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Monoclonal Immunoglobulin Deposition Disease

MedGen UID:
423650
Concept ID:
C2939462
Neoplastic Process
Synonyms: Immunoglobulin deposition disease; Immunoglobulin Deposition Disease; Primary amyloidosis; Systemic light chain disease
SNOMED CT: Systemic light chain disease (128817004); Primary amyloidosis (128817004); Immunoglobulin deposition disease (128817004)

Definition

A plasma cell neoplasm characterized by the deposition of immunoglobulin in tissues, resulting in impaired organ function. It includes the following entities: primary amyloidosis, heavy chain deposition disease, and light chain deposition disease. [from NCI]

Professional guidelines

PubMed

Gavriatopoulou M, Musto P, Caers J, Merlini G, Kastritis E, van de Donk N, Gay F, Hegenbart U, Hajek R, Zweegman S, Bruno B, Straka C, Dimopoulos MA, Einsele H, Boccadoro M, Sonneveld P, Engelhardt M, Terpos E
Leukemia 2018 Sep;32(9):1883-1898. Epub 2018 Jul 23 doi: 10.1038/s41375-018-0209-7. PMID: 30038381
Ziogas DC, Kastritis E, Terpos E, Roussou M, Migkou M, Gavriatopoulou M, Spanomichou D, Eleutherakis-Papaiakovou E, Fotiou D, Panagiotidis I, Kafantari E, Psimenou E, Boletis I, Vlahakos DV, Gakiopoulou H, Matsouka C, Dimopoulos MA
Leuk Lymphoma 2017 Aug;58(8):1832-1839. Epub 2016 Dec 14 doi: 10.1080/10428194.2016.1267349. PMID: 27967286

Recent clinical studies

Etiology

Tewari R, Chatterjee T, Mendonca S, Dogra M, Pramanik SK, Yanamandra U
Saudi J Kidney Dis Transpl 2021 Mar-Apr;32(2):298-306. doi: 10.4103/1319-2442.335440. PMID: 35017322
Joly F, Cohen C, Javaugue V, Bender S, Belmouaz M, Arnulf B, Knebelmann B, Nouvier M, Audard V, Provot F, Gnemmi V, Nochy D, Goujon JM, Jaccard A, Touchard G, Fermand JP, Sirac C, Bridoux F
Blood 2019 Feb 7;133(6):576-587. Epub 2018 Dec 21 doi: 10.1182/blood-2018-09-872028. PMID: 30578255
Kourelis TV, Nasr SH, Dispenzieri A, Kumar SK, Gertz MA, Fervenza FC, Buadi FK, Lacy MQ, Erickson SB, Cosio FG, Kapoor P, Lust JA, Hayman SR, Rajkumar V, Zeldenrust SR, Russell SJ, Dingli D, Lin Y, Gonsalves W, Lorenz EC, Zand L, Kyle RA, Leung N
Am J Hematol 2016 Nov;91(11):1123-1128. Epub 2016 Aug 29 doi: 10.1002/ajh.24528. PMID: 27501122
Stratta P, Gravellone L, Cena T, Rossi D, Gaidano G, Fenoglio R, Lazzarich E, Quaglia M, Airoldi A, Bozzola C, Monga G, Valente G, Canavese C, Magnani C
Crit Rev Oncol Hematol 2011 Jul;79(1):31-42. Epub 2010 May 31 doi: 10.1016/j.critrevonc.2010.05.001. PMID: 20570173
Buxbaum J, Gallo G
Hematol Oncol Clin North Am 1999 Dec;13(6):1235-48. doi: 10.1016/s0889-8588(05)70123-4. PMID: 10626147

Diagnosis

Joly F, Cohen C, Javaugue V, Bender S, Belmouaz M, Arnulf B, Knebelmann B, Nouvier M, Audard V, Provot F, Gnemmi V, Nochy D, Goujon JM, Jaccard A, Touchard G, Fermand JP, Sirac C, Bridoux F
Blood 2019 Feb 7;133(6):576-587. Epub 2018 Dec 21 doi: 10.1182/blood-2018-09-872028. PMID: 30578255
Chan JK
Int J Surg Pathol 2014 Feb;22(1):12-32. Epub 2014 Jan 9 doi: 10.1177/1066896913517939. PMID: 24406626
Oe Y, Soma J, Sato H, Ito S
Clin Exp Nephrol 2013 Dec;17(6):771-8. Epub 2013 May 8 doi: 10.1007/s10157-013-0812-x. PMID: 23652830
Stratta P, Gravellone L, Cena T, Rossi D, Gaidano G, Fenoglio R, Lazzarich E, Quaglia M, Airoldi A, Bozzola C, Monga G, Valente G, Canavese C, Magnani C
Crit Rev Oncol Hematol 2011 Jul;79(1):31-42. Epub 2010 May 31 doi: 10.1016/j.critrevonc.2010.05.001. PMID: 20570173
Merlini G, Stone MJ
Blood 2006 Oct 15;108(8):2520-30. Epub 2006 Jun 22 doi: 10.1182/blood-2006-03-001164. PMID: 16794250

