu.2020.599117. PMID: 33505394Free PMC Article
Role of Epicardial Adipose Tissue in Health and Disease: A Matter of Fat?
Gaborit B, Sengenes C, Ancel P, Jacquier A, Dutour A
Compr Physiol 2017 Jun 18;7(3):1051-1082. doi: 10.1002/cphy.c160034. PMID: 28640452
Complications Following Stem Cell Therapy in Inflammatory Bowel Disease.
Wei H, Liu X, Ouyang C, Zhang J, Chen S, Lu F, Chen L
Curr Stem Cell Res Ther 2017;12(6):471-475. doi: 10.2174/1574888X12666170315105556. PMID: 28302045
The endometrium in adenomyosis.
Benagiano G, Brosens I
Womens Health (Lond) 2012 May;8(3):301-12. doi: 10.2217/whe.12.8. PMID: 22554177

Recent systematic reviews

Ectopic mammary tissue in vulva: case report and systematic literature review.
Buitrago-Flechas SM, Barrera-Latorre SJ, Morante-Caicedo C
Rev Colomb Obstet Ginecol 2021 Sep 30;72(3):271-290. doi: 10.18597/rcog.3593. PMID: 34851570Free PMC Article
Mesenchymal stromal cells as treatment or prophylaxis for acute or chronic graft-versus-host disease in haematopoietic stem cell transplant (HSCT) recipients with a haematological condition.
Fisher SA, Cutler A, Doree C, Brunskill SJ, Stanworth SJ, Navarrete C, Girdlestone J
Cochrane Database Syst Rev 2019 Jan 30;1(1):CD009768. doi: 10.1002/14651858.CD009768.pub2. PMID: 30697701Free PMC Article
Systematic review of epidemiology, presentation, and management of Meckel's diverticulum in the 21st century.
Hansen CC, Søreide K
Medicine (Baltimore) 2018 Aug;97(35):e12154. doi: 10.1097/MD.0000000000012154. PMID: 30170459Free PMC Article
Abnormal peritoneal regulation of chemokine activation-The role of IL-8 in pathogenesis of endometriosis.
Sikora J, Smycz-Kubańska M, Mielczarek-Palacz A, Kondera-Anasz Z
Am J Reprod Immunol 2017 Apr;77(4) Epub 2017 Jan 25 doi: 10.1111/aji.12622. PMID: 28120482

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