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Idiopathic growth hormone deficiency(IGHD)

MedGen UID:
450529
Concept ID:
C0342381
Disease or Syndrome
Synonym: IGHD
SNOMED CT: Idiopathic growth hormone insufficiency (237688008); IGHD - Idiopathic growth hormone deficiency (237688008); Idiopathic growth hormone deficiency (237688008)
 
Related genes: GH1, BTK

Professional guidelines

PubMed

Al Shaikh A, Daftardar H, Alghamdi AA, Jamjoom M, Awidah S, Ahmed ME, Soliman AT
Acta Biomed 2020 Mar 19;91(1):29-40. doi: 10.23750/abm.v91i1.9182. PMID: 32191651Free PMC Article
Grimberg A, Allen DB
Curr Opin Pediatr 2017 Aug;29(4):466-471. doi: 10.1097/MOP.0000000000000505. PMID: 28525404Free PMC Article
Grimberg A, DiVall SA, Polychronakos C, Allen DB, Cohen LE, Quintos JB, Rossi WC, Feudtner C, Murad MH; Drug and Therapeutics Committee and Ethics Committee of the Pediatric Endocrine Society
Horm Res Paediatr 2016;86(6):361-397. Epub 2016 Nov 25 doi: 10.1159/000452150. PMID: 27884013

Recent clinical studies

Etiology

Sánchez Malo MJ, Hidalgo Sanz J, Hernández Tejedor C, García Ventura M, Ferrer Lozano M, Labarta Aizpún JI, de Arriba Muñoz A
An Pediatr (Engl Ed) 2022 Mar;96(3):221-229. Epub 2022 Feb 28 doi: 10.1016/j.anpede.2021.04.008. PMID: 35241406
Sánchez Malo MJ, Hidalgo Sanz J, Hernández Abadía R, Arlabán Carpintero L, Ferrer Lozano M, Labarta Aizpún JI, de Arriba Muñoz A
Endocrinol Diabetes Nutr (Engl Ed) 2021 Oct;68(8):534-541. Epub 2021 Nov 24 doi: 10.1016/j.endien.2021.11.013. PMID: 34872636
Al Shaikh A, Daftardar H, Alghamdi AA, Jamjoom M, Awidah S, Ahmed ME, Soliman AT
Acta Biomed 2020 Mar 19;91(1):29-40. doi: 10.23750/abm.v91i1.9182. PMID: 32191651Free PMC Article
Kurnaz E, Çetinkaya S, Aycan Z
J Paediatr Child Health 2018 Nov;54(11):1221-1226. Epub 2018 May 28 doi: 10.1111/jpc.14061. PMID: 29806866
Rona RJ, Tanner JM
Arch Dis Child 1977 Mar;52(3):197-208. doi: 10.1136/adc.52.3.197. PMID: 848998Free PMC Article

Diagnosis

Smyczyńska J, Hilczer M, Smyczyńska U, Lewiński A, Stawerska R
Int J Mol Sci 2024 May 24;25(11) doi: 10.3390/ijms25115739. PMID: 38891927Free PMC Article
Witt S, Bloemeke J, Bullinger M, Dörr HG, Silva N, Quitmann JH
J Pediatr Endocrinol Metab 2024 Apr 25;37(4):326-335. Epub 2024 Mar 1 doi: 10.1515/jpem-2023-0420. PMID: 38421314
Gizli Çoban Ö, Bedel A, Önder A, Sürer Adanır A, Tuhan H, Parlak M
Clin Pediatr (Phila) 2022 Oct;61(10):684-691. Epub 2022 May 17 doi: 10.1177/00099228221096654. PMID: 35581721
Galazzi E, Persani LG
Minerva Endocrinol 2020 Dec;45(4):354-375. Epub 2020 Jul 23 doi: 10.23736/S0391-1977.20.03228-9. PMID: 32720501
Pfäffle R, Blankenstein O, Wüller S, Heimann K, Heimann G
Horm Res 2000;53 Suppl 3:1-8. doi: 10.1159/000023524. PMID: 10971095

