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Malignant ear neoplasm

MedGen UID:
418247
•Concept ID:
C2350059
•
Neoplastic Process
Synonyms: Cancer of Ear; Cancer of the Ear; Ear Cancer
SNOMED CT: Malignant neoplasm of ear (443648003)
 
Monarch Initiative: MONDO:0003277

Definition

A malignant neoplasm that affects the ear. Representative examples include ceruminous adenocarcinoma and squamous cell carcinoma of the external ear and adenocarcinoma of the middle ear. [from NCI]

Professional guidelines

PubMed

2021 American Thyroid Association Guidelines for Management of Patients with Anaplastic Thyroid Cancer.
Bible KC, Kebebew E, Brierley J, Brito JP, Cabanillas ME, Clark TJ Jr, Di Cristofano A, Foote R, Giordano T, Kasperbauer J, Newbold K, Nikiforov YE, Randolph G, Rosenthal MS, Sawka AM, Shah M, Shaha A, Smallridge R, Wong-Clark CK
Thyroid 2021 Mar;31(3):337-386. doi: 10.1089/thy.2020.0944. PMID: 33728999Free PMC Article
Management of locally recurrent nasopharyngeal carcinoma.
Lee AWM, Ng WT, Chan JYW, Corry J, Mäkitie A, Mendenhall WM, Rinaldo A, Rodrigo JP, Saba NF, Strojan P, Suárez C, Vermorken JB, Yom SS, Ferlito A
Cancer Treat Rev 2019 Sep;79:101890. Epub 2019 Aug 21 doi: 10.1016/j.ctrv.2019.101890. PMID: 31470314
2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer.
Haugen BR, Alexander EK, Bible KC, Doherty GM, Mandel SJ, Nikiforov YE, Pacini F, Randolph GW, Sawka AM, Schlumberger M, Schuff KG, Sherman SI, Sosa JA, Steward DL, Tuttle RM, Wartofsky L
Thyroid 2016 Jan;26(1):1-133. doi: 10.1089/thy.2015.0020. PMID: 26462967Free PMC Article

Recent clinical studies

Etiology

Treatment Strategies for Malignancies of the External Auditory Canal.
Zhong S, Zuo W
Curr Treat Options Oncol 2022 Jan;23(1):43-53. Epub 2022 Feb 15 doi: 10.1007/s11864-021-00931-3. PMID: 35167009Free PMC Article
Ear canal and middle-ear tumors: a single-institution series of 87 patients.
Nicoli TK, Atula T, Sinkkonen ST, Korpi J, Vnencak M, Tarkkanen J, Mäkitie AA, Jero J
Acta Otolaryngol 2022 Feb;142(2):132-139. Epub 2022 Feb 11 doi: 10.1080/00016489.2022.2032824. PMID: 35148225
Nevi of special sites.
Mason AR, Mohr MR, Koch LH, Hood AF
Clin Lab Med 2011 Jun;31(2):229-42. doi: 10.1016/j.cll.2011.03.001. PMID: 21549237
Middle ear meningiomas.
Prayson RA
Ann Diagn Pathol 2000 Jun;4(3):149-53. doi: 10.1016/s1092-9134(00)90037-6. PMID: 10919384
Intracanalicular acoustic neurinomas.
Samii M, Matthies C, Tatagiba M
Neurosurgery 1991 Aug;29(2):189-98; discussion 198-9. doi: 10.1097/00006123-199108000-00004. PMID: 1886656

