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Primary angle-closure glaucoma

MedGen UID:
42225
•Concept ID:
C0017606
•
Disease or Syndrome
Synonyms: primary angle closure glaucoma; primary angle-closure glaucoma
SNOMED CT: Primary angle-closure glaucoma (392288006)
 
Monarch Initiative: MONDO:0001868

Definition

An angle-closure glaucoma characterized by closure of the anterior chamber angle by an intrinsic defect such that aqueous outflow is blocked and the intraocular pressure becomes inappropriately elevated leading to optic nerve damage and visual field loss. Primary angle-closure glaucoma has symptom progressive peripheral vision loss, decreased vision, and pain, redness, and headache in acute cases. Primary angle closure glaucoma can be caused by anatomically narrow angle, defects in the trabecular meshwork, and iris abnormalities. Primary angle-closure glaucoma has a strong genetic component. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  

Professional guidelines

PubMed

Genetics and genetic testing for glaucoma.
Miller MA, Fingert JH, Bettis DI
Curr Opin Ophthalmol 2017 Mar;28(2):133-138. doi: 10.1097/ICU.0000000000000344. PMID: 27898466
Effectiveness of early lens extraction for the treatment of primary angle-closure glaucoma (EAGLE): a randomised controlled trial.
Azuara-Blanco A, Burr J, Ramsay C, Cooper D, Foster PJ, Friedman DS, Scotland G, Javanbakht M, Cochrane C, Norrie J; EAGLE study group
Lancet 2016 Oct 1;388(10052):1389-1397. doi: 10.1016/S0140-6736(16)30956-4. PMID: 27707497
PLATEAU IRIS--DIAGNOSIS AND TREATMENT.
Stefan C, Iliescu DA, Batras M, Timaru CM, De Simone A
Rom J Ophthalmol 2015 Jan-Mar;59(1):14-8. PMID: 27373109Free PMC Article

Recent clinical studies

Etiology

Ankylosing spondylitis and glaucoma in European population: A Mendelian randomization study.
Li S, Chen M, Zhang Q, Fang M, Xiong W, Bai L
Front Immunol 2023;14:1120742. Epub 2023 Mar 20 doi: 10.3389/fimmu.2023.1120742. PMID: 37020551Free PMC Article
Laser peripheral iridotomy for the prevention of angle closure: a single-centre, randomised controlled trial.
He M, Jiang Y, Huang S, Chang DS, Munoz B, Aung T, Foster PJ, Friedman DS
Lancet 2019 Apr 20;393(10181):1609-1618. Epub 2019 Mar 14 doi: 10.1016/S0140-6736(18)32607-2. PMID: 30878226
Genetics of glaucoma.
Wiggs JL, Pasquale LR
Hum Mol Genet 2017 Aug 1;26(R1):R21-R27. doi: 10.1093/hmg/ddx184. PMID: 28505344Free PMC Article
Glaucoma.
Gupta D, Chen PP
Am Fam Physician 2016 Apr 15;93(8):668-74. PMID: 27175839
Primary angle-closure glaucoma: an update.
Wright C, Tawfik MA, Waisbourd M, Katz LJ
Acta Ophthalmol 2016 May;94(3):217-25. Epub 2015 Jun 27 doi: 10.1111/aos.12784. PMID: 26119516

Diagnosis

Glaucoma.
Jonas JB, Aung T, Bourne RR, Bron AM, Ritch R, Panda-Jonas S
Lancet 2017 Nov 11;390(10108):2183-2193. Epub 2017 May 31 doi: 10.1016/S0140-6736(17)31469-1. PMID: 28577860
Genetics of glaucoma.
Wiggs JL, Pasquale LR
Hum Mol Genet 2017 Aug 1;26(R1):R21-R27. doi: 10.1093/hmg/ddx184. PMID: 28505344Free PMC Article
Primary angle closure glaucoma: What we know and what we don't know.
Sun X, Dai Y, Chen Y, Yu DY, Cringle SJ, Chen J, Kong X, Wang X, Jiang C
Prog Retin Eye Res 2017 Mar;57:26-45. Epub 2016 Dec 28 doi: 10.1016/j.preteyeres.2016.12.003. PMID: 28039061
Glaucoma.
Gupta D, Chen PP
Am Fam Physician 2016 Apr 15;93(8):668-74. PMID: 27175839
Primary angle-closure glaucoma: an update.
Wright C, Tawfik MA, Waisbourd M, Katz LJ
Acta Ophthalmol 2016 May;94(3):217-25. Epub 2015 Jun 27 doi: 10.1111/aos.12784. PMID: 26119516

Therapy

Causal association between common rheumatic diseases and glaucoma: a Mendelian randomization study.
Meng Y, Tan Z, Su Y, Li L, Chen C
Front Immunol 2023;14:1227138. Epub 2023 Sep 19 doi: 10.3389/fimmu.2023.1227138. PMID: 37799717Free PMC Article
Ankylosing spondylitis and glaucoma in European population: A Mendelian randomization study.
Li S, Chen M, Zhang Q, Fang M, Xiong W, Bai L
Front Immunol 2023;14:1120742. Epub 2023 Mar 20 doi: 10.3389/fimmu.2023.1120742. PMID: 37020551Free PMC Article
Laser peripheral iridotomy for the prevention of angle closure: a single-centre, randomised controlled trial.
He M, Jiang Y, Huang S, Chang DS, Munoz B, Aung T, Foster PJ, Friedman DS
Lancet 2019 Apr 20;393(10181):1609-1618. Epub 2019 Mar 14 doi: 10.1016/S0140-6736(18)32607-2. PMID: 30878226
Simplifying "target" intraocular pressure for different stages of primary open-angle glaucoma and primary angle-closure glaucoma.
Sihota R, Angmo D, Ramaswamy D, Dada T
Indian J Ophthalmol 2018 Apr;66(4):495-505. doi: 10.4103/ijo.IJO_1130_17. PMID: 29582808Free PMC Article
Glaucoma.
Gupta D, Chen PP
Am Fam Physician 2016 Apr 15;93(8):668-74. PMID: 27175839