Therapy

Mizuno S, Kitayama C, Sanada S, Sato T
CEN Case Rep 2021 Nov;10(4):537-542. Epub 2021 Apr 28 doi: 10.1007/s13730-021-00603-z. PMID: 33909224Free PMC Article
Joly F, Cohen C, Javaugue V, Bender S, Belmouaz M, Arnulf B, Knebelmann B, Nouvier M, Audard V, Provot F, Gnemmi V, Nochy D, Goujon JM, Jaccard A, Touchard G, Fermand JP, Sirac C, Bridoux F
Blood 2019 Feb 7;133(6):576-587. Epub 2018 Dec 21 doi: 10.1182/blood-2018-09-872028. PMID: 30578255
Ziogas DC, Kastritis E, Terpos E, Roussou M, Migkou M, Gavriatopoulou M, Spanomichou D, Eleutherakis-Papaiakovou E, Fotiou D, Panagiotidis I, Kafantari E, Psimenou E, Boletis I, Vlahakos DV, Gakiopoulou H, Matsouka C, Dimopoulos MA
Leuk Lymphoma 2017 Aug;58(8):1832-1839. Epub 2016 Dec 14 doi: 10.1080/10428194.2016.1267349. PMID: 27967286
Kourelis TV, Nasr SH, Dispenzieri A, Kumar SK, Gertz MA, Fervenza FC, Buadi FK, Lacy MQ, Erickson SB, Cosio FG, Kapoor P, Lust JA, Hayman SR, Rajkumar V, Zeldenrust SR, Russell SJ, Dingli D, Lin Y, Gonsalves W, Lorenz EC, Zand L, Kyle RA, Leung N
Am J Hematol 2016 Nov;91(11):1123-1128. Epub 2016 Aug 29 doi: 10.1002/ajh.24528. PMID: 27501122
Canaud G, Audard V, Kofman T, Lang P, Legendre C, Grimbert P
Transpl Int 2012 Aug;25(8):812-24. Epub 2012 Apr 16 doi: 10.1111/j.1432-2277.2012.01483.x. PMID: 22507183

Prognosis

Joly F, Cohen C, Javaugue V, Bender S, Belmouaz M, Arnulf B, Knebelmann B, Nouvier M, Audard V, Provot F, Gnemmi V, Nochy D, Goujon JM, Jaccard A, Touchard G, Fermand JP, Sirac C, Bridoux F
Blood 2019 Feb 7;133(6):576-587. Epub 2018 Dec 21 doi: 10.1182/blood-2018-09-872028. PMID: 30578255
Kourelis TV, Nasr SH, Dispenzieri A, Kumar SK, Gertz MA, Fervenza FC, Buadi FK, Lacy MQ, Erickson SB, Cosio FG, Kapoor P, Lust JA, Hayman SR, Rajkumar V, Zeldenrust SR, Russell SJ, Dingli D, Lin Y, Gonsalves W, Lorenz EC, Zand L, Kyle RA, Leung N
Am J Hematol 2016 Nov;91(11):1123-1128. Epub 2016 Aug 29 doi: 10.1002/ajh.24528. PMID: 27501122
Stratta P, Gravellone L, Cena T, Rossi D, Gaidano G, Fenoglio R, Lazzarich E, Quaglia M, Airoldi A, Bozzola C, Monga G, Valente G, Canavese C, Magnani C
Crit Rev Oncol Hematol 2011 Jul;79(1):31-42. Epub 2010 May 31 doi: 10.1016/j.critrevonc.2010.05.001. PMID: 20570173
Masai R, Wakui H, Togashi M, Maki N, Ohtani H, Komatsuda A, Sawada K
Clin Nephrol 2009 Jan;71(1):9-20. doi: 10.5414/cnp71009. PMID: 19203545
Buxbaum J, Gallo G
Hematol Oncol Clin North Am 1999 Dec;13(6):1235-48. doi: 10.1016/s0889-8588(05)70123-4. PMID: 10626147

Clinical prediction guides

Jacquet-Francillon N, Dijoud F, Karlin L, Dietz M, Flaus A, Tordo J
Clin Nucl Med 2023 Dec 1;48(12):e611-e613. Epub 2023 Oct 23 doi: 10.1097/RLU.0000000000004927. PMID: 37883135
Tewari R, Chatterjee T, Mendonca S, Dogra M, Pramanik SK, Yanamandra U
Saudi J Kidney Dis Transpl 2021 Mar-Apr;32(2):298-306. doi: 10.4103/1319-2442.335440. PMID: 35017322
Joly F, Cohen C, Javaugue V, Bender S, Belmouaz M, Arnulf B, Knebelmann B, Nouvier M, Audard V, Provot F, Gnemmi V, Nochy D, Goujon JM, Jaccard A, Touchard G, Fermand JP, Sirac C, Bridoux F
Blood 2019 Feb 7;133(6):576-587. Epub 2018 Dec 21 doi: 10.1182/blood-2018-09-872028. PMID: 30578255
Kourelis TV, Nasr SH, Dispenzieri A, Kumar SK, Gertz MA, Fervenza FC, Buadi FK, Lacy MQ, Erickson SB, Cosio FG, Kapoor P, Lust JA, Hayman SR, Rajkumar V, Zeldenrust SR, Russell SJ, Dingli D, Lin Y, Gonsalves W, Lorenz EC, Zand L, Kyle RA, Leung N
Am J Hematol 2016 Nov;91(11):1123-1128. Epub 2016 Aug 29 doi: 10.1002/ajh.24528. PMID: 27501122
Chan JK
Int J Surg Pathol 2014 Feb;22(1):12-32. Epub 2014 Jan 9 doi: 10.1177/1066896913517939. PMID: 24406626

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