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Hemangioendothelioma

MedGen UID:
42384
Concept ID:
C0018915
Neoplastic Process
Synonyms: Endothelioma, Vascular; Endotheliomas, Vascular; Hemangio Endothelioma; Hemangio-Endothelioma; Hemangio-Endotheliomas; Hemangioendotheliomas; Vascular Endothelioma; Vascular Endotheliomas
SNOMED CT: Hemangioendothelioma (66229009); Angioendothelioma (66229009); Hemangioendothelioma (403980002)
 
Monarch Initiative: MONDO:0021121

Definition

A vascular proliferation characterized by the presence of prominent endothelial cells and the formation of vascular channels. Hemangioendotheliomas may display borderline or low grade characteristics. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHemangioendothelioma

Professional guidelines

PubMed

Subramaniam A, Giani C, Napolitano A, Ravi V, Frezza AM, Jones RL
Surg Oncol Clin N Am 2022 Jul;31(3):485-510. doi: 10.1016/j.soc.2022.03.014. PMID: 35715146
Rosenberg A, Agulnik M
Curr Treat Options Oncol 2018 Mar 15;19(4):19. doi: 10.1007/s11864-018-0536-y. PMID: 29546487
Liu XH, Li JY, Qu XH, Yan WL, Zhang L, Yang C, Zheng JW
Int J Cancer 2016 Oct 1;139(7):1658-66. Epub 2016 Jun 28 doi: 10.1002/ijc.30216. PMID: 27252149

Recent clinical studies

Etiology

Folpe AL
Hum Pathol 2024 May;147:114-128. Epub 2024 Feb 13 doi: 10.1016/j.humpath.2024.01.014. PMID: 38360216
Torrence D, Antonescu CR
Histopathology 2022 Jan;80(1):19-32. doi: 10.1111/his.14458. PMID: 34958509Free PMC Article
Stacchiotti S, Miah AB, Frezza AM, Messiou C, Morosi C, Caraceni A, Antonescu CR, Bajpai J, Baldini E, Bauer S, Biagini R, Bielack S, Blay JY, Bonvalot S, Boukovinas I, Bovee JVMG, Boye K, Brodowicz T, Callegaro D, De Alava E, Deoras-Sutliff M, Dufresne A, Eriksson M, Errani C, Fedenko A, Ferraresi V, Ferrari A, Fletcher CDM, Garcia Del Muro X, Gelderblom H, Gladdy RA, Gouin F, Grignani G, Gutkovich J, Haas R, Hindi N, Hohenberger P, Huang P, Joensuu H, Jones RL, Jungels C, Kasper B, Kawai A, Le Cesne A, Le Grange F, Leithner A, Leonard H, Lopez Pousa A, Martin Broto J, Merimsky O, Merriam P, Miceli R, Mir O, Molinari M, Montemurro M, Oldani G, Palmerini E, Pantaleo MA, Patel S, Piperno-Neumann S, Raut CP, Ravi V, Razak ARA, Reichardt P, Rubin BP, Rutkowski P, Safwat AA, Sangalli C, Sapisochin G, Sbaraglia M, Scheipl S, Schöffski P, Strauss D, Strauss SJ, Sundby Hall K, Tap WD, Trama A, Tweddle A, van der Graaf WTA, Van De Sande MAJ, Van Houdt W, van Oortmerssen G, Wagner AJ, Wartenberg M, Wood J, Zaffaroni N, Zimmermann C, Casali PG, Dei Tos AP, Gronchi A
ESMO Open 2021 Jun;6(3):100170. Epub 2021 Jun 2 doi: 10.1016/j.esmoop.2021.100170. PMID: 34090171Free PMC Article
Ji Y, Chen S, Yang K, Xia C, Li L
Orphanet J Rare Dis 2020 Feb 3;15(1):39. doi: 10.1186/s13023-020-1320-1. PMID: 32014025Free PMC Article
Ha C, Regan J, Cetindag IB, Ali A, Mellinger JD
Surg Clin North Am 2015 Jun;95(3):491-514. Epub 2015 Mar 21 doi: 10.1016/j.suc.2015.02.005. PMID: 25965126

Diagnosis

Al-Qaderi A, Mansour AT
Arch Pathol Lab Med 2019 Jun;143(6):763-767. Epub 2018 Dec 21 doi: 10.5858/arpa.2017-0430-RS. PMID: 30576238
Rosenberg A, Agulnik M
Curr Treat Options Oncol 2018 Mar 15;19(4):19. doi: 10.1007/s11864-018-0536-y. PMID: 29546487
Horan NA, DiMaio DJ
Cutis 2017 Dec;100(6):E13-E16. PMID: 29360904
Shon W, Billings SD
Clin Lab Med 2017 Sep;37(3):633-646. Epub 2017 Jul 13 doi: 10.1016/j.cll.2017.06.004. PMID: 28802504
MACOMBER WB, WANG MK
GP 1953 Nov;8(5):41-9. PMID: 13107859

