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Heart block

MedGen UID:
42363
•Concept ID:
C0018794
•
Disease or Syndrome; Finding
Synonyms: Block, Heart; Blocks, Heart; Heart Block; Heart Blocks
SNOMED CT: Heart block (233916004); HB - Heart block (233916004)
 
HPO: HP:0012722

Definition

Impaired conduction of cardiac impulse occurring anywhere along the conduction pathway. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHeart block

Conditions with this feature

Meier-Gorlin syndrome 7
MedGen UID:
934705
•Concept ID:
C4310738
•
Disease or Syndrome
Any Meier-Gorlin syndrome in which the cause of the disease is a mutation in the CDC45 gene.
See: Condition Record
Meier-Gorlin syndrome 7

Professional guidelines

PubMed

Fetal Arrhythmia Diagnosis and Pharmacologic Management.
Strasburger JF, Eckstein G, Butler M, Noffke P, Wacker-Gussmann A
J Clin Pharmacol 2022 Sep;62 Suppl 1(Suppl 1):S53-S66. doi: 10.1002/jcph.2129. PMID: 36106782Free PMC Article
2018 ACC/AHA/HRS Guideline on the Evaluation and Management of Patients With Bradycardia and Cardiac Conduction Delay: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society.
Kusumoto FM, Schoenfeld MH, Barrett C, Edgerton JR, Ellenbogen KA, Gold MR, Goldschlager NF, Hamilton RM, Joglar JA, Kim RJ, Lee R, Marine JE, McLeod CJ, Oken KR, Patton KK, Pellegrini CN, Selzman KA, Thompson A, Varosy PD
Circulation 2019 Aug 20;140(8):e382-e482. Epub 2018 Nov 6 doi: 10.1161/CIR.0000000000000628. PMID: 30586772
HRS expert consensus statement on the diagnosis and management of arrhythmias associated with cardiac sarcoidosis.
Birnie DH, Sauer WH, Bogun F, Cooper JM, Culver DA, Duvernoy CS, Judson MA, Kron J, Mehta D, Cosedis Nielsen J, Patel AR, Ohe T, Raatikainen P, Soejima K
Heart Rhythm 2014 Jul;11(7):1305-23. Epub 2014 May 9 doi: 10.1016/j.hrthm.2014.03.043. PMID: 24819193

Recent clinical studies

Etiology

Congenital Heart Block.
Steinberg L
Cardiol Clin 2023 Aug;41(3):399-410. doi: 10.1016/j.ccl.2023.03.002. PMID: 37321690
Congenital Heart Block.
Steinberg L
Card Electrophysiol Clin 2021 Dec;13(4):691-702. doi: 10.1016/j.ccep.2021.07.006. PMID: 34689896
Hydroxychloroquine to Prevent Recurrent Congenital Heart Block in Fetuses of Anti-SSA/Ro-Positive Mothers.
Izmirly P, Kim M, Friedman DM, Costedoat-Chalumeau N, Clancy R, Copel JA, Phoon CKL, Cuneo BF, Cohen RE, Robins K, Masson M, Wainwright BJ, Zahr N, Saxena A, Buyon JP
J Am Coll Cardiol 2020 Jul 21;76(3):292-302. doi: 10.1016/j.jacc.2020.05.045. PMID: 32674792Free PMC Article
Fetal dysrhythmias.
Carvalho JS
Best Pract Res Clin Obstet Gynaecol 2019 Jul;58:28-41. Epub 2019 Jan 9 doi: 10.1016/j.bpobgyn.2019.01.002. PMID: 30738635
Cardiac manifestations of systemic lupus erythematosus.
Miner JJ, Kim AH
Rheum Dis Clin North Am 2014 Feb;40(1):51-60. doi: 10.1016/j.rdc.2013.10.003. PMID: 24268009

Diagnosis

Congenital Heart Block.
Steinberg L
Cardiol Clin 2023 Aug;41(3):399-410. doi: 10.1016/j.ccl.2023.03.002. PMID: 37321690
Congenital Heart Block.
Steinberg L
Card Electrophysiol Clin 2021 Dec;13(4):691-702. doi: 10.1016/j.ccep.2021.07.006. PMID: 34689896
Autoimmune-mediated congenital heart block.
Wainwright B, Bhan R, Trad C, Cohen R, Saxena A, Buyon J, Izmirly P
Best Pract Res Clin Obstet Gynaecol 2020 Apr;64:41-51. Epub 2019 Oct 8 doi: 10.1016/j.bpobgyn.2019.09.001. PMID: 31685414
Prenatal diagnosis and management of congenital complete heart block.
Pruetz JD, Miller JC, Loeb GE, Silka MJ, Bar-Cohen Y, Chmait RH
Birth Defects Res 2019 May 1;111(8):380-388. Epub 2019 Mar 1 doi: 10.1002/bdr2.1459. PMID: 30821931Free PMC Article
Neonatal congenital heart block.
Yildirim A, Tunaoolu FS, Karaaoac AT
Indian Pediatr 2013 May 8;50(5):483-8. doi: 10.1007/s13312-013-0156-3. PMID: 23778728