Therapy

Smyczyńska J, Hilczer M, Smyczyńska U, Lewiński A, Stawerska R
Int J Mol Sci 2024 May 24;25(11) doi: 10.3390/ijms25115739. PMID: 38891927Free PMC Article
Sánchez Malo MJ, Hidalgo Sanz J, Hernández Tejedor C, García Ventura M, Ferrer Lozano M, Labarta Aizpún JI, de Arriba Muñoz A
An Pediatr (Engl Ed) 2022 Mar;96(3):221-229. Epub 2022 Feb 28 doi: 10.1016/j.anpede.2021.04.008. PMID: 35241406
Al Shaikh A, Daftardar H, Alghamdi AA, Jamjoom M, Awidah S, Ahmed ME, Soliman AT
Acta Biomed 2020 Mar 19;91(1):29-40. doi: 10.23750/abm.v91i1.9182. PMID: 32191651Free PMC Article
Grimberg A, Allen DB
Curr Opin Pediatr 2017 Aug;29(4):466-471. doi: 10.1097/MOP.0000000000000505. PMID: 28525404Free PMC Article
Ranke MB, Lindberg A
Horm Res Paediatr 2011;75(6):423-32. Epub 2011 Feb 25 doi: 10.1159/000324117. PMID: 21358173

Prognosis

Sánchez Malo MJ, Hidalgo Sanz J, Hernández Tejedor C, García Ventura M, Ferrer Lozano M, Labarta Aizpún JI, de Arriba Muñoz A
An Pediatr (Engl Ed) 2022 Mar;96(3):221-229. Epub 2022 Feb 28 doi: 10.1016/j.anpede.2021.04.008. PMID: 35241406
Galazzi E, Persani LG
Minerva Endocrinol 2020 Dec;45(4):354-375. Epub 2020 Jul 23 doi: 10.23736/S0391-1977.20.03228-9. PMID: 32720501
Al Shaikh A, Daftardar H, Alghamdi AA, Jamjoom M, Awidah S, Ahmed ME, Soliman AT
Acta Biomed 2020 Mar 19;91(1):29-40. doi: 10.23750/abm.v91i1.9182. PMID: 32191651Free PMC Article
Ranke MB, Lindberg A
Horm Res Paediatr 2011;75(6):423-32. Epub 2011 Feb 25 doi: 10.1159/000324117. PMID: 21358173
Wit JM, Kamp GA, Rikken B
Pediatr Res 1996 Feb;39(2):295-302. doi: 10.1203/00006450-199602000-00018. PMID: 8825803

Clinical prediction guides

Smyczyńska J, Hilczer M, Smyczyńska U, Lewiński A, Stawerska R
Int J Mol Sci 2024 May 24;25(11) doi: 10.3390/ijms25115739. PMID: 38891927Free PMC Article
Sánchez Malo MJ, Hidalgo Sanz J, Hernández Tejedor C, García Ventura M, Ferrer Lozano M, Labarta Aizpún JI, de Arriba Muñoz A
An Pediatr (Engl Ed) 2022 Mar;96(3):221-229. Epub 2022 Feb 28 doi: 10.1016/j.anpede.2021.04.008. PMID: 35241406
Galazzi E, Persani LG
Minerva Endocrinol 2020 Dec;45(4):354-375. Epub 2020 Jul 23 doi: 10.23736/S0391-1977.20.03228-9. PMID: 32720501
Al Shaikh A, Daftardar H, Alghamdi AA, Jamjoom M, Awidah S, Ahmed ME, Soliman AT
Acta Biomed 2020 Mar 19;91(1):29-40. doi: 10.23750/abm.v91i1.9182. PMID: 32191651Free PMC Article
Ranke MB, Lindberg A
Horm Res Paediatr 2011;75(6):423-32. Epub 2011 Feb 25 doi: 10.1159/000324117. PMID: 21358173

Recent systematic reviews

Zaffanello M, Pietrobelli A, Cavarzere P, Guzzo A, Antoniazzi F
Front Endocrinol (Lausanne) 2023;14:1332114. Epub 2024 Jan 24 doi: 10.3389/fendo.2023.1332114. PMID: 38327902Free PMC Article
Laurer E, Sirovina A, Blaschitz A, Tischlinger K, Montero-Lopez R, Hörtenhuber T, Wimleitner M, Högler W
Eur J Endocrinol 2022 Aug 1;187(2):265-278. Epub 2022 Jun 29 doi: 10.1530/EJE-21-1179. PMID: 35670597

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