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Bone fibrosarcoma

MedGen UID:
404782
•Concept ID:
C2733623
•
Neoplastic Process
Synonyms: Bone Fibrosarcoma; bone fibrosarcoma; bone tissue fibrosarcoma (disease); Fibrosarcoma of Bone; fibrosarcoma of bone; Fibrosarcoma of the Bone; fibrosarcoma of the bone
 
Monarch Initiative: MONDO:0002619

Definition

A usually aggressive malignant neoplasm arising from the bone. It is characterized by the presence of spindle-shaped fibroblasts and collagenous stroma formation in a herringbone growth pattern. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBone fibrosarcoma

Professional guidelines

PubMed

Biology and Management of High-Grade Chondrosarcoma: An Update on Targets and Treatment Options.
Tlemsani C, Larousserie F, De Percin S, Audard V, Hadjadj D, Chen J, Biau D, Anract P, Terris B, Goldwasser F, Pasmant E, Boudou-Rouquette P
Int J Mol Sci 2023 Jan 10;24(2) doi: 10.3390/ijms24021361. PMID: 36674874Free PMC Article
Management of Myxofibrosarcoma and Undifferentiated Pleomorphic Sarcoma.
Crago AM, Cardona K, Koseła-Paterczyk H, Rutkowski P
Surg Oncol Clin N Am 2022 Jul;31(3):419-430. doi: 10.1016/j.soc.2022.03.006. PMID: 35715142
Resveratrol in management of bone and spinal cancers.
Chen G, Xia H, Zhang ZG, Yu HL
Nat Prod Res 2019 Feb;33(4):516-526. Epub 2017 Oct 20 doi: 10.1080/14786419.2017.1389936. PMID: 29052449

Recent clinical studies

Etiology

Subsequent cancer in patients with Ewing's sarcoma.
Greene MH, Glaubiger DL, Mead GD, Fraumeni JF Jr
Cancer Treat Rep 1979 Nov-Dec;63(11-12):2043-6. PMID: 118804

Diagnosis

Recurrent adult-type fibrosarcoma of the frontal bone in a child.
Novello M, Di Rocco C, Tamburrini G, Frassanito P, Aguirre DT, Rosenberg AE, Coli A
Childs Nerv Syst 2016 Jun;32(6):1169-73. Epub 2016 Jan 7 doi: 10.1007/s00381-015-2998-6. PMID: 26743922
Primary fibrosarcoma and malignant fibrous histiocytoma of bone--a comparative ultrastructural study: evidence of a spectrum of fibroblastic differentiation.
Antonescu CR, Erlandson RA, Huvos AG
Ultrastruct Pathol 2000 Mar-Apr;24(2):83-91. doi: 10.1080/01913120050118558. PMID: 10808553

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