Diagnosis

Neoplasms of the Ear Canal.
Raymond M
Otolaryngol Clin North Am 2023 Oct;56(5):965-976. Epub 2023 Jul 24 doi: 10.1016/j.otc.2023.06.003. PMID: 37495430
Middle ear adenoma: Cytohistologic features and differential diagnosis.
Almajnooni A, Vega M, Cheng L, Gattuso P, Allen-Proctor MK
Diagn Cytopathol 2023 Apr;51(4):E137-E141. Epub 2023 Jan 23 doi: 10.1002/dc.25103. PMID: 36688374
Ear canal and middle-ear tumors: a single-institution series of 87 patients.
Nicoli TK, Atula T, Sinkkonen ST, Korpi J, Vnencak M, Tarkkanen J, Mäkitie AA, Jero J
Acta Otolaryngol 2022 Feb;142(2):132-139. Epub 2022 Feb 11 doi: 10.1080/00016489.2022.2032824. PMID: 35148225
Acquired ear defects.
Elsahy NI
Clin Plast Surg 2002 Apr;29(2):175-86, v-vi. doi: 10.1016/s0094-1298(01)00002-5. PMID: 12120675
Temporal bone carcinoma.
Barrs DM
Otolaryngol Clin North Am 2001 Dec;34(6):1197-218, x. doi: 10.1016/s0030-6665(05)70374-1. PMID: 11728941

Therapy

Effectiveness of Electroacupuncture or Auricular Acupuncture vs Usual Care for Chronic Musculoskeletal Pain Among Cancer Survivors: The PEACE Randomized Clinical Trial.
Mao JJ, Liou KT, Baser RE, Bao T, Panageas KS, Romero SAD, Li QS, Gallagher RM, Kantoff PW
JAMA Oncol 2021 May 1;7(5):720-727. doi: 10.1001/jamaoncol.2021.0310. PMID: 33734288Free PMC Article
Mushroom extracts and compounds with suppressive action on breast cancer: evidence from studies using cultured cancer cells, tumor-bearing animals, and clinical trials.
Wong JH, Ng TB, Chan HHL, Liu Q, Man GCW, Zhang CZ, Guan S, Ng CCW, Fang EF, Wang H, Liu F, Ye X, Rolka K, Naude R, Zhao S, Sha O, Li C, Xia L
Appl Microbiol Biotechnol 2020 Jun;104(11):4675-4703. Epub 2020 Apr 9 doi: 10.1007/s00253-020-10476-4. PMID: 32274562
Effectiveness of auricular acupuncture in the treatment of cancer pain: randomized clinical trial.
Ruela LO, Iunes DH, Nogueira DA, Stefanello J, Gradim CVC
Rev Esc Enferm USP 2018 Dec 13;52:e03402. doi: 10.1590/S1980-220X2017040503402. PMID: 30570087
Vagolysis.
Hutchinson CD, Jardine DL, Hurrell M
Age Ageing 2008 Sep;37(5):602-4. Epub 2008 Jun 12 doi: 10.1093/ageing/afn105. PMID: 18556705
Temporal bone resection.
Willging JP, Pensak ML
Ear Nose Throat J 1991 Sep;70(9):612-7. PMID: 1743111

Prognosis

Treatment Strategies for Malignancies of the External Auditory Canal.
Zhong S, Zuo W
Curr Treat Options Oncol 2022 Jan;23(1):43-53. Epub 2022 Feb 15 doi: 10.1007/s11864-021-00931-3. PMID: 35167009Free PMC Article
A systematic review on external ear melanoma.
Toia F, Garbo G, Tripoli M, Rinaldi G, Moschella F, Cordova A
J Plast Reconstr Aesthet Surg 2015 Jul;68(7):883-94. Epub 2015 Apr 20 doi: 10.1016/j.bjps.2015.04.003. PMID: 25971418
Adenomatous tumors of the middle ear.
Pelosi S, Koss S
Otolaryngol Clin North Am 2015 Apr;48(2):305-15. doi: 10.1016/j.otc.2014.12.005. PMID: 25769353
Glomus tympanicum tumors.
Sweeney AD, Carlson ML, Wanna GB, Bennett ML
Otolaryngol Clin North Am 2015 Apr;48(2):293-304. Epub 2015 Feb 4 doi: 10.1016/j.otc.2014.12.004. PMID: 25659513
Middle ear adenoma.
Berns S, Pearl G
Arch Pathol Lab Med 2006 Jul;130(7):1067-9. doi: 10.5858/2006-130-1067-MEA. PMID: 16831038