Therapy

Pati S, Das MK, Rana A, Das E, Sarkar S, Sherpa N, Datta S
Indian J Pediatr 2021 Nov;88(11):1142-1144. Epub 2021 Jun 9 doi: 10.1007/s12098-021-03817-2. PMID: 34106442
Rosenberg A, Agulnik M
Curr Treat Options Oncol 2018 Mar 15;19(4):19. doi: 10.1007/s11864-018-0536-y. PMID: 29546487
Haberal Reyhan N
Exp Clin Transplant 2017 Mar;15(Suppl 2):69-73. doi: 10.6002/ect.TOND16.L18. PMID: 28302003
Liu XH, Li JY, Qu XH, Yan WL, Zhang L, Yang C, Zheng JW
Int J Cancer 2016 Oct 1;139(7):1658-66. Epub 2016 Jun 28 doi: 10.1002/ijc.30216. PMID: 27252149
Ravi V, Patel S
Curr Oncol Rep 2013 Aug;15(4):347-55. doi: 10.1007/s11912-013-0328-2. PMID: 23852636

Prognosis

Caballero GA, Roitman PD
Arch Pathol Lab Med 2020 Apr;144(4):529-533. Epub 2019 Apr 24 doi: 10.5858/arpa.2018-0395-RS. PMID: 31017450
Al-Qaderi A, Mansour AT
Arch Pathol Lab Med 2019 Jun;143(6):763-767. Epub 2018 Dec 21 doi: 10.5858/arpa.2017-0430-RS. PMID: 30576238
Studer LL, Selby DM
Arch Pathol Lab Med 2018 Feb;142(2):263-267. doi: 10.5858/arpa.2016-0171-RS. PMID: 29372848
Shon W, Billings SD
Clin Lab Med 2017 Sep;37(3):633-646. Epub 2017 Jul 13 doi: 10.1016/j.cll.2017.06.004. PMID: 28802504
Antonescu C
Mod Pathol 2014 Jan;27 Suppl 1:S30-8. doi: 10.1038/modpathol.2013.176. PMID: 24384851

Clinical prediction guides

Paulson KG, Ravi V, Rubin BP, Park M, Loggers ET, Cranmer LD, Wagner MJ
Cancer Med 2023 Jul;12(14):15101-15106. Epub 2023 Jun 1 doi: 10.1002/cam4.6181. PMID: 37260142Free PMC Article
Rosenbaum E, Jadeja B, Xu B, Zhang L, Agaram NP, Travis W, Singer S, Tap WD, Antonescu CR
Mod Pathol 2020 Apr;33(4):591-602. Epub 2019 Sep 19 doi: 10.1038/s41379-019-0368-8. PMID: 31537895Free PMC Article
Schaefer IM, Hornick JL
Adv Anat Pathol 2018 Nov;25(6):400-412. doi: 10.1097/PAP.0000000000000204. PMID: 30134255Free PMC Article
Antonescu C
Mod Pathol 2014 Jan;27 Suppl 1:S30-8. doi: 10.1038/modpathol.2013.176. PMID: 24384851
Ravi V, Patel S
Curr Oncol Rep 2013 Aug;15(4):347-55. doi: 10.1007/s11912-013-0328-2. PMID: 23852636

Recent systematic reviews

Maza-Morales M, Valdés-Loperena S, Durán-McKinster LC, García-Romero MT
Pediatr Dermatol 2023 May-Jun;40(3):440-445. Epub 2023 Jan 30 doi: 10.1111/pde.15262. PMID: 36716766
Martins ACA, Costa Neto DCD, Silva JDDE, Moraes YM, LeÃo CS, Martins C
Rev Col Bras Cir 2020;47:e20202647. Epub 2020 Nov 30 doi: 10.1590/0100-6991e-20202647. PMID: 33263653
Liu XH, Li JY, Qu XH, Yan WL, Zhang L, Yang C, Zheng JW
Int J Cancer 2016 Oct 1;139(7):1658-66. Epub 2016 Jun 28 doi: 10.1002/ijc.30216. PMID: 27252149
Surov A, Gottschling S, Wienke A, Meyer HJ, Spielmann RP, Dralle H
Anticancer Res 2015 Oct;35(10):5185-91. PMID: 26408676
Ravaioli M, Ercolani G, Neri F, Cescon M, Stacchini G, Del Gaudio M, Cucchetti A, Pinna AD
World J Gastroenterol 2014 May 14;20(18):5345-52. doi: 10.3748/wjg.v20.i18.5345. PMID: 24833864Free PMC Article

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