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Fox-Fordyce disease

MedGen UID:
42092
•Concept ID:
C0016632
•
Disease or Syndrome
Synonyms: Fox-Fordyce syndrome; Miliaria, apocrine
SNOMED CT: Fox-Fordyce disease (65038009); Apocrine miliaria (65038009); Fox Fordyce disease (65038009)
 
Monarch Initiative: MONDO:0006553

Definition

A chronic inflammatory skin disorder characterized by pruritic papular eruptions in areas with apocrine glands. It usually affects the axillae bilaterally. There is rupture of the apocrine ducts resulting in inflammation and formation of the papular skin lesions. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFox-Fordyce disease

Professional guidelines

PubMed

Pathophysiology, clinical findings, and management of Fox-Fordyce disease: A systematic review.
Salloum A, Bouferraa Y, Bazzi N, Bou Zerdan M, Abi Chebl J, Chu T, Bachour J, Benedetto A
J Cosmet Dermatol 2022 Feb;21(2):482-500. Epub 2021 Apr 18 doi: 10.1111/jocd.14135. PMID: 33817950
Treatment of pruritus with botulinum toxin in a pediatric patient with Fox-Fordyce disease.
Klager S, Kumar MG
Pediatr Dermatol 2021 Jul;38(4):950-951. Epub 2021 Jun 1 doi: 10.1111/pde.14552. PMID: 34060125
Treatment of Fox-Fordyce disease.
Pinkus H
JAMA 1973 Feb 19;223(8):924. doi: 10.1001/jama.1973.03220080054025. PMID: 4739247

Recent clinical studies

Etiology

Fox-Fordyce disease exacerbated by hyperhidrosis.
Alikhan A, Gorouhi F, Zargari O
Pediatr Dermatol 2010 Mar-Apr;27(2):162-5. doi: 10.1111/j.1525-1470.2010.01102.x. PMID: 20537067
Apoeccrine sweat duct obstruction as a cause for Fox-Fordyce disease.
Kamada A, Saga K, Jimbow K
J Am Acad Dermatol 2003 Mar;48(3):453-5. doi: 10.1067/mjd.2003.93. PMID: 12637930
Fox-Fordyce disease in the post-menopausal period treated successfully with electrocoagulation.
Pasricha JS, Nayyar KC
Dermatologica 1973;147(4):271-3. doi: 10.1159/000251880. PMID: 4780778

Diagnosis

Pathophysiology, clinical findings, and management of Fox-Fordyce disease: A systematic review.
Salloum A, Bouferraa Y, Bazzi N, Bou Zerdan M, Abi Chebl J, Chu T, Bachour J, Benedetto A
J Cosmet Dermatol 2022 Feb;21(2):482-500. Epub 2021 Apr 18 doi: 10.1111/jocd.14135. PMID: 33817950
Inflammatory and glandular skin disease in pregnancy.
Yang CS, Teeple M, Muglia J, Robinson-Bostom L
Clin Dermatol 2016 May-Jun;34(3):335-43. Epub 2016 Feb 11 doi: 10.1016/j.clindermatol.2016.02.005. PMID: 27265071
Fox-Fordyce Disease: An under-diagnosed adverse event of laser hair removal?
Sammour R, Nasser S, Debahy N, El Habr C
J Eur Acad Dermatol Venereol 2016 Sep;30(9):1578-82. Epub 2016 May 2 doi: 10.1111/jdv.13680. PMID: 27135989
Histopathology attributes of Fox-Fordyce disease.
Brau Javier CN, Morales A, Sanchez JL
Int J Dermatol 2012 Nov;51(11):1313-8. doi: 10.1111/j.1365-4632.2011.05236.x. PMID: 23067079
Fox-Fordyce disease: response to adapalene 0.1%.
Kassuga LE, Medrado MM, Chevrand NS, Salles Sde A, Vilar EG
An Bras Dermatol 2012 Mar-Apr;87(2):329-31. doi: 10.1590/s0365-05962012000200029. PMID: 22570049