Prognosis

Rethinking Prophylactic Laser Peripheral Iridotomy in Primary Angle-Closure Suspects: A Review.
Filippopoulos T, Danias J, Karmiris E, Mégevand GS, Rhee DJ, Gazzard G, Topouzis F, Xu B
Ophthalmol Glaucoma 2023 Nov-Dec;6(6):657-667. Epub 2023 Jun 13 doi: 10.1016/j.ogla.2023.06.004. PMID: 37321374
Iris clues in ACG.
Singh K, Singh A, Bhattacharyya M
Int Ophthalmol 2021 May;41(5):1959-1964. Epub 2021 Feb 23 doi: 10.1007/s10792-021-01740-1. PMID: 33620668
Iris and its relevance to angle closure disease: a review.
Soh ZD, Thakur S, Majithia S, Nongpiur ME, Cheng CY
Br J Ophthalmol 2021 Jan;105(1):3-8. Epub 2020 Mar 19 doi: 10.1136/bjophthalmol-2020-316075. PMID: 32193222
Glaucoma.
Jonas JB, Aung T, Bourne RR, Bron AM, Ritch R, Panda-Jonas S
Lancet 2017 Nov 11;390(10108):2183-2193. Epub 2017 May 31 doi: 10.1016/S0140-6736(17)31469-1. PMID: 28577860
Primary angle closure glaucoma: What we know and what we don't know.
Sun X, Dai Y, Chen Y, Yu DY, Cringle SJ, Chen J, Kong X, Wang X, Jiang C
Prog Retin Eye Res 2017 Mar;57:26-45. Epub 2016 Dec 28 doi: 10.1016/j.preteyeres.2016.12.003. PMID: 28039061

Clinical prediction guides

Causal association between common rheumatic diseases and glaucoma: a Mendelian randomization study.
Meng Y, Tan Z, Su Y, Li L, Chen C
Front Immunol 2023;14:1227138. Epub 2023 Sep 19 doi: 10.3389/fimmu.2023.1227138. PMID: 37799717Free PMC Article
Risk Factors for Primary Angle-closure Glaucoma: A Systematic Review and Meta-analysis of 45 Studies.
Wang Y, Dong XX, Hou XW, Pan CW
Optom Vis Sci 2023 Sep 1;100(9):606-613. Epub 2023 Sep 26 doi: 10.1097/OPX.0000000000002050. PMID: 37747945
Iris clues in ACG.
Singh K, Singh A, Bhattacharyya M
Int Ophthalmol 2021 May;41(5):1959-1964. Epub 2021 Feb 23 doi: 10.1007/s10792-021-01740-1. PMID: 33620668
Iris and its relevance to angle closure disease: a review.
Soh ZD, Thakur S, Majithia S, Nongpiur ME, Cheng CY
Br J Ophthalmol 2021 Jan;105(1):3-8. Epub 2020 Mar 19 doi: 10.1136/bjophthalmol-2020-316075. PMID: 32193222
Laser peripheral iridotomy for the prevention of angle closure: a single-centre, randomised controlled trial.
He M, Jiang Y, Huang S, Chang DS, Munoz B, Aung T, Foster PJ, Friedman DS
Lancet 2019 Apr 20;393(10181):1609-1618. Epub 2019 Mar 14 doi: 10.1016/S0140-6736(18)32607-2. PMID: 30878226

Recent systematic reviews

Risk Factors for Primary Angle-closure Glaucoma: A Systematic Review and Meta-analysis of 45 Studies.
Wang Y, Dong XX, Hou XW, Pan CW
Optom Vis Sci 2023 Sep 1;100(9):606-613. Epub 2023 Sep 26 doi: 10.1097/OPX.0000000000002050. PMID: 37747945
Iridotomy to slow progression of visual field loss in angle-closure glaucoma.
Rouse B, Le JT, Gazzard G
Cochrane Database Syst Rev 2023 Jan 9;1(1):CD012270. doi: 10.1002/14651858.CD012270.pub3. PMID: 36621864Free PMC Article
Genetic Associations of Primary Angle-Closure Disease: A Systematic Review and Meta-analysis.
Rong SS, Tang FY, Chu WK, Ma L, Yam JC, Tang SM, Li J, Gu H, Young AL, Tham CC, Pang CP, Chen LJ
Ophthalmology 2016 Jun;123(6):1211-21. Epub 2016 Feb 4 doi: 10.1016/j.ophtha.2015.12.027. PMID: 26854036
Guidelines for treatment of chronic primary angle-closure glaucoma.
Muñoz-Negrete FJ, González-Martín-Moro J, Casas-Llera P, Urcelay-Segura JL, Rebolleda G, Ussa F, Güerri Monclús N, Méndez Hernández C, Moreno-Montañés J, Villegas Pérez MP, Pablo LE, García-Feijoó J
Arch Soc Esp Oftalmol 2015 Mar;90(3):119-38. Epub 2014 Nov 15 doi: 10.1016/j.oftal.2014.09.014. PMID: 25459683
Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis.
Tham YC, Li X, Wong TY, Quigley HA, Aung T, Cheng CY
Ophthalmology 2014 Nov;121(11):2081-90. Epub 2014 Jun 26 doi: 10.1016/j.ophtha.2014.05.013. PMID: 24974815

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