Therapy

Electrocautery-Induced Complete Heart Block.
Alghanem H, Patoli D, Greenberg SB, Szokol JW, Silk VL
J Cardiothorac Vasc Anesth 2021 Jul;35(7):2230-2232. Epub 2020 Nov 10 doi: 10.1053/j.jvca.2020.11.018. PMID: 33268040
Beta-blockers for congestive heart failure in children.
Alabed S, Sabouni A, Al Dakhoul S, Bdaiwi Y
Cochrane Database Syst Rev 2020 Jul 23;7(7):CD007037. doi: 10.1002/14651858.CD007037.pub4. PMID: 32700759Free PMC Article
Hydroxychloroquine to Prevent Recurrent Congenital Heart Block in Fetuses of Anti-SSA/Ro-Positive Mothers.
Izmirly P, Kim M, Friedman DM, Costedoat-Chalumeau N, Clancy R, Copel JA, Phoon CKL, Cuneo BF, Cohen RE, Robins K, Masson M, Wainwright BJ, Zahr N, Saxena A, Buyon JP
J Am Coll Cardiol 2020 Jul 21;76(3):292-302. doi: 10.1016/j.jacc.2020.05.045. PMID: 32674792Free PMC Article
Fetal dysrhythmias.
Carvalho JS
Best Pract Res Clin Obstet Gynaecol 2019 Jul;58:28-41. Epub 2019 Jan 9 doi: 10.1016/j.bpobgyn.2019.01.002. PMID: 30738635
Beta-blockers for congestive heart failure in children.
Alabed S, Sabouni A, Al Dakhoul S, Bdaiwi Y, Frobel-Mercier AK
Cochrane Database Syst Rev 2016 Jan 28;(1):CD007037. doi: 10.1002/14651858.CD007037.pub3. PMID: 26820557

Prognosis

Transcatheter aortic valve replacement and cardiac conduction.
Shreenivas S, Schloss E, Choo J, Sarembock I, Lilly S, Kereiakes D
Expert Rev Cardiovasc Ther 2019 Apr;17(4):293-304. doi: 10.1080/14779072.2019.1598264. PMID: 30912984
Congenitally corrected transposition.
Wallis GA, Debich-Spicer D, Anderson RH
Orphanet J Rare Dis 2011 May 14;6:22. doi: 10.1186/1750-1172-6-22. PMID: 21569592Free PMC Article
Athletes and arrhythmias.
Link MS, Estes NA
J Cardiovasc Electrophysiol 2010 Oct;21(10):1184-9. doi: 10.1111/j.1540-8167.2010.01808.x. PMID: 20522153
Postoperative arrhythmia.
Lan YT, Lee JC, Wetzel G
Curr Opin Cardiol 2003 Mar;18(2):73-8. doi: 10.1097/00001573-200303000-00001. PMID: 12652209
Neonatal lupus erythematosus.
Lee LA
J Invest Dermatol 1993 Jan;100(1):9S-13S. doi: 10.1111/1523-1747.ep12355173. PMID: 8423406

Clinical prediction guides

Autoimmune-mediated congenital heart block.
Wainwright B, Bhan R, Trad C, Cohen R, Saxena A, Buyon J, Izmirly P
Best Pract Res Clin Obstet Gynaecol 2020 Apr;64:41-51. Epub 2019 Oct 8 doi: 10.1016/j.bpobgyn.2019.09.001. PMID: 31685414
Arrhythmogenic Anticancer Drugs in Cardio-Oncology.
Rhea I, Burgos PH, Fradley MG
Cardiol Clin 2019 Nov;37(4):459-468. doi: 10.1016/j.ccl.2019.07.011. PMID: 31587787
Cardiac manifestations of systemic lupus erythematosus.
Miner JJ, Kim AH
Rheum Dis Clin North Am 2014 Feb;40(1):51-60. doi: 10.1016/j.rdc.2013.10.003. PMID: 24268009
Syncope diagnostic scores.
Sheldon R
Prog Cardiovasc Dis 2013 Jan-Feb;55(4):390-5. doi: 10.1016/j.pcad.2012.10.011. PMID: 23472776
Pregnancy in lupus.
Meng C, Lockshin M
Curr Opin Rheumatol 1999 Sep;11(5):348-51. doi: 10.1097/00002281-199909000-00004. PMID: 10503653

Recent systematic reviews

Characteristics of bradyarrhythmia in patients with COVID-19: Systematic scoping review.
Nagamine T, Randhawa S, Nishimura Y, Huang R, Leesutipornchai T, Benavente K, Yoshimura S, Zhang J, Kanitsorphan C
Pacing Clin Electrophysiol 2022 Apr;45(4):556-566. Epub 2022 Mar 3 doi: 10.1111/pace.14466. PMID: 35182433Free PMC Article
Beta-blockers for congestive heart failure in children.
Alabed S, Sabouni A, Al Dakhoul S, Bdaiwi Y
Cochrane Database Syst Rev 2020 Jul 23;7(7):CD007037. doi: 10.1002/14651858.CD007037.pub4. PMID: 32700759Free PMC Article
Outcome of prenatally diagnosed fetal heterotaxy: systematic review and meta-analysis.
Buca DIP, Khalil A, Rizzo G, Familiari A, Di Giovanni S, Liberati M, Murgano D, Ricciardulli A, Fanfani F, Scambia G, D'Antonio F
Ultrasound Obstet Gynecol 2018 Mar;51(3):323-330. doi: 10.1002/uog.17546. PMID: 28603940
Clinical and electrocardiographic features of complete heart block after blunt cardiac injury: A systematic review of the literature.
Ali H, Furlanello F, Lupo P, Foresti S, De Ambroggi G, Epicoco G, Semprini L, Fundaliotis A, Cappato R
Heart Rhythm 2017 Oct;14(10):1561-1569. Epub 2017 Jun 3 doi: 10.1016/j.hrthm.2017.05.040. PMID: 28583850
Prolonged PR interval, first-degree heart block and adverse cardiovascular outcomes: a systematic review and meta-analysis.
Kwok CS, Rashid M, Beynon R, Barker D, Patwala A, Morley-Davies A, Satchithananda D, Nolan J, Myint PK, Buchan I, Loke YK, Mamas MA
Heart 2016 May;102(9):672-80. Epub 2016 Feb 15 doi: 10.1136/heartjnl-2015-308956. PMID: 26879241

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