Clinical prediction guides

Symptoms and clinical features in patients affected by endolymphatic sac tumor: a systematic review and meta-analysis.
Gioacchini FM, Kaleci S, Chiarella G, Viola P, Pisani D, Scarpa A, Tulli M, Pace A, Iannella G, Re M
Eur Arch Otorhinolaryngol 2022 Nov;279(11):5081-5088. Epub 2022 Jun 15 doi: 10.1007/s00405-022-07469-6. PMID: 35704074
External auditory canal carcinoma: clinical characteristics and long-term treatment outcomes.
Correia-Rodrigues P, Ramalho S, Montalvão P, Magalhães M
Eur Arch Otorhinolaryngol 2020 Oct;277(10):2709-2720. Epub 2020 May 4 doi: 10.1007/s00405-020-06019-2. PMID: 32367152
Single-Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Head and Neck Cancer.
Puram SV, Tirosh I, Parikh AS, Patel AP, Yizhak K, Gillespie S, Rodman C, Luo CL, Mroz EA, Emerick KS, Deschler DG, Varvares MA, Mylvaganam R, Rozenblatt-Rosen O, Rocco JW, Faquin WC, Lin DT, Regev A, Bernstein BE
Cell 2017 Dec 14;171(7):1611-1624.e24. Epub 2017 Nov 30 doi: 10.1016/j.cell.2017.10.044. PMID: 29198524Free PMC Article
2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer.
Haugen BR, Alexander EK, Bible KC, Doherty GM, Mandel SJ, Nikiforov YE, Pacini F, Randolph GW, Sawka AM, Schlumberger M, Schuff KG, Sherman SI, Sosa JA, Steward DL, Tuttle RM, Wartofsky L
Thyroid 2016 Jan;26(1):1-133. doi: 10.1089/thy.2015.0020. PMID: 26462967Free PMC Article
Lymphoepithelial-like carcinomas of the head and neck.
Wenig BM
Semin Diagn Pathol 2015 Jan;32(1):74-86. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.004. PMID: 25804344

Recent systematic reviews

Hyperbaric oxygen therapy for late radiation tissue injury.
Lin ZC, Bennett MH, Hawkins GC, Azzopardi CP, Feldmeier J, Smee R, Milross C
Cochrane Database Syst Rev 2023 Aug 15;8(8):CD005005. doi: 10.1002/14651858.CD005005.pub5. PMID: 37585677Free PMC Article
Artificial Intelligence in Head and Neck Cancer: A Systematic Review of Systematic Reviews.
Mäkitie AA, Alabi RO, Ng SP, Takes RP, Robbins KT, Ronen O, Shaha AR, Bradley PJ, Saba NF, Nuyts S, Triantafyllou A, Piazza C, Rinaldo A, Ferlito A
Adv Ther 2023 Aug;40(8):3360-3380. Epub 2023 Jun 8 doi: 10.1007/s12325-023-02527-9. PMID: 37291378Free PMC Article
Managing Cachexia in Head and Neck Cancer: a Systematic Scoping Review.
Mäkitie AA, Alabi RO, Orell H, Youssef O, Almangush A, Homma A, Takes RP, López F, de Bree R, Rodrigo JP, Ferlito A
Adv Ther 2022 Apr;39(4):1502-1523. Epub 2022 Feb 27 doi: 10.1007/s12325-022-02074-9. PMID: 35224702Free PMC Article
2021 American Thyroid Association Guidelines for Management of Patients with Anaplastic Thyroid Cancer.
Bible KC, Kebebew E, Brierley J, Brito JP, Cabanillas ME, Clark TJ Jr, Di Cristofano A, Foote R, Giordano T, Kasperbauer J, Newbold K, Nikiforov YE, Randolph G, Rosenthal MS, Sawka AM, Shah M, Shaha A, Smallridge R, Wong-Clark CK
Thyroid 2021 Mar;31(3):337-386. doi: 10.1089/thy.2020.0944. PMID: 33728999Free PMC Article
Risk Factors for Cutaneous Squamous Cell Carcinoma Recurrence, Metastasis, and Disease-Specific Death: A Systematic Review and Meta-analysis.
Thompson AK, Kelley BF, Prokop LJ, Murad MH, Baum CL
JAMA Dermatol 2016 Apr;152(4):419-28. doi: 10.1001/jamadermatol.2015.4994. PMID: 26762219Free PMC Article

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