Therapy

Adverse Events of Light-Assisted Hair Removal: An Updated Review.
Mallat F, Chaaya C, Aoun M, Soutou B, Helou J
J Cutan Med Surg 2023 Jul-Aug;27(4):375-387. Epub 2023 Jun 5 doi: 10.1177/12034754231174852. PMID: 37272371
Pathophysiology, clinical findings, and management of Fox-Fordyce disease: A systematic review.
Salloum A, Bouferraa Y, Bazzi N, Bou Zerdan M, Abi Chebl J, Chu T, Bachour J, Benedetto A
J Cosmet Dermatol 2022 Feb;21(2):482-500. Epub 2021 Apr 18 doi: 10.1111/jocd.14135. PMID: 33817950
Fox-Fordyce Disease: An under-diagnosed adverse event of laser hair removal?
Sammour R, Nasser S, Debahy N, El Habr C
J Eur Acad Dermatol Venereol 2016 Sep;30(9):1578-82. Epub 2016 May 2 doi: 10.1111/jdv.13680. PMID: 27135989
Fox-Fordyce disease.
Yost J, Robinson M, Meehan SA
Dermatol Online J 2012 Dec 15;18(12):28. PMID: 23286818
Fox-Fordyce disease: response to adapalene 0.1%.
Kassuga LE, Medrado MM, Chevrand NS, Salles Sde A, Vilar EG
An Bras Dermatol 2012 Mar-Apr;87(2):329-31. doi: 10.1590/s0365-05962012000200029. PMID: 22570049

Prognosis

Pathophysiology, clinical findings, and management of Fox-Fordyce disease: A systematic review.
Salloum A, Bouferraa Y, Bazzi N, Bou Zerdan M, Abi Chebl J, Chu T, Bachour J, Benedetto A
J Cosmet Dermatol 2022 Feb;21(2):482-500. Epub 2021 Apr 18 doi: 10.1111/jocd.14135. PMID: 33817950
Inflammatory and glandular skin disease in pregnancy.
Yang CS, Teeple M, Muglia J, Robinson-Bostom L
Clin Dermatol 2016 May-Jun;34(3):335-43. Epub 2016 Feb 11 doi: 10.1016/j.clindermatol.2016.02.005. PMID: 27265071
Apoeccrine sweat duct obstruction as a cause for Fox-Fordyce disease.
Kamada A, Saga K, Jimbow K
J Am Acad Dermatol 2003 Mar;48(3):453-5. doi: 10.1067/mjd.2003.93. PMID: 12637930
Fox-Fordyce disease in the post-menopausal period treated successfully with electrocoagulation.
Pasricha JS, Nayyar KC
Dermatologica 1973;147(4):271-3. doi: 10.1159/000251880. PMID: 4780778

Clinical prediction guides

Adverse Events of Light-Assisted Hair Removal: An Updated Review.
Mallat F, Chaaya C, Aoun M, Soutou B, Helou J
J Cutan Med Surg 2023 Jul-Aug;27(4):375-387. Epub 2023 Jun 5 doi: 10.1177/12034754231174852. PMID: 37272371
Inflammatory and glandular skin disease in pregnancy.
Yang CS, Teeple M, Muglia J, Robinson-Bostom L
Clin Dermatol 2016 May-Jun;34(3):335-43. Epub 2016 Feb 11 doi: 10.1016/j.clindermatol.2016.02.005. PMID: 27265071
Fox-Fordyce disease: response to adapalene 0.1%.
Kassuga LE, Medrado MM, Chevrand NS, Salles Sde A, Vilar EG
An Bras Dermatol 2012 Mar-Apr;87(2):329-31. doi: 10.1590/s0365-05962012000200029. PMID: 22570049
Fox-Fordyce disease following axillary laser hair removal.
Tetzlaff MT, Evans K, DeHoratius DM, Weiss R, Cotsarelis G, Elenitsas R
Arch Dermatol 2011 May;147(5):573-6. doi: 10.1001/archdermatol.2011.103. PMID: 21576577
Perifollicular xanthomatosis as the hallmark of axillary Fox-Fordyce disease: an evaluation of histopathologic features of 7 cases.
Bormate AB Jr, Leboit PE, McCalmont TH
Arch Dermatol 2008 Aug;144(8):1020-4. doi: 10.1001/archinternmed.2008.3. PMID: 18711075

Recent systematic reviews

Pathophysiology, clinical findings, and management of Fox-Fordyce disease: A systematic review.
Salloum A, Bouferraa Y, Bazzi N, Bou Zerdan M, Abi Chebl J, Chu T, Bachour J, Benedetto A
J Cosmet Dermatol 2022 Feb;21(2):482-500. Epub 2021 Apr 18 doi: 10.1111/jocd.14135. PMID: 33817950

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